PROJECT #18319 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 144,770

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 26,837 644,088 AMD
2 12TH GEN CORE I7-12700K 20 29,413 588,260 Intel
3 RYZEN 9 5950X 16-CORE 32 15,902 508,864 AMD
4 RYZEN 9 3900XT 12-CORE 24 20,645 495,480 AMD
5 RYZEN 7 5800X 8-CORE 16 29,242 467,872 AMD
6 RYZEN 7 5700X 8-CORE 16 24,570 393,120 AMD
7 RYZEN 7 3800X 8-CORE 16 23,856 381,696 AMD
8 RYZEN 9 3900X 12-CORE 24 14,137 339,288 AMD
9 11TH GEN CORE I7-11700K @ 3.60GHZ 16 19,142 306,272 Intel
10 RYZEN 9 5900HS 16 15,052 240,832 AMD
11 RYZEN 7 PRO 4750G 16 13,275 212,400 AMD
12 RYZEN 5 3600 6-CORE 12 16,017 192,204 AMD
13 CORE I7-8700 CPU @ 3.20GHZ 12 15,542 186,504 Intel
14 XEON CPU E5-2650L V4 @ 1.70GHZ 28 6,158 172,424 Intel
15 CORE I7-4790K CPU @ 4.00GHZ 8 9,915 79,320 Intel
16 CORE I7-10700K CPU @ 3.80GHZ 16 4,538 72,608 Intel
17 CORE I5-8600T CPU @ 2.30GHZ 6 11,270 67,620 Intel
18 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,019 56,152 Intel
19 CORE I5-6600K CPU @ 3.50GHZ 4 13,864 55,456 Intel
20 CORE I5-7400 CPU @ 3.00GHZ 4 13,829 55,316 Intel
21 CORE I5-4590 CPU @ 3.30GHZ 4 11,648 46,592 Intel
22 CORE I5-6500T CPU @ 2.50GHZ 4 11,413 45,652 Intel
23 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,099 40,792 Intel
24 CORE I5-4570 CPU @ 3.20GHZ 4 9,973 39,892 Intel
25 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,242 33,936 Intel
26 XEON CPU E31245 @ 3.30GHZ 8 4,139 33,112 Intel
27 RYZEN 7 3700X 8-CORE 16 1,953 31,248 AMD
28 CORE I3-4170 CPU @ 3.70GHZ 4 4,576 18,304 Intel
29 CORE I3-6006U CPU @ 2.00GHZ 4 2,213 8,852 Intel
30 PRO A10-9700 R7, 10 COMPUTE CORES 4C+6G 4 686 2,744 AMD