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Research: MYOSINS Folding Project #18312

Project #18312 overview

Project Summary AI Beta

This project looks at how different myosins work in the body. Myosins are proteins that make our muscles move and help things move inside our cells. Understanding how they differ could lead to new treatments for diseases like heart problems caused by faulty myosins.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Jeff Lotthammer
Institution
Washington University in St. Louis

Work unit

Atoms
264,807
Core
GRO_A8
Status
Public
Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Performance data

Hardware Performance for Project 18312

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:52:13

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 39,598 1,267,136 AMD
2 RYZEN 9 3900 12-CORE 24 26,213 629,112 AMD
3 RYZEN 9 3950X 16-CORE 32 19,026 608,832 AMD
4 RYZEN 7 5800X 8-CORE 16 33,249 531,984 AMD
5 RYZEN 9 3900XT 12-CORE 24 21,976 527,424 AMD
6 11TH GEN CORE I9-11900K @ 3.50GHZ 16 27,214 435,424 Intel
7 RYZEN 7 3800X 8-CORE 16 27,185 434,960 AMD
8 12TH GEN CORE I7-12700 20 18,915 378,300 Intel
9 XEON CPU E5-2680 V3 @ 2.50GHZ 24 12,294 295,056 Intel
10 CORE I7-8700 CPU @ 3.20GHZ 12 20,963 251,556 Intel
11 RYZEN 5 3600 6-CORE 12 20,731 248,772 AMD
12 RYZEN 9 5900HS 16 12,618 201,888 AMD
13 RYZEN 7 PRO 4750G 16 7,037 112,592 AMD
14 CORE I7-4790K CPU @ 4.00GHZ 8 12,462 99,696 Intel
15 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,714 91,424 Intel
16 CORE I3-9100F CPU @ 3.60GHZ 4 22,034 88,136 Intel
17 CORE I9-8950HK CPU @ 2.90GHZ 12 7,050 84,600 Intel
18 CORE I7-10700T CPU @ 2.00GHZ 16 5,157 82,512 Intel
19 CORE I7-4790 CPU @ 3.60GHZ 8 9,983 79,864 Intel
20 RYZEN 5 1600 SIX-CORE 12 6,379 76,548 AMD
21 CORE I5-7400 CPU @ 3.00GHZ 4 16,130 64,520 Intel
22 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,993 63,944 Intel
23 CORE I3-8300 CPU @ 3.70GHZ 4 14,429 57,716 Intel
24 CORE I5-6600K CPU @ 3.50GHZ 4 14,140 56,560 Intel
25 CORE I7-9700K CPU @ 3.60GHZ 8 6,658 53,264 Intel
26 CORE I5-6500T CPU @ 2.50GHZ 4 13,171 52,684 Intel
27 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,304 50,432 Intel
28 CORE I5-4590 CPU @ 3.30GHZ 4 12,309 49,236 Intel
29 XEON CPU E3-1240 V2 @ 3.40GHZ 8 5,399 43,192 Intel
30 RYZEN 5 5600G 12 3,404 40,848 AMD
31 XEON CPU E3-1245 V2 @ 3.40GHZ 8 3,925 31,400 Intel
32 XEON CPU E31245 @ 3.30GHZ 8 3,575 28,600 Intel
33 CORE I5-2520M CPU @ 2.50GHZ 4 6,333 25,332 Intel
34 CORE I5-3470 CPU @ 3.20GHZ 4 6,012 24,048 Intel
35 CORE I3-6006U CPU @ 2.00GHZ 4 4,053 16,212 Intel
36 CORE I3-3240 CPU @ 3.40GHZ 4 3,767 15,068 Intel
37 CORE I3-3220 CPU @ 3.30GHZ 4 3,245 12,980 Intel
38 A8-6410 APU 4 226 904 AMD