PROJECT #18322 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

The rise in antibiotic resistant bacteria is a looming public health issue.

This project simulates AmpC β-lactamases found in many cephalosporin resistant bacteria.

This protein mediates resistance to most antibiotics by breaking down the drug.

Because it reduces the types of antibiotics that can be used to treat various infections, physicians have fewer ways to kill bacteria having this resistance protein.

Therefore, to design new antibiotics against these bacteria, we are interested in understanding how AmpC β-lactamase dynamics affects binding of various therapeutics.

This knowledge will help develop drugs that disrupt this enzyme, which will permit the use of broad spectrum antibiotics on these resistant bacteria again..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 54,526

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
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WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 12TH GEN CORE I7-12700K 20 34,840 696,800 Intel
2 RYZEN 5 5600X 6-CORE 12 22,991 275,892 AMD
3 RYZEN 9 5900HS 16 14,116 225,856 AMD
4 RYZEN 7 3800X 8-CORE 16 13,837 221,392 AMD
5 RYZEN 9 3900X 12-CORE 24 8,053 193,272 AMD
6 RYZEN 7 3700X 8-CORE 16 12,054 192,864 AMD
7 CORE I7-8700 CPU @ 3.20GHZ 12 15,663 187,956 Intel
8 RYZEN 5 3600 6-CORE 12 13,078 156,936 AMD
9 11TH GEN CORE I7-11700K @ 3.60GHZ 16 7,647 122,352 Intel
10 RYZEN 5 1600 SIX-CORE 12 7,544 90,528 AMD
11 CORE I7-10510U CPU @ 1.80GHZ 8 7,148 57,184 Intel
12 CORE I5-7400 CPU @ 3.00GHZ 4 13,456 53,824 Intel
13 CORE I5-4590 CPU @ 3.30GHZ 4 11,929 47,716 Intel
14 CORE I5-6600K CPU @ 3.50GHZ 4 11,278 45,112 Intel
15 CORE I7-8650U CPU @ 1.90GHZ 8 5,234 41,872 Intel
16 CORE I5-4570 CPU @ 3.20GHZ 4 8,648 34,592 Intel
17 CORE I5-5200U CPU @ 2.20GHZ 4 4,663 18,652 Intel
18 CORE M-5Y51 CPU @ 1.10GHZ 4 1,297 5,188 Intel
19 CORE2 DUO CPU E6550 @ 2.33GHZ 2 929 1,858 Intel