Folding project #14950, DIABETES research

Research section Research projects and references

Project #14950 overview

Project Summary AI Beta

This project studies how Class B G-protein coupled receptors (important for things like blood sugar and bone health) change shape. Understanding these changes can help scientists design better drugs to treat conditions like diabetes and osteoporosis.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prateek Bansal
Institution: University of Illinois Urbana-Champaign

Work unit

Atoms: 112,616
Core: 0x22
Status: Public

Source material

Official Project Description

Class B G-Protein Coupled Receptors: Class B G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Class B G-Protein Coupled Receptors

Membrane proteins involved in various diseases.

Scientific: BiotechnologyPharmacology / Drug Discovery

Class B G-Protein Coupled Receptors are a type of membrane protein that plays a role in many biological processes. They are important targets for drug development because they are involved in diseases like diabetes, high blood pressure, and osteoporosis.

GPCRs

G-Protein Coupled Receptors

Acronym: BiotechnologyPharmacology / Drug Discovery

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from outside the cell to inside. They are involved in various physiological processes and are targets for many drugs.

Glucagon Receptor

A receptor that binds to glucagon.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon Receptor is a protein found on the surface of cells. It binds to the hormone glucagon, which helps regulate blood sugar levels.

Glucagon-like Peptide 1 receptor

A receptor that binds to glucagon-like peptide 1.

Scientific: BiotechnologyPharmacology / Endocrinology

The Glucagon-like Peptide 1 receptor is a protein found on the surface of cells. It binds to the hormone glucagon-like peptide 1, which helps regulate blood sugar levels and promotes insulin release.

PArathyroid Hormone Receptor

A receptor that binds to parathyroid hormone.

Scientific: BiotechnologyPharmacology / Endocrinology

The Parathyroid Hormone Receptor is a protein found on the surface of cells. It binds to the hormone parathyroid hormone, which helps regulate calcium levels in the blood.

Pituitary Adenylate Cyclase Receptor

A receptor that activates adenylate cyclase.

Scientific: BiotechnologyPharmacology / Endocrinology

The Pituitary Adenylate Cyclase Receptor is a protein found on the surface of cells. It binds to hormones like gonadotropin-releasing hormone (GnRH) and stimulates the production of cyclic AMP, which plays a role in various cellular processes.

Secretin Receptor

A receptor that binds to the hormone secretin.

Scientific: BiotechnologyPharmacology / Endocrinology

The Secretin Receptor is a protein found on the surface of cells. It binds to the hormone secretin, which stimulates the pancreas to release bicarbonate, helping regulate digestion.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 4090 AD102 [GeForce RTX 4090]	Nvidia	AD102	21,594,780	202,290	106.75	0 ^hrs 13 ^mins
2	GeForce RTX 4080 AD103 [GeForce RTX 4080]	Nvidia	AD103	16,852,790	230,034	73.26	0 ^hrs 20 ^mins
3	GeForce RTX 4080 SUPER AD103 [GeForce RTX 4080 SUPER]	Nvidia	AD103	13,977,302	231,695	60.33	0 ^hrs 24 ^mins
4	GeForce RTX 4070 Ti SUPER AD103 [GeForce RTX 4070 Ti SUPER]	Nvidia	AD103	13,910,292	231,916	59.98	0 ^hrs 24 ^mins
5	GeForce RTX 4070 SUPER AD104 [GeForce RTX 4070 SUPER]	Nvidia	AD104	12,608,600	218,561	57.69	0 ^hrs 25 ^mins
6	GeForce RTX 4070 Ti AD104 [GeForce RTX 4070 Ti]	Nvidia	AD104	11,964,661	209,342	57.15	0 ^hrs 25 ^mins
7	RTX A6000 GA102GL [RTX A6000]	Nvidia	GA102GL	11,127,713	25,000	445.11	0 ^hrs 3 ^mins
8	GeForce RTX 3090 Ti GA102 [GeForce RTX 3090 Ti]	Nvidia	GA102	10,169,387	202,670	50.18	0 ^hrs 29 ^mins
9	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	9,562,238	190,586	50.17	0 ^hrs 29 ^mins
10	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	9,427,021	189,120	49.85	0 ^hrs 29 ^mins
11	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	8,367,418	189,018	44.27	0 ^hrs 33 ^mins
12	GeForce RTX 4070 AD104 [GeForce RTX 4070]	Nvidia	AD104	7,694,124	185,927	41.38	0 ^hrs 35 ^mins
13	GeForce RTX 3080 12GB GA102 [GeForce RTX 3080 12GB]	Nvidia	GA102	6,989,150	154,175	45.33	0 ^hrs 32 ^mins
14	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	6,716,694	174,459	38.50	0 ^hrs 37 ^mins
15	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	6,414,580	163,842	39.15	0 ^hrs 37 ^mins
16	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	6,357,863	170,772	37.23	0 ^hrs 39 ^mins
17	GeForce RTX 4060 Ti AD106 [GeForce RTX 4060 Ti]	Nvidia	AD106	6,199,606	131,083	47.30	0 ^hrs 30 ^mins
18	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	5,830,255	157,925	36.92	0 ^hrs 39 ^mins
19	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	5,478,144	159,249	34.40	0 ^hrs 42 ^mins

20	TITAN V GV100 [TITAN V] M 12288	Nvidia	GV100	5,365,827	169,643	31.63	0 ^hrs 46 ^mins
21	L4 AD104GL [L4]	Nvidia	AD104GL	5,361,393	165,516	32.39	0 ^hrs 44 ^mins
22	Radeon RX 7900XT/XTX/GRE Navi 31 [Radeon RX 7900XT/XTX/GRE]	AMD	Navi 31	5,282,247	91,260	57.88	0 ^hrs 25 ^mins
23	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	4,484,998	147,841	30.34	0 ^hrs 47 ^mins
24	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	4,221,411	153,837	27.44	0 ^hrs 52 ^mins
25	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	4,070,065	144,628	28.14	0 ^hrs 51 ^mins
26	GeForce RTX 4060 AD107 [GeForce RTX 4060]	Nvidia	AD107	3,765,909	149,805	25.14	0 ^hrs 57 ^mins
27	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,480,985	123,971	28.08	0 ^hrs 51 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070]	Nvidia	TU106	3,309,608	143,219	23.11	1 ^hrs 2 ^mins
29	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	3,294,584	120,391	27.37	0 ^hrs 53 ^mins
30	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A]	Nvidia	TU106	3,105,837	117,036	26.54	0 ^hrs 54 ^mins
31	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,917,336	131,083	22.26	1 ^hrs 5 ^mins
32	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,889,489	137,764	20.97	1 ^hrs 9 ^mins
33	Radeon RX 6800/6800XT/6900XT Navi 21 [Radeon RX 6800/6800XT/6900XT]	AMD	Navi 21	2,887,981	134,228	21.52	1 ^hrs 7 ^mins
34	Radeon RX 7900XT/XTX Navi 31 [Radeon RX 7900XT/XTX]	AMD	Navi 31	2,783,563	112,951	24.64	0 ^hrs 58 ^mins
35	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,781,199	127,079	21.89	1 ^hrs 6 ^mins
36	GeForce RTX 3060 GA104 [GeForce RTX 3060]	Nvidia	GA104	2,678,169	112,232	23.86	1 ^hrs 0 ^mins
37	Radeon RX 7700XT/7800XT Navi 32 [Radeon RX 7700XT/7800XT]	AMD	Navi 32	2,639,269	133,843	19.72	1 ^hrs 13 ^mins
38	RTX A4000 GA104GL [RTX A4000]	Nvidia	GA104GL	2,619,106	111,343	23.52	1 ^hrs 1 ^mins
39	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,614,279	121,103	21.59	1 ^hrs 7 ^mins

40	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	2,387,494	129,740	18.40	1 ^hrs 18 ^mins
41	GeForce RTX 2070 Mobile / Max-Q Refresh TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]	Nvidia	TU106M	2,341,011	128,968	18.15	1 ^hrs 19 ^mins
42	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,857,320	119,636	15.52	1 ^hrs 33 ^mins
43	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,844,898	119,061	15.50	1 ^hrs 33 ^mins
44	GeForce RTX 2070 Mobile TU106M [GeForce RTX 2070 Mobile]	Nvidia	TU106M	1,766,546	116,483	15.17	1 ^hrs 35 ^mins
45	RTX A2000 GA106 [RTX A2000]	Nvidia	GA106	1,729,518	108,689	15.91	1 ^hrs 30 ^mins
46	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,668,507	115,436	14.45	1 ^hrs 40 ^mins
47	RTX 5000 Ada Generation AD102GL [RTX 5000 Ada Generation]	Nvidia	AD102GL	1,637,014	114,178	14.34	1 ^hrs 40 ^mins
48	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,557,030	99,704	15.62	1 ^hrs 32 ^mins
49	Geforce RTX 3050 GA106 [Geforce RTX 3050]	Nvidia	GA106	1,554,733	96,655	16.09	1 ^hrs 30 ^mins
50	RTX A2000 12GB GA106 [RTX A2000 12GB]	Nvidia	GA106	1,526,222	111,364	13.70	1 ^hrs 45 ^mins
51	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,504,803	92,639	16.24	1 ^hrs 29 ^mins
52	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,459,976	108,578	13.45	1 ^hrs 47 ^mins
53	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,457,558	110,569	13.18	1 ^hrs 49 ^mins
54	Radeon RX 6700/6700XT/6800M Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]	AMD	Navi 22 XT-XL	1,429,870	85,575	16.71	1 ^hrs 26 ^mins
55	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 Super]	Nvidia	TU104	1,159,839	25,000	46.39	0 ^hrs 31 ^mins
56	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	954,878	95,072	10.04	2 ^hrs 23 ^mins
57	Radeon RX 7700S/7600S Navi 33 [Radeon RX 7700S/7600S]	AMD	Navi 33	928,355	25,000	37.13	0 ^hrs 39 ^mins
58	Quadro P3200 Mobile GP104GLM [Quadro P3200 Mobile]	Nvidia	GP104GLM	927,127	95,099	9.75	2 ^hrs 28 ^mins
59	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	921,567	86,519	10.65	2 ^hrs 15 ^mins

60	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	892,234	57,180	15.60	1 ^hrs 32 ^mins
61	GeForce GTX 1650 Ti Mobile TU117M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU117M	806,981	90,308	8.94	2 ^hrs 41 ^mins
62	GeForce GTX 1650 TU116 [GeForce GTX 1650] 3091	Nvidia	TU116	759,188	85,197	8.91	2 ^hrs 42 ^mins
63	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	675,878	70,947	9.53	2 ^hrs 31 ^mins
64	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	610,785	68,513	8.91	2 ^hrs 42 ^mins
65	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	569,296	67,524	8.43	2 ^hrs 51 ^mins
66	RX 470/480/570/580/590 Ellesmere XT [RX 470/480/570/580/590]	AMD	Ellesmere XT	477,536	76,078	6.28	3 ^hrs 49 ^mins
67	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	400,602	73,623	5.44	4 ^hrs 25 ^mins
68	Quadro M4000 GM204GL [Quadro M4000]	Nvidia	GM204GL	395,417	71,449	5.53	4 ^hrs 20 ^mins
69	GeForce GTX 1050 3 GB Max-Q GP107M [GeForce GTX 1050 3 GB Max-Q]	Nvidia	GP107M	368,220	70,176	5.25	4 ^hrs 34 ^mins
70	RX 5600 OEM/5600XT/5700/5700XT Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]	AMD	Navi 10	304,559	65,269	4.67	5 ^hrs 9 ^mins
71	Tesla K40m GK110 [Tesla K40m] 5046	Nvidia	GK110	246,741	51,938	4.75	5 ^hrs 3 ^mins
72	Radeon 660M-680M Rembrandt [Radeon 660M-680M]	AMD	Rembrandt	176,631	25,000	7.07	3 ^hrs 24 ^mins
73	RX Vega M GL Polaris 22 XL [RX Vega M GL]	AMD	Polaris 22 XL	140,862	42,062	3.35	7 ^hrs 10 ^mins
74	HD 7850/R7 265/R9 270 1024SP Pitcairn PRO [HD 7850/R7 265/R9 270 1024SP]	AMD	Pitcairn PRO	116,401	47,687	2.44	9 ^hrs 50 ^mins
75	GeForce GT 1030 GP108 [GeForce GT 1030]	Nvidia	GP108	113,324	41,533	2.73	8 ^hrs 48 ^mins
76	RX 5500/5500M/Pro 5500M Navi 14 [RX 5500/5500M/Pro 5500M]	AMD	Navi 14	110,762	39,066	2.84	8 ^hrs 28 ^mins
77	Radeon RX 460/560D Baffin [Radeon RX 460/560D]	AMD	Baffin	81,649	39,081	2.09	11 ^hrs 29 ^mins
78	R7 370/R9 270X/370X Curacao XT/Trinidad XT [R7 370/R9 270X/370X]	AMD	Curacao XT/Trinidad XT	31,837	24,741	1.29	18 ^hrs 39 ^mins
79	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	22,110	25,000	0.88	27 ^hrs 8 ^mins

80	Vega Mobile 5000 series APU Cezanne [Vega Mobile 5000 series APU]	AMD	Cezanne	18,539	23,406	0.79	30 ^hrs 18 ^mins

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