G-Protein Coupled Receptors
Cell surface receptors that activate intracellular signaling pathways.
Scientific: BiotechnologyPharmacology / Drug Discovery
G-Protein Coupled Receptors (GPCRs) are a large family of proteins found on the surface of cells. They play a crucial role in transmitting signals from outside the cell to inside, influencing various bodily functions like vision, smell, and hormone regulation. Many drugs target GPCRs to treat diseases such as diabetes, high blood pressure, and pain.
Glucagon Receptor
A type of GPCR that binds to the hormone glucagon.
Scientific: BiotechnologyPharmacology / Endocrinology
The Glucagon Receptor is a protein on the surface of liver cells. When glucagon binds to this receptor, it signals the liver to release glucose into the bloodstream, raising blood sugar levels. This process is essential for regulating blood sugar and providing energy to the body.
Glucagon-like Peptide 1 receptor
A type of GPCR that binds to the hormone GLP-1.
Scientific: BiotechnologyPharmacology / Endocrinology
The Glucagon-like Peptide 1 receptor (GLP-1R) is a protein found on cells in the pancreas and other organs. When GLP-1 binds to this receptor, it stimulates insulin release from the pancreas, lowers blood sugar levels, and slows down gastric emptying. This makes GLP-1R a target for medications used to treat type 2 diabetes.
PArathyroid Hormone Receptor
A type of GPCR that binds to the hormone parathyroid hormone (PTH).
Scientific: BiotechnologyPharmacology / Endocrinology
The Parathyroid Hormone Receptor (PTHrR) is a protein found on various cells throughout the body. When PTH binds to this receptor, it stimulates calcium release from bones, increases calcium absorption in the intestines, and promotes reabsorption of calcium in the kidneys. This helps regulate calcium levels in the blood, which are essential for bone health, muscle function, and nerve signaling.
Pituitary Adenylate Cyclase Receptor
A type of GPCR that activates adenylate cyclase.
Scientific: BiotechnologyPharmacology / Endocrinology
The Pituitary Adenylate Cyclase Receptor (PACR) is a protein found on cells in the pituitary gland. When activated by hormones like Gonadotropin-Releasing Hormone (GnRH), it triggers the production of cyclic AMP (cAMP), which acts as a messenger molecule to regulate various cellular processes. This receptor plays a crucial role in controlling hormone release from the pituitary gland, affecting reproductive function, growth, and metabolism.
Secretin Receptor
A type of GPCR that binds to the hormone secretin.
Scientific: BiotechnologyPharmacology / Gastroenterology
The Secretin Receptor is a protein found on cells in the pancreas and other organs. When secretin binds to this receptor, it stimulates bicarbonate secretion from the pancreas, which neutralizes stomach acid entering the duodenum. This helps protect the intestinal lining and facilitate digestion.