Folding project #14968, DIABETES research

Research section Research projects and references

Project #14968 overview

Project Summary AI Beta

This project relates to studying how certain cell receptors change shape. These receptors are involved in diseases like diabetes and high blood pressure. Understanding how they work can help scientists develop better drugs to treat these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 90,355
Core: 0x22
Status: Public

Source material

Official Project Description

Class B G-Protein Coupled Receptors: Class B G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, Parathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor, Secretin Receptor and Calcitonin Receptor- All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class B G-Protein Coupled Receptors

Membrane proteins involved in various physiological processes.

Scientific: BiotechnologyPharmacology / Drug Discovery

Class B G-Protein Coupled Receptors are a group of cell surface receptors that play crucial roles in transmitting signals within the body. They are essential for regulating diverse functions like blood pressure, hormone secretion, and metabolism. Understanding their structure and function is vital for developing targeted therapies for diseases such as diabetes and cardiovascular disorders.

GPCRs

G-Protein Coupled Receptors

Acronym: BiotechnologyPharmacology / Drug Discovery

GPCRs are a large family of cell surface receptors that play a vital role in transmitting signals within the body. They are involved in various physiological processes, including sensory perception, hormone regulation, and immune responses. Because of their widespread involvement in human health, GPCRs are a major target for drug development.

Glucagon Receptor

Receptor for glucagon hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a type of protein found on the surface of certain cells in the body. It binds to the hormone glucagon, which raises blood sugar levels. This receptor plays a crucial role in regulating blood glucose homeostasis.

Glucagon-like Peptide 1 receptor

Receptor for glucagon-like peptide 1 hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 receptor is a type of protein found on the surface of certain cells in the body. It binds to the hormone GLP-1, which lowers blood sugar levels and stimulates insulin release. This receptor plays a crucial role in regulating blood glucose homeostasis.

Parathyroid Hormone Receptor

Receptor for parathyroid hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor is a type of protein found on the surface of certain cells in the body. It binds to parathyroid hormone, which regulates calcium levels in the blood. This receptor plays a crucial role in maintaining bone health and overall mineral balance.

Pituitary Adenylate Cyclase Activating Polypeptide Receptor

Receptor for pituitary adenylate cyclase activating polypeptide.

Scientific: BiotechnologyPharmacology / Neuroendocrinology

The Pituitary Adenylate Cyclase Activating Polypeptide Receptor is a type of protein found on the surface of certain cells in the brain. It binds to PACAP, which plays roles in various physiological processes, including stress response, mood regulation, and appetite control.

Secretin Receptor

Receptor for secretin hormone.

Scientific: BiotechnologyPharmacology / Gastroenterology

The Secretin Receptor is a type of protein found on the surface of cells lining the digestive system. It binds to the hormone secretin, which stimulates the release of bicarbonate from the pancreas. This helps neutralize stomach acid and protect the intestines.

Calcitonin Receptor

Receptor for calcitonin hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Calcitonin Receptor is a type of protein found on the surface of certain cells in the body. It binds to calcitonin hormone, which lowers blood calcium levels. This receptor plays a role in regulating bone metabolism and calcium homeostasis.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	8,825,539	258,240	34.18	0 ^hrs 42 ^mins
2	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,271,270	39,500	209.40	0 ^hrs 7 ^mins
3	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,252,800	255,388	32.31	0 ^hrs 45 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,563,492	245,714	26.71	0 ^hrs 54 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,249,870	242,655	25.76	0 ^hrs 56 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,067,078	239,993	25.28	0 ^hrs 57 ^mins
7	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,476,214	228,707	23.94	1 ^hrs 0 ^mins
8	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,978,981	225,135	22.12	1 ^hrs 5 ^mins
9	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	4,828,343	219,442	22.00	1 ^hrs 5 ^mins
10	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,528,127	216,827	20.88	1 ^hrs 9 ^mins
11	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	4,368,778	216,313	20.20	1 ^hrs 11 ^mins
12	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,760,905	203,048	18.52	1 ^hrs 18 ^mins
13	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,461,283	199,297	17.37	1 ^hrs 23 ^mins
14	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,449,912	127,688	27.02	0 ^hrs 53 ^mins
15	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,358,462	197,554	17.00	1 ^hrs 25 ^mins
16	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,169,431	193,795	16.35	1 ^hrs 28 ^mins
17	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,973,253	187,593	15.85	1 ^hrs 31 ^mins
18	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,949,914	188,325	15.66	1 ^hrs 32 ^mins
19	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,946,449	159,975	18.42	1 ^hrs 18 ^mins

20	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,863,268	150,654	19.01	1 ^hrs 16 ^mins
21	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,416,250	172,204	14.03	1 ^hrs 43 ^mins
22	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,404,554	176,391	13.63	1 ^hrs 46 ^mins
23	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,379,319	175,565	13.55	1 ^hrs 46 ^mins
24	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,328,874	173,171	13.45	1 ^hrs 47 ^mins
25	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,293,160	167,196	13.72	1 ^hrs 45 ^mins
26	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,154,165	169,327	12.72	1 ^hrs 53 ^mins
27	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,138,571	170,755	12.52	1 ^hrs 55 ^mins
28	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,102,104	169,487	12.40	1 ^hrs 56 ^mins
29	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,018,583	165,353	12.21	1 ^hrs 58 ^mins
30	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,865,972	162,448	11.49	2 ^hrs 5 ^mins
31	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,586,724	152,941	10.37	2 ^hrs 19 ^mins
32	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,387,353	146,627	9.46	2 ^hrs 32 ^mins
33	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,381,798	144,045	9.59	2 ^hrs 30 ^mins
34	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,353,114	119,760	11.30	2 ^hrs 7 ^mins
35	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,233,851	141,374	8.73	2 ^hrs 45 ^mins
36	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	1,212,790	141,634	8.56	2 ^hrs 48 ^mins
37	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,211,777	120,707	10.04	2 ^hrs 23 ^mins
38	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,196,300	140,401	8.52	2 ^hrs 49 ^mins
39	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,152,207	98,829	11.66	2 ^hrs 4 ^mins

40	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,140,755	138,161	8.26	2 ^hrs 54 ^mins
41	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	1,040,689	39,500	26.35	0 ^hrs 55 ^mins
42	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	866,921	126,402	6.86	3 ^hrs 30 ^mins
43	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	701,069	116,231	6.03	3 ^hrs 59 ^mins
44	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	653,098	39,500	16.53	1 ^hrs 27 ^mins
45	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	611,477	112,769	5.42	4 ^hrs 26 ^mins
46	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	569,211	112,771	5.05	4 ^hrs 45 ^mins
47	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	569,197	110,210	5.16	4 ^hrs 39 ^mins
48	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	553,930	103,562	5.35	4 ^hrs 29 ^mins
49	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	365,614	93,875	3.89	6 ^hrs 10 ^mins
50	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	289,646	84,240	3.44	6 ^hrs 59 ^mins
51	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	238,853	55,220	4.33	5 ^hrs 33 ^mins
52	GeForce GTX 1050 Mobile GP107M [GeForce GTX 1050 Mobile]	Nvidia	GP107M	232,886	81,628	2.85	8 ^hrs 25 ^mins
53	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	144,032	69,467	2.07	11 ^hrs 35 ^mins
54	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	119,185	65,145	1.83	13 ^hrs 7 ^mins
55	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	68,125	63,260	1.08	22 ^hrs 17 ^mins
56	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	52,303	49,318	1.06	22 ^hrs 38 ^mins
57	Quadro NVS 510 GK107 [Quadro NVS 510]	Nvidia	GK107	6,404	39,500	0.16	148 ^hrs 2 ^mins

Research: DIABETES Folding Project #14968

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14968

GPU PPD Averages

Research: DIABETES Folding Project #14968

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages