Folding project #14915, DIABETES research

Research section Research projects and references

Project #14915 overview

Project Summary AI Beta

This project looks at how certain proteins on our cells change shape when they get activated by hormones. These proteins are linked to diseases like diabetes and osteoporosis. By understanding how they work, scientists hope to create better medicines that target them.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 101,265
Core: OPENMM_22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood proessure, skin cancer, osteoporosis, etc.

Here, we are trying to studying the conformational dynamics of Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

GPCRs

Scientific: BiotechnologyPharmacology / Drug Discovery

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play crucial roles in signal transduction pathways. They are involved in diverse physiological processes, including hormone regulation, neurotransmission, and immune responses.

Glucagon Receptor

A receptor protein that binds to glucagon hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a type of G protein-coupled receptor found on the surface of cells in the liver and other tissues. When glucagon hormone binds to this receptor, it triggers a cascade of events that ultimately lead to increased glucose production by the liver.

Glucagon-like Peptide 1 Receptor

GLP-1R

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a type of G protein-coupled receptor found on the surface of cells in the pancreas and brain. When GLP-1 hormone binds to this receptor, it stimulates insulin release from pancreatic beta cells and suppresses glucagon secretion.

Parathyroid Hormone Receptor

PTH1R

Scientific: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor (PTH1R) is a type of G protein-coupled receptor found on various tissues, including bone, kidneys, and intestines. When parathyroid hormone binds to this receptor, it regulates calcium homeostasis by stimulating calcium release from bones, promoting calcium reabsorption in the kidneys, and increasing vitamin D activation.

Pituitary Adenylate Cyclase Activating Receptor

PACAP R

Scientific: BiotechnologyPharmacology / Endocrinology

The Pituitary Adenylate Cyclase Activating Receptor (PACAP R) is a type of G protein-coupled receptor found on various tissues. When pituitary adenylate cyclase activating peptide (PACAP) binds to this receptor, it activates signaling pathways that regulate hormone release, cell proliferation, and survival.

Secretin Receptor

A receptor protein that binds to the hormone secretin.

Scientific: BiotechnologyPharmacology / Gastroenterology

The Secretin Receptor is a type of G protein-coupled receptor found on cells lining the pancreas and intestines. When secretin hormone binds to this receptor, it stimulates bicarbonate secretion from the pancreas, which neutralizes stomach acid in the duodenum.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,382,020	130,459	48.92	0 ^hrs 29 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,523,645	123,483	44.73	0 ^hrs 32 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,660,261	118,135	39.45	0 ^hrs 37 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,365,313	115,442	37.81	0 ^hrs 38 ^mins
5	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,542,272	107,062	33.09	0 ^hrs 44 ^mins
6	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,451,950	108,945	31.69	0 ^hrs 45 ^mins
7	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,258,413	104,203	31.27	0 ^hrs 46 ^mins
8	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,138,454	104,267	30.10	0 ^hrs 48 ^mins
9	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,916,500	101,249	28.81	0 ^hrs 50 ^mins
10	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,799,169	100,099	27.96	0 ^hrs 51 ^mins
11	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,625,663	98,114	26.76	0 ^hrs 54 ^mins
12	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,551,648	96,528	26.43	0 ^hrs 54 ^mins
13	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,382,628	94,153	25.31	0 ^hrs 57 ^mins
14	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,228,321	90,230	24.70	0 ^hrs 58 ^mins
15	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,026,553	89,830	22.56	1 ^hrs 4 ^mins
16	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,743,368	83,279	20.93	1 ^hrs 9 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,731,250	85,143	20.33	1 ^hrs 11 ^mins
18	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,649,621	83,955	19.65	1 ^hrs 13 ^mins
19	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,568,494	81,817	19.17	1 ^hrs 15 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,360,397	79,061	17.21	1 ^hrs 24 ^mins
21	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,242,029	77,285	16.07	1 ^hrs 30 ^mins
22	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,129,001	72,860	15.50	1 ^hrs 33 ^mins
23	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,017,147	70,608	14.41	1 ^hrs 40 ^mins
24	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	976,652	70,527	13.85	1 ^hrs 44 ^mins
25	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	897,966	68,585	13.09	1 ^hrs 50 ^mins
26	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	877,677	67,673	12.97	1 ^hrs 51 ^mins
27	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	868,119	67,898	12.79	1 ^hrs 53 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	800,725	43,626	18.35	1 ^hrs 18 ^mins
29	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	673,215	62,434	10.78	2 ^hrs 14 ^mins
30	P104-100 GP104 [P104-100]	Nvidia	GP104	663,981	62,109	10.69	2 ^hrs 15 ^mins
31	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	632,391	60,811	10.40	2 ^hrs 18 ^mins
32	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	616,327	60,634	10.16	2 ^hrs 22 ^mins
33	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	593,834	59,981	9.90	2 ^hrs 25 ^mins
34	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	549,614	58,197	9.44	2 ^hrs 32 ^mins
35	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	526,602	57,402	9.17	2 ^hrs 37 ^mins
36	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	516,968	56,243	9.19	2 ^hrs 37 ^mins
37	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	514,971	44,109	11.67	2 ^hrs 3 ^mins
38	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	453,829	54,782	8.28	2 ^hrs 54 ^mins
39	P106-100 GP106 [P106-100]	Nvidia	GP106	438,642	54,082	8.11	2 ^hrs 58 ^mins

40	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	391,140	51,805	7.55	3 ^hrs 11 ^mins
41	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	384,712	51,760	7.43	3 ^hrs 14 ^mins
42	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	365,266	50,991	7.16	3 ^hrs 21 ^mins
43	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	349,550	49,661	7.04	3 ^hrs 25 ^mins
44	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	292,259	43,080	6.78	3 ^hrs 32 ^mins
45	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	262,253	45,772	5.73	4 ^hrs 11 ^mins
46	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	254,817	44,738	5.70	4 ^hrs 13 ^mins
47	P106-090 GP106 [P106-090]	Nvidia	GP106	235,731	44,020	5.36	4 ^hrs 29 ^mins
48	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	204,365	41,875	4.88	4 ^hrs 55 ^mins
49	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	167,609	38,815	4.32	5 ^hrs 33 ^mins
50	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	163,798	39,123	4.19	5 ^hrs 44 ^mins
51	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	158,102	38,202	4.14	5 ^hrs 48 ^mins
52	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	156,991	38,307	4.10	5 ^hrs 51 ^mins
53	Quadro P1000 Mobile GP107GLM [Quadro P1000 Mobile]	Nvidia	GP107GLM	145,040	37,603	3.86	6 ^hrs 13 ^mins
54	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	128,917	36,019	3.58	6 ^hrs 42 ^mins
55	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	128,158	35,999	3.56	6 ^hrs 44 ^mins
56	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	117,819	33,819	3.48	6 ^hrs 53 ^mins
57	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	117,295	34,964	3.35	7 ^hrs 9 ^mins
58	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	92,199	32,188	2.86	8 ^hrs 23 ^mins
59	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	79,339	30,690	2.59	9 ^hrs 17 ^mins

60	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	52,370	26,767	1.96	12 ^hrs 16 ^mins
61	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	29,191	22,130	1.32	18 ^hrs 12 ^mins

Research: DIABETES Folding Project #14915

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14915

GPU PPD Averages

Research: DIABETES Folding Project #14915

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages