Folding project #14913, DIABETES research

Research section Research projects and references

Project #14913 overview

Project Summary AI Beta

This project looks at how certain proteins on our cells change shape. These proteins are involved in things like diabetes and high blood pressure. By understanding how they work, scientists hope to create better medicines that target these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 109,840
Core: OPENMM_22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood proessure, skin cancer, osteoporosis, etc.

Here, we are trying to studying the conformational dynamics of Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

G-Protein coupled receptors (GPCRs)

Scientific: BiotechnologyPharmacology / Drug Discovery

G-Protein Coupled Receptors are a large family of cell surface proteins that play a crucial role in transmitting signals from outside the cell to the inside. They are involved in a wide range of biological processes, including sensory perception, hormone action, and immune responses. GPCRs are important drug targets for many diseases, such as diabetes, cancer, and cardiovascular disease.

Glucagon Receptor

A protein receptor that binds to glucagon and initiates signaling pathways.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a type of G-Protein Coupled Receptor found on the surface of liver cells. When glucagon binds to this receptor, it triggers a series of events that lead to the release of glucose into the bloodstream. This helps regulate blood sugar levels.

Glucagon-like Peptide 1 Receptor

GLP-1 receptor

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a type of G-Protein Coupled Receptor found on various cells in the body. When GLP-1 binds to this receptor, it stimulates insulin release from pancreatic beta cells, suppresses glucagon secretion, and slows gastric emptying. This helps regulate blood sugar levels and has therapeutic potential for treating type 2 diabetes.

Parathyroid Hormone Receptor

PTH receptor

Scientific: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor (PTHr) is a G-Protein Coupled Receptor found on various cells in the body. When parathyroid hormone binds to this receptor, it stimulates calcium release from bone, increases calcium reabsorption in the kidneys, and activates vitamin D synthesis. This helps regulate calcium levels in the blood.

Pituitary Adenylate Cyclase Activating Polypeptide Receptor

PACAP receptor

Scientific: BiotechnologyPharmacology / Neuroendocrinology

The Pituitary Adenylate Cyclase Activating Polypeptide Receptor (PACAPr) is a G-Protein Coupled Receptor involved in various physiological processes. It mediates the effects of PACAP, a neuropeptide that plays roles in stress response, neurotransmission, and immune modulation.

Secretin Receptor

A protein receptor that binds to secretin and triggers the release of bicarbonate from the pancreas.

Scientific: BiotechnologyPharmacology / Gastroenterology

The Secretin Receptor is a G-Protein Coupled Receptor found on cells in the pancreas. When secretin binds to this receptor, it stimulates the release of bicarbonate-rich fluid into the duodenum. This helps neutralize acidic chyme coming from the stomach and creates an optimal environment for digestion.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,295,189	156,901	46.50	0 ^hrs 31 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,510,298	140,539	39.21	0 ^hrs 37 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,849,072	136,685	35.48	0 ^hrs 41 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,443,170	133,299	33.33	0 ^hrs 43 ^mins
5	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,458,520	123,230	28.07	0 ^hrs 51 ^mins
6	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,422,995	119,803	28.57	0 ^hrs 50 ^mins
7	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,189,951	118,749	26.86	0 ^hrs 54 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,131,089	118,239	26.48	0 ^hrs 54 ^mins
9	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,936,930	115,643	25.40	0 ^hrs 57 ^mins
10	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,845,141	113,433	25.08	0 ^hrs 57 ^mins
11	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,630,546	112,497	23.38	1 ^hrs 2 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,584,401	110,608	23.37	1 ^hrs 2 ^mins
13	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,509,516	110,094	22.79	1 ^hrs 3 ^mins
14	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,336,164	107,209	21.79	1 ^hrs 6 ^mins
15	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	1,986,160	101,921	19.49	1 ^hrs 14 ^mins
16	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,865,158	99,819	18.69	1 ^hrs 17 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,734,148	97,375	17.81	1 ^hrs 21 ^mins
18	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,702,257	97,161	17.52	1 ^hrs 22 ^mins
19	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,595,940	94,843	16.83	1 ^hrs 26 ^mins

20	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,384,447	89,459	15.48	1 ^hrs 33 ^mins
21	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,354,018	90,213	15.01	1 ^hrs 36 ^mins
22	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,222,329	86,280	14.17	1 ^hrs 42 ^mins
23	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,158,075	85,315	13.57	1 ^hrs 46 ^mins
24	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,030,262	82,105	12.55	1 ^hrs 55 ^mins
25	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,020,448	79,767	12.79	1 ^hrs 53 ^mins
26	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	943,356	78,040	12.09	1 ^hrs 59 ^mins
27	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	929,517	75,079	12.38	1 ^hrs 56 ^mins
28	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	818,830	75,973	10.78	2 ^hrs 14 ^mins
29	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	783,789	72,598	10.80	2 ^hrs 13 ^mins
30	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	652,390	70,714	9.23	2 ^hrs 36 ^mins
31	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	617,935	68,915	8.97	2 ^hrs 41 ^mins
32	P104-100 GP104 [P104-100]	Nvidia	GP104	590,441	68,246	8.65	2 ^hrs 46 ^mins
33	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	561,385	67,156	8.36	2 ^hrs 52 ^mins
34	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	546,205	66,471	8.22	2 ^hrs 55 ^mins
35	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	539,730	65,842	8.20	2 ^hrs 56 ^mins
36	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	533,427	65,806	8.11	2 ^hrs 58 ^mins
37	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	527,122	65,983	7.99	3 ^hrs 0 ^mins
38	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	436,791	61,633	7.09	3 ^hrs 23 ^mins
39	P106-100 GP106 [P106-100]	Nvidia	GP106	405,689	60,266	6.73	3 ^hrs 34 ^mins

40	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	378,256	58,604	6.45	3 ^hrs 43 ^mins
41	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	372,920	56,823	6.56	3 ^hrs 39 ^mins
42	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	301,512	28,789	10.47	2 ^hrs 17 ^mins
43	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	290,150	53,640	5.41	4 ^hrs 26 ^mins
44	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	255,962	51,861	4.94	4 ^hrs 52 ^mins
45	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	241,608	50,707	4.76	5 ^hrs 2 ^mins
46	P106-090 GP106 [P106-090]	Nvidia	GP106	230,732	49,973	4.62	5 ^hrs 12 ^mins
47	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	228,583	47,847	4.78	5 ^hrs 1 ^mins
48	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	182,664	45,949	3.98	6 ^hrs 2 ^mins
49	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	166,742	44,963	3.71	6 ^hrs 28 ^mins
50	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	155,934	43,702	3.57	6 ^hrs 44 ^mins
51	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	152,625	43,726	3.49	6 ^hrs 53 ^mins
52	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	140,289	42,390	3.31	7 ^hrs 15 ^mins
53	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	133,685	41,656	3.21	7 ^hrs 29 ^mins
54	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	124,340	40,742	3.05	7 ^hrs 52 ^mins
55	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	114,497	39,634	2.89	8 ^hrs 18 ^mins
56	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	89,485	36,487	2.45	9 ^hrs 47 ^mins
57	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	78,297	34,946	2.24	10 ^hrs 43 ^mins
58	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	50,067	30,104	1.66	14 ^hrs 26 ^mins
59	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	31,489	25,994	1.21	19 ^hrs 49 ^mins

60	Radeon HD 5800/6800 Cypress [Radeon HD 5800/6800]	AMD	Cypress	23,957	23,596	1.02	23 ^hrs 38 ^mins

Research: DIABETES Folding Project #14913

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14913

GPU PPD Averages

Research: DIABETES Folding Project #14913

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages