PROJECT #19316 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 185,988

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 16,199,781 279,329 58.00 0 hrs 25 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 8,545,701 229,947 37.16 0 hrs 39 mins
3 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 7,320,129 216,799 33.76 0 hrs 43 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,704,587 211,378 31.72 0 hrs 45 mins
5 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,502,882 211,199 30.79 0 hrs 47 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,253,518 194,411 27.02 0 hrs 53 mins
7 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,176,735 192,508 26.89 0 hrs 54 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,099,192 194,565 26.21 0 hrs 55 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,669,561 189,389 24.66 0 hrs 58 mins
10 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,436,044 185,388 23.93 1 hrs 0 mins
11 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,735,435 174,009 21.47 1 hrs 7 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,572,093 172,393 20.72 1 hrs 9 mins
13 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,441,851 166,736 20.64 1 hrs 10 mins
14 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,256,713 166,109 19.61 1 hrs 13 mins
15 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,961,483 162,508 18.22 1 hrs 19 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,944,358 161,788 18.20 1 hrs 19 mins
17 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,745,539 157,769 17.40 1 hrs 23 mins
18 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,744,801 157,583 17.42 1 hrs 23 mins
19 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,689,121 155,960 17.24 1 hrs 24 mins
20 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,651,056 147,122 18.02 1 hrs 20 mins
21 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,629,806 155,936 16.86 1 hrs 25 mins
22 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,406,465 151,492 15.89 2 hrs 31 mins
23 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,117,938 145,330 14.57 2 hrs 39 mins
24 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,868,010 139,331 13.41 2 hrs 47 mins
25 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,593,555 138,099 11.54 2 hrs 5 mins
26 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,268,960 122,190 10.39 2 hrs 19 mins
27 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,149,694 118,327 9.72 2 hrs 28 mins
28 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,136,476 117,665 9.66 2 hrs 29 mins
29 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,027,048 113,389 9.06 3 hrs 39 mins
30 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 998,349 110,719 9.02 3 hrs 40 mins
31 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 976,999 112,152 8.71 3 hrs 45 mins
32 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 757,081 103,134 7.34 3 hrs 16 mins
33 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 632,597 97,217 6.51 4 hrs 41 mins
34 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 506,200 90,082 5.62 4 hrs 16 mins
35 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 360,674 76,306 4.73 5 hrs 5 mins
36 Radeon RX 460/560D
Baffin [Radeon RX 460/560D]
AMD Baffin 77,499 39,065 1.98 12 hrs 6 mins
37 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 56,803 46,124 1.23 19 hrs 29 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make