Folding project #14952, CANCER research

Research section Research projects and references

Project #14952 overview

Project Summary AI Beta

This project studies how Class F receptors and Patched proteins control cell growth. When these proteins are messed up, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to learn how these proteins work so we can better understand and treat these diseases.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 104,357
Core: 0x22
Status: Public

Source material

Official Project Description

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class F Receptors

A family of G protein-coupled receptors involved in cell signaling.

Scientific: BiopharmaceuticalsBiotechnology / Cellular Biology

Class F Receptors are a group of proteins on the surface of cells that receive signals from other molecules. These signals help control how cells grow and develop. Dysregulation of Class F Receptors can contribute to diseases like Basal Cell Carcinoma.

Patched

A protein that regulates cell growth and differentiation.

Scientific: BiopharmaceuticalsBiotechnology / Developmental Biology

Patched is a protein that acts as a brake on cell growth. When Patched is working properly, it prevents cells from dividing too quickly. However, mutations in the Patched gene can lead to uncontrolled cell growth, which contributes to cancers like Medulloblastoma.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Medical: HealthcareMedicine / Oncology

Basal Cell Carcinoma is the most common type of skin cancer. It develops in the basal cells, which are found in the deepest layer of the epidermis (outermost skin layer). Early detection and treatment are crucial for successful management.

Medulloblastoma

A type of brain tumor that arises from the cerebellum.

Medical: HealthcareMedicine / Neurology, Oncology

Medulloblastoma is a malignant brain tumor that primarily affects children. It originates in the cerebellum, a region of the brain responsible for balance and coordination. Treatment typically involves surgery, chemotherapy, and radiation therapy.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,110,514	118,760	34.61	0 ^hrs 42 ^mins
2	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,998,193	107,276	27.95	0 ^hrs 52 ^mins
3	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,987,332	104,346	28.63	0 ^hrs 50 ^mins
4	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	2,954,344	106,771	27.67	0 ^hrs 52 ^mins
5	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	2,801,222	106,168	26.38	0 ^hrs 55 ^mins
6	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,339,656	97,684	23.95	1 ^hrs 0 ^mins
7	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,307,814	98,615	23.40	1 ^hrs 2 ^mins
8	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,203,203	95,714	23.02	1 ^hrs 3 ^mins
9	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,093,475	93,539	22.38	1 ^hrs 4 ^mins
10	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,007,507	94,694	21.20	1 ^hrs 8 ^mins
11	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	1,890,834	92,512	20.44	1 ^hrs 10 ^mins
12	Quadro RTX 5000 Mobile / Max-Q TU104GLM [Quadro RTX 5000 Mobile / Max-Q]	Nvidia	TU104GLM	1,804,100	90,143	20.01	1 ^hrs 12 ^mins
13	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,667,046	86,118	19.36	1 ^hrs 14 ^mins
14	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,494,808	83,891	17.82	1 ^hrs 21 ^mins
15	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,378,025	83,352	16.53	1 ^hrs 27 ^mins
16	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,261,812	77,064	16.37	1 ^hrs 28 ^mins
17	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,217,106	79,620	15.29	1 ^hrs 34 ^mins
18	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,181,389	75,859	15.57	1 ^hrs 32 ^mins
19	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,102,108	75,605	14.58	1 ^hrs 39 ^mins

20	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,077,654	75,362	14.30	1 ^hrs 41 ^mins
21	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,044,019	74,700	13.98	1 ^hrs 43 ^mins
22	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,002,738	74,136	13.53	1 ^hrs 46 ^mins
23	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	924,096	71,048	13.01	1 ^hrs 51 ^mins
24	P104-100 GP104 [P104-100]	Nvidia	GP104	921,152	72,300	12.74	1 ^hrs 53 ^mins
25	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	893,215	71,558	12.48	1 ^hrs 55 ^mins
26	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	822,922	69,870	11.78	2 ^hrs 2 ^mins
27	Radeon PRO WX 9100 Vega 10 XT [Radeon PRO WX 9100]	AMD	Vega 10 XT	756,570	66,823	11.32	2 ^hrs 7 ^mins
28	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	736,248	67,059	10.98	2 ^hrs 11 ^mins
29	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	711,852	64,557	11.03	2 ^hrs 11 ^mins
30	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	694,343	65,965	10.53	2 ^hrs 17 ^mins
31	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	626,595	63,982	9.79	2 ^hrs 27 ^mins
32	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	599,800	62,921	9.53	2 ^hrs 31 ^mins
33	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	597,803	57,854	10.33	2 ^hrs 19 ^mins
34	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	583,497	62,359	9.36	2 ^hrs 34 ^mins
35	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	404,719	54,708	7.40	3 ^hrs 15 ^mins
36	Quadro K6000 GK110GL [Quadro K6000]	Nvidia	GK110GL	390,220	53,892	7.24	3 ^hrs 19 ^mins
37	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	318,044	51,004	6.24	3 ^hrs 51 ^mins
38	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	305,559	50,536	6.05	3 ^hrs 58 ^mins
39	P106-090 GP106 [P106-090]	Nvidia	GP106	296,143	49,824	5.94	4 ^hrs 2 ^mins

40	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	280,237	49,548	5.66	4 ^hrs 15 ^mins
41	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	269,545	48,083	5.61	4 ^hrs 17 ^mins
42	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	241,735	46,038	5.25	4 ^hrs 34 ^mins
43	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	232,827	44,937	5.18	4 ^hrs 38 ^mins
44	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	227,610	45,593	4.99	4 ^hrs 48 ^mins
45	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	200,044	43,658	4.58	5 ^hrs 14 ^mins
46	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	180,509	41,220	4.38	5 ^hrs 29 ^mins
47	Radeon R9 285/380 Tonga PRO [Radeon R9 285/380]	AMD	Tonga PRO	177,693	42,266	4.20	5 ^hrs 43 ^mins
48	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	140,205	38,922	3.60	6 ^hrs 40 ^mins
49	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	130,537	38,857	3.36	7 ^hrs 9 ^mins
50	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	125,096	37,569	3.33	7 ^hrs 12 ^mins
51	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	116,148	36,213	3.21	7 ^hrs 29 ^mins
52	Radeon 540/540X/550/550X/RX 540X/550/550X Lexa PRO [Radeon 540/540X/550/550X/RX 540X/550/550X]	AMD	Lexa PRO	53,024	28,124	1.89	12 ^hrs 44 ^mins
53	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	51,427	27,801	1.85	12 ^hrs 58 ^mins
54	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	48,017	26,525	1.81	13 ^hrs 15 ^mins

Research: CANCER Folding Project #14952

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14952

GPU PPD Averages

Research: CANCER Folding Project #14952

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages