PROJECT #19321 RESEARCH FOR AAA-PROTEIN-SUPERFAMILY
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Atomistic insights into AAA+ protein superfamily ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion.

Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis.

Typically, genomes encode approximately ten to several hundred AAA+ family members, each of which is thought to be adapted to specific functional niches that necessitate precise mechanisms of substrate recognition and processing.

The striking adaptive radiation of AAA+ proteins to operate in diverse settings illustrates the versatile utility of the AAA+ domain.

AAA+ proteins typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes.

Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

Rubisco activase (Rca) belongs to the AAA+ superfamily of proteins and it hydrolyzes ATP to ADP.

The complementarity of nucleotide-binding sites between AAA+ interfaces, the mechanism of ATP hydrolysis and the conformational changes activating or deactivating their ATP-binding pocket ensure a functional cycle that creates mechanical force to promote remodeling of substrates.

In this study, we will investigated the ADP/ATP and Mg2+ ion binding mechanism in Rca monomer and homodimers using extensive longtime scale simulations.

We will also try to find the binding pathway for ADP and ATP.

Simulations will also helps to predicts the crucial residues that involved in this binding process..

PROJECT INFO

Manager(s): Rabindranath Paul

Institution: University of Illinois at Urbana-Champaign

PROJECT WORK UNIT SUMMARY

Atoms: 138,384

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 14,614,645 196,399 74.41 0 hrs 19 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,266,097 172,854 53.61 0 hrs 27 mins
3 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,917,394 154,943 44.64 0 hrs 32 mins
4 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,793,207 155,613 43.65 0 hrs 33 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,596,843 153,365 43.01 0 hrs 33 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,833,271 148,207 39.36 0 hrs 37 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,331,090 145,215 36.71 0 hrs 39 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,203,959 142,659 36.48 0 hrs 39 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,754,513 137,678 34.53 0 hrs 42 mins
10 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 3,482,782 123,598 28.18 0 hrs 51 mins
11 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,394,769 124,529 27.26 0 hrs 53 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,372,249 110,570 30.50 0 hrs 47 mins
13 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,362,958 123,251 27.29 0 hrs 53 mins
14 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,988,422 119,259 25.06 0 hrs 57 mins
15 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,965,884 118,315 25.07 0 hrs 57 mins
16 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,911,525 114,843 25.35 0 hrs 57 mins
17 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,463,656 110,472 22.30 1 hrs 5 mins
18 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,457,542 109,261 22.49 1 hrs 4 mins
19 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,444,956 111,163 21.99 1 hrs 5 mins
20 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,066,194 105,103 19.66 1 hrs 13 mins
21 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,035,138 104,887 19.40 1 hrs 14 mins
22 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,684,901 107,892 15.62 2 hrs 32 mins
23 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,642,257 96,729 16.98 1 hrs 25 mins
24 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,401,987 90,245 15.54 2 hrs 33 mins
25 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,316,020 90,448 14.55 2 hrs 39 mins
26 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,262,575 88,529 14.26 2 hrs 41 mins
27 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,125,301 85,450 13.17 2 hrs 49 mins
28 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,112,407 84,914 13.10 2 hrs 50 mins
29 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,100,098 85,106 12.93 2 hrs 51 mins
30 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,026,086 80,366 12.77 2 hrs 53 mins
31 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 1,018,480 80,838 12.60 2 hrs 54 mins
32 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,002,998 82,111 12.22 2 hrs 58 mins
33 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 945,463 79,359 11.91 2 hrs 1 mins
34 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 912,091 79,400 11.49 2 hrs 5 mins
35 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 712,377 73,549 9.69 2 hrs 29 mins
36 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 710,469 73,654 9.65 2 hrs 29 mins
37 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 656,797 72,180 9.10 3 hrs 38 mins
38 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 370,288 59,406 6.23 4 hrs 51 mins
39 P106-090
GP106 [P106-090]
Nvidia GP106 341,103 57,548 5.93 4 hrs 3 mins
40 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 197,329 37,250 5.30 5 hrs 32 mins
41 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 166,639 45,382 3.67 7 hrs 32 mins
42 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 21,323 22,817 0.93 26 hrs 41 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:20

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make