Folding project #14942, CANCER research

Research section Research projects and references

Project #14942 overview

Project Summary AI Beta

This project looks at Class F Receptors and Patched, proteins that control how cells grow. When these proteins go haywire, they can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By creating computer models, scientists hope to figure out how these proteins work, which could help us understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 105,995
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

A family of G protein-coupled receptors involved in cell differentiation.

Scientific: BiotechnologyCellular Biology / Signal Transduction

Class F receptors are a type of protein found on the surface of cells. They act as receptors for signaling molecules and play a crucial role in regulating cell growth and development. When activated, they trigger a cascade of events inside the cell that ultimately influence how cells behave. Disruptions in Class F receptor function can contribute to various diseases, including cancer.

Patched Membrane Protein

A transmembrane protein that regulates the activity of Hedgehog signaling pathway.

Scientific: BiotechnologyCellular Biology / Signal Transduction

Patched is a membrane protein that acts as a 'brake' on the Hedgehog signaling pathway. This pathway is essential for embryonic development and tissue repair. When Patched is functioning correctly, it prevents excessive Hedgehog signaling. However, mutations in Patched can lead to uncontrolled Hedgehog activity, contributing to cancer development.

Basal Cell Carcinoma

A common type of skin cancer that originates in the basal cells.

Pathological: HealthcareOncology / Skin Cancer

Basal cell carcinoma is a slow-growing skin cancer that arises from the basal cells, which are located in the deepest layer of the epidermis (the outermost layer of skin). It typically appears as a pearly or waxy bump and can often be treated effectively with surgery or other therapies.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Pathological: HealthcareOncology / Brain Tumors

Medulloblastoma is a highly aggressive brain tumor that originates in the cerebellum, the part of the brain responsible for coordinating movement and balance. It is most common in children and can spread to other parts of the body if not treated promptly.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,164,098	187,082	81.06	0 ^hrs 18 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,840,459	179,337	71.60	0 ^hrs 20 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,701,215	159,116	60.97	0 ^hrs 24 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,302,994	160,875	57.83	0 ^hrs 25 ^mins
5	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,206,392	147,985	48.70	0 ^hrs 30 ^mins
6	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,195,013	146,530	49.10	0 ^hrs 29 ^mins
7	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,564,623	143,118	45.87	0 ^hrs 31 ^mins
8	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,463,155	139,691	46.27	0 ^hrs 31 ^mins
9	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,432,144	142,439	45.16	0 ^hrs 32 ^mins
10	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,360,783	140,775	45.18	0 ^hrs 32 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,382,763	134,686	39.97	0 ^hrs 36 ^mins
12	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,029,681	132,673	37.91	0 ^hrs 38 ^mins
13	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,990,254	131,552	37.93	0 ^hrs 38 ^mins
14	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,861,723	130,368	37.29	0 ^hrs 39 ^mins
15	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,936,699	121,184	32.49	0 ^hrs 44 ^mins
16	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	3,679,954	119,801	30.72	0 ^hrs 47 ^mins
17	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,620,576	117,124	30.91	0 ^hrs 47 ^mins
18	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,446,726	115,927	29.73	0 ^hrs 48 ^mins
19	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,330,368	112,304	29.65	0 ^hrs 49 ^mins

20	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,326,659	114,384	29.08	0 ^hrs 50 ^mins
21	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,194,112	112,667	28.35	0 ^hrs 51 ^mins
22	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	3,175,953	112,140	28.32	0 ^hrs 51 ^mins
23	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,105,384	112,675	27.56	0 ^hrs 52 ^mins
24	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,090,694	111,905	27.62	0 ^hrs 52 ^mins
25	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,067,603	112,264	27.32	0 ^hrs 53 ^mins
26	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,480,665	101,932	24.34	0 ^hrs 59 ^mins
27	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,420,931	103,249	23.45	1 ^hrs 1 ^mins
28	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,407,903	102,832	23.42	1 ^hrs 1 ^mins
29	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,378,001	102,902	23.11	1 ^hrs 2 ^mins
30	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,369,333	102,006	23.23	1 ^hrs 2 ^mins
31	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,351,385	103,224	22.78	1 ^hrs 3 ^mins
32	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,313,438	98,232	23.55	1 ^hrs 1 ^mins
33	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,168,068	96,252	22.52	1 ^hrs 4 ^mins
34	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,106,247	98,926	21.29	1 ^hrs 8 ^mins
35	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,015,791	95,971	21.00	1 ^hrs 9 ^mins
36	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,616,802	88,905	18.19	1 ^hrs 19 ^mins
37	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,470,914	87,606	16.79	1 ^hrs 26 ^mins
38	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,423,417	86,891	16.38	1 ^hrs 28 ^mins
39	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,419,284	86,386	16.43	1 ^hrs 28 ^mins

40	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,359,484	84,101	16.16	1 ^hrs 29 ^mins
41	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,254,860	83,351	15.06	1 ^hrs 36 ^mins
42	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,240,754	82,896	14.97	1 ^hrs 36 ^mins
43	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,203,140	82,303	14.62	1 ^hrs 39 ^mins
44	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,195,785	80,887	14.78	1 ^hrs 37 ^mins
45	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,184,064	80,499	14.71	1 ^hrs 38 ^mins
46	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,151,099	80,608	14.28	1 ^hrs 41 ^mins
47	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,117,800	80,384	13.91	1 ^hrs 44 ^mins
48	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,033,122	77,985	13.25	1 ^hrs 49 ^mins
49	P104-100 GP104 [P104-100]	Nvidia	GP104	985,954	77,089	12.79	1 ^hrs 53 ^mins
50	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	944,640	74,868	12.62	1 ^hrs 54 ^mins
51	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	876,590	73,041	12.00	1 ^hrs 60 ^mins
52	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	791,193	71,169	11.12	2 ^hrs 10 ^mins
53	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	724,168	69,532	10.41	2 ^hrs 18 ^mins
54	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	605,680	65,935	9.19	2 ^hrs 37 ^mins
55	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	529,847	62,629	8.46	2 ^hrs 50 ^mins
56	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	523,748	59,129	8.86	2 ^hrs 43 ^mins
57	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	514,660	61,411	8.38	2 ^hrs 52 ^mins
58	Geforce RTX 3070 Ti Laptop GPU GA104 [Geforce RTX 3070 Ti Laptop GPU]	Nvidia	GA104	463,331	40,548	11.43	2 ^hrs 6 ^mins
59	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	345,079	54,121	6.38	3 ^hrs 46 ^mins

60	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	337,836	53,720	6.29	3 ^hrs 49 ^mins
61	P106-090 GP106 [P106-090]	Nvidia	GP106	319,977	53,079	6.03	3 ^hrs 59 ^mins
62	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	246,006	49,275	4.99	4 ^hrs 48 ^mins
63	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	243,463	48,124	5.06	4 ^hrs 45 ^mins
64	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	189,033	42,878	4.41	5 ^hrs 27 ^mins
65	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	147,995	41,078	3.60	6 ^hrs 40 ^mins
66	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	108,553	37,156	2.92	8 ^hrs 13 ^mins
67	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	92,462	38,590	2.40	10 ^hrs 1 ^mins
68	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	85,622	37,519	2.28	10 ^hrs 31 ^mins
69	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	85,259	34,460	2.47	9 ^hrs 42 ^mins
70	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	55,859	29,659	1.88	12 ^hrs 45 ^mins
71	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	38,252	29,453	1.30	18 ^hrs 29 ^mins

Research: CANCER Folding Project #14942

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14942

GPU PPD Averages

Research: CANCER Folding Project #14942

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages