PROJECT #18321 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 155,128

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3900X 12-CORE 24 24,606 590,544 AMD
2 12TH GEN CORE I7-12700K 20 28,657 573,140 Intel
3 RYZEN 9 5950X 16-CORE 32 17,718 566,976 AMD
4 RYZEN 9 3900XT 12-CORE 24 20,706 496,944 AMD
5 RYZEN 7 5700X 8-CORE 16 29,248 467,968 AMD
6 RYZEN 7 5800X 8-CORE 16 28,935 462,960 AMD
7 RYZEN 7 3800X 8-CORE 16 24,824 397,184 AMD
8 11TH GEN CORE I5-11600K @ 3.90GHZ 12 26,794 321,528 Intel
9 RYZEN 9 5900HS 16 14,254 228,064 AMD
10 CORE I7-9700K CPU @ 3.60GHZ 8 26,986 215,888 Intel
11 RYZEN 7 PRO 4750G 16 13,145 210,320 AMD
12 XEON CPU E5-2680 V4 @ 2.40GHZ 28 7,138 199,864 Intel
13 RYZEN 5 3600 6-CORE 12 15,378 184,536 AMD
14 CORE I7-10700 CPU @ 2.90GHZ 16 8,909 142,544 Intel
15 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,404 86,464 Intel
16 CORE I9-8950HK CPU @ 2.90GHZ 12 7,066 84,792 Intel
17 CORE I7-4790K CPU @ 4.00GHZ 8 7,250 58,000 Intel
18 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,127 57,016 Intel
19 RYZEN 7 4700U 8 7,023 56,184 AMD
20 CORE I5-6600K CPU @ 3.50GHZ 4 12,820 51,280 Intel
21 CORE I5-4590 CPU @ 3.30GHZ 4 11,525 46,100 Intel
22 CORE I5-6500T CPU @ 2.50GHZ 4 11,405 45,620 Intel
23 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,497 43,976 Intel
24 CORE I5-4570 CPU @ 3.20GHZ 4 10,125 40,500 Intel
25 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,840 38,720 Intel
26 CORE I3-6006U CPU @ 2.00GHZ 4 1,878 7,512 Intel