PROJECT #18322 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

The rise in antibiotic resistant bacteria is a looming public health issue.

This project simulates AmpC β-lactamases found in many cephalosporin resistant bacteria.

This protein mediates resistance to most antibiotics by breaking down the drug.

Because it reduces the types of antibiotics that can be used to treat various infections, physicians have fewer ways to kill bacteria having this resistance protein.

Therefore, to design new antibiotics against these bacteria, we are interested in understanding how AmpC β-lactamase dynamics affects binding of various therapeutics.

This knowledge will help develop drugs that disrupt this enzyme, which will permit the use of broad spectrum antibiotics on these resistant bacteria again..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 54,526

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank Project	CPU Model	Logical Processors (LP)	PPD-PLP AVG PPD per 1 LP	ALL LP-PPD (Estimated)	Make
1	12TH GEN CORE I9-12900K	24	32,217	773,208	Intel
2	RYZEN 9 5950X 16-CORE	32	19,057	609,824	AMD
3	RYZEN 9 5900X 12-CORE	24	20,890	501,360	AMD
4	12TH GEN CORE I7-12700K	20	23,078	461,560	Intel
5	RYZEN 7 5800X 8-CORE	16	24,641	394,256	AMD
6	RYZEN 9 3900 12-CORE	24	16,244	389,856	AMD
7	RYZEN 7 5700X 8-CORE	16	19,392	310,272	AMD
8	RYZEN 9 3900XT 12-CORE	24	12,304	295,296	AMD
9	12TH GEN CORE I5-12600K	16	17,977	287,632	Intel
10	RYZEN 9 3950X 16-CORE	32	8,509	272,288	AMD
11	11TH GEN CORE I7-11700K @ 3.60GHZ	16	15,381	246,096	Intel
12	CORE I9-10900X CPU @ 3.70GHZ	20	12,047	240,940	Intel
13	RYZEN 7 3800X 8-CORE	16	14,268	228,288	AMD
14	RYZEN 9 5900HS	16	14,116	225,856	AMD
15	RYZEN 9 3900X 12-CORE	24	8,053	193,272	AMD
16	CORE I9-10850K CPU @ 3.60GHZ	20	8,801	176,020	Intel
17	XEON CPU E5-2698 V4 @ 2.20GHZ	16	10,462	167,392	Intel
18	XEON CPU E5-2680 V2 @ 2.80GHZ	40	4,161	166,440	Intel
19	CORE I7-10700K CPU @ 3.80GHZ	16	10,151	162,416	Intel
20	CORE I7-8700 CPU @ 3.20GHZ	12	13,387	160,644	Intel
21	RYZEN 5 5600X 6-CORE	12	13,357	160,284	AMD
22	RYZEN 5 5600G	12	12,973	155,676	AMD
23	CORE I9-9900KS CPU @ 4.00GHZ	16	9,515	152,240	Intel
24	RYZEN 7 5800H	16	8,639	138,224	AMD
25	RYZEN 7 5700G	16	8,362	133,792	AMD
26	XEON CPU E5-2650 V2 @ 2.60GHZ	32	4,044	129,408	Intel
27	RYZEN 7 PRO 4750G	16	7,872	125,952	AMD
28	XEON CPU E5-2697 V2 @ 2.70GHZ	24	5,107	122,568	Intel
29	APPLE M1 MAX	10	12,196	121,960	Apple
30	CORE I7-7700K CPU @ 4.20GHZ	8	14,947	119,576	Intel
31	RYZEN 5 3600 6-CORE	12	9,759	117,108	AMD
32	CORE I7-9700K CPU @ 3.60GHZ	8	14,105	112,840	Intel
33	11TH GEN CORE I5-11400 @ 2.60GHZ	12	9,375	112,500	Intel
34	RYZEN 7 3700X 8-CORE	16	6,936	110,976	AMD
35	CORE I7-8705G CPU @ 3.10GHZ	8	13,542	108,336	Intel
36	RYZEN 7 2700X EIGHT-CORE	16	6,212	99,392	AMD
37	RYZEN 7 4800H	16	6,190	99,040	AMD
38	CORE I5-8500 CPU @ 3.00GHZ	6	16,074	96,444	Intel
39	CORE I7-6700 CPU @ 3.40GHZ	8	11,518	92,144	Intel
40	CORE I7-10700T CPU @ 2.00GHZ	16	5,103	81,648	Intel
41	RYZEN 5 1600 SIX-CORE	12	6,758	81,096	AMD
42	CORE I7-9750H CPU @ 2.60GHZ	12	6,176	74,112	Intel
43	12TH GEN CORE I3-12100F	8	8,868	70,944	Intel
44	XEON GOLD 6128 CPU @ 3.40GHZ	12	5,886	70,632	Intel
45	XEON CPU E3-1270 V5 @ 3.60GHZ	8	8,226	65,808	Intel
46	CORE I9-8950HK CPU @ 2.90GHZ	12	5,422	65,064	Intel
47	RYZEN 7 1700 EIGHT-CORE	16	3,962	63,392	AMD
48	CORE I7-10510U CPU @ 1.80GHZ	8	7,148	57,184	Intel
49	XEON CPU E5-1630 V3 @ 3.70GHZ	8	6,965	55,720	Intel
50	APPLE M1	8	6,955	55,640	Apple
51	CORE I5-7400 CPU @ 3.00GHZ	4	12,003	48,012	Intel
52	XEON CPU E5-2680 0 @ 2.70GHZ	16	2,873	45,968	Intel
53	APPLE M1 PRO	10	4,352	43,520	Apple
54	CORE I5-4690 CPU @ 3.50GHZ	4	10,709	42,836	Intel
55	CORE I7-3770 CPU @ 3.40GHZ	8	4,995	39,960	Intel
56	CORE I7-8650U CPU @ 1.90GHZ	8	4,980	39,840	Intel
57	CORE I5-6400 CPU @ 2.70GHZ	4	9,642	38,568	Intel
58	CORE I5-9300H CPU @ 2.40GHZ	8	4,803	38,424	Intel
59	CORE I5-4590 CPU @ 3.30GHZ	4	9,515	38,060	Intel
60	CORE I5-6600K CPU @ 3.50GHZ	4	9,405	37,620	Intel
61	XEON CPU E3-1240 V2 @ 3.40GHZ	8	4,675	37,400	Intel
62	CORE I7-3820 CPU @ 3.60GHZ	8	4,460	35,680	Intel
63	CORE I7-4770HQ CPU @ 2.20GHZ	8	4,354	34,832	Intel
64	CORE I5-4570 CPU @ 3.20GHZ	4	8,141	32,564	Intel
65	CORE I7 CPU 975 @ 3.33GHZ	8	3,730	29,840	Intel
66	11TH GEN CORE I5-1135G7 @ 2.40GHZ	8	3,627	29,016	Intel
67	CORE I7-3770K CPU @ 3.50GHZ	8	3,349	26,792	Intel
68	CORE I5-3570S CPU @ 3.10GHZ	4	6,085	24,340	Intel
69	CORE I5-3570K CPU @ 3.40GHZ	4	5,849	23,396	Intel
70	CORE I5-4278U CPU @ 2.60GHZ	4	5,516	22,064	Intel
71	CORE I5-1035G4 CPU @ 1.10GHZ	8	2,702	21,616	Intel
72	RYZEN 7 5800X3D 8-CORE	16	1,346	21,536	AMD
73	CORE I5-5200U CPU @ 2.20GHZ	4	4,663	18,652	Intel
74	CORE I7-4980HQ CPU @ 2.80GHZ	8	2,256	18,048	Intel
75	XEON CPU E31220 @ 3.10GHZ	4	2,646	10,584	Intel
76	CORE I3-6006U CPU @ 2.00GHZ	4	2,030	8,120	Intel
77	CORE M-5Y51 CPU @ 1.10GHZ	4	1,297	5,188	Intel
78	CORE I5-3210M CPU @ 2.50GHZ	4	798	3,192	Intel
79	ATHLON SILVER 3050U	2	1,548	3,096	AMD
80	CORE2 DUO CPU E6550 @ 2.33GHZ	2	929	1,858	Intel
81	ATHLON(TM) 64 X2 DUAL CORE 4200+	2	155	310	AMD