PROJECT #13449 RESEARCH FOR COVID-19
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

https://www.youtube.com/watch?v=VnyaAmM1nhEThese projects are rapid sprints of relative alchemical free energy calculations for prioritizing compound designs from chemists from the COVID Moonshot for synthesis.

Top-scoring molecules will be made and tested in a laboratory by the COVID Moonshot as it works to develop an open science patent-free inexpensive therapy for COVID-19 that shuts down the essential SARS-CoV-2 main viral protease.

The COVID Moonshot has already made and tested hundreds of compounds, and is pursuing several good lead series.

You can see their progress in real time here:
https://covid.postera.ai/covid/submissions/compounds To learn more about what the Moonshot is and how it came about, you can read our blog post or watch this video. In addition to helping us prioritize compounds, you can help us purchase more compounds for synthesis at cost from Enamine by sponsoring our GoFundMe page for patent-free open science COVID-19 drug discovery! This is a radical new approach to drug discovery that aims to rapidly produce inexpensive new therapies. SARS-CoV-2 main viral protease SARS-CoV-2 main viral potease (Mpro) with ligand bound, from the RCSB.

PROJECT INFO

Manager(s): Dr. John Chodera

Institution: Memorial Sloan Kettering Cancer Center

Project URL: http://choderalab.org

PROJECT WORK UNIT SUMMARY

Atoms: 4,082

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 29 March 2023 06:15:42

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce GTX 1070 Mobile GP104M [GeForce GTX 1070 Mobile]	Nvidia	GP104M	876,865	17,903	48.98	0 ^hrs 29 ^mins
2	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	797,669	17,354	45.96	0 ^hrs 31 ^mins
3	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	451,970	14,053	32.16	0 ^hrs 45 ^mins
4	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	385,015	13,020	29.57	0 ^hrs 49 ^mins
5	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	356,195	12,893	27.63	0 ^hrs 52 ^mins
6	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	333,394	12,817	26.01	0 ^hrs 55 ^mins
7	Quadro K2200 GM107GL [Quadro K2200]	Nvidia	GM107GL	226,764	11,267	20.13	1 ^hrs 12 ^mins
8	GeForce GTX 850M GM107 [GeForce GTX 850M] 1155	Nvidia	GM107	221,980	11,330	19.59	1 ^hrs 13 ^mins
9	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	203,818	10,738	18.98	1 ^hrs 16 ^mins
10	GTX 650 Ti Boost GK106 [GTX 650 Ti Boost]	Nvidia	GK106	193,702	10,813	17.91	1 ^hrs 20 ^mins
11	Quadro M1200 GM107GLM [Quadro M1200] 1399	Nvidia	GM107GLM	187,891	10,721	17.53	1 ^hrs 22 ^mins
12	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	186,903	9,756	19.16	1 ^hrs 15 ^mins
13	GeForce GTX 960M GM107 [GeForce GTX 960M] 1439	Nvidia	GM107	166,992	9,763	17.10	1 ^hrs 24 ^mins
14	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	163,328	9,505	17.18	1 ^hrs 24 ^mins
15	Quadro K1200 GM107GL [Quadro K1200]	Nvidia	GM107GL	161,246	9,996	16.13	1 ^hrs 29 ^mins
16	Quadro K620 GM107GL [Quadro K620]	Nvidia	GM107GL	113,784	8,901	12.78	2 ^hrs 53 ^mins
17	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	112,470	9,003	12.49	2 ^hrs 55 ^mins
18	GeForce 920M GK208 [GeForce 920M]	Nvidia	GK208	80,924	8,111	9.98	2 ^hrs 24 ^mins
19	GeForce GTX 470 GF100 [GeForce GTX 470] 1088	Nvidia	GF100	41,380	5,987	6.91	3 ^hrs 28 ^mins
20	GeForce GTX 670M GF114 [GeForce GTX 670M]	Nvidia	GF114	39,130	6,228	6.28	4 ^hrs 49 ^mins
21	Iris(R) Graphics 540 SKL GT3 [Iris(R) Graphics 540]	Intel	SKL GT3	34,731	6,100	5.69	4 ^hrs 13 ^mins
22	HD Graphics 630 KBL GT2 [HD Graphics 630]	Intel	KBL GT2	26,372	5,547	4.75	5 ^hrs 3 ^mins
23	GeForce GT 710 GK208B [GeForce GT 710] 366	Nvidia	GK208B	24,940	5,466	4.56	5 ^hrs 16 ^mins
24	UHD Graphics 630 CFL GT2 [UHD Graphics 630]	Intel	CFL GT2	16,584	4,679	3.54	7 ^hrs 46 ^mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA