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Research: MYOSINS Folding Project #18311

Project #18311 overview

Project Summary AI Beta

The project simulates different types of myosins found in the human body. Myosins are proteins that create force for things like muscle contraction and moving materials inside cells. The project looks at how fast and strong each type of myosin is, which could help understand diseases caused by faulty myosins, like heart conditions. This knowledge can be used to design better treatments with fewer side effects.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Jeff Lotthammer
Institution
Washington University in St. Louis

Work unit

Atoms
269,382
Core
GRO_A8
Status
Public
Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Performance data

Hardware Performance for Project 18311

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:52:14

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 41,406 1,324,992 AMD
2 RYZEN 9 3900 12-CORE 24 25,593 614,232 AMD
3 RYZEN 7 5800X 8-CORE 16 34,500 552,000 AMD
4 RYZEN 9 3900XT 12-CORE 24 21,684 520,416 AMD
5 11TH GEN CORE I9-11900K @ 3.50GHZ 16 26,839 429,424 Intel
6 RYZEN 7 3800X 8-CORE 16 23,855 381,680 AMD
7 12TH GEN CORE I7-12700 20 18,971 379,420 Intel
8 RYZEN 5 5600X 6-CORE 12 30,322 363,864 AMD
9 XEON CPU E5-2680 V3 @ 2.50GHZ 24 11,101 266,424 Intel
10 XEON CPU E5-2680 V4 @ 2.40GHZ 28 8,123 227,444 Intel
11 CORE I7-8700 CPU @ 3.20GHZ 12 18,851 226,212 Intel
12 RYZEN 7 5800H 16 13,861 221,776 AMD
13 RYZEN 9 5900HS 16 12,335 197,360 AMD
14 RYZEN 5 3600 6-CORE 12 15,615 187,380 AMD
15 CORE I7-4790K CPU @ 4.00GHZ 8 12,917 103,336 Intel
16 CORE I3-9100F CPU @ 3.60GHZ 4 21,819 87,276 Intel
17 CORE I9-8950HK CPU @ 2.90GHZ 12 6,404 76,848 Intel
18 RYZEN 5 1600 SIX-CORE 12 6,093 73,116 AMD
19 CORE I7-3720QM CPU @ 2.60GHZ 8 8,892 71,136 Intel
20 CORE I5-7400 CPU @ 3.00GHZ 4 14,527 58,108 Intel
21 CORE I3-8300 CPU @ 3.70GHZ 4 14,316 57,264 Intel
22 XEON CPU E5-2698 V4 @ 2.20GHZ 16 3,568 57,088 Intel
23 CORE I7-6700 CPU @ 3.40GHZ 8 7,095 56,760 Intel
24 CORE I5-6500T CPU @ 2.50GHZ 4 13,002 52,008 Intel
25 CORE I5-6600K CPU @ 3.50GHZ 4 12,591 50,364 Intel
26 CORE I5-4590 CPU @ 3.30GHZ 4 12,209 48,836 Intel
27 CORE I5-4570 CPU @ 3.20GHZ 4 11,917 47,668 Intel
28 XEON CPU E3-1240 V2 @ 3.40GHZ 8 5,805 46,440 Intel
29 CORE I7-9700K CPU @ 3.60GHZ 8 5,540 44,320 Intel
30 CORE I5-6500 CPU @ 3.20GHZ 4 10,691 42,764 Intel
31 CORE I5-2520M CPU @ 2.50GHZ 4 6,977 27,908 Intel
32 XEON CPU E31245 @ 3.30GHZ 8 3,096 24,768 Intel
33 CORE I5-3470 CPU @ 3.20GHZ 4 5,909 23,636 Intel
34 CORE I3-3240 CPU @ 3.40GHZ 4 3,834 15,336 Intel
35 CORE I3-3225 CPU @ 3.30GHZ 4 3,725 14,900 Intel
36 CORE I3-6006U CPU @ 2.00GHZ 4 3,315 13,260 Intel
37 CORE I3-3220 CPU @ 3.30GHZ 4 2,957 11,828 Intel
38 FX-4300 QUAD-CORE 4 1,648 6,592 AMD
39 PRO A10-9700 R7, 10 COMPUTE CORES 4C+6G 4 554 2,216 AMD