PROJECT #18210 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 September 2021 17:59:03

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 September 2021 17:59:03

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 29,160 933,120 AMD
2 RYZEN THREADRIPPER 3960X 24-CORE 48 12,624 605,952 AMD
3 RYZEN 9 5950X 16-CORE 32 18,237 583,584 AMD
4 RYZEN 7 5800X 8-CORE 16 32,383 518,128 AMD
5 RYZEN 9 5900X 12-CORE 24 17,927 430,248 AMD
6 RYZEN 7 3800X 8-CORE 16 24,355 389,680 AMD
7 RYZEN 9 3900X 12-CORE 24 15,376 369,024 AMD
8 XEON CPU E5-2680 V3 @ 2.50GHZ 24 13,105 314,520 Intel
9 XEON CPU E5-2690 V4 @ 2.60GHZ 28 9,841 275,548 Intel
10 CORE I9-10850K CPU @ 3.60GHZ 20 13,665 273,300 Intel
11 CORE I9-10900X CPU @ 3.70GHZ 20 13,598 271,960 Intel
12 RYZEN 9 3900XT 12-CORE 24 10,353 248,472 AMD
13 XEON W-2175 CPU @ 2.50GHZ 28 7,770 217,560 Intel
14 11TH GEN CORE I7-11700K @ 3.60GHZ 16 13,279 212,464 Intel
15 RYZEN 5 5600X 6-CORE 12 17,679 212,148 AMD
16 RYZEN THREADRIPPER 1920X 12-CORE 24 8,808 211,392 AMD
17 CORE I7-9700KF CPU @ 3.60GHZ 8 26,163 209,304 Intel
18 11TH GEN CORE I5-11600K @ 3.90GHZ 12 17,101 205,212 Intel
19 RYZEN 7 3700X 8-CORE 16 10,782 172,512 AMD
20 CORE I7-8700 CPU @ 3.20GHZ 12 13,670 164,040 Intel
21 CORE I7-8700K CPU @ 3.70GHZ 12 12,950 155,400 Intel
22 CORE I7-9700 CPU @ 3.00GHZ 8 19,243 153,944 Intel
23 RYZEN 5 2600X SIX-CORE 12 12,754 153,048 AMD
24 RYZEN 7 2700X EIGHT-CORE 16 9,251 148,016 AMD
25 RYZEN 5 3600 6-CORE 12 12,321 147,852 AMD
26 RYZEN 7 4800H 16 8,767 140,272 AMD
27 RYZEN 5 3600X 6-CORE 12 10,278 123,336 AMD
28 CORE I5-10400F CPU @ 2.90GHZ 12 10,163 121,956 Intel
29 CORE I5-10400 CPU @ 2.90GHZ 12 9,204 110,448 Intel
30 CORE I7-5820K CPU @ 3.30GHZ 12 8,438 101,256 Intel
31 CORE I5-9600K CPU @ 3.70GHZ 6 16,695 100,170 Intel
32 RYZEN 7 PRO 4750G 16 5,092 81,472 AMD
33 CORE I7-8705G CPU @ 3.10GHZ 8 9,944 79,552 Intel
34 11TH GEN CORE I5-11400 @ 2.60GHZ 12 6,386 76,632 Intel
35 CORE I7-6700K CPU @ 4.00GHZ 8 9,457 75,656 Intel
36 CORE I7-10750H CPU @ 2.60GHZ 12 6,216 74,592 Intel
37 XEON W-10855M CPU @ 2.80GHZ 12 6,069 72,828 Intel
38 CORE I7-4790K CPU @ 4.00GHZ 8 7,760 62,080 Intel
39 CORE I9-8950HK CPU @ 2.90GHZ 12 5,087 61,044 Intel
40 RYZEN 5 2600 SIX-CORE 12 4,919 59,028 AMD
41 CORE I5-7400 CPU @ 3.00GHZ 4 14,451 57,804 Intel
42 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,225 57,800 Intel
43 CORE I7-9700K CPU @ 3.60GHZ 8 7,154 57,232 Intel
44 CORE I7-4980HQ CPU @ 2.80GHZ 8 5,714 45,712 Intel
45 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,495 43,960 Intel
46 CORE I5-4590 CPU @ 3.30GHZ 4 10,971 43,884 Intel
47 CORE I7-4770 CPU @ 3.40GHZ 8 5,348 42,784 Intel
48 CORE I7-10870H CPU @ 2.20GHZ 16 2,527 40,432 Intel
49 CORE I5-6400 CPU @ 2.70GHZ 4 9,649 38,596 Intel
50 XEON CPU E5-2620 0 @ 2.00GHZ 12 3,173 38,076 Intel
51 RYZEN 5 4600H 12 3,087 37,044 AMD
52 CORE I7-6700 CPU @ 3.40GHZ 8 4,424 35,392 Intel
53 CORE I5-7600 CPU @ 3.50GHZ 4 8,614 34,456 Intel
54 CORE I3-6100 CPU @ 3.70GHZ 4 8,566 34,264 Intel
55 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 4,242 33,936 Intel
56 CORE I5-6600K CPU @ 3.50GHZ 4 8,267 33,068 Intel
57 CORE I7-2600 CPU @ 3.40GHZ 8 3,608 28,864 Intel
58 CORE I7-4770K CPU @ 3.50GHZ 8 2,696 21,568 Intel
59 CORE I5-2500S CPU @ 2.70GHZ 4 5,047 20,188 Intel
60 FX-8350 EIGHT-CORE 8 2,382 19,056 AMD
61 CORE I5-7200U CPU @ 2.50GHZ 4 4,500 18,000 Intel
62 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,285 17,140 Intel
63 CORE I7-1065G7 CPU @ 1.30GHZ 8 1,772 14,176 Intel
64 RYZEN 3 3200G 4 3,376 13,504 AMD
65 CORE I3-6006U CPU @ 2.00GHZ 4 2,649 10,596 Intel
66 CORE2 DUO CPU E8400 @ 3.00GHZ 2 4,506 9,012 Intel
67 RYZEN 5 3500U 8 901 7,208 AMD
68 A8-6410 APU 4 429 1,716 AMD