PROJECT #18318 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 144,744

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN THREADRIPPER 3960X 24-CORE 48 17,647 847,056 AMD
2 RYZEN 9 5900X 12-CORE 24 33,328 799,872 AMD
3 RYZEN 9 5950X 16-CORE 32 20,572 658,304 AMD
4 RYZEN 9 3900 12-CORE 24 26,306 631,344 AMD
5 12TH GEN CORE I9-12900K 24 23,699 568,776 Intel
6 RYZEN 7 5800X3D 8-CORE 16 30,600 489,600 AMD
7 RYZEN 9 3900XT 12-CORE 24 19,935 478,440 AMD
8 12TH GEN CORE I7-12700K 20 22,978 459,560 Intel
9 RYZEN 7 5800X 8-CORE 16 25,947 415,152 AMD
10 RYZEN 7 5700X 8-CORE 16 24,620 393,920 AMD
11 CORE I9-10850K CPU @ 3.60GHZ 20 19,351 387,020 Intel
12 RYZEN 7 3800X 8-CORE 16 22,751 364,016 AMD
13 11TH GEN CORE I7-11700K @ 3.60GHZ 16 22,115 353,840 Intel
14 XEON CPU E5-2680 V2 @ 2.80GHZ 40 8,272 330,880 Intel
15 XEON CPU E5-2690 V4 @ 2.60GHZ 28 11,031 308,868 Intel
16 CORE I9-9900KS CPU @ 4.00GHZ 16 17,130 274,080 Intel
17 XEON CPU E5-2650 V2 @ 2.60GHZ 32 8,319 266,208 Intel
18 12TH GEN CORE I5-12600K 16 15,507 248,112 Intel
19 RYZEN 7 5700G 16 15,027 240,432 AMD
20 RYZEN 9 5900HS 16 14,602 233,632 AMD
21 CORE I7-10700K CPU @ 3.80GHZ 16 14,517 232,272 Intel
22 RYZEN 7 PRO 4750G 16 13,810 220,960 AMD
23 APPLE M1 MAX 10 21,642 216,420 Apple
24 RYZEN 5 3600 6-CORE 12 15,705 188,460 AMD
25 RYZEN 5 5600G 12 15,295 183,540 AMD
26 RYZEN 7 3700X 8-CORE 16 11,470 183,520 AMD
27 XEON CPU E5-2697 V2 @ 2.70GHZ 24 7,622 182,928 Intel
28 CORE I7-8700 CPU @ 3.20GHZ 12 15,044 180,528 Intel
29 RYZEN 5 5600X 6-CORE 12 14,831 177,972 AMD
30 RYZEN 7 2700X EIGHT-CORE 16 10,615 169,840 AMD
31 XEON CPU E5-2698 V4 @ 2.20GHZ 16 9,604 153,664 Intel
32 CORE I7-9700K CPU @ 3.60GHZ 8 17,840 142,720 Intel
33 CORE I7-8700K CPU @ 3.70GHZ 12 11,828 141,936 Intel
34 CORE I7-7700K CPU @ 4.20GHZ 8 16,756 134,048 Intel
35 XEON GOLD 6128 CPU @ 3.40GHZ 12 9,665 115,980 Intel
36 CORE I5-8500 CPU @ 3.00GHZ 6 19,171 115,026 Intel
37 CORE I5-9500 CPU @ 3.00GHZ 6 17,316 103,896 Intel
38 CORE I7-10700T CPU @ 2.00GHZ 16 6,340 101,440 Intel
39 CORE I9-8950HK CPU @ 2.90GHZ 12 7,668 92,016 Intel
40 RYZEN 5 1600 SIX-CORE 12 7,524 90,288 AMD
41 RYZEN 7 4800H 16 5,499 87,984 AMD
42 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,819 77,104 Intel
43 CORE I5-8600T CPU @ 2.30GHZ 6 11,590 69,540 Intel
44 APPLE M1 PRO 10 6,761 67,610 Apple
45 XEON CPU E3-1270 V5 @ 3.60GHZ 8 8,441 67,528 Intel
46 CORE I7-4790 CPU @ 3.60GHZ 8 7,621 60,968 Intel
47 XEON CPU E5-1630 V3 @ 3.70GHZ 8 7,586 60,688 Intel
48 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,182 57,456 Intel
49 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 7,081 56,648 Intel
50 CORE I5-4690 CPU @ 3.50GHZ 4 14,042 56,168 Intel
51 RYZEN 7 4700U 8 6,877 55,016 AMD
52 CORE I5-7400 CPU @ 3.00GHZ 4 13,580 54,320 Intel
53 CORE I7-3770 CPU @ 3.40GHZ 8 6,749 53,992 Intel
54 CORE I5-6600K CPU @ 3.50GHZ 4 12,801 51,204 Intel
55 CORE I5-6500T CPU @ 2.50GHZ 4 11,547 46,188 Intel
56 CORE I5-4590 CPU @ 3.30GHZ 4 11,493 45,972 Intel
57 APPLE M1 8 5,686 45,488 Apple
58 CORE I5-9300H CPU @ 2.40GHZ 8 5,317 42,536 Intel
59 CORE I3-8100 CPU @ 3.60GHZ 4 10,418 41,672 Intel
60 CORE I5-4570 CPU @ 3.20GHZ 4 9,606 38,424 Intel
61 RYZEN 7 5700U 16 2,364 37,824 AMD
62 CORE I5-3570K CPU @ 3.40GHZ 4 9,314 37,256 Intel
63 CORE I7 CPU 975 @ 3.33GHZ 8 4,589 36,712 Intel
64 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 4,526 36,208 Intel
65 XEON CPU E5-2650L V4 @ 1.70GHZ 28 1,081 30,268 Intel
66 CORE I5-2500K CPU @ 3.30GHZ 4 6,187 24,748 Intel
67 XEON CPU E3-1240 V2 @ 3.40GHZ 8 3,047 24,376 Intel
68 RYZEN 5 PRO 2400G 8 3,031 24,248 AMD
69 CORE I7-2760QM CPU @ 2.40GHZ 8 2,109 16,872 Intel
70 ATHLON 3000G 4 3,113 12,452 AMD
71 CORE I3-6006U CPU @ 2.00GHZ 4 2,359 9,436 Intel
72 CORE I5-5200U CPU @ 2.20GHZ 4 723 2,892 Intel