PROJECT #18321 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 155,128

Core: 0xa8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 07 February 2023 06:14:50

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 07 February 2023 06:14:50

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 EPYC 7V12 64-CORE 64 23,317 1,492,288 AMD
2 RYZEN 9 5900X 12-CORE 24 31,141 747,384 AMD
3 RYZEN 9 3900 12-CORE 24 25,256 606,144 AMD
4 RYZEN 9 5950X 16-CORE 32 16,565 530,080 AMD
5 12TH GEN CORE I9-12900K 24 21,397 513,528 Intel
6 RYZEN 9 3900XT 12-CORE 24 20,351 488,424 AMD
7 12TH GEN CORE I7-12700K 20 23,890 477,800 Intel
8 RYZEN 7 5800X 8-CORE 16 28,919 462,704 AMD
9 RYZEN 7 5700X 8-CORE 16 26,765 428,240 AMD
10 RYZEN 9 3900X 12-CORE 24 17,555 421,320 AMD
11 RYZEN 7 3800X 8-CORE 16 23,062 368,992 AMD
12 11TH GEN CORE I7-11700K @ 3.60GHZ 16 21,805 348,880 Intel
13 11TH GEN CORE I5-11600K @ 3.90GHZ 12 26,794 321,528 Intel
14 XEON CPU E5-2680 V2 @ 2.80GHZ 40 7,800 312,000 Intel
15 CORE I9-10900X CPU @ 3.70GHZ 20 15,203 304,060 Intel
16 CORE I9-10850K CPU @ 3.60GHZ 20 14,365 287,300 Intel
17 RYZEN 7 5800X3D 8-CORE 16 17,570 281,120 AMD
18 CORE I7-10700K CPU @ 3.80GHZ 16 14,613 233,808 Intel
19 RYZEN 7 PRO 4750G 16 14,391 230,256 AMD
20 RYZEN 9 5900HS 16 14,254 228,064 AMD
21 RYZEN 5 5600G 12 18,906 226,872 AMD
22 RYZEN 7 5700G 16 14,115 225,840 AMD
23 CORE I9-9900KS CPU @ 4.00GHZ 16 13,623 217,968 Intel
24 APPLE M1 MAX 10 20,046 200,460 Apple
25 XEON CPU E5-2680 V4 @ 2.40GHZ 28 7,138 199,864 Intel
26 RYZEN 5 3600 6-CORE 12 15,509 186,108 AMD
27 RYZEN 5 5600X 6-CORE 12 15,058 180,696 AMD
28 CORE I7-9700K CPU @ 3.60GHZ 8 21,714 173,712 Intel
29 RYZEN 7 4800H 16 10,142 162,272 AMD
30 RYZEN 7 3700X 8-CORE 16 10,107 161,712 AMD
31 RYZEN 7 2700X EIGHT-CORE 16 9,980 159,680 AMD
32 CORE I7-8700 CPU @ 3.20GHZ 12 13,131 157,572 Intel
33 XEON CPU E5-2698 V4 @ 2.20GHZ 16 9,292 148,672 Intel
34 XEON GOLD 6128 CPU @ 3.40GHZ 12 12,293 147,516 Intel
35 CORE I7-10700 CPU @ 2.90GHZ 16 8,909 142,544 Intel
36 CORE I7-7700K CPU @ 4.20GHZ 8 16,828 134,624 Intel
37 RYZEN 5 2600X SIX-CORE 12 9,904 118,848 AMD
38 CORE I7-10700T CPU @ 2.00GHZ 16 7,366 117,856 Intel
39 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,701 116,412 Intel
40 CORE I5-8500 CPU @ 3.00GHZ 6 19,011 114,066 Intel
41 12TH GEN CORE I3-12100 8 14,127 113,016 Intel
42 CORE I7-9750H CPU @ 2.60GHZ 12 8,592 103,104 Intel
43 CORE I5-9500 CPU @ 3.00GHZ 6 17,147 102,882 Intel
44 XEON CPU E5-2650L V4 @ 1.70GHZ 28 3,498 97,944 Intel
45 CORE I9-8950HK CPU @ 2.90GHZ 12 7,580 90,960 Intel
46 CORE I5-10400 CPU @ 2.90GHZ 12 7,377 88,524 Intel
47 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,139 82,224 Intel
48 RYZEN 5 1600 SIX-CORE 12 6,035 72,420 AMD
49 XEON CPU E5-2697 V2 @ 2.70GHZ 24 2,764 66,336 Intel
50 APPLE M1 PRO 10 6,595 65,950 Apple
51 XEON CPU E5-1630 V3 @ 3.70GHZ 8 7,697 61,576 Intel
52 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,344 58,752 Intel
53 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 7,278 58,224 Intel
54 XEON CPU E3-1270 V5 @ 3.60GHZ 8 7,265 58,120 Intel
55 CORE I7-4790K CPU @ 4.00GHZ 8 7,250 58,000 Intel
56 RYZEN 7 4700U 8 7,023 56,184 AMD
57 12TH GEN CORE I3-12100F 8 6,998 55,984 Intel
58 CORE I5-4690 CPU @ 3.50GHZ 4 13,989 55,956 Intel
59 CORE I5-7400 CPU @ 3.00GHZ 4 13,881 55,524 Intel
60 APPLE M1 8 6,857 54,856 Apple
61 CORE I5-6600K CPU @ 3.50GHZ 4 12,915 51,660 Intel
62 CORE I7-4980HQ CPU @ 2.80GHZ 8 6,427 51,416 Intel
63 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,865 46,920 Intel
64 CORE I7 CPU 975 @ 3.33GHZ 8 5,837 46,696 Intel
65 RYZEN 3 2200G 4 11,509 46,036 AMD
66 CORE I7-3770 CPU @ 3.40GHZ 8 5,719 45,752 Intel
67 CORE I5-6500T CPU @ 2.50GHZ 4 11,405 45,620 Intel
68 CORE I5-4590 CPU @ 3.30GHZ 4 11,167 44,668 Intel
69 CORE I5-9300H CPU @ 2.40GHZ 8 5,533 44,264 Intel
70 CORE I5-4570 CPU @ 3.20GHZ 4 10,309 41,236 Intel
71 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,840 38,720 Intel
72 CORE I5-3570K CPU @ 3.40GHZ 4 9,539 38,156 Intel
73 CORE I5-8350U CPU @ 1.70GHZ 8 4,288 34,304 Intel
74 CORE I7-2760QM CPU @ 2.40GHZ 8 3,578 28,624 Intel
75 CORE I5-2500K CPU @ 3.30GHZ 4 6,002 24,008 Intel
76 CORE I3-6006U CPU @ 2.00GHZ 4 2,271 9,084 Intel
77 A8-6410 APU 4 509 2,036 AMD