PROJECT #18318 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 144,744

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 7 5800X 8-CORE 16 34,658 554,528 AMD
2 CORE I9-10850K CPU @ 3.60GHZ 20 25,554 511,080 Intel
3 RYZEN 9 3900XT 12-CORE 24 20,607 494,568 AMD
4 RYZEN 9 5950X 16-CORE 32 13,990 447,680 AMD
5 12TH GEN CORE I7-12700K 20 21,108 422,160 Intel
6 RYZEN 7 5700X 8-CORE 16 24,615 393,840 AMD
7 RYZEN 7 3800X 8-CORE 16 22,635 362,160 AMD
8 XEON CPU E5-2690 V4 @ 2.60GHZ 28 11,031 308,868 Intel
9 RYZEN 9 5900HS 16 14,602 233,632 AMD
10 RYZEN 5 5600X 6-CORE 12 18,958 227,496 AMD
11 RYZEN 5 3600 6-CORE 12 17,858 214,296 AMD
12 RYZEN 7 PRO 4750G 16 12,804 204,864 AMD
13 CORE I7-8700 CPU @ 3.20GHZ 12 16,361 196,332 Intel
14 RYZEN 7 3700X 8-CORE 16 12,250 196,000 AMD
15 XEON CPU E5-2697 V2 @ 2.70GHZ 24 7,542 181,008 Intel
16 CORE I7-10700T CPU @ 2.00GHZ 16 4,907 78,512 Intel
17 CORE I5-8600T CPU @ 2.30GHZ 6 11,584 69,504 Intel
18 CORE I7-4790 CPU @ 3.60GHZ 8 7,621 60,968 Intel
19 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,100 56,800 Intel
20 CORE I5-7400 CPU @ 3.00GHZ 4 14,027 56,108 Intel
21 RYZEN 7 4700U 8 6,877 55,016 AMD
22 CORE I5-6600K CPU @ 3.50GHZ 4 13,108 52,432 Intel
23 CORE I5-6500T CPU @ 2.50GHZ 4 11,547 46,188 Intel
24 CORE I5-4590 CPU @ 3.30GHZ 4 11,443 45,772 Intel
25 CORE I5-4570 CPU @ 3.20GHZ 4 10,249 40,996 Intel
26 RYZEN 5 PRO 2400G 8 3,031 24,248 AMD
27 CORE I3-6006U CPU @ 2.00GHZ 4 2,616 10,464 Intel