PROJECT #13429 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

https://www.youtube.com/watch?v=VnyaAmM1nhEThese projects are rapid sprints of relative alchemical free energy calculations for prioritizing compound designs from chemists from the COVID Moonshot for synthesis. Top-scoring molecules will be made and tested in a laboratory by the COVID Moonshot as it works to develop an open science patent-free inexpensive therapy for COVID-19 that shuts down the essential SARS-CoV-2 main viral protease

The COVID Moonshot has already made and tested hundreds of compounds, and is pursuing several good lead series. You can see their progress in real time here:
https://covid.postera.ai/covid/submissions/compounds

To learn more about what the Moonshot is and how it came about, you can read our blog post or watch this video.

In addition to helping us prioritize compounds, you can help us purchase more compounds for synthesis at cost from Enamine by sponsoring our GoFundMe page for patent-free open science COVID-19 drug discovery! This is a radical new approach to drug discovery that aims to rapidly produce inexpensive new therapies.

 

SARS-CoV-2 main viral protease

SARS-CoV-2 main viral potease (Mpro) with ligand bound, from the RCSB

PROJECT INFO

Manager(s): Dr. John Chodera

Institution: Memorial Sloan Kettering Cancer Center

Project URL: http://choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 4,082

Core: OPENMM_22

Status: Beta

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Thursday, 28 January 2021 02:48:14

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 949,816 18,306 51.89 0 hrs 28 mins
2 GeForce GTX 1080 Mobile
GP104M [GeForce GTX 1080 Mobile]
Nvidia GP104M 898,268 17,180 52.29 0 hrs 28 mins
3 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 724,516 16,722 43.33 1 hrs 33 mins
4 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 666,624 16,133 41.32 1 hrs 35 mins
5 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 574,118 15,460 37.14 1 hrs 39 mins
6 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 554,904 15,394 36.05 1 hrs 40 mins
7 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 354,515 12,868 27.55 1 hrs 52 mins
8 GeForce GTX 780 Ti
GK110 [GeForce GTX 780 Ti] 5046
Nvidia GK110 347,615 12,865 27.02 1 hrs 53 mins
9 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 334,614 12,914 25.91 1 hrs 56 mins
10 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 285,992 12,154 23.53 1 hrs 1 mins
11 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 278,024 11,757 23.65 1 hrs 1 mins
12 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 246,340 11,395 21.62 1 hrs 7 mins
13 Quadro K4200
GK104 [Quadro K4200]
Nvidia GK104 238,465 11,508 20.72 1 hrs 9 mins
14 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 236,675 11,302 20.94 1 hrs 9 mins
15 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 214,241 10,913 19.63 1 hrs 13 mins
16 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 187,077 10,550 17.73 1 hrs 21 mins
17 GRID M40
GM107GL [GRID M40]
Nvidia GM107GL 186,007 10,685 17.41 1 hrs 23 mins
18 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 172,084 10,276 16.75 1 hrs 26 mins
19 GeForce MX150
GP108 [GeForce MX150]
Nvidia GP108 169,658 10,132 16.74 1 hrs 26 mins
20 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 140,326 9,752 14.39 2 hrs 40 mins
21 GeForce MX250
GP108M [GeForce MX250]
Nvidia GP108M 137,267 9,188 14.94 2 hrs 36 mins
22 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 133,794 9,439 14.17 2 hrs 42 mins
23 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 131,984 9,387 14.06 2 hrs 42 mins
24 Radeon HD 7790
Bonaire XT [Radeon HD 7790]
AMD Bonaire XT 131,052 9,513 13.78 2 hrs 45 mins
25 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 126,227 7,280 17.34 1 hrs 23 mins
26 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]
AMD Hawaii 124,351 8,748 14.21 2 hrs 41 mins
27 GeForce MX230
GP108M [GeForce MX230]
Nvidia GP108M 119,970 9,005 13.32 2 hrs 48 mins
28 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 117,017 8,942 13.09 2 hrs 50 mins
29 Radeon R9 280/HD 7900/8950
Tahiti PRO [Radeon R9 280/HD 7900/8950]
AMD Tahiti PRO 98,001 8,101 12.10 2 hrs 59 mins
30 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 95,913 8,475 11.32 2 hrs 7 mins
31 Quadro K4000
GK104 [Quadro K4000]
Nvidia GK104 88,631 8,215 10.79 2 hrs 13 mins
32 GeForce GTX 560 Ti
GF114 [GeForce GTX 560 Ti]
Nvidia GF114 83,945 8,124 10.33 2 hrs 19 mins
33 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 82,281 7,979 10.31 2 hrs 20 mins
34 Quadro K5100M
GK104 [Quadro K5100M]
Nvidia GK104 81,932 7,223 11.34 2 hrs 7 mins
35 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 80,915 7,949 10.18 2 hrs 21 mins
36 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 78,045 8,014 9.74 2 hrs 28 mins
37 Radeon R7 250X/HD 7700/8760
R575A [Radeon R7 250X/HD 7700/8760]
AMD R575A 75,916 7,857 9.66 2 hrs 29 mins
38 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 74,095 7,789 9.51 3 hrs 31 mins
39 GeForce GTX 460 v2
GF114 [GeForce GTX 460 v2] 1045.6
Nvidia GF114 65,249 7,102 9.19 3 hrs 37 mins
40 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 55,456 4,172 13.29 2 hrs 48 mins
41 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 51,791 6,868 7.54 3 hrs 11 mins
42 GeForce GTX 550 Ti
GF116 [GeForce GTX 550 Ti] 691
Nvidia GF116 50,151 6,746 7.43 3 hrs 14 mins
43 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 46,908 4,779 9.82 2 hrs 27 mins
44 GeForce GTS 450
GF106 [GeForce GTS 450]
Nvidia GF106 38,610 6,288 6.14 4 hrs 55 mins
45 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 33,584 6,030 5.57 4 hrs 19 mins
46 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 33,010 5,134 6.43 4 hrs 44 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Thursday, 28 January 2021 02:48:15

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
 

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