PROJECT #18322 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

The rise in antibiotic resistant bacteria is a looming public health issue.

This project simulates AmpC β-lactamases found in many cephalosporin resistant bacteria.

This protein mediates resistance to most antibiotics by breaking down the drug.

Because it reduces the types of antibiotics that can be used to treat various infections, physicians have fewer ways to kill bacteria having this resistance protein.

Therefore, to design new antibiotics against these bacteria, we are interested in understanding how AmpC β-lactamase dynamics affects binding of various therapeutics.

This knowledge will help develop drugs that disrupt this enzyme, which will permit the use of broad spectrum antibiotics on these resistant bacteria again..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 54,526

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 12TH GEN CORE I9-12900K 24 32,217 773,208 Intel
2 RYZEN 9 5950X 16-CORE 32 19,057 609,824 AMD
3 RYZEN 9 5900X 12-CORE 24 20,890 501,360 AMD
4 12TH GEN CORE I7-12700K 20 23,078 461,560 Intel
5 RYZEN 7 5800X 8-CORE 16 24,641 394,256 AMD
6 RYZEN 9 3900 12-CORE 24 16,244 389,856 AMD
7 RYZEN 7 5700X 8-CORE 16 19,392 310,272 AMD
8 RYZEN 9 3900XT 12-CORE 24 12,304 295,296 AMD
9 12TH GEN CORE I5-12600K 16 17,977 287,632 Intel
10 RYZEN 9 3950X 16-CORE 32 8,509 272,288 AMD
11 11TH GEN CORE I7-11700K @ 3.60GHZ 16 15,381 246,096 Intel
12 CORE I9-10900X CPU @ 3.70GHZ 20 12,047 240,940 Intel
13 RYZEN 7 3800X 8-CORE 16 14,268 228,288 AMD
14 RYZEN 9 5900HS 16 14,116 225,856 AMD
15 RYZEN 9 3900X 12-CORE 24 8,053 193,272 AMD
16 CORE I9-10850K CPU @ 3.60GHZ 20 8,801 176,020 Intel
17 XEON CPU E5-2698 V4 @ 2.20GHZ 16 10,462 167,392 Intel
18 XEON CPU E5-2680 V2 @ 2.80GHZ 40 4,161 166,440 Intel
19 CORE I7-10700K CPU @ 3.80GHZ 16 10,151 162,416 Intel
20 CORE I7-8700 CPU @ 3.20GHZ 12 13,387 160,644 Intel
21 RYZEN 5 5600X 6-CORE 12 13,357 160,284 AMD
22 RYZEN 5 5600G 12 12,973 155,676 AMD
23 CORE I9-9900KS CPU @ 4.00GHZ 16 9,515 152,240 Intel
24 RYZEN 7 5800H 16 8,639 138,224 AMD
25 RYZEN 7 5700G 16 8,362 133,792 AMD
26 XEON CPU E5-2650 V2 @ 2.60GHZ 32 4,044 129,408 Intel
27 RYZEN 7 PRO 4750G 16 7,872 125,952 AMD
28 XEON CPU E5-2697 V2 @ 2.70GHZ 24 5,107 122,568 Intel
29 APPLE M1 MAX 10 12,196 121,960 Apple
30 CORE I7-7700K CPU @ 4.20GHZ 8 14,947 119,576 Intel
31 RYZEN 5 3600 6-CORE 12 9,759 117,108 AMD
32 CORE I7-9700K CPU @ 3.60GHZ 8 14,105 112,840 Intel
33 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,375 112,500 Intel
34 RYZEN 7 3700X 8-CORE 16 6,936 110,976 AMD
35 CORE I7-8705G CPU @ 3.10GHZ 8 13,542 108,336 Intel
36 RYZEN 7 2700X EIGHT-CORE 16 6,212 99,392 AMD
37 RYZEN 7 4800H 16 6,190 99,040 AMD
38 CORE I5-8500 CPU @ 3.00GHZ 6 16,074 96,444 Intel
39 CORE I7-6700 CPU @ 3.40GHZ 8 11,518 92,144 Intel
40 CORE I7-10700T CPU @ 2.00GHZ 16 5,103 81,648 Intel
41 RYZEN 5 1600 SIX-CORE 12 6,758 81,096 AMD
42 CORE I7-9750H CPU @ 2.60GHZ 12 6,176 74,112 Intel
43 12TH GEN CORE I3-12100F 8 8,868 70,944 Intel
44 XEON GOLD 6128 CPU @ 3.40GHZ 12 5,886 70,632 Intel
45 XEON CPU E3-1270 V5 @ 3.60GHZ 8 8,226 65,808 Intel
46 CORE I9-8950HK CPU @ 2.90GHZ 12 5,422 65,064 Intel
47 RYZEN 7 1700 EIGHT-CORE 16 3,962 63,392 AMD
48 CORE I7-10510U CPU @ 1.80GHZ 8 7,148 57,184 Intel
49 XEON CPU E5-1630 V3 @ 3.70GHZ 8 6,965 55,720 Intel
50 APPLE M1 8 6,955 55,640 Apple
51 CORE I5-7400 CPU @ 3.00GHZ 4 12,003 48,012 Intel
52 XEON CPU E5-2680 0 @ 2.70GHZ 16 2,873 45,968 Intel
53 APPLE M1 PRO 10 4,352 43,520 Apple
54 CORE I5-4690 CPU @ 3.50GHZ 4 10,709 42,836 Intel
55 CORE I7-3770 CPU @ 3.40GHZ 8 4,995 39,960 Intel
56 CORE I7-8650U CPU @ 1.90GHZ 8 4,980 39,840 Intel
57 CORE I5-6400 CPU @ 2.70GHZ 4 9,642 38,568 Intel
58 CORE I5-9300H CPU @ 2.40GHZ 8 4,803 38,424 Intel
59 CORE I5-4590 CPU @ 3.30GHZ 4 9,515 38,060 Intel
60 CORE I5-6600K CPU @ 3.50GHZ 4 9,405 37,620 Intel
61 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,675 37,400 Intel
62 CORE I7-3820 CPU @ 3.60GHZ 8 4,460 35,680 Intel
63 CORE I7-4770HQ CPU @ 2.20GHZ 8 4,354 34,832 Intel
64 CORE I5-4570 CPU @ 3.20GHZ 4 8,141 32,564 Intel
65 CORE I7 CPU 975 @ 3.33GHZ 8 3,730 29,840 Intel
66 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 3,627 29,016 Intel
67 CORE I7-3770K CPU @ 3.50GHZ 8 3,349 26,792 Intel
68 CORE I5-3570S CPU @ 3.10GHZ 4 6,085 24,340 Intel
69 CORE I5-3570K CPU @ 3.40GHZ 4 5,849 23,396 Intel
70 CORE I5-4278U CPU @ 2.60GHZ 4 5,516 22,064 Intel
71 CORE I5-1035G4 CPU @ 1.10GHZ 8 2,702 21,616 Intel
72 RYZEN 7 5800X3D 8-CORE 16 1,346 21,536 AMD
73 CORE I5-5200U CPU @ 2.20GHZ 4 4,663 18,652 Intel
74 CORE I7-4980HQ CPU @ 2.80GHZ 8 2,256 18,048 Intel
75 XEON CPU E31220 @ 3.10GHZ 4 2,646 10,584 Intel
76 CORE I3-6006U CPU @ 2.00GHZ 4 2,030 8,120 Intel
77 CORE M-5Y51 CPU @ 1.10GHZ 4 1,297 5,188 Intel
78 CORE I5-3210M CPU @ 2.50GHZ 4 798 3,192 Intel
79 ATHLON SILVER 3050U 2 1,548 3,096 AMD
80 CORE2 DUO CPU E6550 @ 2.33GHZ 2 929 1,858 Intel
81 ATHLON(TM) 64 X2 DUAL CORE 4200+ 2 155 310 AMD