PROJECT #18213 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. In other p182XX projects we have simulated ApoE variants to try to understand the conformations that ApoE adopts in solution.

We are also working to verify these findings in the laboratory.

To do this, we must introduce some additional mutations to ApoE to enable it's study.

To ensure our experimental and simulation results agree, we are also simulating ApoE with the mutations required to perform our experiments. As a whole, we hope the simulations of p182XX lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 16 May 2022 12:52:29

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,452,615 542,677 17.42 1 hrs 23 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,526,241 533,844 15.97 2 hrs 30 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,974,387 519,109 15.36 2 hrs 34 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,337,741 505,206 14.52 2 hrs 39 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,215,964 476,503 13.04 2 hrs 50 mins
6 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,913,383 473,484 12.49 2 hrs 55 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,754,660 469,598 12.25 2 hrs 58 mins
8 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,565,911 464,421 11.98 2 hrs 0 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,979,924 441,709 11.27 2 hrs 8 mins
10 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 4,685,850 432,249 10.84 2 hrs 13 mins
11 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,600,206 432,456 10.64 2 hrs 15 mins
12 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,335,382 427,334 10.15 2 hrs 22 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,288,358 422,263 10.16 2 hrs 22 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,788,928 408,876 9.27 3 hrs 35 mins
15 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,706,788 407,367 9.10 3 hrs 38 mins
16 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,687,621 401,752 9.18 3 hrs 37 mins
17 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 3,391,815 393,735 8.61 3 hrs 47 mins
18 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 3,380,983 394,221 8.58 3 hrs 48 mins
19 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 3,351,289 393,149 8.52 3 hrs 49 mins
20 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 3,328,797 384,050 8.67 3 hrs 46 mins
21 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,300,044 384,990 8.57 3 hrs 48 mins
22 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,292,790 391,000 8.42 3 hrs 51 mins
23 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,251,433 387,312 8.39 3 hrs 52 mins
24 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 3,127,283 384,869 8.13 3 hrs 57 mins
25 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 3,043,676 380,657 8.00 3 hrs 0 mins
26 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,963,530 376,739 7.87 3 hrs 3 mins
27 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,933,744 373,799 7.85 3 hrs 3 mins
28 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 2,528,601 357,025 7.08 3 hrs 23 mins
29 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,420,697 353,849 6.84 4 hrs 30 mins
30 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,345,111 346,280 6.77 4 hrs 33 mins
31 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 2,335,040 348,067 6.71 4 hrs 35 mins
32 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,177,841 332,821 6.54 4 hrs 40 mins
33 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,112,291 335,373 6.30 4 hrs 49 mins
34 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,093,557 322,703 6.49 4 hrs 42 mins
35 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,758,815 309,968 5.67 4 hrs 14 mins
36 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,513,390 301,625 5.02 5 hrs 47 mins
37 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,482,831 296,451 5.00 5 hrs 48 mins
38 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,462,080 299,813 4.88 5 hrs 55 mins
39 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,459,079 289,454 5.04 5 hrs 46 mins
40 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,394,272 294,480 4.73 5 hrs 4 mins
41 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,377,716 292,355 4.71 5 hrs 6 mins
42 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,376,979 300,849 4.58 5 hrs 15 mins
43 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,367,035 285,849 4.78 5 hrs 1 mins
44 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,331,767 292,790 4.55 5 hrs 17 mins
45 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,311,510 284,832 4.60 5 hrs 13 mins
46 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,296,292 261,804 4.95 5 hrs 51 mins
47 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,200,657 234,209 5.13 5 hrs 41 mins
48 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,151,753 274,982 4.19 6 hrs 44 mins
49 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 1,124,969 266,141 4.23 6 hrs 41 mins
50 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,087,806 263,037 4.14 6 hrs 48 mins
51 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 953,527 255,349 3.73 6 hrs 26 mins
52 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 931,876 257,049 3.63 7 hrs 37 mins
53 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 897,444 205,150 4.37 5 hrs 29 mins
54 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 762,692 240,107 3.18 8 hrs 33 mins
55 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 737,485 236,389 3.12 8 hrs 42 mins
56 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 728,402 235,324 3.10 8 hrs 45 mins
57 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 663,217 230,012 2.88 8 hrs 19 mins
58 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 651,100 228,579 2.85 8 hrs 26 mins
59 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 560,729 217,111 2.58 9 hrs 18 mins
60 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 553,797 218,151 2.54 9 hrs 27 mins
61 P106-090
GP106 [P106-090]
Nvidia GP106 552,751 215,753 2.56 9 hrs 22 mins
62 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 468,038 203,908 2.30 10 hrs 27 mins
63 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 454,358 199,901 2.27 11 hrs 34 mins
64 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 447,062 200,417 2.23 11 hrs 46 mins
65 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 420,308 197,530 2.13 11 hrs 17 mins
66 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 417,703 196,487 2.13 11 hrs 17 mins
67 T600
TU117GL [T600]
Intel TU117GL 389,015 192,628 2.02 12 hrs 53 mins
68 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 369,379 187,602 1.97 12 hrs 11 mins
69 Radeon RX Vega M XT/ M GH
[Radeon RX Vega M XT/ M GH]
AMD 356,320 183,857 1.94 12 hrs 23 mins
70 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 353,077 188,945 1.87 13 hrs 51 mins
71 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 316,894 160,614 1.97 12 hrs 10 mins
72 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 310,885 177,078 1.76 14 hrs 40 mins
73 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 274,025 170,859 1.60 15 hrs 58 mins
74 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 224,251 146,646 1.53 16 hrs 42 mins
75 Radeon RX 6400 / 6500 XT
Navi 24 [Radeon RX 6400 / 6500 XT]
AMD Navi 24 200,427 153,955 1.30 18 hrs 26 mins
76 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 189,410 150,549 1.26 19 hrs 5 mins
77 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 181,262 148,797 1.22 20 hrs 42 mins
78 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 172,187 146,174 1.18 20 hrs 22 mins
79 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 167,535 70,000 2.39 10 hrs 2 mins
80 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 154,332 141,006 1.09 22 hrs 56 mins
81 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 149,392 139,643 1.07 22 hrs 26 mins
82 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 131,215 135,892 0.97 25 hrs 51 mins
83 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 124,796 131,786 0.95 25 hrs 21 mins
84 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 124,670 128,100 0.97 25 hrs 40 mins
85 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 107,688 122,640 0.88 27 hrs 20 mins
86 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 103,873 122,058 0.85 28 hrs 12 mins
87 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 95,701 120,218 0.80 30 hrs 9 mins
88 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 79,293 112,971 0.70 34 hrs 12 mins
89 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 71,215 109,204 0.65 37 hrs 48 mins
90 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 67,603 106,775 0.63 38 hrs 54 mins
91 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 67,439 99,247 0.68 35 hrs 19 mins
92 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 66,315 86,448 0.77 31 hrs 17 mins
93 Radeon WX 3100
[Radeon WX 3100]
AMD 58,807 100,059 0.59 41 hrs 50 mins
94 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 55,673 97,126 0.57 42 hrs 52 mins
95 GeForce 940MX
GM108M [GeForce 940MX]
Nvidia GM108M 49,660 86,185 0.58 42 hrs 39 mins
96 Radeon R9 200/300 Series
Tonga [Radeon R9 200/300 Series]
AMD Tonga 49,548 79,156 0.63 38 hrs 20 mins
97 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 39,456 70,000 0.56 43 hrs 35 mins
98 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 28,000 70,000 0.40 60 hrs 0 mins
99 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 17,190 70,000 0.25 98 hrs 44 mins
100 Radeon R7/R6/R5 Series
Carrizo [Radeon R7/R6/R5 Series]
AMD Carrizo 14,560 70,000 0.21 115 hrs 23 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 16 May 2022 12:52:29

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make