PROJECT #18322 RESEARCH FOR UNSPECIFIED
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

The rise in antibiotic resistant bacteria is a looming public health issue.

This project simulates AmpC β-lactamases found in many cephalosporin resistant bacteria.

This protein mediates resistance to most antibiotics by breaking down the drug.

Because it reduces the types of antibiotics that can be used to treat various infections, physicians have fewer ways to kill bacteria having this resistance protein.

Therefore, to design new antibiotics against these bacteria, we are interested in understanding how AmpC β-lactamase dynamics affects binding of various therapeutics.

This knowledge will help develop drugs that disrupt this enzyme, which will permit the use of broad spectrum antibiotics on these resistant bacteria again..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 54,526

Core: GRO_A8

Status: Public