PROJECT #19323 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 161,472

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 17,392,759 246,871 70.45 0 hrs 20 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 14,439,955 228,555 63.18 0 hrs 23 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,076,178 208,251 48.38 0 hrs 30 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,744,773 191,754 40.39 0 hrs 36 mins
5 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,638,064 189,007 40.41 0 hrs 36 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,486,173 178,965 36.24 0 hrs 40 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,306,460 165,204 32.12 0 hrs 45 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,271,869 169,067 31.18 0 hrs 46 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,045,732 166,075 30.38 0 hrs 47 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,998,035 165,097 30.27 0 hrs 48 mins
11 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,057,903 153,601 26.42 0 hrs 55 mins
12 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,649,232 145,514 25.08 0 hrs 57 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,647,664 148,870 24.50 0 hrs 59 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,360,591 143,695 23.39 1 hrs 2 mins
15 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,072,640 139,690 22.00 1 hrs 5 mins
16 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,964,581 137,665 21.53 1 hrs 7 mins
17 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,784,935 136,165 20.45 1 hrs 10 mins
18 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,738,010 134,210 20.40 1 hrs 11 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,608,590 123,639 21.10 1 hrs 8 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,424,033 130,343 18.60 1 hrs 17 mins
21 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,253,032 127,731 17.64 1 hrs 22 mins
22 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,067,205 123,586 16.73 1 hrs 26 mins
23 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,035,811 122,491 16.62 1 hrs 27 mins
24 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,962,450 120,927 16.23 1 hrs 29 mins
25 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,694,736 138,488 12.24 2 hrs 58 mins
26 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,193,934 100,313 11.90 2 hrs 1 mins
27 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,138,749 101,000 11.27 2 hrs 8 mins
28 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 1,014,763 95,345 10.64 2 hrs 15 mins
29 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 995,716 97,440 10.22 2 hrs 21 mins
30 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 983,199 92,283 10.65 2 hrs 15 mins
31 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 955,974 90,786 10.53 2 hrs 17 mins
32 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 586,619 80,563 7.28 3 hrs 18 mins
33 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 312,113 65,470 4.77 5 hrs 2 mins
34 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 206,101 57,309 3.60 7 hrs 40 mins
35 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 167,031 53,756 3.11 8 hrs 43 mins
36 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 166,880 42,826 3.90 6 hrs 10 mins
37 Radeon RX 460/560D
Baffin [Radeon RX 460/560D]
AMD Baffin 116,642 47,763 2.44 10 hrs 50 mins
38 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 91,208 43,497 2.10 11 hrs 27 mins
39 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 83,002 42,202 1.97 12 hrs 12 mins
40 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 62,048 33,141 1.87 13 hrs 49 mins
41 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 54,699 36,845 1.48 16 hrs 10 mins
42 Radeon PRO WX3100
Lexa XT [Radeon PRO WX3100]
AMD Lexa XT 36,923 38,047 0.97 25 hrs 44 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make