Folding project #14945, DIABETES research

Research section Research projects and references

Project #14945 overview

Project Summary AI Beta

This project relates to studying how special proteins on our cells change shape when they're triggered by hormones like glucagon and parathyroid hormone. Understanding these changes can help us create better medications for diseases like diabetes, high blood pressure, and osteoporosis.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 107,715
Core: 0x22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

G protein-coupled receptors (GPCRs)

Technical: BiotechnologyPharmacology / Drug Discovery

G-Protein Coupled Receptors are a large family of proteins found on the surface of cells that bind to signaling molecules. They play a crucial role in transmitting signals within the body, influencing various processes like hormone regulation, sensory perception, and immune responses.

Glucagon Receptor

A type of G protein-coupled receptor that binds to glucagon.

Technical: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a protein found on the surface of liver cells. It binds to the hormone glucagon, triggering processes that release glucose into the bloodstream.

Glucagon-like Peptide 1 receptor

GLP-1 Receptor

Technical: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 receptor is a protein that binds to the hormone GLP-1. It plays a role in regulating blood sugar levels and stimulating insulin release.

PArathyroid Hormone Receptor

Parathyroid Hormone 1 Receptor (PTH1R)

Technical: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor is a protein found on various cells in the body. It binds to parathyroid hormone, which regulates calcium levels in the blood.

Pituitary Adenlyate Cyclase Receptor

Adenylate Cyclase-Coupled Receptors (ACRs)

Technical: BiotechnologyPharmacology / Endocrinology

Pituitary Adenylate Cyclase Receptors are proteins that play a role in regulating hormone release from the pituitary gland. They bind to various hormones and activate signaling pathways that control cellular processes.

Secretin Receptor

A type of G protein-coupled receptor that binds to the hormone secretin.

Technical: BiotechnologyPharmacology / Gastroenterology

The Secretin Receptor is a protein found on cells in the pancreas and intestine. It binds to the hormone secretin, triggering the release of bicarbonate from the pancreas, which neutralizes stomach acid in the duodenum.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	16,980,631	142,069	119.52	0 ^hrs 12 ^mins
2	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,497,961	52,690	256.18	0 ^hrs 6 ^mins
3	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	11,989,367	158,186	75.79	0 ^hrs 19 ^mins
4	RTX 6000 Ada Generation AD102GL [RTX 6000 Ada Generation]	Nvidia	AD102GL	9,735,057	164,639	59.13	0 ^hrs 24 ^mins
5	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	8,772,815	123,747	70.89	0 ^hrs 20 ^mins
6	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	8,451,500	135,881	62.20	0 ^hrs 23 ^mins
7	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	7,889,812	18,000	438.32	0 ^hrs 3 ^mins
8	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,526,199	141,107	53.34	0 ^hrs 27 ^mins
9	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,010,139	146,791	47.76	0 ^hrs 30 ^mins
10	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	6,935,190	18,000	385.29	0 ^hrs 4 ^mins
11	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	6,427,797	143,224	44.88	0 ^hrs 32 ^mins
12	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,344,465	139,153	45.59	0 ^hrs 32 ^mins
13	RTX 5000 Ada Generation Laptop GPU AD103GLM [RTX 5000 Ada Generation Laptop GPU]	Nvidia	AD103GLM	6,228,180	140,799	44.23	0 ^hrs 33 ^mins
14	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	6,207,383	142,322	43.62	0 ^hrs 33 ^mins
15	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,049,232	133,923	45.17	0 ^hrs 32 ^mins
16	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	6,010,863	134,092	44.83	0 ^hrs 32 ^mins
17	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,902,083	113,392	43.23	0 ^hrs 33 ^mins
18	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,329,841	96,137	45.04	0 ^hrs 32 ^mins
19	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	4,283,102	95,403	44.89	0 ^hrs 32 ^mins

20	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,220,247	123,549	34.16	0 ^hrs 42 ^mins
21	L4 AD104GL [L4]	Nvidia	AD104GL	3,882,126	120,201	32.30	0 ^hrs 45 ^mins
22	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	3,875,315	122,498	31.64	0 ^hrs 46 ^mins
23	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,739,016	118,535	31.54	0 ^hrs 46 ^mins
24	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	3,565,312	115,887	30.77	0 ^hrs 47 ^mins
25	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	3,430,326	106,069	32.34	0 ^hrs 45 ^mins
26	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,388,033	102,948	32.91	0 ^hrs 44 ^mins
27	Radeon RX 6950 XT Navi 21 [Radeon RX 6950 XT]	AMD	Navi 21	3,383,449	116,676	29.00	0 ^hrs 50 ^mins
28	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	3,205,689	75,006	42.74	0 ^hrs 34 ^mins
29	GeForce RTX 4070 Max-Q / Mobile AD106M [GeForce RTX 4070 Max-Q / Mobile]	Nvidia	AD106M	3,184,516	18,000	176.92	0 ^hrs 8 ^mins
30	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,134,296	113,531	27.61	0 ^hrs 52 ^mins
31	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,120,920	49,485	63.07	0 ^hrs 23 ^mins
32	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,042,370	110,526	27.53	0 ^hrs 52 ^mins
33	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	2,980,532	111,302	26.78	0 ^hrs 54 ^mins
34	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,811,874	103,086	27.28	0 ^hrs 53 ^mins
35	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,728,516	108,750	25.09	0 ^hrs 57 ^mins
36	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,715,807	106,679	25.46	0 ^hrs 57 ^mins
37	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,713,020	108,306	25.05	0 ^hrs 57 ^mins
38	GeForce RTX 3070 Mobile / Max-Q GA104M [GeForce RTX 3070 Mobile / Max-Q]	Nvidia	GA104M	2,491,950	105,601	23.60	1 ^hrs 1 ^mins
39	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,348,735	93,224	25.19	0 ^hrs 57 ^mins

40	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,284,812	101,200	22.58	1 ^hrs 4 ^mins
41	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	2,261,536	100,021	22.61	1 ^hrs 4 ^mins
42	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,151,240	99,379	21.65	1 ^hrs 7 ^mins
43	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,122,052	101,784	20.85	1 ^hrs 9 ^mins
44	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,087,715	99,091	21.07	1 ^hrs 8 ^mins
45	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,043,092	89,799	22.75	1 ^hrs 3 ^mins
46	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,007,513	43,189	46.48	0 ^hrs 31 ^mins
47	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	1,993,400	50,318	39.62	0 ^hrs 36 ^mins
48	RTX 2000 Ada Generation Laptop GPU AD107GLM [RTX 2000 Ada Generation Laptop GPU]	Nvidia	AD107GLM	1,981,377	98,974	20.02	1 ^hrs 12 ^mins
49	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	1,927,545	92,082	20.93	1 ^hrs 9 ^mins
50	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,799,396	94,745	18.99	1 ^hrs 16 ^mins
51	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	1,711,188	93,514	18.30	1 ^hrs 19 ^mins
52	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,476,692	88,114	16.76	1 ^hrs 26 ^mins
53	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,381,691	85,928	16.08	1 ^hrs 30 ^mins
54	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,353,361	84,297	16.05	1 ^hrs 30 ^mins
55	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,347,182	79,761	16.89	1 ^hrs 25 ^mins
56	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,338,658	85,761	15.61	1 ^hrs 32 ^mins
57	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,289,741	85,187	15.14	1 ^hrs 35 ^mins
58	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,235,662	82,660	14.95	1 ^hrs 36 ^mins
59	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,200,365	76,956	15.60	1 ^hrs 32 ^mins

60	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,056,343	79,417	13.30	1 ^hrs 48 ^mins
61	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,046,578	71,679	14.60	1 ^hrs 39 ^mins
62	Radeon RX 6650XT Navi 23 [Radeon RX 6650XT]	AMD	Navi 23	1,044,544	76,194	13.71	1 ^hrs 45 ^mins
63	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,031,185	68,183	15.12	1 ^hrs 35 ^mins
64	Quadro M6000 GM200GL [Quadro M6000]	Nvidia	GM200GL	880,743	74,812	11.77	2 ^hrs 2 ^mins
65	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	820,196	71,169	11.52	2 ^hrs 5 ^mins
66	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	819,659	71,669	11.44	2 ^hrs 6 ^mins
67	Radeon PRO W6600 Navi 23 XL [Radeon PRO W6600]	AMD	Navi 23 XL	806,215	72,985	11.05	2 ^hrs 10 ^mins
68	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	794,309	67,568	11.76	2 ^hrs 2 ^mins
69	P106-100 GP106 [P106-100]	Nvidia	GP106	710,020	69,899	10.16	2 ^hrs 22 ^mins
70	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	649,780	67,022	9.70	2 ^hrs 29 ^mins
71	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	628,706	66,808	9.41	2 ^hrs 33 ^mins
72	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	584,221	65,022	8.98	2 ^hrs 40 ^mins
73	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	523,210	31,594	16.56	1 ^hrs 27 ^mins
74	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	454,180	24,677	18.40	1 ^hrs 18 ^mins
75	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	446,845	59,044	7.57	3 ^hrs 10 ^mins
76	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	434,847	59,221	7.34	3 ^hrs 16 ^mins
77	GeForce GTX Titan Black GK110 [GeForce GTX Titan Black] 5121	Nvidia	GK110	433,971	59,541	7.29	3 ^hrs 18 ^mins
78	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	411,304	55,271	7.44	3 ^hrs 14 ^mins
79	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	386,071	56,831	6.79	3 ^hrs 32 ^mins

80	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	344,634	54,871	6.28	3 ^hrs 49 ^mins
81	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	324,515	45,947	7.06	3 ^hrs 24 ^mins
82	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	271,050	50,847	5.33	4 ^hrs 30 ^mins
83	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	237,683	48,478	4.90	4 ^hrs 54 ^mins
84	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	237,106	48,281	4.91	4 ^hrs 53 ^mins
85	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	209,813	41,367	5.07	4 ^hrs 44 ^mins
86	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	184,997	43,564	4.25	5 ^hrs 39 ^mins
87	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	138,456	18,000	7.69	3 ^hrs 7 ^mins
88	GeForce MX450 TU117M [GeForce MX450]	Nvidia	TU117M	136,373	39,901	3.42	7 ^hrs 1 ^mins
89	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	130,448	38,717	3.37	7 ^hrs 7 ^mins
90	GeForce MX150 GP107M [GeForce MX150]	Nvidia	GP107M	117,369	38,406	3.06	7 ^hrs 51 ^mins
91	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	109,489	36,382	3.01	7 ^hrs 58 ^mins
92	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	102,162	29,401	3.47	6 ^hrs 54 ^mins
93	R7 370/R9 270/370 OEM Curacao Pro [R7 370/R9 270/370 OEM]	AMD	Curacao Pro	96,540	33,511	2.88	8 ^hrs 20 ^mins
94	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	90,857	37,279	2.44	9 ^hrs 51 ^mins
95	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	80,872	34,006	2.38	10 ^hrs 6 ^mins
96	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	74,441	32,250	2.31	10 ^hrs 24 ^mins
97	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	72,648	34,392	2.11	11 ^hrs 22 ^mins
98	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	48,591	27,484	1.77	13 ^hrs 34 ^mins
99	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	43,832	18,000	2.44	9 ^hrs 51 ^mins

Research: DIABETES Folding Project #14945

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14945

GPU PPD Averages

Research: DIABETES Folding Project #14945

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages