Folding project #14921, DIABETES research

Research section Research projects and references

Project #14921 overview

Project Summary AI Beta

This project studies how certain receptors in the body change shape when activated by hormones. These receptors are linked to diseases like diabetes and high blood pressure. Understanding how they work can help scientists design better drugs to treat these conditions.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 107,185
Core: OPENMM_22
Status: Public

Source material

Official Project Description

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

G-Protein Coupled Receptors

GPCRs

Scientific: BiotechnologyPharmacology / Drug Discovery

G-Protein Coupled Receptors are a large family of cell surface proteins that play a crucial role in transmitting signals within the body. They are involved in a wide range of physiological processes, including hormone regulation, neurotransmission, and immune response.

Glucagon Receptor

A type of G-protein coupled receptor that binds to the hormone glucagon.

Technical: BiotechnologyEndocrinology / Diabetes Research

The Glucagon Receptor is a protein found on the surface of cells in the liver and other tissues. It plays a vital role in regulating blood sugar levels by responding to the hormone glucagon. When glucagon binds to its receptor, it triggers a cascade of events that lead to the release of glucose from the liver into the bloodstream.

Glucagon-like Peptide 1 Receptor

GLP-1R

Technical: BiotechnologyEndocrinology / Diabetes Research

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a protein found on the surface of cells in the pancreas and other tissues. It plays a crucial role in regulating blood sugar levels by responding to the hormone GLP-1. When GLP-1 binds to its receptor, it stimulates the release of insulin from the pancreas.

PArathyroid Hormone Receptor

PTH1R

Technical: BiotechnologyEndocrinology / Calcium Metabolism

The Parathyroid Hormone Receptor (PTH1R) is a protein found on the surface of various cells in the body. It plays a crucial role in regulating calcium levels by responding to the hormone parathyroid hormone (PTH). When PTH binds to its receptor, it stimulates bone breakdown and calcium release into the bloodstream.

Pituitary Adenylate Cyclase Receptor

PACR

Technical: BiotechnologyEndocrinology / Hormone Regulation

The Pituitary Adenylate Cyclase Receptor (PACR) is a protein found on the surface of pituitary cells. It plays a crucial role in hormone regulation by responding to various hormones released from the hypothalamus. When these hormones bind to PACR, it triggers a cascade of events that lead to the production and release of other hormones.

Secretin Receptor

A type of G-protein coupled receptor that binds to the hormone secretin.

Technical: BiotechnologyGastroenterology / Digestive System

The Secretin Receptor is a protein found on the surface of cells in the pancreas and other tissues. It plays a crucial role in regulating digestion by responding to the hormone secretin. When secretin binds to its receptor, it stimulates the release of bicarbonate from the pancreas into the small intestine, which helps neutralize acidic chyme.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	6,810,645	136,310	49.96	0 ^hrs 29 ^mins
2	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,329,052	136,440	46.39	0 ^hrs 31 ^mins
3	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,315,060	138,873	45.47	0 ^hrs 32 ^mins
4	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,246,886	133,654	46.74	0 ^hrs 31 ^mins
5	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,848,635	134,774	43.40	0 ^hrs 33 ^mins
6	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,946,795	127,143	38.91	0 ^hrs 37 ^mins
7	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,807,828	126,067	38.14	0 ^hrs 38 ^mins
8	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,476,835	123,086	36.37	0 ^hrs 40 ^mins
9	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,097,206	120,398	34.03	0 ^hrs 42 ^mins
10	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,999,961	118,470	33.76	0 ^hrs 43 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,438,651	113,384	30.33	0 ^hrs 47 ^mins
12	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	3,061,934	107,180	28.57	0 ^hrs 50 ^mins
13	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	2,670,528	104,047	25.67	0 ^hrs 56 ^mins
14	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,547,695	102,346	24.89	0 ^hrs 58 ^mins
15	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,489,957	101,825	24.45	0 ^hrs 59 ^mins
16	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,284,412	99,034	23.07	1 ^hrs 2 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,235,997	98,342	22.74	1 ^hrs 3 ^mins
18	GeForce RTX 3080 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,050,792	94,944	21.60	1 ^hrs 7 ^mins
19	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	2,036,429	95,582	21.31	1 ^hrs 8 ^mins

20	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	1,913,487	92,674	20.65	1 ^hrs 10 ^mins
21	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,553,616	87,489	17.76	1 ^hrs 21 ^mins
22	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,535,223	86,435	17.76	1 ^hrs 21 ^mins
23	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,389,727	83,641	16.62	1 ^hrs 27 ^mins
24	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,373,078	83,587	16.43	1 ^hrs 28 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,125,639	77,428	14.54	1 ^hrs 39 ^mins
26	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	1,089,254	51,655	21.09	1 ^hrs 8 ^mins
27	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,084,145	75,373	14.38	1 ^hrs 40 ^mins
28	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,079,569	75,923	14.22	1 ^hrs 41 ^mins
29	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	818,755	69,884	11.72	2 ^hrs 3 ^mins
30	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	655,251	65,417	10.02	2 ^hrs 24 ^mins
31	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	588,448	63,029	9.34	2 ^hrs 34 ^mins
32	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	584,902	62,866	9.30	2 ^hrs 35 ^mins
33	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	550,648	61,575	8.94	2 ^hrs 41 ^mins
34	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	499,710	59,298	8.43	2 ^hrs 51 ^mins
35	P106-090 GP106 [P106-090]	Nvidia	GP106	320,773	51,549	6.22	3 ^hrs 51 ^mins
36	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	285,847	49,667	5.76	4 ^hrs 10 ^mins
37	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	231,158	46,104	5.01	4 ^hrs 47 ^mins
38	Quadro P1000 GP107GL [Quadro P1000]	Nvidia	GP107GL	204,661	44,693	4.58	5 ^hrs 14 ^mins
39	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	147,406	39,986	3.69	6 ^hrs 31 ^mins

40	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	122,488	37,483	3.27	7 ^hrs 21 ^mins
41	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	105,378	35,804	2.94	8 ^hrs 9 ^mins
42	GeForce GTX 750 GM107 [GeForce GTX 750] 1111	Nvidia	GM107	96,531	34,523	2.80	8 ^hrs 35 ^mins
43	GeForce GTX 660 GK106 [GeForce GTX 660]	Nvidia	GK106	69,316	30,837	2.25	10 ^hrs 41 ^mins
44	GeForce GTX 950M GM107 [GeForce GTX 950M] 1439	Nvidia	GM107	46,634	23,713	1.97	12 ^hrs 12 ^mins
45	GeForce GT 730 GK208B [GeForce GT 730] 692.7	Nvidia	GK208B	31,584	23,792	1.33	18 ^hrs 5 ^mins

Research: DIABETES Folding Project #14921

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 14921

GPU PPD Averages

Research: DIABETES Folding Project #14921

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages