Folding project #14951, DIABETES research

Research section Research projects and references

Project #14951 overview

Project Summary AI Beta

This project studies how certain proteins on cell surfaces change shape when activated. These proteins are linked to diseases like diabetes and high blood pressure. Understanding their movements can help scientists design new and better drugs to treat these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 101,265
Core: 0x22
Status: Public

Source material

Official Project Description

Class B G-Protein Coupled Receptors: Class B G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class B G-Protein Coupled Receptors

Membrane proteins involved in various physiological processes.

Scientific: BiotechnologyPharmacology / Receptor Biology

Class B G-Protein Coupled Receptors (GPCRs) are a group of membrane proteins that play crucial roles in transmitting signals within cells. They are involved in a wide range of physiological processes, including hormone regulation, metabolism, and immune responses. These receptors bind to specific ligands, such as hormones or neurotransmitters, which triggers a cascade of events inside the cell, ultimately leading to a biological response.

GPCRs

G-Protein Coupled Receptors

Acronym: BiotechnologyPharmacology / Receptor Biology

GPCRs are a large family of cell surface receptors that play a vital role in signal transduction. They bind to various ligands, including hormones, neurotransmitters, and light, and activate intracellular signaling pathways.

Glucagon Receptor

Receptor for the hormone glucagon.

Scientific: BiotechnologyPharmacology / Endocrine System

The Glucagon Receptor is a cell surface protein that binds to the hormone glucagon. When glucagon binds to its receptor, it triggers signaling pathways that increase blood glucose levels by stimulating the liver to release stored glucose.

Glucagon-like Peptide 1 Receptor

Receptor for the hormone GLP-1.

Scientific: BiotechnologyPharmacology / Endocrine System

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a cell surface protein that binds to the hormone GLP-1. Activation of GLP-1R promotes insulin secretion, suppresses glucagon release, and slows gastric emptying, contributing to blood glucose control.

PArathyroid Hormone Receptor

Receptor for the hormone parathyroid hormone.

Scientific: BiotechnologyPharmacology / Endocrine System

The Parathyroid Hormone Receptor (PTH1R) is a cell surface protein that binds to parathyroid hormone. Activation of PTH1R increases blood calcium levels by stimulating bone resorption and promoting calcium reabsorption in the kidneys.

Secretin Receptor

Receptor for the hormone secretin.

Scientific: BiotechnologyPharmacology / Digestive System

The Secretin Receptor is a cell surface protein that binds to the hormone secretin. Activation of secretin receptor stimulates pancreatic bicarbonate secretion, which neutralizes acidic chyme entering the duodenum.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	15,710,318	142,720	110.08	0 ^hrs 13 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	12,834,065	154,641	82.99	0 ^hrs 17 ^mins
3	RTX 6000 Ada Generation AD102GL [RTX 6000 Ada Generation]	Nvidia	AD102GL	12,021,463	167,687	71.69	0 ^hrs 20 ^mins
4	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	10,696,039	162,800	65.70	0 ^hrs 22 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	9,436,675	147,975	63.77	0 ^hrs 23 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	9,310,822	156,153	59.63	0 ^hrs 24 ^mins
7	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	8,599,859	17,000	505.87	0 ^hrs 3 ^mins
8	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	8,471,581	148,889	56.90	0 ^hrs 25 ^mins
9	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	8,074,857	148,819	54.26	0 ^hrs 27 ^mins
10	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,749,190	138,185	56.08	0 ^hrs 26 ^mins
11	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	7,518,981	41,398	181.63	0 ^hrs 8 ^mins
12	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,490,490	137,252	47.29	0 ^hrs 30 ^mins
13	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,072,323	135,181	44.92	0 ^hrs 32 ^mins
14	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,992,888	134,414	44.59	0 ^hrs 32 ^mins
15	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	5,647,131	130,976	43.12	0 ^hrs 33 ^mins
16	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	5,631,144	133,295	42.25	0 ^hrs 34 ^mins
17	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,237,896	129,543	40.43	0 ^hrs 36 ^mins
18	GeForce RTX 4060 Ti 16GB AD106 [GeForce RTX 4060 Ti 16GB]	Nvidia	AD106	4,778,918	126,461	37.79	0 ^hrs 38 ^mins
19	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,714,344	112,185	42.02	0 ^hrs 34 ^mins

20	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,498,495	122,944	36.59	0 ^hrs 39 ^mins
21	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	4,455,654	123,696	36.02	0 ^hrs 40 ^mins
22	L4 AD104GL [L4]	Nvidia	AD104GL	4,019,800	118,253	33.99	0 ^hrs 42 ^mins
23	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	3,912,731	117,246	33.37	0 ^hrs 43 ^mins
24	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,774,384	116,220	32.48	0 ^hrs 44 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,464,623	80,922	42.81	0 ^hrs 34 ^mins
26	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,396,804	111,629	30.43	0 ^hrs 47 ^mins
27	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,361,132	108,565	30.96	0 ^hrs 47 ^mins
28	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,250,701	110,346	29.46	0 ^hrs 49 ^mins
29	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,205,178	110,327	29.05	0 ^hrs 50 ^mins
30	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,137,069	103,797	30.22	0 ^hrs 48 ^mins
31	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	2,981,031	95,130	31.34	0 ^hrs 46 ^mins
32	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,931,177	107,001	27.39	0 ^hrs 53 ^mins
33	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,911,510	107,304	27.13	0 ^hrs 53 ^mins
34	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,813,795	104,862	26.83	0 ^hrs 54 ^mins
35	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,623,839	103,310	25.40	0 ^hrs 57 ^mins
36	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,617,160	73,121	35.79	0 ^hrs 40 ^mins
37	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,502,697	101,567	24.64	0 ^hrs 58 ^mins
38	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,465,084	94,017	26.22	0 ^hrs 55 ^mins
39	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,389,448	98,935	24.15	0 ^hrs 60 ^mins

40	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,347,072	99,414	23.61	1 ^hrs 1 ^mins
41	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,328,588	95,033	24.50	0 ^hrs 59 ^mins
42	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,273,276	83,407	27.26	0 ^hrs 53 ^mins
43	GeForce RTX 4060 Max-Q / Mobile AD107M [GeForce RTX 4060 Max-Q / Mobile]	Nvidia	AD107M	2,150,229	96,442	22.30	1 ^hrs 5 ^mins
44	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,123,756	96,144	22.09	1 ^hrs 5 ^mins
45	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,099,612	85,184	24.65	0 ^hrs 58 ^mins
46	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,062,673	95,546	21.59	1 ^hrs 7 ^mins
47	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,023,368	95,479	21.19	1 ^hrs 8 ^mins
48	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	1,991,537	56,531	35.23	0 ^hrs 41 ^mins
49	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,806,681	91,221	19.81	1 ^hrs 13 ^mins
50	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,727,109	89,252	19.35	1 ^hrs 14 ^mins
51	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,534,465	86,289	17.78	1 ^hrs 21 ^mins
52	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,514,867	85,653	17.69	1 ^hrs 21 ^mins
53	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,341,720	82,382	16.29	1 ^hrs 28 ^mins
54	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,336,407	80,229	16.66	1 ^hrs 26 ^mins
55	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,279,262	72,976	17.53	1 ^hrs 22 ^mins
56	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,274,574	77,765	16.39	1 ^hrs 28 ^mins
57	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,261,144	80,901	15.59	1 ^hrs 32 ^mins
58	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,247,448	81,141	15.37	1 ^hrs 34 ^mins
59	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,193,480	69,060	17.28	1 ^hrs 23 ^mins

60	RTX 5000 Ada Generation AD102GL [RTX 5000 Ada Generation]	Nvidia	AD102GL	1,176,959	79,862	14.74	1 ^hrs 38 ^mins
61	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,069,765	74,473	14.36	1 ^hrs 40 ^mins
62	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,042,086	76,269	13.66	1 ^hrs 45 ^mins
63	Radeon RX 6600/6600 XT/6600M Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]	AMD	Navi 23 XT-XL	1,004,500	76,600	13.11	1 ^hrs 50 ^mins
64	Quadro M6000 GM200GL [Quadro M6000]	Nvidia	GM200GL	904,987	72,616	12.46	1 ^hrs 56 ^mins
65	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	797,828	68,144	11.71	2 ^hrs 3 ^mins
66	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	676,915	65,674	10.31	2 ^hrs 20 ^mins
67	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	611,291	60,490	10.11	2 ^hrs 22 ^mins
68	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	602,335	63,681	9.46	2 ^hrs 32 ^mins
69	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	592,724	62,774	9.44	2 ^hrs 33 ^mins
70	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	587,886	21,655	27.15	0 ^hrs 53 ^mins
71	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	581,776	60,545	9.61	2 ^hrs 30 ^mins
72	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	574,383	55,239	10.40	2 ^hrs 18 ^mins
73	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	513,266	32,214	15.93	1 ^hrs 30 ^mins
74	GeForce GTX Titan Black GK110 [GeForce GTX Titan Black] 5121	Nvidia	GK110	442,584	57,620	7.68	3 ^hrs 7 ^mins
75	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	436,931	17,000	25.70	0 ^hrs 56 ^mins
76	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	378,322	54,447	6.95	3 ^hrs 27 ^mins
77	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	373,906	53,953	6.93	3 ^hrs 28 ^mins
78	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	321,444	51,458	6.25	3 ^hrs 51 ^mins
79	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	299,152	50,272	5.95	4 ^hrs 2 ^mins

80	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	262,186	28,596	9.17	2 ^hrs 37 ^mins
81	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	259,200	17,000	15.25	1 ^hrs 34 ^mins
82	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	255,958	47,963	5.34	4 ^hrs 30 ^mins
83	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	252,876	47,376	5.34	4 ^hrs 30 ^mins
84	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	236,548	46,842	5.05	4 ^hrs 45 ^mins
85	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	228,100	45,493	5.01	4 ^hrs 47 ^mins
86	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	211,693	44,907	4.71	5 ^hrs 5 ^mins
87	Radeon Pro W5700 Navi 10 [Radeon Pro W5700]	AMD	Navi 10	193,853	17,000	11.40	2 ^hrs 6 ^mins
88	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	122,297	17,000	7.19	3 ^hrs 20 ^mins
89	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	118,508	37,038	3.20	7 ^hrs 30 ^mins
90	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	108,064	35,780	3.02	7 ^hrs 57 ^mins
91	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	88,413	36,590	2.42	9 ^hrs 56 ^mins
92	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	84,538	33,062	2.56	9 ^hrs 23 ^mins
93	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	63,704	27,217	2.34	10 ^hrs 15 ^mins
94	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	44,131	26,572	1.66	14 ^hrs 27 ^mins
95	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	36,095	23,954	1.51	15 ^hrs 56 ^mins
96	Quadro K4000 GK104 [Quadro K4000]	Nvidia	GK104	16,635	24,102	0.69	34 ^hrs 46 ^mins
97	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	8,042	17,000	0.47	50 ^hrs 44 ^mins

Research: DIABETES Folding Project #14951

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14951

GPU PPD Averages

Research: DIABETES Folding Project #14951

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages