Folding project #14912, DIABETES research

Research section Research projects and references

Project #14912 overview

Project Summary AI Beta

This project studies how certain proteins change shape when they receive signals. These proteins are involved in diseases like diabetes and high blood pressure. By understanding these changes, scientists hope to design better drugs that target these proteins.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 109,533
Core: OPENMM_22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood proessure, skin cancer, osteoporosis, etc.

Here, we are trying to studying the conformational dynamics of Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

GPCRs

Scientific: BiotechnologyPharmacology / Receptor Pharmacology

G-Protein Coupled Receptors (GPCRs) are a large family of cell surface receptors that play crucial roles in various physiological processes. They bind to signaling molecules like hormones and neurotransmitters, triggering intracellular cascades that regulate diverse cellular functions.

Glucagon Receptor

A receptor on the surface of cells that binds to glucagon, a hormone that raises blood sugar levels.

Scientific: BiotechnologyPharmacology / Endocrine Pharmacology

The Glucagon Receptor is a protein found on the surfaces of various cells. When it binds to glucagon, a hormone produced by the pancreas, it triggers a series of events inside the cell that lead to an increase in blood sugar levels.

Glucagon-like Peptide 1 receptor

GLP-1R

Scientific: BiotechnologyPharmacology / Endocrine Pharmacology

The Glucagon-like Peptide 1 receptor (GLP-1R) is a cell surface receptor that binds to GLP-1, a hormone produced by the gut. Activation of this receptor lowers blood sugar levels and promotes insulin release.

PArathyroid Hormone Receptor

PTH Receptor

Scientific: BiotechnologyPharmacology / Endocrine Pharmacology

The Parathyroid Hormone receptor (PTH Receptor) is a cell surface protein that binds to parathyroid hormone (PTH). This binding triggers various cellular responses involved in calcium homeostasis and bone metabolism.

Pituitary Adenylate Cyclase Activating Polypeptide

A peptide hormone that activates adenylate cyclase in the pituitary gland.

Scientific: BiotechnologyPharmacology / Endocrine Pharmacology

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a hormone produced by various tissues, including the brain. It plays a role in regulating several physiological functions, such as hormone release, stress response, and cognitive processes.

Secretin Receptor

A receptor on the surface of cells that binds to secretin, a hormone involved in regulating pancreatic secretions.

Scientific: BiotechnologyPharmacology / Endocrine Pharmacology

The Secretin Receptor is a protein found on the surfaces of various cells. When it binds to secretin, a hormone produced by the intestines, it triggers a series of events inside the cell that lead to the release of digestive enzymes from the pancreas.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,189,949	149,890	47.97	0 ^hrs 30 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,653,099	136,261	41.49	0 ^hrs 35 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,906,740	131,509	37.31	0 ^hrs 39 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,555,493	129,731	35.11	0 ^hrs 41 ^mins
5	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,676,815	121,359	30.30	0 ^hrs 48 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,573,536	116,721	30.62	0 ^hrs 47 ^mins
7	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,519,218	118,122	29.79	0 ^hrs 48 ^mins
8	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,193,044	114,950	27.78	0 ^hrs 52 ^mins
9	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,997,893	111,917	26.79	0 ^hrs 54 ^mins
10	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,671,756	109,274	24.45	0 ^hrs 59 ^mins
11	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,640,083	108,695	24.29	0 ^hrs 59 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,547,847	106,242	23.98	1 ^hrs 0 ^mins
13	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,508,686	106,493	23.56	1 ^hrs 1 ^mins
14	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,093,172	100,359	20.86	1 ^hrs 9 ^mins
15	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	2,059,717	99,994	20.60	1 ^hrs 10 ^mins
16	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,023,619	104,687	19.33	1 ^hrs 14 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,819,389	95,714	19.01	1 ^hrs 16 ^mins
18	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,729,713	94,373	18.33	1 ^hrs 19 ^mins
19	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,569,457	91,045	17.24	1 ^hrs 24 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,495,246	89,401	16.73	1 ^hrs 26 ^mins
21	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,285,823	87,894	14.63	1 ^hrs 38 ^mins
22	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,085,717	80,718	13.45	1 ^hrs 47 ^mins
23	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,066,359	80,589	13.23	1 ^hrs 49 ^mins
24	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,043,694	76,201	13.70	1 ^hrs 45 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,016,009	77,348	13.14	1 ^hrs 50 ^mins
26	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,008,884	78,919	12.78	1 ^hrs 53 ^mins
27	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	767,784	68,425	11.22	2 ^hrs 8 ^mins
28	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	750,971	71,059	10.57	2 ^hrs 16 ^mins
29	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	701,687	69,991	10.03	2 ^hrs 24 ^mins
30	P104-100 GP104 [P104-100]	Nvidia	GP104	692,473	69,608	9.95	2 ^hrs 25 ^mins
31	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	605,116	66,688	9.07	2 ^hrs 39 ^mins
32	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	586,369	62,278	9.42	2 ^hrs 33 ^mins
33	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	559,559	64,510	8.67	2 ^hrs 46 ^mins
34	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	556,532	64,659	8.61	2 ^hrs 47 ^mins
35	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	545,567	64,525	8.46	2 ^hrs 50 ^mins
36	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	515,795	62,599	8.24	2 ^hrs 55 ^mins
37	P106-100 GP106 [P106-100]	Nvidia	GP106	457,446	60,645	7.54	3 ^hrs 11 ^mins
38	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	412,500	58,719	7.02	3 ^hrs 25 ^mins
39	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	408,075	58,060	7.03	3 ^hrs 25 ^mins

40	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	307,868	51,107	6.02	3 ^hrs 59 ^mins
41	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	281,879	51,135	5.51	4 ^hrs 21 ^mins
42	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	269,967	50,976	5.30	4 ^hrs 32 ^mins
43	P106-090 GP106 [P106-090]	Nvidia	GP106	231,845	48,416	4.79	5 ^hrs 1 ^mins
44	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	198,537	45,814	4.33	5 ^hrs 32 ^mins
45	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	170,183	43,766	3.89	6 ^hrs 10 ^mins
46	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	136,166	40,444	3.37	7 ^hrs 8 ^mins
47	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	132,620	40,197	3.30	7 ^hrs 16 ^mins
48	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	131,941	38,852	3.40	7 ^hrs 4 ^mins
49	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	128,155	39,793	3.22	7 ^hrs 27 ^mins
50	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	121,859	39,103	3.12	7 ^hrs 42 ^mins
51	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	90,897	34,347	2.65	9 ^hrs 4 ^mins
52	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	82,576	34,340	2.40	9 ^hrs 59 ^mins
53	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	53,757	29,753	1.81	13 ^hrs 17 ^mins
54	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	30,015	24,543	1.22	19 ^hrs 37 ^mins
55	GeForce GT 635 GF116 [GeForce GT 635] 336	Nvidia	GF116	21,851	22,128	0.99	24 ^hrs 18 ^mins
56	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	7,110	13,055	0.54	44 ^hrs 4 ^mins
57	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	2,612	11,500	0.23	105 ^hrs 40 ^mins

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