PROJECT #18320 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 169,250

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 22 May 2022 15:22:30

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 32,129 771,096 AMD
2 12TH GEN CORE I7-12700K 20 32,650 653,000 Intel
3 RYZEN 9 5950X 16-CORE 32 16,650 532,800 AMD
4 RYZEN 9 3900XT 12-CORE 24 20,345 488,280 AMD
5 CORE I9-10850K CPU @ 3.60GHZ 20 23,257 465,140 Intel
6 RYZEN 7 5700X 8-CORE 16 28,262 452,192 AMD
7 RYZEN 7 5800X 8-CORE 16 25,642 410,272 AMD
8 RYZEN 7 3800X 8-CORE 16 23,798 380,768 AMD
9 RYZEN 9 3900X 12-CORE 24 14,057 337,368 AMD
10 RYZEN 9 5900HS 16 14,347 229,552 AMD
11 RYZEN 7 PRO 4750G 16 12,098 193,568 AMD
12 RYZEN 7 2700X EIGHT-CORE 16 11,788 188,608 AMD
13 RYZEN 5 3600 6-CORE 12 14,889 178,668 AMD
14 RYZEN 7 3700X 8-CORE 16 10,675 170,800 AMD
15 RYZEN 5 5600G 12 13,699 164,388 AMD
16 RYZEN 5 5600X 6-CORE 12 12,830 153,960 AMD
17 CORE I7-8700 CPU @ 3.20GHZ 12 12,586 151,032 Intel
18 RYZEN 5 1600 SIX-CORE 12 9,251 111,012 AMD
19 CORE I7-6700K CPU @ 4.00GHZ 8 9,873 78,984 Intel
20 CORE I7-4790K CPU @ 4.00GHZ 8 9,582 76,656 Intel
21 11TH GEN CORE I5-1145G7 @ 2.60GHZ 8 7,105 56,840 Intel
22 XEON CPU E5-1630 V3 @ 3.70GHZ 8 7,086 56,688 Intel
23 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,971 55,768 Intel
24 CORE I5-7400 CPU @ 3.00GHZ 4 13,597 54,388 Intel
25 CORE I5-6600K CPU @ 3.50GHZ 4 13,180 52,720 Intel
26 CORE I5-4590 CPU @ 3.30GHZ 4 11,365 45,460 Intel
27 CORE I5-6500T CPU @ 2.50GHZ 4 11,290 45,160 Intel
28 CORE I5-4570 CPU @ 3.20GHZ 4 10,073 40,292 Intel
29 XEON CPU E31245 @ 3.30GHZ 8 4,048 32,384 Intel
30 RYZEN 5 PRO 2400G 8 3,044 24,352 AMD
31 CORE I3-6006U CPU @ 2.00GHZ 4 1,955 7,820 Intel
32 PRO A10-9700 R7, 10 COMPUTE CORES 4C+6G 4 1,069 4,276 AMD
33 FX-4300 QUAD-CORE 4 744 2,976 AMD