Folding project #14941, CANCER research

Research section Research projects and references

Project #14941 overview

Project Summary AI Beta

This project looks at Class F Receptors and Patched, proteins that control how cells develop. When these proteins don't work right, it can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to learn how these proteins are activated so we can better understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 104,552
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

A type of cell surface receptor involved in signal transduction.

Technical: BiotechnologyProtein Biology / Receptor Signaling

Class F receptors are a group of proteins found on the surface of cells. They act as receptors, binding to specific molecules and triggering signaling pathways inside the cell. These pathways regulate various cellular processes, including growth, differentiation, and survival. Disruptions in Class F receptor function can contribute to diseases like cancer.

Patched Membrane Protein

A transmembrane protein that regulates the activity of Hedgehog signaling.

Technical: BiotechnologyProtein Biology / Signal Transduction

Patched is a protein embedded in cell membranes. It plays a crucial role in the Hedgehog signaling pathway, which is essential for embryonic development and tissue maintenance. Patched acts as a brake on this pathway, preventing excessive signaling. Mutations in Patched can lead to uncontrolled cell growth and contribute to cancers like medulloblastoma.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Clinical: MedicineOncology / Skin Cancer

Basal cell carcinoma is the most common type of skin cancer. It arises from abnormal growth of basal cells, which are found in the deepest layer of the epidermis (skin). Basal cell carcinomas typically appear as pearly or waxy bumps and can be treated effectively with surgery, radiation therapy, or topical medications.

Medulloblastoma

A type of malignant brain tumor that originates in the cerebellum.

Clinical: MedicineOncology / Brain Tumor

Medulloblastoma is a highly aggressive brain tumor that develops in the cerebellum, a part of the brain responsible for balance and coordination. It's most common in children and can cause symptoms such as headaches, nausea, vomiting, and difficulty with movement. Treatment typically involves surgery, radiation therapy, and chemotherapy.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	14,275,922	180,865	78.93	0 ^hrs 18 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,417,796	175,931	70.58	0 ^hrs 20 ^mins
3	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,254,080	157,114	58.90	0 ^hrs 24 ^mins
4	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,201,938	159,359	57.74	0 ^hrs 25 ^mins
5	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,159,657	145,864	49.08	0 ^hrs 29 ^mins
6	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,142,175	146,132	48.87	0 ^hrs 29 ^mins
7	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,440,207	141,336	45.57	0 ^hrs 32 ^mins
8	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,337,279	138,455	45.77	0 ^hrs 31 ^mins
9	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,312,619	139,670	45.20	0 ^hrs 32 ^mins
10	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,211,601	138,079	44.99	0 ^hrs 32 ^mins
11	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,406,251	133,906	40.37	0 ^hrs 36 ^mins
12	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,929,962	130,835	37.68	0 ^hrs 38 ^mins
13	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,890,015	129,813	37.67	0 ^hrs 38 ^mins
14	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,840,738	129,519	37.37	0 ^hrs 39 ^mins
15	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,985,350	120,243	33.14	0 ^hrs 43 ^mins
16	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,656,123	116,913	31.27	0 ^hrs 46 ^mins
17	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,357,871	113,813	29.50	0 ^hrs 49 ^mins
18	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	3,277,388	112,552	29.12	0 ^hrs 49 ^mins
19	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,276,804	112,558	29.11	0 ^hrs 49 ^mins

20	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,190,620	112,331	28.40	0 ^hrs 51 ^mins
21	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,130,067	111,086	28.18	0 ^hrs 51 ^mins
22	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,024,037	109,923	27.51	0 ^hrs 52 ^mins
23	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,960,337	108,779	27.21	0 ^hrs 53 ^mins
24	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	2,916,850	109,162	26.72	0 ^hrs 54 ^mins
25	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,845,734	107,355	26.51	0 ^hrs 54 ^mins
26	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,478,204	102,907	24.08	0 ^hrs 60 ^mins
27	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,416,385	101,326	23.85	1 ^hrs 0 ^mins
28	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,403,000	102,496	23.44	1 ^hrs 1 ^mins
29	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,373,186	101,952	23.28	1 ^hrs 2 ^mins
30	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,340,498	102,134	22.92	1 ^hrs 3 ^mins
31	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,282,558	95,757	23.84	1 ^hrs 0 ^mins
32	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,038,015	95,720	21.29	1 ^hrs 8 ^mins
33	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,881,451	94,437	19.92	1 ^hrs 12 ^mins
34	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,650,849	88,802	18.59	1 ^hrs 17 ^mins
35	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,533,923	88,164	17.40	1 ^hrs 23 ^mins
36	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,433,495	86,062	16.66	1 ^hrs 26 ^mins
37	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,432,780	85,897	16.68	1 ^hrs 26 ^mins
38	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,258,673	82,795	15.20	1 ^hrs 35 ^mins
39	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,238,750	81,766	15.15	1 ^hrs 35 ^mins

40	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,235,254	81,170	15.22	1 ^hrs 35 ^mins
41	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,156,241	79,149	14.61	1 ^hrs 39 ^mins
42	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,085,755	78,348	13.86	1 ^hrs 44 ^mins
43	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,072,813	76,805	13.97	1 ^hrs 43 ^mins
44	P104-100 GP104 [P104-100]	Nvidia	GP104	979,274	75,657	12.94	1 ^hrs 51 ^mins
45	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	954,402	71,845	13.28	1 ^hrs 48 ^mins
46	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	904,821	74,078	12.21	1 ^hrs 58 ^mins
47	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	904,090	73,323	12.33	1 ^hrs 57 ^mins
48	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	651,162	66,321	9.82	2 ^hrs 27 ^mins
49	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	639,490	66,120	9.67	2 ^hrs 29 ^mins
50	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	499,867	60,695	8.24	2 ^hrs 55 ^mins
51	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	496,526	59,390	8.36	2 ^hrs 52 ^mins
52	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	449,159	58,707	7.65	3 ^hrs 8 ^mins
53	Vega 8 Mobile Raven Ridge APU [Vega 8 Mobile]	AMD	Raven Ridge APU	363,983	53,340	6.82	3 ^hrs 31 ^mins
54	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	325,955	51,718	6.30	3 ^hrs 48 ^mins
55	P106-090 GP106 [P106-090]	Nvidia	GP106	311,249	51,865	6.00	3 ^hrs 60 ^mins
56	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	310,725	51,423	6.04	3 ^hrs 58 ^mins
57	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	254,746	49,288	5.17	4 ^hrs 39 ^mins
58	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	236,270	47,411	4.98	4 ^hrs 49 ^mins
59	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	235,465	47,652	4.94	4 ^hrs 51 ^mins

60	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	213,696	45,922	4.65	5 ^hrs 9 ^mins
61	R9 380X/R9 M295X Tonga XT/Amethyst XT [R9 380X/R9 M295X]	AMD	Tonga XT/Amethyst XT	204,365	44,381	4.60	5 ^hrs 13 ^mins
62	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	169,592	24,763	6.85	3 ^hrs 30 ^mins
63	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	155,244	41,074	3.78	6 ^hrs 21 ^mins
64	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	145,528	40,478	3.60	6 ^hrs 41 ^mins
65	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	145,272	40,222	3.61	6 ^hrs 39 ^mins
66	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	134,053	39,270	3.41	7 ^hrs 2 ^mins
67	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	110,893	37,259	2.98	8 ^hrs 4 ^mins
68	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	56,201	29,505	1.90	12 ^hrs 36 ^mins
69	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	45,721	25,881	1.77	13 ^hrs 35 ^mins
70	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	40,900	28,408	1.44	16 ^hrs 40 ^mins

Research: CANCER Folding Project #14941

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14941

GPU PPD Averages

Research: CANCER Folding Project #14941

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages