PROJECT #18320 RESEARCH FOR MYOSINS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although structurally similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

We are using this information to understand and design specific theraputics that don't have off-target effects.

Myosin was featured as the PDB Molecule of the Month in June 2001. Preliminary results from p18300-18308 have provided some promising insights into drug specificity for these myosin motors.

P18312-18321 are expanding upon the previous stretch of simulations and looking to refine our models for these drug binding sites..

PROJECT INFO

Manager(s): Jeff Lotthammer

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 169,250

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:27

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5900X 12-CORE 24 31,206 748,944 AMD
2 12TH GEN CORE I9-12900K 24 27,760 666,240 Intel
3 RYZEN 9 3900 12-CORE 24 25,245 605,880 AMD
4 RYZEN 9 5950X 16-CORE 32 16,511 528,352 AMD
5 RYZEN 9 3900XT 12-CORE 24 20,682 496,368 AMD
6 12TH GEN CORE I7-12700K 20 23,593 471,860 Intel
7 RYZEN 7 5800X3D 8-CORE 16 29,371 469,936 AMD
8 RYZEN 7 5800X 8-CORE 16 27,437 438,992 AMD
9 RYZEN 7 5700X 8-CORE 16 26,021 416,336 AMD
10 RYZEN 9 3900X 12-CORE 24 16,271 390,504 AMD
11 11TH GEN CORE I7-11700K @ 3.60GHZ 16 23,091 369,456 Intel
12 RYZEN 7 3800X 8-CORE 16 22,491 359,856 AMD
13 CORE I9-10850K CPU @ 3.60GHZ 20 17,217 344,340 Intel
14 RYZEN 7 6800H 16 21,165 338,640 AMD
15 CORE I9-10900X CPU @ 3.70GHZ 20 15,931 318,620 Intel
16 XEON CPU E5-2680 V2 @ 2.80GHZ 40 7,788 311,520 Intel
17 CORE I9-9900KS CPU @ 4.00GHZ 16 17,363 277,808 Intel
18 RYZEN 9 5900HS 16 14,347 229,552 AMD
19 RYZEN 7 5800H 16 13,821 221,136 AMD
20 APPLE M1 MAX 10 21,316 213,160 Apple
21 RYZEN 7 PRO 4750G 16 12,708 203,328 AMD
22 XEON CPU E5-2698 V4 @ 2.20GHZ 16 11,997 191,952 Intel
23 XEON CPU E5-2697 V2 @ 2.70GHZ 24 7,761 186,264 Intel
24 RYZEN 5 3600 6-CORE 12 14,391 172,692 AMD
25 RYZEN 7 3700X 8-CORE 16 10,670 170,720 AMD
26 RYZEN 7 2700X EIGHT-CORE 16 10,580 169,280 AMD
27 CORE I7-10700K CPU @ 3.80GHZ 16 10,304 164,864 Intel
28 RYZEN 7 5700G 16 10,253 164,048 AMD
29 RYZEN 5 5600X 6-CORE 12 13,237 158,844 AMD
30 RYZEN 5 5600G 12 12,924 155,088 AMD
31 CORE I7-9700K CPU @ 3.60GHZ 8 18,136 145,088 Intel
32 XEON GOLD 6128 CPU @ 3.40GHZ 12 12,039 144,468 Intel
33 CORE I7-8700 CPU @ 3.20GHZ 12 11,573 138,876 Intel
34 11TH GEN CORE I5-11400 @ 2.60GHZ 12 10,888 130,656 Intel
35 CORE I7-7700K CPU @ 4.20GHZ 8 15,779 126,232 Intel
36 CORE I5-8500 CPU @ 3.00GHZ 6 18,679 112,074 Intel
37 RYZEN 5 1600 SIX-CORE 12 9,251 111,012 AMD
38 RYZEN 7 1700 EIGHT-CORE 16 6,236 99,776 AMD
39 CORE I5-10400 CPU @ 2.90GHZ 12 8,099 97,188 Intel
40 CORE I7-10700T CPU @ 2.00GHZ 16 5,951 95,216 Intel
41 CORE I9-8950HK CPU @ 2.90GHZ 12 7,547 90,564 Intel
42 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,991 79,856 Intel
43 CORE I5-10500T CPU @ 2.30GHZ 12 6,641 79,692 Intel
44 CORE I7-6700K CPU @ 4.00GHZ 8 9,873 78,984 Intel
45 CORE I7-4790K CPU @ 4.00GHZ 8 9,582 76,656 Intel
46 APPLE M1 PRO 10 7,331 73,310 Apple
47 CORE I5-8600T CPU @ 2.30GHZ 6 11,300 67,800 Intel
48 11TH GEN CORE I5-1145G7 @ 2.60GHZ 8 7,105 56,840 Intel
49 XEON CPU E5-1630 V3 @ 3.70GHZ 8 7,102 56,816 Intel
50 CORE I5-4690 CPU @ 3.50GHZ 4 13,850 55,400 Intel
51 CORE I5-7400 CPU @ 3.00GHZ 4 13,577 54,308 Intel
52 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,752 54,016 Intel
53 CORE I7-3770 CPU @ 3.40GHZ 8 6,730 53,840 Intel
54 CORE I5-6600K CPU @ 3.50GHZ 4 12,669 50,676 Intel
55 XEON CPU E3-1240 V2 @ 3.40GHZ 8 5,944 47,552 Intel
56 XEON CPU E3-1270 V5 @ 3.60GHZ 8 5,938 47,504 Intel
57 CORE I5-6500T CPU @ 2.50GHZ 4 11,290 45,160 Intel
58 APPLE M1 8 5,606 44,848 Apple
59 CORE I5-4590 CPU @ 3.30GHZ 4 11,013 44,052 Intel
60 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,503 44,024 Intel
61 CORE I7-3770K CPU @ 3.50GHZ 8 5,336 42,688 Intel
62 CORE I5-4570 CPU @ 3.20GHZ 4 9,874 39,496 Intel
63 CORE I5-1035G4 CPU @ 1.10GHZ 8 4,756 38,048 Intel
64 XEON CPU E5-2650L V4 @ 1.70GHZ 28 1,300 36,400 Intel
65 CORE I5-3570K CPU @ 3.40GHZ 4 9,001 36,004 Intel
66 XEON CPU E31245 @ 3.30GHZ 8 4,048 32,384 Intel
67 CORE I5-8350U CPU @ 1.70GHZ 8 3,620 28,960 Intel
68 RYZEN 5 PRO 2400G 8 3,044 24,352 AMD
69 CORE I7-2760QM CPU @ 2.40GHZ 8 2,879 23,032 Intel
70 CORE I7-7700HQ CPU @ 2.80GHZ 8 1,574 12,592 Intel
71 CORE I3-6006U CPU @ 2.00GHZ 4 2,066 8,264 Intel
72 PRO A10-9700 R7, 10 COMPUTE CORES 4C+6G 4 1,069 4,276 AMD
73 FX-4300 QUAD-CORE 4 744 2,976 AMD