Folding project #14969, CANCER research

Research section Research projects and references

Project #14969 overview

Project Summary AI Beta

This project looks at how two proteins, Class F Receptors and Patched, control cell growth. When these proteins go haywire, they can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By creating computer models, researchers hope to figure out how these proteins work so they can better understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 133,139
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

A class of cell surface receptors involved in signal transduction.

Technical: BiotechnologyHuman Biology / Cellular Signaling

Class F receptors are proteins found on the surface of cells. They receive signals from other molecules and transmit them inside the cell, influencing various cellular processes like growth and differentiation. These receptors play a crucial role in normal development but can be implicated in diseases when their activity is disrupted.

Patched Membrane Protein

A transmembrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Technical: BiotechnologyHuman Biology / Cellular Signaling

Patched is a protein embedded in the cell membrane. It acts like a brake on the Hedgehog signaling pathway, which controls cell growth and development. When Patched is inactive, the pathway becomes overactive, leading to potential problems like cancer.

Basal Cell Carcinoma

A type of skin cancer that arises from the basal cells.

Medical: PharmaceuticalsHuman Health / Oncology

Basal cell carcinoma is a common form of skin cancer that originates in the basal layer of the epidermis. It often presents as a pearly or waxy bump and can grow slowly. Early detection and treatment are crucial to prevent spread.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medical: PharmaceuticalsHuman Health / Neurology, Pediatrics

Medulloblastoma is an aggressive brain tumor that typically affects children. It originates in the cerebellum, a region responsible for balance and coordination. Treatment often involves surgery, chemotherapy, and radiation therapy.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	11,309,040	440,974	25.65	0 ^hrs 56 ^mins
2	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	9,668,607	72,000	134.29	0 ^hrs 11 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,280,493	409,564	22.66	1 ^hrs 4 ^mins
4	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,062,222	409,180	22.15	1 ^hrs 5 ^mins
5	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	7,383,661	382,726	19.29	1 ^hrs 15 ^mins
6	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,824,226	371,408	18.37	1 ^hrs 18 ^mins
7	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,657,253	350,824	16.13	1 ^hrs 29 ^mins
8	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,513,254	348,748	15.81	1 ^hrs 31 ^mins
9	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,498,150	347,500	15.82	1 ^hrs 31 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,239,150	331,514	15.80	1 ^hrs 31 ^mins
11	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,034,152	337,720	14.91	1 ^hrs 37 ^mins
12	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,437,992	324,162	13.69	1 ^hrs 45 ^mins
13	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	4,254,648	318,135	13.37	1 ^hrs 48 ^mins
14	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,147,664	314,849	13.17	1 ^hrs 49 ^mins
15	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,683,275	304,338	12.10	1 ^hrs 59 ^mins
16	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,440,333	291,251	11.81	2 ^hrs 2 ^mins
17	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,310,760	293,742	11.27	2 ^hrs 8 ^mins
18	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,893,482	283,637	10.20	2 ^hrs 21 ^mins
19	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,767,638	209,903	13.19	1 ^hrs 49 ^mins

20	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,722,238	223,036	12.21	1 ^hrs 58 ^mins
21	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,668,037	272,749	9.78	2 ^hrs 27 ^mins
22	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,541,759	267,955	9.49	2 ^hrs 32 ^mins
23	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,531,801	238,970	10.59	2 ^hrs 16 ^mins
24	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,439,517	262,971	9.28	2 ^hrs 35 ^mins
25	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,428,102	265,520	9.14	2 ^hrs 37 ^mins
26	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,426,159	264,713	9.17	2 ^hrs 37 ^mins
27	GeForce RTX 2060 12GB TU106 [GeForce RTX 2060 12GB]	Nvidia	TU106	2,379,173	266,136	8.94	2 ^hrs 41 ^mins
28	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,377,126	257,116	9.25	2 ^hrs 36 ^mins
29	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,327,966	251,108	9.27	2 ^hrs 35 ^mins
30	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,233,516	256,793	8.70	2 ^hrs 46 ^mins
31	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,975,795	247,852	7.97	3 ^hrs 1 ^mins
32	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,920,225	245,562	7.82	3 ^hrs 4 ^mins
33	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,802,221	72,000	25.03	0 ^hrs 58 ^mins
34	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,545,284	228,039	6.78	3 ^hrs 33 ^mins
35	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,422,311	221,187	6.43	3 ^hrs 44 ^mins
36	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,359,410	220,547	6.16	3 ^hrs 54 ^mins
37	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,348,192	110,748	12.17	1 ^hrs 58 ^mins
38	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,270,324	212,027	5.99	4 ^hrs 0 ^mins
39	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,268,366	211,161	6.01	3 ^hrs 60 ^mins

40	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,220,621	209,168	5.84	4 ^hrs 7 ^mins
41	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,203,231	210,317	5.72	4 ^hrs 12 ^mins
42	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,202,673	77,623	15.49	1 ^hrs 33 ^mins
43	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,178,037	199,375	5.91	4 ^hrs 4 ^mins
44	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,143,437	182,274	6.27	3 ^hrs 50 ^mins
45	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	999,450	72,000	13.88	1 ^hrs 44 ^mins
46	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	999,209	196,896	5.07	4 ^hrs 44 ^mins
47	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	855,233	188,463	4.54	5 ^hrs 17 ^mins
48	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	812,712	184,917	4.40	5 ^hrs 28 ^mins
49	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	755,336	180,321	4.19	5 ^hrs 44 ^mins
50	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	752,295	191,180	3.94	6 ^hrs 6 ^mins
51	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	733,167	178,224	4.11	5 ^hrs 50 ^mins
52	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	550,939	163,274	3.37	7 ^hrs 7 ^mins
53	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	550,807	72,000	7.65	3 ^hrs 8 ^mins
54	R9 Fury X/NANO Fiji XT [R9 Fury X/NANO]	AMD	Fiji XT	540,725	157,999	3.42	7 ^hrs 1 ^mins
55	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	435,847	72,000	6.05	3 ^hrs 58 ^mins
56	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	369,108	72,000	5.13	4 ^hrs 41 ^mins
57	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	248,203	138,032	1.80	13 ^hrs 21 ^mins
58	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	220,899	135,673	1.63	14 ^hrs 44 ^mins
59	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	206,343	133,053	1.55	15 ^hrs 29 ^mins

60	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	178,714	126,094	1.42	16 ^hrs 56 ^mins
61	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	147,577	104,659	1.41	17 ^hrs 1 ^mins
62	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	57,851	83,931	0.69	34 ^hrs 49 ^mins

Research: CANCER Folding Project #14969

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14969

GPU PPD Averages

Research: CANCER Folding Project #14969

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages