Folding project #14957, CANCER research

Research section Research projects and references

Project #14957 overview

Project Summary AI Beta

This project studies how Class F Receptors and Patched proteins control cell growth. When these proteins malfunction, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, researchers hope to understand how these proteins work and find ways to treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 109,195
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

A type of receptor protein involved in cell signaling.

Scientific: BiotechnologyCellular Biology / Signal Transduction

Class F receptors are a family of proteins found on the surface of cells. They play a crucial role in receiving and transmitting signals that regulate various cellular processes, including growth, differentiation, and survival. These receptors are essential for maintaining normal tissue development and function.

Patched Membrane Protein

A membrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Scientific: BiotechnologyCellular Biology / Signal Transduction

Patched is a crucial protein embedded in the cell membrane. Its primary function is to suppress the Hedgehog signaling pathway, which is essential for embryonic development and tissue repair. When Patched is absent or malfunctioning, the Hedgehog pathway becomes overactive, leading to uncontrolled cell growth and potentially cancer.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Medical: MedicineOncology / Skin Cancer

Basal cell carcinoma is the most common form of skin cancer. It arises from the basal cells, which are found in the deepest layer of the epidermis (outer skin layer). Early detection and treatment are crucial to prevent its spread.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medical: MedicineOncology / Brain Cancer

Medulloblastoma is a rare but aggressive type of brain cancer that primarily affects children. It originates in the cerebellum, a region responsible for coordinating movement and balance. Treatment typically involves surgery, radiation therapy, and chemotherapy.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,539,977	312,442	49.74	0 ^hrs 29 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	11,891,412	311,434	38.18	0 ^hrs 38 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	10,692,739	120,913	88.43	0 ^hrs 16 ^mins
4	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,609,072	294,487	32.63	0 ^hrs 44 ^mins
5	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	9,498,778	332,289	28.59	0 ^hrs 50 ^mins
6	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	9,244,942	77,664	119.04	0 ^hrs 12 ^mins
7	GeForce RTX 4090 Laptop GPU AD103M / GN21-X11 [GeForce RTX 4090 Laptop GPU]	Nvidia	AD103M / GN21-X11	8,874,118	317,276	27.97	0 ^hrs 51 ^mins
8	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,130,849	292,260	27.82	0 ^hrs 52 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,420,735	171,575	43.25	0 ^hrs 33 ^mins
10	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,528,077	291,245	22.41	1 ^hrs 4 ^mins
11	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,449,191	154,939	41.62	0 ^hrs 35 ^mins
12	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,171,918	253,552	24.34	0 ^hrs 59 ^mins
13	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,073,559	185,519	32.74	0 ^hrs 44 ^mins
14	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,949,930	219,143	27.15	0 ^hrs 53 ^mins
15	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,911,682	51,000	115.92	0 ^hrs 12 ^mins
16	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,537,523	235,614	23.50	1 ^hrs 1 ^mins
17	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,354,033	205,301	21.21	1 ^hrs 8 ^mins
18	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,302,085	147,899	29.09	0 ^hrs 50 ^mins
19	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	4,038,064	248,575	16.24	1 ^hrs 29 ^mins

20	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,979,327	236,045	16.86	1 ^hrs 25 ^mins
21	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,852,057	242,046	15.91	1 ^hrs 30 ^mins
22	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	3,625,674	239,124	15.16	1 ^hrs 35 ^mins
23	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,289,026	97,395	33.77	0 ^hrs 43 ^mins
24	Radeon RX 9070(XT) Navi 48 [Radeon RX 9070(XT)]	AMD	Navi 48	3,245,148	232,938	13.93	1 ^hrs 43 ^mins
25	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,203,377	184,717	17.34	1 ^hrs 23 ^mins
26	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	2,976,602	225,347	13.21	1 ^hrs 49 ^mins
27	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,914,947	125,730	23.18	1 ^hrs 2 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,518,002	213,104	11.82	2 ^hrs 2 ^mins
29	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,441,545	185,062	13.19	1 ^hrs 49 ^mins
30	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,418,839	191,089	12.66	1 ^hrs 54 ^mins
31	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,407,729	51,000	47.21	0 ^hrs 31 ^mins
32	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,220,048	203,706	10.90	2 ^hrs 12 ^mins
33	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,144,871	157,912	13.58	1 ^hrs 46 ^mins
34	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,116,806	163,390	12.96	1 ^hrs 51 ^mins
35	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,007,054	196,979	10.19	2 ^hrs 21 ^mins
36	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,007,031	197,158	10.18	2 ^hrs 21 ^mins
37	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,869,855	128,405	14.56	1 ^hrs 39 ^mins
38	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,814,052	190,081	9.54	2 ^hrs 31 ^mins
39	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,567,293	182,265	8.60	2 ^hrs 47 ^mins

40	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,559,627	157,095	9.93	2 ^hrs 25 ^mins
41	GeForce RTX 3050 8GB GA107 [GeForce RTX 3050 8GB]	Nvidia	GA107	1,492,362	172,268	8.66	2 ^hrs 46 ^mins
42	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,394,441	175,189	7.96	3 ^hrs 1 ^mins
43	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,356,185	158,026	8.58	2 ^hrs 48 ^mins
44	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,335,032	174,396	7.66	3 ^hrs 8 ^mins
45	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,178,966	51,000	23.12	1 ^hrs 2 ^mins
46	Radeon RX 6700(XT)/6800M Navi 22 XT-XL [Radeon RX 6700(XT)/6800M]	AMD	Navi 22 XT-XL	1,178,495	51,000	23.11	1 ^hrs 2 ^mins
47	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,172,193	165,429	7.09	3 ^hrs 23 ^mins
48	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	1,161,400	51,000	22.77	1 ^hrs 3 ^mins
49	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,150,874	108,228	10.63	2 ^hrs 15 ^mins
50	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	1,081,640	162,796	6.64	3 ^hrs 37 ^mins
51	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,064,771	159,906	6.66	3 ^hrs 36 ^mins
52	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,033,926	105,719	9.78	2 ^hrs 27 ^mins
53	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,006,256	154,796	6.50	3 ^hrs 42 ^mins
54	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	1,005,396	90,814	11.07	2 ^hrs 10 ^mins
55	GeForce RTX 3050 6GB GA107 [GeForce RTX 3050 6GB]	Nvidia	GA107	1,001,090	51,000	19.63	1 ^hrs 13 ^mins
56	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	983,969	155,775	6.32	3 ^hrs 48 ^mins
57	P104-100 GP104 [P104-100]	Nvidia	GP104	983,769	156,096	6.30	3 ^hrs 48 ^mins
58	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	842,304	79,245	10.63	2 ^hrs 15 ^mins
59	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	817,356	143,097	5.71	4 ^hrs 12 ^mins

60	Radeon RX 6600(XT/M) Navi 23 XT-XL [Radeon RX 6600(XT/M)]	AMD	Navi 23 XT-XL	765,601	142,404	5.38	4 ^hrs 28 ^mins
61	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	735,503	91,237	8.06	2 ^hrs 59 ^mins
62	P106-100 GP106 [P106-100]	Nvidia	GP106	720,623	140,442	5.13	4 ^hrs 41 ^mins
63	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	708,966	138,975	5.10	4 ^hrs 42 ^mins
64	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	697,054	139,297	5.00	4 ^hrs 48 ^mins
65	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	549,640	134,092	4.10	5 ^hrs 51 ^mins
66	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	495,519	56,691	8.74	2 ^hrs 45 ^mins
67	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	491,363	51,000	9.63	2 ^hrs 29 ^mins
68	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	426,144	63,213	6.74	3 ^hrs 34 ^mins
69	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	396,227	55,317	7.16	3 ^hrs 21 ^mins
70	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	328,919	108,319	3.04	7 ^hrs 54 ^mins
71	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	237,791	97,317	2.44	9 ^hrs 49 ^mins
72	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	229,607	68,641	3.35	7 ^hrs 10 ^mins
73	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	194,920	89,613	2.18	11 ^hrs 2 ^mins
74	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	192,882	90,523	2.13	11 ^hrs 16 ^mins
75	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	183,400	89,325	2.05	11 ^hrs 41 ^mins
76	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	139,806	81,492	1.72	13 ^hrs 59 ^mins
77	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	135,201	80,538	1.68	14 ^hrs 18 ^mins
78	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	124,318	78,382	1.59	15 ^hrs 8 ^mins
79	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	82,766	68,867	1.20	19 ^hrs 58 ^mins

80	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	79,917	57,502	1.39	17 ^hrs 16 ^mins
81	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	67,790	75,533	0.90	26 ^hrs 44 ^mins
82	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	29,929	51,000	0.59	40 ^hrs 54 ^mins
83	GeForce GTX 745 GM107 [GeForce GTX 745] 793	Nvidia	GM107	26,894	51,000	0.53	45 ^hrs 31 ^mins

Research: CANCER Folding Project #14957

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14957

GPU PPD Averages

Research: CANCER Folding Project #14957

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages