PROJECT #13458 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

https://www.youtube.com/watch?v=VnyaAmM1nhE These projects are rapid sprints of relative alchemical free energy calculations for prioritizing compound designs from chemists from the COVID Moonshot for synthesis.

Top-scoring molecules will be made and tested in a laboratory by the COVID Moonshot as it works to develop an open science patent-free inexpensive therapy for COVID-19 that shuts down the essential SARS-CoV-2 main viral protease.

The COVID Moonshot has already made and tested hundreds of compounds, and is pursuing several good lead series.

You can see their progress in real time here:
https://covid.postera.ai/covid/submissions/compounds To learn more about what the Moonshot is and how it came about, you can read our blog post or watch this video. In addition to helping us prioritize compounds, you can help us purchase more compounds for synthesis at cost from Enamine by sponsoring our GoFundMe page for patent-free open science COVID-19 drug discovery! This is a radical new approach to drug discovery that aims to rapidly produce inexpensive new therapies. SARS-CoV-2 main viral protease SARS-CoV-2 main viral potease (Mpro) with ligand bound, from the RCSB.

PROJECT INFO

Manager(s): Dr. John Chodera

Institution: Memorial Sloan Kettering Cancer Center

Project URL: http://choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 89,709

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 04 December 2022 18:13:29

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 6,559,089 302,180 21.71 1 hrs 6 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,082,793 295,597 20.58 1 hrs 10 mins
3 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 5,555,998 285,484 19.46 1 hrs 14 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,498,840 285,864 19.24 1 hrs 15 mins
5 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,477,262 268,683 16.66 1 hrs 26 mins
6 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,287,397 264,441 16.21 1 hrs 29 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,123,728 260,389 15.84 2 hrs 31 mins
8 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,048,616 260,537 15.54 2 hrs 33 mins
9 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,726,326 253,114 14.72 2 hrs 38 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,438,260 245,310 14.02 2 hrs 43 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,277,862 242,979 13.49 2 hrs 47 mins
12 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,119,552 239,055 13.05 2 hrs 50 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,034,675 237,808 12.76 2 hrs 53 mins
14 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,983,933 235,494 12.67 2 hrs 54 mins
15 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,808,166 230,375 12.19 2 hrs 58 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,666,479 213,029 12.52 2 hrs 55 mins
17 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,530,435 220,440 11.48 2 hrs 5 mins
18 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,518,269 220,397 11.43 2 hrs 6 mins
19 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 2,309,597 216,039 10.69 2 hrs 15 mins
20 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,246,404 213,809 10.51 2 hrs 17 mins
21 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,070,928 208,527 9.93 2 hrs 25 mins
22 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 2,044,721 207,546 9.85 2 hrs 26 mins
23 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,911,524 196,447 9.73 2 hrs 28 mins
24 Quadro RTX 5000
TU104GL [Quadro RTX 5000]
Nvidia TU104GL 1,862,106 164,328 11.33 2 hrs 7 mins
25 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 1,845,445 172,339 10.71 2 hrs 14 mins
26 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,824,879 193,644 9.42 3 hrs 33 mins
27 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,790,620 193,472 9.26 3 hrs 36 mins
28 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 1,720,154 194,806 8.83 3 hrs 43 mins
29 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 1,537,863 191,092 8.05 3 hrs 59 mins
30 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,430,803 175,215 8.17 3 hrs 56 mins
31 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,408,847 169,780 8.30 3 hrs 54 mins
32 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,372,106 181,466 7.56 3 hrs 10 mins
33 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,366,425 180,517 7.57 3 hrs 10 mins
34 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile] 4608
Nvidia TU106M 1,359,358 181,307 7.50 3 hrs 12 mins
35 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,297,234 177,267 7.32 3 hrs 17 mins
36 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,262,209 173,719 7.27 3 hrs 18 mins
37 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,219,290 171,111 7.13 3 hrs 22 mins
38 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,215,486 173,602 7.00 3 hrs 26 mins
39 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,038,850 159,699 6.51 4 hrs 41 mins
40 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,019,591 164,240 6.21 4 hrs 52 mins
41 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,017,086 164,484 6.18 4 hrs 53 mins
42 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 919,217 156,752 5.86 4 hrs 6 mins
43 P104-100
GP104 [P104-100]
Nvidia GP104 824,876 153,355 5.38 4 hrs 28 mins
44 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 778,195 150,934 5.16 5 hrs 39 mins
45 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 742,304 148,633 4.99 5 hrs 48 mins
46 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 708,298 145,736 4.86 5 hrs 56 mins
47 GeForce GTX 1650
TU117 [GeForce GTX 1650] 3091
Nvidia TU117 668,963 143,686 4.66 5 hrs 9 mins
48 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 662,785 142,542 4.65 5 hrs 10 mins
49 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 508,201 131,423 3.87 6 hrs 12 mins
50 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 441,693 120,796 3.66 7 hrs 34 mins
51 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 363,595 113,666 3.20 8 hrs 30 mins
52 T600
TU117GL [T600]
Intel TU117GL 347,220 112,770 3.08 8 hrs 48 mins
53 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 151,597 84,747 1.79 13 hrs 25 mins
54 Polaris11
Baffin [Polaris11]
AMD Baffin 25,094 54,400 0.46 52 hrs 2 mins
55 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 9,834 54,400 0.18 133 hrs 46 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 04 December 2022 18:13:29

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make