PROJECT #18210 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one varaiants of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 07 December 2022 06:13:23

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 Iris(R) Iris Xe Graphics
TGL GT2 [Iris(R) Iris Xe Graphics]
Intel TGL GT2 4,785 4,776 1.00 24 hrs 57 mins
2 Quadro NVS 4200M
GF108 [Quadro NVS 4200M] 155
Nvidia GF108 964 2,470 0.39 61 hrs 30 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 07 December 2022 06:13:23

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 5950X 16-CORE 32 41,917 1,341,344 AMD
2 12TH GEN CORE I9-12900K 24 49,241 1,181,784 Intel
3 FX-4300 QUAD-CORE 4 176,601 706,404 AMD
4 RYZEN 9 3950X 16-CORE 32 21,154 676,928 AMD
5 RYZEN THREADRIPPER 3960X 24-CORE 48 12,124 581,952 AMD
6 12TH GEN CORE I7-12700K 20 26,200 524,000 Intel
7 RYZEN 7 5800X 8-CORE 16 32,686 522,976 AMD
8 RYZEN 9 3900 12-CORE 24 21,198 508,752 AMD
9 RYZEN 9 3900XT 12-CORE 24 19,760 474,240 AMD
10 EPYC 7V12 64-CORE 64 7,305 467,520 AMD
11 CORE I9-7920X CPU @ 2.90GHZ 24 19,414 465,936 Intel
12 RYZEN 7 5700X 8-CORE 16 28,940 463,040 AMD
13 RYZEN 9 5900X 12-CORE 24 17,067 409,608 AMD
14 RYZEN 9 3900X 12-CORE 24 17,012 408,288 AMD
15 11TH GEN CORE I9-11900K @ 3.50GHZ 16 22,113 353,808 Intel
16 RYZEN 7 3800X 8-CORE 16 21,846 349,536 AMD
17 GENUINE CPU 0000 @ 2.10GHZ 44 7,718 339,592 Intel
18 EPYC 7401P 24-CORE 48 6,510 312,480 AMD
19 RYZEN THREADRIPPER 2950X 16-CORE 32 8,940 286,080 AMD
20 XEON CPU E5-2690 V4 @ 2.60GHZ 28 9,907 277,396 Intel
21 XEON CPU E5-2680 V3 @ 2.50GHZ 24 11,525 276,600 Intel
22 CORE I9-10850K CPU @ 3.60GHZ 20 13,505 270,100 Intel
23 XEON W-2175 CPU @ 2.50GHZ 28 9,183 257,124 Intel
24 CORE I9-10900X CPU @ 3.70GHZ 20 12,810 256,200 Intel
25 RYZEN THREADRIPPER 2970WX 24-CORE 48 4,938 237,024 AMD
26 12TH GEN CORE I7-12700H 20 11,718 234,360 Intel
27 CORE I7-5960X CPU @ 3.00GHZ 16 14,088 225,408 Intel
28 11TH GEN CORE I7-11700K @ 3.60GHZ 16 14,043 224,688 Intel
29 CORE M-5Y71 CPU @ 1.20GHZ 4 55,098 220,392 Intel
30 CORE I9-9900K CPU @ 3.60GHZ 16 13,556 216,896 Intel
31 RYZEN THREADRIPPER 1920X 12-CORE 24 9,017 216,408 AMD
32 RYZEN 7 5700G 16 13,517 216,272 AMD
33 XEON CPU E5-2660 V3 @ 2.60GHZ 20 10,774 215,480 Intel
34 RYZEN 7 3700X 8-CORE 16 13,160 210,560 AMD
35 CORE I7-9700KF CPU @ 3.60GHZ 8 26,163 209,304 Intel
36 RYZEN THREADRIPPER 1950X 16-CORE 32 6,505 208,160 AMD
37 RYZEN 5 5600X 6-CORE 12 17,151 205,812 AMD
38 11TH GEN CORE I5-11600K @ 3.90GHZ 12 17,101 205,212 Intel
39 CORE I9-9900 CPU @ 3.10GHZ 16 11,635 186,160 Intel
40 RYZEN 7 1700 EIGHT-CORE 16 11,010 176,160 AMD
41 APPLE M1 8 21,603 172,824 Apple
42 RYZEN 5 3600 6-CORE 12 14,005 168,060 AMD
43 11TH GEN CORE I7-11850H @ 2.50GHZ 16 10,425 166,800 Intel
44 XEON CPU E5-2698 V4 @ 2.20GHZ 16 10,326 165,216 Intel
45 CORE I7-8700 CPU @ 3.20GHZ 12 13,531 162,372 Intel
46 RYZEN 5 3600XT 6-CORE 12 13,432 161,184 AMD
47 RYZEN 5 5600G 12 13,391 160,692 AMD
48 CORE I5-10600 CPU @ 3.30GHZ 12 13,297 159,564 Intel
49 CORE I7-9700K CPU @ 3.60GHZ 8 19,730 157,840 Intel
50 CORE I9-9900X CPU @ 3.50GHZ 20 7,872 157,440 Intel
51 CORE I7-8700K CPU @ 3.70GHZ 12 12,950 155,400 Intel
52 RYZEN 5 2600X SIX-CORE 12 12,642 151,704 AMD
53 RYZEN 7 5800H 16 9,317 149,072 AMD
54 CORE I7-9700 CPU @ 3.00GHZ 8 18,632 149,056 Intel
55 RYZEN 7 4800H 16 8,760 140,160 AMD
56 RYZEN 9 5900HS 16 8,669 138,704 AMD
57 XEON CPU E5-1650 V3 @ 3.50GHZ 12 11,198 134,376 Intel
58 11TH GEN CORE I9-11900F @ 2.50GHZ 16 8,289 132,624 Intel
59 12TH GEN CORE I5-12600K 16 8,204 131,264 Intel
60 CORE I5-9500 CPU @ 3.00GHZ 6 21,716 130,296 Intel
61 RYZEN 7 2700X EIGHT-CORE 16 8,085 129,360 AMD
62 CORE I7-10700 CPU @ 2.90GHZ 16 7,894 126,304 Intel
63 CORE I9-9900KF CPU @ 3.60GHZ 16 7,762 124,192 Intel
64 CORE I5-10400 CPU @ 2.90GHZ 12 10,056 120,672 Intel
65 APPLE M1 MAX 10 11,770 117,700 Apple
66 XEON CPU E5-2650L V4 @ 1.70GHZ 28 4,126 115,528 Intel
67 RYZEN 5 3600X 6-CORE 12 9,571 114,852 AMD
68 RYZEN 7 PRO 4750G 16 7,176 114,816 AMD
69 CORE I7-9750H CPU @ 2.60GHZ 12 9,382 112,584 Intel
70 CORE I5-10400F CPU @ 2.90GHZ 12 9,116 109,392 Intel
71 CORE I5-9600K CPU @ 3.70GHZ 6 16,893 101,358 Intel
72 CORE I7-5820K CPU @ 3.30GHZ 12 8,438 101,256 Intel
73 CORE I7-7700 CPU @ 3.60GHZ 8 12,568 100,544 Intel
74 CORE I9-9880H CPU @ 2.30GHZ 16 6,021 96,336 Intel
75 CORE I7-6700K CPU @ 4.00GHZ 8 11,986 95,888 Intel
76 RYZEN 5 3500X 6-CORE 6 15,669 94,014 AMD
77 XEON CPU E5-2673 V3 @ 2.40GHZ 24 3,906 93,744 Intel
78 CORE I7-10870H CPU @ 2.20GHZ 16 5,819 93,104 Intel
79 GENUINE CPU 0000 @ 2.70GHZ 8 11,623 92,984 Intel
80 CORE I7-10700T CPU @ 2.00GHZ 16 5,774 92,384 Intel
81 RYZEN 5 2600 SIX-CORE 12 7,663 91,956 AMD
82 EPYC 7251 8-CORE 16 5,618 89,888 AMD
83 CORE I5-8500 CPU @ 3.00GHZ 6 14,899 89,394 Intel
84 A8-6410 APU 4 22,125 88,500 AMD
85 CORE I7-4790K CPU @ 4.00GHZ 8 11,049 88,392 Intel
86 11TH GEN CORE I5-11400 @ 2.60GHZ 12 7,011 84,132 Intel
87 CORE I7-8705G CPU @ 3.10GHZ 8 9,886 79,088 Intel
88 RYZEN 5 1600 SIX-CORE 12 6,546 78,552 AMD
89 CORE I7-4790 CPU @ 3.60GHZ 8 9,796 78,368 Intel
90 XEON CPU E5-2680 0 @ 2.70GHZ 16 4,840 77,440 Intel
91 CORE I7-10750H CPU @ 2.60GHZ 12 6,336 76,032 Intel
92 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 9,300 74,400 Intel
93 XEON W-10855M CPU @ 2.80GHZ 12 6,163 73,956 Intel
94 XEON CPU X5570 @ 2.93GHZ 16 4,608 73,728 Intel
95 CORE I7-6700 CPU @ 3.40GHZ 8 8,728 69,824 Intel
96 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 8,343 66,744 Intel
97 RYZEN 7 1800X EIGHT-CORE 16 4,128 66,048 AMD
98 CORE I7-4980HQ CPU @ 2.80GHZ 8 7,961 63,688 Intel
99 CORE I9-8950HK CPU @ 2.90GHZ 12 5,193 62,316 Intel
100 RYZEN 5 5500U 12 5,145 61,740 AMD
101 11TH GEN CORE I7-11370H @ 3.30GHZ 8 7,513 60,104 Intel
102 CORE I5-8400 CPU @ 2.80GHZ 6 9,527 57,162 Intel
103 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,112 56,896 Intel
104 CORE I5-7400 CPU @ 3.00GHZ 4 13,845 55,380 Intel
105 CORE I5-8600T CPU @ 2.30GHZ 6 9,170 55,020 Intel
106 CORE I7-10510U CPU @ 1.80GHZ 8 6,630 53,040 Intel
107 CORE I5-7500 CPU @ 3.40GHZ 4 12,765 51,060 Intel
108 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,379 51,032 Intel
109 CORE I7-8650U CPU @ 1.90GHZ 8 6,318 50,544 Intel
110 CORE I5-8259U CPU @ 2.30GHZ 8 6,174 49,392 Intel
111 CORE I7-10610U CPU @ 1.80GHZ 8 6,108 48,864 Intel
112 CORE I7-4770K CPU @ 3.50GHZ 8 5,973 47,784 Intel
113 CORE I5-6500T CPU @ 2.50GHZ 4 11,675 46,700 Intel
114 CORE I5-4670 CPU @ 3.40GHZ 4 11,037 44,148 Intel
115 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,495 43,960 Intel
116 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,385 43,080 Intel
117 CORE I7-4770 CPU @ 3.40GHZ 8 5,294 42,352 Intel
118 12TH GEN CORE I3-12100F 8 5,124 40,992 Intel
119 CORE I7-3770 CPU @ 3.40GHZ 8 5,116 40,928 Intel
120 CORE I5-4590 CPU @ 3.30GHZ 4 10,218 40,872 Intel
121 CORE I5-6600K CPU @ 3.50GHZ 4 10,184 40,736 Intel
122 CORE I7-4790T CPU @ 2.70GHZ 8 5,023 40,184 Intel
123 CORE I5-7600 CPU @ 3.50GHZ 4 9,961 39,844 Intel
124 CORE I5-4570 CPU @ 3.20GHZ 4 9,775 39,100 Intel
125 CORE I5-6600 CPU @ 3.30GHZ 4 9,562 38,248 Intel
126 XEON CPU E5-2620 0 @ 2.00GHZ 12 3,163 37,956 Intel
127 CORE I5-6400 CPU @ 2.70GHZ 4 9,371 37,484 Intel
128 RYZEN 5 4600H 12 3,087 37,044 AMD
129 XEON CPU E3-1220 V2 @ 3.10GHZ 4 9,132 36,528 Intel
130 CORE I3-8100T CPU @ 3.10GHZ 4 8,744 34,976 Intel
131 RYZEN 3 3200G 4 8,639 34,556 AMD
132 RYZEN 5 3500 6-CORE 6 5,614 33,684 AMD
133 CORE I3-6100 CPU @ 3.70GHZ 4 8,369 33,476 Intel
134 OPTERON(TM) 6380 64 509 32,576 AMD
135 XEON CPU E3-1245 V2 @ 3.40GHZ 8 4,050 32,400 Intel
136 XEON E-2124G CPU @ 3.40GHZ 4 7,888 31,552 Intel
137 RYZEN 5 3400G 8 3,826 30,608 AMD
138 CORE I5-9300H CPU @ 2.40GHZ 8 3,627 29,016 Intel
139 XEON CPU E5-2450 0 @ 2.10GHZ 10 2,890 28,900 Intel
140 CORE I5-4690K CPU @ 3.50GHZ 4 7,222 28,888 Intel
141 RYZEN 3 PRO 2200G 4 7,076 28,304 AMD
142 CORE I5-3570K CPU @ 3.40GHZ 4 7,052 28,208 Intel
143 XEON CPU E31245 @ 3.30GHZ 8 3,520 28,160 Intel
144 CORE I5-3570 CPU @ 3.40GHZ 4 6,868 27,472 Intel
145 XEON CPU E3-1240 V2 @ 3.40GHZ 8 3,379 27,032 Intel
146 CORE I5-10210U CPU @ 1.60GHZ 7 3,735 26,145 Intel
147 CORE I5-4278U CPU @ 2.60GHZ 4 6,382 25,528 Intel
148 CORE I7 CPU 950 @ 3.07GHZ 8 3,156 25,248 Intel
149 CORE I3-3225 CPU @ 3.30GHZ 4 6,200 24,800 Intel
150 CORE I5-2520M CPU @ 2.50GHZ 4 6,009 24,036 Intel
151 XEON CPU W3550 @ 3.07GHZ 8 2,911 23,288 Intel
152 CORE I5-3470 CPU @ 3.20GHZ 4 5,813 23,252 Intel
153 CORE I7 CPU 975 @ 3.33GHZ 8 2,820 22,560 Intel
154 CORE I7-2600 CPU @ 3.40GHZ 8 2,685 21,480 Intel
155 CORE I5-2500S CPU @ 2.70GHZ 4 5,047 20,188 Intel
156 CORE I7-7Y75 CPU @ 1.30GHZ 4 5,044 20,176 Intel
157 CORE I5-6200U CPU @ 2.30GHZ 4 4,855 19,420 Intel
158 FX-8350 EIGHT-CORE 8 2,382 19,056 AMD
159 CORE I5-7200U CPU @ 2.50GHZ 4 4,581 18,324 Intel
160 ATHLON 200GE 4 4,313 17,252 AMD
161 CORE I5-2500K CPU @ 3.30GHZ 4 4,290 17,160 Intel
162 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,285 17,140 Intel
163 CORE I5-4300U CPU @ 1.90GHZ 4 4,226 16,904 Intel
164 CORE I7-1065G7 CPU @ 1.30GHZ 8 1,772 14,176 Intel
165 CORE I3-3240 CPU @ 3.40GHZ 4 3,319 13,276 Intel
166 CORE I3-3220 CPU @ 3.30GHZ 4 3,088 12,352 Intel
167 CORE I3-2120 CPU @ 3.30GHZ 4 3,071 12,284 Intel
168 CORE I3-6006U CPU @ 2.00GHZ 4 2,929 11,716 Intel
169 ATHLON 3000G 4 2,357 9,428 AMD
170 CORE I5-5200U CPU @ 2.20GHZ 4 2,311 9,244 Intel
171 CORE I5-4210H CPU @ 2.90GHZ 4 2,289 9,156 Intel
172 RYZEN 5 3500U 8 1,093 8,744 AMD
173 CORE I3 CPU 550 @ 3.20GHZ 4 1,861 7,444 Intel
174 CORE I5-3337U CPU @ 1.80GHZ 4 1,475 5,900 Intel
175 ATHLON SILVER 3050U 2 2,374 4,748 AMD
176 CORE2 EXTREME CPU X9000 @ 2.80GHZ 2 2,202 4,404 Intel
177 A12-9800 RADEON R7, 12 COMPUTE CORES 4C+8G 4 1,083 4,332 AMD
178 CORE2 DUO CPU E8400 @ 3.00GHZ 2 1,843 3,686 Intel
179 CORE I3-2310M CPU @ 2.10GHZ 4 806 3,224 Intel
180 A10-8700P RADEON R6, 10 COMPUTE CORES 4C+6G 4 793 3,172 AMD
181 CORE2 DUO CPU E6550 @ 2.33GHZ 2 563 1,126 Intel
182 CORE2 DUO CPU T6570 @ 2.10GHZ 2 276 552 Intel