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Research: MYOSINS Folding Project #18309

Project #18309 overview

Project Summary AI Beta

This project studies different types of myosins found in the human body. Myosins are proteins that power our movements, from muscle contractions to moving things inside cells. The project looks at how fast and strong each type is, which can help understand diseases like heart problems and Usher syndrome. By learning more about myosins, scientists hope to develop better treatments without harmful side effects.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Jeff Lotthammer
Institution
Washington University in St. Louis

Work unit

Atoms
273,717
Core
GRO_A8
Status
Public
Source material

Official Project Description

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Performance data

Hardware Performance for Project 18309

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:52:16

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 5950X 16-CORE 32 37,732 1,207,424 AMD
2 RYZEN 9 3900XT 12-CORE 24 21,139 507,336 AMD
3 RYZEN 7 5800X 8-CORE 16 31,175 498,800 AMD
4 RYZEN 7 3800X 8-CORE 16 26,871 429,936 AMD
5 11TH GEN CORE I9-11900K @ 3.50GHZ 16 26,665 426,640 Intel
6 XEON CPU E5-2650 V2 @ 2.60GHZ 32 8,932 285,824 Intel
7 CORE I9-7920X CPU @ 2.90GHZ 24 11,082 265,968 Intel
8 11TH GEN CORE I5-11400F @ 2.60GHZ 12 19,393 232,716 Intel
9 XEON CPU E5-2680 V3 @ 2.50GHZ 24 9,553 229,272 Intel
10 CORE I7-8700 CPU @ 3.20GHZ 12 17,634 211,608 Intel
11 RYZEN 9 5900HS 16 12,305 196,880 AMD
12 XEON CPU E5-2680 V4 @ 2.40GHZ 28 6,870 192,360 Intel
13 RYZEN 5 3600 6-CORE 12 12,747 152,964 AMD
14 RYZEN 7 3700X 8-CORE 16 9,497 151,952 AMD
15 CORE I9-9900KF CPU @ 3.60GHZ 16 8,168 130,688 Intel
16 CORE I5-8400 CPU @ 2.80GHZ 6 18,610 111,660 Intel
17 CORE I7-10700T CPU @ 2.00GHZ 16 6,222 99,552 Intel
18 CORE I7-4790K CPU @ 4.00GHZ 8 12,137 97,096 Intel
19 RYZEN 5 1600 SIX-CORE 12 7,634 91,608 AMD
20 CORE I7-4790 CPU @ 3.60GHZ 8 10,765 86,120 Intel
21 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,359 85,744 Intel
22 CORE I7-6700 CPU @ 3.40GHZ 8 8,063 64,504 Intel
23 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,888 63,104 Intel
24 CORE I3-8300 CPU @ 3.70GHZ 4 15,535 62,140 Intel
25 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,384 59,072 Intel
26 CORE I5-6500T CPU @ 2.50GHZ 4 12,578 50,312 Intel
27 CORE I5-6600K CPU @ 3.50GHZ 4 12,148 48,592 Intel
28 CORE I5-4590 CPU @ 3.30GHZ 4 11,975 47,900 Intel
29 CORE I7-4770K CPU @ 3.50GHZ 8 5,775 46,200 Intel
30 XEON CPU E3-1240 V2 @ 3.40GHZ 8 5,336 42,688 Intel
31 XEON CPU E5-2698 V4 @ 2.20GHZ 16 2,427 38,832 Intel
32 XEON CPU E31245 @ 3.30GHZ 8 3,680 29,440 Intel
33 CORE I5-2520M CPU @ 2.50GHZ 4 6,881 27,524 Intel
34 CORE I5-3470 CPU @ 3.20GHZ 4 5,960 23,840 Intel
35 CORE I3-4170 CPU @ 3.70GHZ 4 5,253 21,012 Intel
36 CORE I3-3240 CPU @ 3.40GHZ 4 3,811 15,244 Intel
37 CORE I3-3220 CPU @ 3.30GHZ 4 3,060 12,240 Intel
38 CORE I3-3225 CPU @ 3.30GHZ 4 3,034 12,136 Intel
39 CORE I3-6006U CPU @ 2.00GHZ 4 2,851 11,404 Intel
40 CELERON(R) J4125 CPU @ 2.00GHZ 4 2,050 8,200 Intel
41 E2-3200 APU RADEON(TM) HD GRAPHICS 2 1,275 2,550 AMD
42 CORE2 DUO CPU E6550 @ 2.33GHZ 2 691 1,382 Intel