PROJECT #18321 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE
PROJECT SUMMARY
This project simulates several myosins found in the human body.
Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.
Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.
This project is studying those differences, especially the differences in speed and power.
We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.
We are using this information to understand and design specific theraputics that don't have off-target effects.
Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.
P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..
PROJECT INFO
Manager(s): Jeff Lotthammer
Institution: Washington University in St. Louis
PROJECT WORK UNIT SUMMARY
Atoms: 155,128
Core: 0xa8
Status: Public
PROJECT FOLDING PPD AVERAGES BY GPU
PPDDB data as of Tuesday, 07 February 2023 06:14:50
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PROJECT FOLDING PPD AVERAGES BY CPU BETA
PPDDB data as of Tuesday, 07 February 2023 06:14:50