Folding project #14947, CANCER research

Research section Research projects and references

Project #14947 overview

Project Summary AI Beta

This project looks at two proteins, Class F Receptors and Patched, which control how cells grow and change. When these proteins are messed up, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, scientists hope to understand how these proteins work so they can find better ways to treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 104,623
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

Group of cell surface receptors involved in signaling pathways.

Technical: BiopharmaceuticalsBiotechnology / Cell Biology

Class F Receptors are a type of protein found on the surface of cells. They act as receivers for signals from other cells and molecules, playing a crucial role in regulating various cellular processes, including growth and differentiation. Disruptions in their function can contribute to diseases like cancer.

Patched

A protein that regulates cell growth and development.

Technical: BiopharmaceuticalsBiotechnology / Cell Biology

Patched is a protein that acts as a brake on cell signaling pathways. It helps control the rate at which cells divide and grow. Mutations in the Patched gene can lead to uncontrolled cell proliferation, contributing to the development of certain cancers.

Basal Cell Carcinoma

A common type of skin cancer that arises from the basal cells.

Pathology: HealthcareMedicine / Oncology

Basal Cell Carcinoma is the most prevalent form of skin cancer. It develops in the basal cells, which are located in the deepest layer of the epidermis (skin). This cancer often appears as a pearly or waxy bump and can spread to nearby tissues if left untreated.

Medulloblastoma

A type of brain cancer that originates in the cerebellum.

Pathology: HealthcareMedicine / Oncology

Medulloblastoma is a malignant tumor that arises from the cells of the cerebellum, a part of the brain responsible for balance and coordination. It's often diagnosed in children and can spread rapidly if not treated promptly.

Pathogenesis

The origin and development of a disease.

Scientific: Research & DevelopmentBiotechnology / Disease Research

Pathogenesis refers to the complex series of events leading to the development of a disease. Scientists study pathogenesis to understand how diseases arise, progress, and ultimately lead to symptoms and complications.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	14,887,849	179,604	82.89	0 ^hrs 17 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,068,658	169,069	71.38	0 ^hrs 20 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,833,904	156,415	62.87	0 ^hrs 23 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	8,456,778	149,986	56.38	0 ^hrs 26 ^mins
5	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,542,194	144,498	52.20	0 ^hrs 28 ^mins
6	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,541,472	137,512	47.57	0 ^hrs 30 ^mins
7	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,495,994	139,189	46.67	0 ^hrs 31 ^mins
8	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,455,846	136,622	47.25	0 ^hrs 30 ^mins
9	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,392,333	135,182	47.29	0 ^hrs 30 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,079,353	134,815	45.09	0 ^hrs 32 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,201,351	124,859	41.66	0 ^hrs 35 ^mins
12	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,708,181	124,741	37.74	0 ^hrs 38 ^mins
13	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,685,925	124,260	37.71	0 ^hrs 38 ^mins
14	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,987,962	118,118	33.76	0 ^hrs 43 ^mins
15	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,665,384	114,053	32.14	0 ^hrs 45 ^mins
16	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,194,453	108,833	29.35	0 ^hrs 49 ^mins
17	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,077,893	108,013	28.50	0 ^hrs 51 ^mins
18	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,037,282	107,735	28.19	0 ^hrs 51 ^mins
19	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,966,627	104,768	28.32	0 ^hrs 51 ^mins

20	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,946,057	105,804	27.84	0 ^hrs 52 ^mins
21	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	2,569,080	47,654	53.91	0 ^hrs 27 ^mins
22	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,563,446	95,135	26.95	0 ^hrs 53 ^mins
23	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,422,607	100,351	24.14	0 ^hrs 60 ^mins
24	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,364,075	97,005	24.37	0 ^hrs 59 ^mins
25	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,362,132	98,199	24.05	0 ^hrs 60 ^mins
26	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,328,627	97,951	23.77	1 ^hrs 1 ^mins
27	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,306,110	96,439	23.91	1 ^hrs 0 ^mins
28	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,275,574	96,875	23.49	1 ^hrs 1 ^mins
29	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,076,820	94,125	22.06	1 ^hrs 5 ^mins
30	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,828,246	87,745	20.84	1 ^hrs 9 ^mins
31	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,808,905	90,279	20.04	1 ^hrs 12 ^mins
32	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,760,652	89,640	19.64	1 ^hrs 13 ^mins
33	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,713,001	86,156	19.88	1 ^hrs 12 ^mins
34	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,446,928	84,228	17.18	1 ^hrs 24 ^mins
35	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,315,773	78,019	16.86	1 ^hrs 25 ^mins
36	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,293,229	81,331	15.90	1 ^hrs 31 ^mins
37	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,267,508	80,488	15.75	1 ^hrs 31 ^mins
38	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,184,459	78,979	15.00	1 ^hrs 36 ^mins
39	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,167,288	77,134	15.13	1 ^hrs 35 ^mins

40	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,079,943	76,396	14.14	1 ^hrs 42 ^mins
41	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,059,963	74,180	14.29	1 ^hrs 41 ^mins
42	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,030,946	73,278	14.07	1 ^hrs 42 ^mins
43	P104-100 GP104 [P104-100]	Nvidia	GP104	959,337	73,604	13.03	1 ^hrs 50 ^mins
44	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	850,237	70,515	12.06	1 ^hrs 59 ^mins
45	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	725,507	66,502	10.91	2 ^hrs 12 ^mins
46	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	651,699	64,658	10.08	2 ^hrs 23 ^mins
47	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	634,531	64,012	9.91	2 ^hrs 25 ^mins
48	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	597,159	62,410	9.57	2 ^hrs 30 ^mins
49	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	548,486	54,927	9.99	2 ^hrs 24 ^mins
50	P106-100 GP106 [P106-100]	Nvidia	GP106	419,695	55,735	7.53	3 ^hrs 11 ^mins
51	Quadro K6000 GK110GL [Quadro K6000]	Nvidia	GK110GL	392,806	53,813	7.30	3 ^hrs 17 ^mins
52	Vega 8 Mobile Raven Ridge APU [Vega 8 Mobile]	AMD	Raven Ridge APU	333,978	51,938	6.43	3 ^hrs 44 ^mins
53	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	330,533	51,485	6.42	3 ^hrs 44 ^mins
54	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	317,433	51,957	6.11	3 ^hrs 56 ^mins
55	P106-090 GP106 [P106-090]	Nvidia	GP106	300,713	49,748	6.04	3 ^hrs 58 ^mins
56	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	253,931	47,149	5.39	4 ^hrs 27 ^mins
57	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	229,248	45,500	5.04	4 ^hrs 46 ^mins
58	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	224,600	44,756	5.02	4 ^hrs 47 ^mins
59	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	206,589	44,111	4.68	5 ^hrs 7 ^mins

60	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	142,194	39,087	3.64	6 ^hrs 36 ^mins
61	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	139,287	39,459	3.53	6 ^hrs 48 ^mins
62	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	115,724	36,527	3.17	7 ^hrs 35 ^mins
63	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	111,510	35,994	3.10	7 ^hrs 45 ^mins
64	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	103,528	37,301	2.78	8 ^hrs 39 ^mins
65	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	62,574	33,268	1.88	12 ^hrs 46 ^mins
66	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	54,089	27,464	1.97	12 ^hrs 11 ^mins
67	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	52,424	27,961	1.87	12 ^hrs 48 ^mins
68	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	50,481	27,506	1.84	13 ^hrs 5 ^mins

Research: CANCER Folding Project #14947

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14947

GPU PPD Averages

Research: CANCER Folding Project #14947

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages