PROJECT #18210 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 16 January 2022 11:42:01

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 Iris(R) Iris Xe Graphics
TGL GT2 [Iris(R) Iris Xe Graphics]
TGL GT2 4,785 4,776 1.00 24 hrs 57 mins
2 Quadro NVS 4200M
GF108 [Quadro NVS 4200M] 155
Nvidia GF108 964 2,470 0.39 61 hrs 30 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 16 January 2022 11:42:01

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 FX-4300 QUAD-CORE 4 350,264 1,401,056 AMD
2 RYZEN 9 5950X 16-CORE 32 40,272 1,288,704 AMD
3 RYZEN 9 3950X 16-CORE 32 26,382 844,224 AMD
4 RYZEN THREADRIPPER 3960X 24-CORE 48 12,124 581,952 AMD
5 RYZEN 9 3900 12-CORE 24 21,415 513,960 AMD
6 RYZEN 9 5900X 12-CORE 24 19,660 471,840 AMD
7 RYZEN 7 5800X 8-CORE 16 29,302 468,832 AMD
8 CORE I9-7920X CPU @ 2.90GHZ 24 19,468 467,232 Intel
9 RYZEN 9 3900X 12-CORE 24 19,279 462,696 AMD
10 RYZEN 7 3800X 8-CORE 16 23,286 372,576 AMD
11 11TH GEN CORE I9-11900K @ 3.50GHZ 16 21,839 349,424 Intel
12 EPYC 7401P 24-CORE 48 6,510 312,480 AMD
13 RYZEN THREADRIPPER 2950X 16-CORE 32 8,940 286,080 AMD
14 XEON CPU E5-2690 V4 @ 2.60GHZ 28 9,907 277,396 Intel
15 XEON CPU E5-2680 V3 @ 2.50GHZ 24 11,501 276,024 Intel
16 RYZEN 7 5700G 16 17,049 272,784 AMD
17 CORE I9-10850K CPU @ 3.60GHZ 20 13,505 270,100 Intel
18 RYZEN 9 3900XT 12-CORE 24 11,191 268,584 AMD
19 XEON W-2175 CPU @ 2.50GHZ 28 9,183 257,124 Intel
20 CORE I9-10900X CPU @ 3.70GHZ 20 12,810 256,200 Intel
21 RYZEN THREADRIPPER 2970WX 24-CORE 48 4,938 237,024 AMD
22 RYZEN 7 3700X 8-CORE 16 14,573 233,168 AMD
23 11TH GEN CORE I7-11700K @ 3.60GHZ 16 14,388 230,208 Intel
24 CORE I7-5960X CPU @ 3.00GHZ 16 14,088 225,408 Intel
25 CORE M-5Y71 CPU @ 1.20GHZ 4 55,098 220,392 Intel
26 CORE I9-9900K CPU @ 3.60GHZ 16 13,556 216,896 Intel
27 RYZEN 5 5600G 12 17,980 215,760 AMD
28 XEON CPU E5-2660 V3 @ 2.60GHZ 20 10,774 215,480 Intel
29 RYZEN 5 5600X 6-CORE 12 17,950 215,400 AMD
30 RYZEN THREADRIPPER 1920X 12-CORE 24 8,808 211,392 AMD
31 CORE I7-9700KF CPU @ 3.60GHZ 8 26,163 209,304 Intel
32 RYZEN THREADRIPPER 1950X 16-CORE 32 6,505 208,160 AMD
33 11TH GEN CORE I5-11600K @ 3.90GHZ 12 17,101 205,212 Intel
34 CORE I9-9900 CPU @ 3.10GHZ 16 11,635 186,160 Intel
35 RYZEN 7 1700 EIGHT-CORE 16 11,010 176,160 AMD
36 11TH GEN CORE I7-11850H @ 2.50GHZ 16 10,425 166,800 Intel
37 RYZEN 5 3600 6-CORE 12 13,574 162,888 AMD
38 CORE I7-8700 CPU @ 3.20GHZ 12 13,468 161,616 Intel
39 RYZEN 5 3600XT 6-CORE 12 13,432 161,184 AMD
40 CORE I5-10600 CPU @ 3.30GHZ 12 13,297 159,564 Intel
41 CORE I9-9900X CPU @ 3.50GHZ 20 7,872 157,440 Intel
42 CORE I7-8700K CPU @ 3.70GHZ 12 12,950 155,400 Intel
43 RYZEN 5 2600X SIX-CORE 12 12,642 151,704 AMD
44 CORE I7-9700 CPU @ 3.00GHZ 8 18,632 149,056 Intel
45 CORE I3-3225 CPU @ 3.30GHZ 4 35,174 140,696 Intel
46 RYZEN 7 4800H 16 8,767 140,272 AMD
47 11TH GEN CORE I9-11900F @ 2.50GHZ 16 8,289 132,624 Intel
48 CORE I5-9500 CPU @ 3.00GHZ 6 21,716 130,296 Intel
49 RYZEN 7 2700X EIGHT-CORE 16 8,131 130,096 AMD
50 CORE I7-10700 CPU @ 2.90GHZ 16 7,894 126,304 Intel
51 CORE I5-10400 CPU @ 2.90GHZ 12 10,396 124,752 Intel
52 CORE I5-10400F CPU @ 2.90GHZ 12 10,163 121,956 Intel
53 CORE I7-9700K CPU @ 3.60GHZ 8 14,712 117,696 Intel
54 RYZEN 5 3600X 6-CORE 12 9,571 114,852 AMD
55 CORE I7-7700 CPU @ 3.60GHZ 8 12,746 101,968 Intel
56 CORE I7-5820K CPU @ 3.30GHZ 12 8,438 101,256 Intel
57 CORE I5-9600K CPU @ 3.70GHZ 6 16,695 100,170 Intel
58 11TH GEN CORE I7-11370H @ 3.30GHZ 8 12,250 98,000 Intel
59 CORE I9-9880H CPU @ 2.30GHZ 16 6,021 96,336 Intel
60 RYZEN 5 3500X 6-CORE 6 15,774 94,644 AMD
61 CORE I7-10870H CPU @ 2.20GHZ 16 5,819 93,104 Intel
62 GENUINE CPU 0000 @ 2.70GHZ 8 11,623 92,984 Intel
63 RYZEN 7 PRO 4750G 16 5,791 92,656 AMD
64 RYZEN 5 2600 SIX-CORE 12 7,663 91,956 AMD
65 EPYC 7251 8-CORE 16 5,618 89,888 AMD
66 CORE I7-4790K CPU @ 4.00GHZ 8 10,796 86,368 Intel
67 11TH GEN CORE I5-11400 @ 2.60GHZ 12 6,983 83,796 Intel
68 CORE I7-8705G CPU @ 3.10GHZ 8 9,886 79,088 Intel
69 RYZEN 5 1600 SIX-CORE 12 6,517 78,204 AMD
70 CORE I7-6700K CPU @ 4.00GHZ 8 9,526 76,208 Intel
71 CORE I7-10750H CPU @ 2.60GHZ 12 6,336 76,032 Intel
72 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 9,300 74,400 Intel
73 XEON W-10855M CPU @ 2.80GHZ 12 6,163 73,956 Intel
74 XEON CPU X5570 @ 2.93GHZ 16 4,608 73,728 Intel
75 CORE I7-6700 CPU @ 3.40GHZ 8 8,728 69,824 Intel
76 CORE I7-4790 CPU @ 3.60GHZ 8 8,397 67,176 Intel
77 RYZEN 5 5500U 12 5,592 67,104 AMD
78 CORE I7-4980HQ CPU @ 2.80GHZ 8 7,961 63,688 Intel
79 CORE I9-8950HK CPU @ 2.90GHZ 12 4,949 59,388 Intel
80 CORE I7-4770HQ CPU @ 2.20GHZ 8 7,164 57,312 Intel
81 CORE I5-8400 CPU @ 2.80GHZ 6 9,527 57,162 Intel
82 CORE I5-7400 CPU @ 3.00GHZ 4 14,256 57,024 Intel
83 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,808 54,464 Intel
84 CORE I7-10510U CPU @ 1.80GHZ 8 6,630 53,040 Intel
85 CORE I7-8650U CPU @ 1.90GHZ 8 6,318 50,544 Intel
86 CORE I5-8259U CPU @ 2.30GHZ 8 6,186 49,488 Intel
87 CORE I7-10610U CPU @ 1.80GHZ 8 6,108 48,864 Intel
88 CORE I7-4770K CPU @ 3.50GHZ 8 5,973 47,784 Intel
89 CORE I5-6500T CPU @ 2.50GHZ 4 11,699 46,796 Intel
90 CORE I5-4690K CPU @ 3.50GHZ 4 11,245 44,980 Intel
91 CORE I5-4670 CPU @ 3.40GHZ 4 11,037 44,148 Intel
92 CORE I7-7700HQ CPU @ 2.80GHZ 8 5,495 43,960 Intel
93 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,385 43,080 Intel
94 CORE I7-4770 CPU @ 3.40GHZ 8 5,348 42,784 Intel
95 CORE I7-3770 CPU @ 3.40GHZ 8 5,325 42,600 Intel
96 CORE I5-4570 CPU @ 3.20GHZ 4 10,085 40,340 Intel
97 XEON CPU E5-2620 0 @ 2.00GHZ 12 3,357 40,284 Intel
98 CORE I7-4790T CPU @ 2.70GHZ 8 5,023 40,184 Intel
99 CORE I5-7600 CPU @ 3.50GHZ 4 9,961 39,844 Intel
100 CORE I5-4590 CPU @ 3.30GHZ 4 9,939 39,756 Intel
101 CORE I5-6400 CPU @ 2.70GHZ 4 9,649 38,596 Intel
102 RYZEN 5 4600H 12 3,087 37,044 AMD
103 CORE I5-6600K CPU @ 3.50GHZ 4 8,647 34,588 Intel
104 RYZEN 3 3200G 4 8,554 34,216 AMD
105 RYZEN 5 3500 6-CORE 6 5,614 33,684 AMD
106 CORE I3-6100 CPU @ 3.70GHZ 4 8,369 33,476 Intel
107 OPTERON(TM) 6380 64 509 32,576 AMD
108 XEON CPU E3-1245 V2 @ 3.40GHZ 8 4,050 32,400 Intel
109 XEON E-2124G CPU @ 3.40GHZ 4 7,888 31,552 Intel
110 RYZEN 5 3400G 8 3,826 30,608 AMD
111 XEON CPU E5-2450 0 @ 2.10GHZ 10 2,890 28,900 Intel
112 XEON CPU E31245 @ 3.30GHZ 8 3,566 28,528 Intel
113 RYZEN 3 PRO 2200G 4 7,076 28,304 AMD
114 CORE I5-3570 CPU @ 3.40GHZ 4 6,893 27,572 Intel
115 CORE I5-3570K CPU @ 3.40GHZ 4 6,720 26,880 Intel
116 CORE I5-4278U CPU @ 2.60GHZ 4 6,382 25,528 Intel
117 CORE I7 CPU 950 @ 3.07GHZ 8 3,156 25,248 Intel
118 XEON CPU W3550 @ 3.07GHZ 8 2,911 23,288 Intel
119 CORE I7 CPU 975 @ 3.33GHZ 8 2,820 22,560 Intel
120 CORE I7-2600 CPU @ 3.40GHZ 8 2,685 21,480 Intel
121 CORE I5-9300H CPU @ 2.40GHZ 8 2,676 21,408 Intel
122 CORE I5-3470 CPU @ 3.20GHZ 4 5,278 21,112 Intel
123 CORE I5-2500S CPU @ 2.70GHZ 4 5,047 20,188 Intel
124 CORE I7-7Y75 CPU @ 1.30GHZ 4 5,044 20,176 Intel
125 CORE I5-6200U CPU @ 2.30GHZ 4 4,855 19,420 Intel
126 FX-8350 EIGHT-CORE 8 2,382 19,056 AMD
127 CORE I5-7200U CPU @ 2.50GHZ 4 4,581 18,324 Intel
128 ATHLON 200GE 4 4,313 17,252 AMD
129 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,285 17,140 Intel
130 CORE I5-2500K CPU @ 3.30GHZ 4 4,274 17,096 Intel
131 CORE I5-4300U CPU @ 1.90GHZ 4 4,226 16,904 Intel
132 CORE I7-1065G7 CPU @ 1.30GHZ 8 1,772 14,176 Intel
133 CORE I5-10210U CPU @ 1.60GHZ 7 1,842 12,894 Intel
134 CORE I3-3240 CPU @ 3.40GHZ 4 3,169 12,676 Intel
135 CORE I3-6006U CPU @ 2.00GHZ 4 3,041 12,164 Intel
136 CORE I5-5200U CPU @ 2.20GHZ 4 2,234 8,936 Intel
137 CORE I3 CPU 550 @ 3.20GHZ 4 1,861 7,444 Intel
138 RYZEN 5 3500U 8 901 7,208 AMD
139 CORE2 DUO CPU E8400 @ 3.00GHZ 2 1,843 3,686 Intel
140 CORE I3-2310M CPU @ 2.10GHZ 4 806 3,224 Intel
141 A8-6410 APU 4 359 1,436 AMD