PROJECT #19323 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 161,472

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 29 March 2023 06:15:34

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 16,885,391 244,373 69.10 0 hrs 21 mins
2 GeForce RTX 4080
AD103 [GeForce RTX 4080]
Nvidia AD103 13,936,773 232,955 59.83 0 hrs 24 mins
3 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 10,039,109 209,545 47.91 0 hrs 30 mins
4 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,446,335 188,534 39.50 0 hrs 36 mins
5 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,363,944 185,944 39.60 0 hrs 36 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,073,475 185,171 38.20 0 hrs 38 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,867,360 171,198 34.27 0 hrs 42 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,277,942 169,077 31.22 0 hrs 46 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,241,911 168,251 31.16 0 hrs 46 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,839,114 163,220 29.65 0 hrs 49 mins
11 Radeon RX 7900XT/XTX
Navi 31 [Radeon RX 7900XT/XTX]
AMD Navi 31 4,831,458 164,423 29.38 0 hrs 49 mins
12 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,484,804 160,340 27.97 0 hrs 51 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,913,807 152,015 25.75 0 hrs 56 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,653,550 148,926 24.53 0 hrs 59 mins
15 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,513,674 144,719 24.28 0 hrs 59 mins
16 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,360,591 143,695 23.39 1 hrs 2 mins
17 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,147,839 141,081 22.31 1 hrs 5 mins
18 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,964,581 137,665 21.53 1 hrs 7 mins
19 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,854,430 137,259 20.80 1 hrs 9 mins
20 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,763,733 128,100 21.57 1 hrs 7 mins
21 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,750,918 135,300 20.33 1 hrs 11 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,415,610 130,581 18.50 1 hrs 18 mins
23 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,350,720 128,715 18.26 1 hrs 19 mins
24 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,349,142 125,882 18.66 1 hrs 17 mins
25 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,078,993 123,663 16.81 1 hrs 26 mins
26 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,008,127 121,826 16.48 1 hrs 27 mins
27 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,962,450 120,927 16.23 1 hrs 29 mins
28 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 1,754,574 116,309 15.09 2 hrs 35 mins
29 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,694,736 138,488 12.24 2 hrs 58 mins
30 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,453,666 110,381 13.17 2 hrs 49 mins
31 Radeon RX 6650XT
Navi 23 [Radeon RX 6650XT]
AMD Navi 23 1,236,128 98,246 12.58 2 hrs 54 mins
32 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,212,679 101,402 11.96 2 hrs 0 mins
33 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,096,686 94,761 11.57 2 hrs 4 mins
34 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,084,505 99,498 10.90 2 hrs 12 mins
35 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,000,166 94,545 10.58 2 hrs 16 mins
36 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 983,199 92,283 10.65 2 hrs 15 mins
37 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 935,468 88,537 10.57 2 hrs 16 mins
38 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 873,294 92,739 9.42 3 hrs 33 mins
39 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 770,619 87,977 8.76 3 hrs 44 mins
40 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 706,763 86,668 8.15 3 hrs 57 mins
41 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 676,963 85,546 7.91 3 hrs 2 mins
42 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 506,843 76,958 6.59 4 hrs 39 mins
43 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 493,158 76,483 6.45 4 hrs 43 mins
44 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 479,672 75,756 6.33 4 hrs 47 mins
45 P106-090
GP106 [P106-090]
Nvidia GP106 363,981 69,109 5.27 5 hrs 33 mins
46 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 312,113 65,470 4.77 5 hrs 2 mins
47 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 206,101 57,309 3.60 7 hrs 40 mins
48 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 167,031 53,756 3.11 8 hrs 43 mins
49 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 166,880 42,826 3.90 6 hrs 10 mins
50 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 118,231 53,361 2.22 11 hrs 50 mins
51 Radeon RX 460/560D
Baffin [Radeon RX 460/560D]
AMD Baffin 116,642 47,763 2.44 10 hrs 50 mins
52 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 91,208 43,497 2.10 11 hrs 27 mins
53 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 62,048 33,141 1.87 13 hrs 49 mins
54 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 54,699 36,845 1.48 16 hrs 10 mins
55 Radeon PRO WX3100
Lexa XT [Radeon PRO WX3100]
AMD Lexa XT 36,923 38,047 0.97 25 hrs 44 mins
56 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 10,111 25,844 0.39 61 hrs 21 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 29 March 2023 06:15:34

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make