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Research: MYOSINS Folding Project #18310

Project #18310 overview

Project Summary AI Beta

This project studies different types of myosin proteins found in the body. Myosins are responsible for muscle contractions and movement inside cells. The project focuses on how fast and strong each myosin type is, which could help us understand diseases like heart conditions caused by faulty myosins. This research can also lead to new treatments that specifically target these diseases.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Jeff Lotthammer
Institution
Washington University in St. Louis

Work unit

Atoms
269,630
Core
GRO_A8
Status
Public
Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Performance data

Hardware Performance for Project 18310

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:52:15

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 39,843 1,274,976 AMD
2 RYZEN 9 3900XT 12-CORE 24 21,616 518,784 AMD
3 RYZEN 7 5800X 8-CORE 16 31,666 506,656 AMD
4 12TH GEN CORE I7-12700 20 23,227 464,540 Intel
5 CORE I9-7920X CPU @ 2.90GHZ 24 17,796 427,104 Intel
6 RYZEN 7 3800X 8-CORE 16 25,852 413,632 AMD
7 RYZEN 5 5600X 6-CORE 12 26,241 314,892 AMD
8 11TH GEN CORE I7-11700K @ 3.60GHZ 16 17,655 282,480 Intel
9 RYZEN 5 3600 6-CORE 12 22,081 264,972 AMD
10 CORE I7-8700 CPU @ 3.20GHZ 12 21,291 255,492 Intel
11 RYZEN 7 3700X 8-CORE 16 12,308 196,928 AMD
12 RYZEN 9 5900HS 16 11,891 190,256 AMD
13 RYZEN 7 5800H 16 11,565 185,040 AMD
14 RYZEN 7 PRO 4750G 16 6,987 111,792 AMD
15 CORE I7-4790K CPU @ 4.00GHZ 8 12,757 102,056 Intel
16 CORE I7-9700K CPU @ 3.60GHZ 8 12,747 101,976 Intel
17 RYZEN 5 1600 SIX-CORE 12 8,262 99,144 AMD
18 CORE I3-9100F CPU @ 3.60GHZ 4 21,970 87,880 Intel
19 CORE I7-4790 CPU @ 3.60GHZ 8 9,897 79,176 Intel
20 XEON CPU E5-2698 V4 @ 2.20GHZ 16 4,471 71,536 Intel
21 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 8,760 70,080 Intel
22 XEON CPU E5-1630 V3 @ 3.70GHZ 8 8,730 69,840 Intel
23 CORE I5-7400 CPU @ 3.00GHZ 4 16,291 65,164 Intel
24 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,755 62,040 Intel
25 CORE I3-8300 CPU @ 3.70GHZ 4 14,636 58,544 Intel
26 CORE I7-6700 CPU @ 3.40GHZ 8 6,822 54,576 Intel
27 CORE I5-6600K CPU @ 3.50GHZ 4 13,498 53,992 Intel
28 CORE I5-6500T CPU @ 2.50GHZ 4 12,983 51,932 Intel
29 CORE I5-4590 CPU @ 3.30GHZ 4 12,153 48,612 Intel
30 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,676 37,408 Intel
31 CORE I5-3570 CPU @ 3.40GHZ 4 8,708 34,832 Intel
32 CORE I5-2520M CPU @ 2.50GHZ 4 6,773 27,092 Intel
33 XEON CPU E31245 @ 3.30GHZ 8 3,318 26,544 Intel
34 CORE I9-8950HK CPU @ 2.90GHZ 12 2,071 24,852 Intel
35 CORE I5-3470 CPU @ 3.20GHZ 4 5,604 22,416 Intel
36 CORE I3-3240 CPU @ 3.40GHZ 4 3,736 14,944 Intel
37 FX-4300 QUAD-CORE 4 1,658 6,632 AMD
38 E2-3200 APU RADEON(TM) HD GRAPHICS 2 1,272 2,544 AMD
39 A8-6410 APU 4 326 1,304 AMD