Folding project #14940, CANCER research

Research section Research projects and references

Project #14940 overview

Project Summary AI Beta

This project looks at proteins called Class F Receptors and Patched that control how cells develop. Too much or too little of these proteins can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, scientists hope to learn how these proteins work, which could help us understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 106,056
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

Membrane receptors that bind ligands and trigger cellular responses.

Technical: BiotechnologyCellular Biology / Signal Transduction

Class F Receptors are a type of protein found on the surface of cells. They act as receivers for signals from other molecules called ligands. When a ligand binds to a Class F Receptor, it triggers a cascade of events inside the cell, leading to changes in cell behavior. These receptors play important roles in various cellular processes, including growth, differentiation, and survival.

Patched Membrane Protein

A transmembrane protein that regulates the activity of Hedgehog signaling pathway.

Technical: BiotechnologyCellular Biology / Signal Transduction

Patched is a protein found on the surface of cells. It acts as a negative regulator of the Hedgehog signaling pathway, which is crucial for embryonic development and tissue regeneration. When Hedgehog ligands bind to Patched, it inhibits the activity of another protein called Smoothened, preventing the activation of downstream signaling events.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Medical: HealthcareOncology / Skin Cancer

Basal Cell Carcinoma is a common type of skin cancer that arises from the basal cells, which are located in the deepest layer of the epidermis. It typically presents as a pearly or waxy bump, often with visible blood vessels. Basal Cell Carcinoma is usually slow-growing and rarely spreads to other parts of the body.

Medulloblastoma

An aggressive type of brain tumor that originates in the cerebellum.

Medical: HealthcareOncology / Brain Tumor

Medulloblastoma is a malignant brain tumor that arises from the cerebellum, the part of the brain responsible for coordinating movement and balance. It is most commonly diagnosed in children and is characterized by rapid growth and spread. Treatment typically involves surgery, chemotherapy, and radiation therapy.

Pathogenesis

The development or progression of a disease.

Scientific: Biomedical ResearchMedicine / Disease Development

Pathogenesis refers to the biological processes that underlie the development and progression of a disease. It encompasses the initial triggers, cellular changes, molecular interactions, and systemic responses involved in the disease process.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	14,461,543	180,928	79.93	0 ^hrs 18 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,051,236	172,564	69.84	0 ^hrs 21 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,659,851	153,916	62.76	0 ^hrs 23 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,818,912	155,652	56.66	0 ^hrs 25 ^mins
5	A40 GA102GL [A40]	Nvidia	GA102GL	7,419,328	146,592	50.61	0 ^hrs 28 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,924,041	142,570	48.57	0 ^hrs 30 ^mins
7	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,752,591	141,904	47.59	0 ^hrs 30 ^mins
8	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,472,085	140,526	46.06	0 ^hrs 31 ^mins
9	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,130,336	135,738	45.16	0 ^hrs 32 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,104,025	136,631	44.68	0 ^hrs 32 ^mins
11	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,031,623	135,270	44.59	0 ^hrs 32 ^mins
12	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,299,766	131,985	40.15	0 ^hrs 36 ^mins
13	RTX A5000 GA102GL [RTX A5000]	Nvidia	GA102GL	5,011,484	129,469	38.71	0 ^hrs 37 ^mins
14	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,732,209	127,317	37.17	0 ^hrs 39 ^mins
15	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,692,624	127,463	36.82	0 ^hrs 39 ^mins
16	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,665,874	115,266	31.80	0 ^hrs 45 ^mins
17	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,576,425	114,757	31.17	0 ^hrs 46 ^mins
18	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,158,380	110,653	28.54	0 ^hrs 50 ^mins
19	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,098,980	110,723	27.99	0 ^hrs 51 ^mins

20	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,023,822	108,505	27.87	0 ^hrs 52 ^mins
21	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,997,180	108,628	27.59	0 ^hrs 52 ^mins
22	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,991,045	107,598	27.80	0 ^hrs 52 ^mins
23	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,990,360	108,862	27.47	0 ^hrs 52 ^mins
24	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,947,136	107,731	27.36	0 ^hrs 53 ^mins
25	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,580,944	100,916	25.58	0 ^hrs 56 ^mins
26	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,569,665	103,527	24.82	0 ^hrs 58 ^mins
27	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,417,077	101,325	23.85	1 ^hrs 0 ^mins
28	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,314,972	100,339	23.07	1 ^hrs 2 ^mins
29	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,288,467	99,180	23.07	1 ^hrs 2 ^mins
30	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,219,103	98,543	22.52	1 ^hrs 4 ^mins
31	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,190,689	99,124	22.10	1 ^hrs 5 ^mins
32	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,125,702	95,843	22.18	1 ^hrs 5 ^mins
33	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,925,599	94,200	20.44	1 ^hrs 10 ^mins
34	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,754,407	88,400	19.85	1 ^hrs 13 ^mins
35	Radeon VII Vega 20 [Radeon VII]	AMD	Vega 20	1,517,332	88,385	17.17	1 ^hrs 24 ^mins
36	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,497,077	85,847	17.44	1 ^hrs 23 ^mins
37	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,441,197	85,433	16.87	1 ^hrs 25 ^mins
38	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,396,701	84,785	16.47	1 ^hrs 27 ^mins
39	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,371,037	83,714	16.38	1 ^hrs 28 ^mins

40	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,286,363	79,634	16.15	1 ^hrs 29 ^mins
41	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,272,354	82,215	15.48	1 ^hrs 33 ^mins
42	Geforce RTX 3070 Ti Laptop GPU GA104 [Geforce RTX 3070 Ti Laptop GPU]	Nvidia	GA104	1,249,320	80,718	15.48	1 ^hrs 33 ^mins
43	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,171,790	79,642	14.71	1 ^hrs 38 ^mins
44	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,115,864	67,552	16.52	1 ^hrs 27 ^mins
45	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,044,770	76,827	13.60	1 ^hrs 46 ^mins
46	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,042,489	78,172	13.34	1 ^hrs 48 ^mins
47	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,007,931	74,184	13.59	1 ^hrs 46 ^mins
48	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	984,558	75,457	13.05	1 ^hrs 50 ^mins
49	P104-100 GP104 [P104-100]	Nvidia	GP104	962,868	75,085	12.82	1 ^hrs 52 ^mins
50	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	920,989	44,764	20.57	1 ^hrs 10 ^mins
51	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	920,200	72,244	12.74	1 ^hrs 53 ^mins
52	Radeon PRO WX 9100 Vega 10 XT [Radeon PRO WX 9100]	AMD	Vega 10 XT	885,952	73,232	12.10	1 ^hrs 59 ^mins
53	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	795,319	67,508	11.78	2 ^hrs 2 ^mins
54	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	703,530	67,765	10.38	2 ^hrs 19 ^mins
55	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	689,028	66,046	10.43	2 ^hrs 18 ^mins
56	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	663,504	66,208	10.02	2 ^hrs 24 ^mins
57	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	628,594	65,413	9.61	2 ^hrs 30 ^mins
58	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	469,962	59,040	7.96	3 ^hrs 1 ^mins
59	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	407,650	56,584	7.20	3 ^hrs 20 ^mins

60	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	344,494	53,868	6.40	3 ^hrs 45 ^mins
61	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	330,044	52,546	6.28	3 ^hrs 49 ^mins
62	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	317,063	51,076	6.21	3 ^hrs 52 ^mins
63	Vega 8 Mobile Raven Ridge APU [Vega 8 Mobile]	AMD	Raven Ridge APU	313,718	53,333	5.88	4 ^hrs 5 ^mins
64	P106-090 GP106 [P106-090]	Nvidia	GP106	303,749	50,971	5.96	4 ^hrs 2 ^mins
65	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	244,129	48,272	5.06	4 ^hrs 45 ^mins
66	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	230,104	46,389	4.96	4 ^hrs 50 ^mins
67	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	224,709	46,259	4.86	4 ^hrs 56 ^mins
68	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	210,987	45,205	4.67	5 ^hrs 9 ^mins
69	R9 380X/R9 M295X Tonga XT/Amethyst XT [R9 380X/R9 M295X]	AMD	Tonga XT/Amethyst XT	198,190	44,533	4.45	5 ^hrs 24 ^mins
70	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	164,269	39,685	4.14	5 ^hrs 48 ^mins
71	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	144,054	39,810	3.62	6 ^hrs 38 ^mins
72	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	142,067	39,750	3.57	6 ^hrs 43 ^mins
73	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	108,273	36,172	2.99	8 ^hrs 1 ^mins
74	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	103,973	37,576	2.77	8 ^hrs 40 ^mins
75	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	102,398	35,622	2.87	8 ^hrs 21 ^mins
76	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	51,124	28,507	1.79	13 ^hrs 23 ^mins
77	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	49,374	28,039	1.76	13 ^hrs 38 ^mins
78	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	47,394	25,877	1.83	13 ^hrs 6 ^mins

Research: CANCER Folding Project #14940

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14940

GPU PPD Averages

Research: CANCER Folding Project #14940

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages