PROJECT #18319 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 144,770

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 27,806 667,344 AMD
2 RYZEN 9 3900 12-CORE 24 24,595 590,280 AMD
3 12TH GEN CORE I7-12700K 20 25,864 517,280 Intel
4 RYZEN 9 5950X 16-CORE 32 15,921 509,472 AMD
5 RYZEN 7 5800X3D 8-CORE 16 31,822 509,152 AMD
6 12TH GEN CORE I5-12600K 16 31,641 506,256 Intel
7 12TH GEN CORE I9-12900K 24 20,890 501,360 Intel
8 RYZEN 9 3900XT 12-CORE 24 20,727 497,448 AMD
9 RYZEN 7 5800X 8-CORE 16 29,165 466,640 AMD
10 RYZEN 7 5700X 8-CORE 16 24,790 396,640 AMD
11 CORE I9-7920X CPU @ 2.90GHZ 24 16,411 393,864 Intel
12 RYZEN 9 3900X 12-CORE 24 15,842 380,208 AMD
13 RYZEN 7 3800X 8-CORE 16 23,379 374,064 AMD
14 11TH GEN CORE I7-11700K @ 3.60GHZ 16 22,750 364,000 Intel
15 CORE I9-10850K CPU @ 3.60GHZ 20 16,072 321,440 Intel
16 CORE I9-10900X CPU @ 3.70GHZ 20 14,384 287,680 Intel
17 XEON CPU E5-2650 V2 @ 2.60GHZ 32 7,834 250,688 Intel
18 RYZEN 9 5900HS 16 15,052 240,832 AMD
19 RYZEN THREADRIPPER 1920X 12-CORE 24 9,816 235,584 AMD
20 CORE I9-9900KS CPU @ 4.00GHZ 16 14,256 228,096 Intel
21 RYZEN 7 5700G 16 13,744 219,904 AMD
22 RYZEN 7 PRO 4750G 16 13,626 218,016 AMD
23 RYZEN 5 3600 6-CORE 12 15,751 189,012 AMD
24 CORE I7-8700K CPU @ 3.70GHZ 12 15,681 188,172 Intel
25 RYZEN 5 5600X 6-CORE 12 14,565 174,780 AMD
26 CORE I7-8700 CPU @ 3.20GHZ 12 14,412 172,944 Intel
27 APPLE M1 MAX 10 17,079 170,790 Apple
28 XEON CPU E5-2698 V4 @ 2.20GHZ 16 10,347 165,552 Intel
29 RYZEN 5 5600G 12 13,066 156,792 AMD
30 RYZEN 7 5800H 16 8,746 139,936 AMD
31 CORE I7-10700K CPU @ 3.80GHZ 16 8,523 136,368 Intel
32 XEON GOLD 6128 CPU @ 3.40GHZ 12 11,341 136,092 Intel
33 CORE I7-7700K CPU @ 4.20GHZ 8 16,786 134,288 Intel
34 12TH GEN CORE I3-12100 8 15,889 127,112 Intel
35 XEON CPU E5-2650L V4 @ 1.70GHZ 28 4,424 123,872 Intel
36 CORE I5-9400F CPU @ 2.90GHZ 6 20,136 120,816 Intel
37 CORE I5-8500 CPU @ 3.00GHZ 6 19,907 119,442 Intel
38 11TH GEN CORE I5-11400 @ 2.60GHZ 12 9,241 110,892 Intel
39 CORE I7-10700T CPU @ 2.00GHZ 16 6,649 106,384 Intel
40 RYZEN 7 4800H 16 6,620 105,920 AMD
41 CORE I5-10400 CPU @ 2.90GHZ 12 8,436 101,232 Intel
42 RYZEN 7 1700 EIGHT-CORE 16 6,085 97,360 AMD
43 CORE I7-9750H CPU @ 2.60GHZ 12 8,012 96,144 Intel
44 RYZEN 5 1600 SIX-CORE 12 7,235 86,820 AMD
45 CORE I9-8950HK CPU @ 2.90GHZ 12 7,016 84,192 Intel
46 APPLE M1 8 10,457 83,656 Apple
47 RYZEN 7 3700X 8-CORE 16 5,076 81,216 AMD
48 CORE I7-4790K CPU @ 4.00GHZ 8 9,915 79,320 Intel
49 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,836 77,376 Intel
50 APPLE M1 PRO 10 7,188 71,880 Apple
51 CORE I5-8600T CPU @ 2.30GHZ 6 11,320 67,920 Intel
52 XEON CPU E3-1270 V5 @ 3.60GHZ 8 8,264 66,112 Intel
53 XEON CPU E5-1630 V3 @ 3.70GHZ 8 7,461 59,688 Intel
54 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,060 56,480 Intel
55 CORE I5-4690 CPU @ 3.50GHZ 4 13,861 55,444 Intel
56 CORE I5-7400 CPU @ 3.00GHZ 4 13,805 55,220 Intel
57 CORE I5-6600K CPU @ 3.50GHZ 4 12,414 49,656 Intel
58 RYZEN 7 1800X EIGHT-CORE 16 3,037 48,592 AMD
59 CORE I5-6500T CPU @ 2.50GHZ 4 11,413 45,652 Intel
60 CORE I5-4590 CPU @ 3.30GHZ 4 11,287 45,148 Intel
61 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,461 43,688 Intel
62 CORE I5-8350U CPU @ 1.70GHZ 8 5,170 41,360 Intel
63 CORE I5-8250U CPU @ 1.60GHZ 8 4,857 38,856 Intel
64 CORE I5-4570 CPU @ 3.20GHZ 4 9,492 37,968 Intel
65 CORE I5-3570K CPU @ 3.40GHZ 4 9,091 36,364 Intel
66 XEON CPU E3-1240 V2 @ 3.40GHZ 8 4,480 35,840 Intel
67 XEON CPU E31245 @ 3.30GHZ 8 4,139 33,112 Intel
68 RYZEN 3 2200G 4 7,857 31,428 AMD
69 CORE I3-4170 CPU @ 3.70GHZ 4 4,576 18,304 Intel
70 CORE I3-6006U CPU @ 2.00GHZ 4 2,171 8,684 Intel
71 ATHLON 3000G 4 1,558 6,232 AMD
72 PRO A10-9700 R7, 10 COMPUTE CORES 4C+6G 4 686 2,744 AMD