Folding project #14916, DIABETES research

Research section Research projects and references

Project #14916 overview

Project Summary AI Beta

This project studies how certain proteins on our cells change shape. These proteins are involved in diseases like diabetes and high blood pressure. By understanding how they work, scientists can design better drugs to treat these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 101,757
Core: OPENMM_22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood proessure, skin cancer, osteoporosis, etc.

Here, we are trying to studying the conformational dynamics of Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

G protein-coupled receptors (GPCRs)

Technical: BiotechnologyPharmacology / Drug Discovery

G Protein Coupled Receptors are a large family of proteins found on the surface of cells. They play a crucial role in transmitting signals from outside the cell to inside, influencing various bodily functions like hormone responses, sensory perception, and mood regulation. Many drugs target GPCRs to treat diseases like high blood pressure, diabetes, and mental health disorders.

Glucagon Receptor

A receptor protein that binds to the hormone glucagon.

Technical: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a protein found on cells in the liver and other organs. When glucagon, a hormone released by the pancreas, binds to this receptor, it triggers processes that raise blood sugar levels. This is important for regulating energy balance and ensuring the body has enough glucose for fuel.

Glucagon-like Peptide 1 Receptor

GLP-1 receptor

Technical: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a protein found on cells in the pancreas and other organs. It binds to the hormone GLP-1, which stimulates insulin release and suppresses glucagon secretion. This helps regulate blood sugar levels and plays a role in appetite control.

Parathyroid Hormone Receptor

A receptor protein that binds to the hormone parathyroid hormone.

Technical: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor (PTHr) is found on various cells in the body. When it binds to parathyroid hormone, it triggers processes like calcium release from bones and increased kidney reabsorption of calcium. This helps regulate blood calcium levels.

Pituitary Adenylate Cyclase-Activating Receptor

PACAP receptor

Technical: BiotechnologyPharmacology / Endocrinology

The Pituitary Adenylate Cyclase-Activating Receptor (PAC1R) is a protein found on cells in the brain and other organs. It binds to the hormone PACAP, which has various effects including stimulating the release of other hormones.

Secretin Receptor

A receptor protein that binds to the hormone secretin.

Technical: BiotechnologyPharmacology / Gastroenterology

The Secretin Receptor is found on cells in the pancreas and other organs. When it binds to the hormone secretin, it stimulates the release of bicarbonate from the pancreas, which helps neutralize stomach acid in the small intestine.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,184,159	128,066	48.29	0 ^hrs 30 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,543,860	123,374	44.94	0 ^hrs 32 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,675,065	118,239	39.54	0 ^hrs 36 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,180,759	113,803	36.74	0 ^hrs 39 ^mins
5	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,557,282	107,632	33.05	0 ^hrs 44 ^mins
6	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,413,729	108,265	31.53	0 ^hrs 46 ^mins
7	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,208,857	103,892	30.89	0 ^hrs 47 ^mins
8	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	2,799,459	100,144	27.95	0 ^hrs 52 ^mins
9	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	2,564,998	89,318	28.72	0 ^hrs 50 ^mins
10	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,549,923	95,689	26.65	0 ^hrs 54 ^mins
11	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,439,642	95,560	25.53	0 ^hrs 56 ^mins
12	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,369,934	93,680	25.30	0 ^hrs 57 ^mins
13	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,358,216	94,470	24.96	0 ^hrs 58 ^mins
14	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,002,810	89,520	22.37	1 ^hrs 4 ^mins
15	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,780,206	80,866	22.01	1 ^hrs 5 ^mins
16	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,745,583	85,368	20.45	1 ^hrs 10 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,651,602	83,324	19.82	1 ^hrs 13 ^mins
18	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,629,932	83,633	19.49	1 ^hrs 14 ^mins
19	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,548,288	82,092	18.86	1 ^hrs 16 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,347,772	78,752	17.11	1 ^hrs 24 ^mins
21	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,226,415	76,132	16.11	1 ^hrs 29 ^mins
22	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	1,167,349	44,586	26.18	0 ^hrs 55 ^mins
23	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,104,183	72,844	15.16	1 ^hrs 35 ^mins
24	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,038,089	72,359	14.35	1 ^hrs 40 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	971,934	70,357	13.81	1 ^hrs 44 ^mins
26	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	866,114	68,166	12.71	1 ^hrs 53 ^mins
27	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	838,058	66,260	12.65	1 ^hrs 54 ^mins
28	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	781,340	63,653	12.27	1 ^hrs 57 ^mins
29	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	718,142	62,642	11.46	2 ^hrs 6 ^mins
30	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	667,382	62,309	10.71	2 ^hrs 14 ^mins
31	P104-100 GP104 [P104-100]	Nvidia	GP104	660,889	61,999	10.66	2 ^hrs 15 ^mins
32	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	603,353	59,150	10.20	2 ^hrs 21 ^mins
33	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	589,114	59,756	9.86	2 ^hrs 26 ^mins
34	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	537,279	57,874	9.28	2 ^hrs 35 ^mins
35	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	504,747	57,100	8.84	2 ^hrs 43 ^mins
36	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	497,376	56,297	8.83	2 ^hrs 43 ^mins
37	GeForce GTX 1070 GP104 [GeForce GTX 1070]	Nvidia	GP104	452,540	54,750	8.27	2 ^hrs 54 ^mins
38	P106-100 GP106 [P106-100]	Nvidia	GP106	430,225	53,585	8.03	2 ^hrs 59 ^mins
39	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	393,114	51,827	7.59	3 ^hrs 10 ^mins

40	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	386,656	51,902	7.45	3 ^hrs 13 ^mins
41	GeForce GTX 780 GK110 [GeForce GTX 780] 3977	Nvidia	GK110	351,023	49,810	7.05	3 ^hrs 24 ^mins
42	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	342,659	46,170	7.42	3 ^hrs 14 ^mins
43	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	310,286	47,826	6.49	3 ^hrs 42 ^mins
44	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	272,843	46,345	5.89	4 ^hrs 5 ^mins
45	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	266,372	44,431	6.00	4 ^hrs 0 ^mins
46	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	239,881	44,422	5.40	4 ^hrs 27 ^mins
47	P106-090 GP106 [P106-090]	Nvidia	GP106	231,402	43,724	5.29	4 ^hrs 32 ^mins
48	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	203,477	41,950	4.85	4 ^hrs 57 ^mins
49	Radeon R9 200/300 Series Tonga [Radeon R9 200/300 Series]	AMD	Tonga	165,762	38,973	4.25	5 ^hrs 39 ^mins
50	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	161,046	38,890	4.14	5 ^hrs 48 ^mins
51	Tesla M40 GM200GL [Tesla M40] 6844	Nvidia	GM200GL	139,937	19,248	7.27	3 ^hrs 18 ^mins
52	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	127,319	35,646	3.57	6 ^hrs 43 ^mins
53	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	126,931	35,898	3.54	6 ^hrs 47 ^mins
54	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	123,354	35,521	3.47	6 ^hrs 55 ^mins
55	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	123,328	35,312	3.49	6 ^hrs 52 ^mins
56	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	115,191	34,681	3.32	7 ^hrs 14 ^mins
57	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	92,918	32,339	2.87	8 ^hrs 21 ^mins
58	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	78,787	30,622	2.57	9 ^hrs 20 ^mins
59	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	51,847	26,656	1.95	12 ^hrs 20 ^mins

60	Radeon R7 250X/HD 7700/8760 R575A [Radeon R7 250X/HD 7700/8760]	AMD	R575A	47,596	25,947	1.83	13 ^hrs 5 ^mins
61	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	24,279	20,724	1.17	20 ^hrs 29 ^mins
62	Radeon HD 5800/6800 Cypress [Radeon HD 5800/6800]	AMD	Cypress	21,832	20,012	1.09	21 ^hrs 60 ^mins
63	Radeon R7 250/HD 7700 R575A [Radeon R7 250/HD 7700]	AMD	R575A	20,813	15,941	1.31	18 ^hrs 23 ^mins

Research: DIABETES Folding Project #14916

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14916

GPU PPD Averages

Research: DIABETES Folding Project #14916

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages