PROJECT #18213 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. In other p182XX projects we have simulated ApoE variants to try to understand the conformations that ApoE adopts in solution.

We are also working to verify these findings in the laboratory.

To do this, we must introduce some additional mutations to ApoE to enable it's study.

To ensure our experimental and simulation results agree, we are also simulating ApoE with the mutations required to perform our experiments. As a whole, we hope the simulations of p182XX lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 02 October 2022 12:16:28

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,347,080 549,208 17.02 1 hrs 25 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 8,634,271 537,652 16.06 1 hrs 30 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 8,310,022 528,476 15.72 2 hrs 32 mins
4 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 7,259,214 505,760 14.35 2 hrs 40 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 7,244,767 508,398 14.25 2 hrs 41 mins
6 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 7,100,471 502,166 14.14 2 hrs 42 mins
7 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 5,561,162 463,373 12.00 2 hrs 60 mins
8 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,556,164 465,080 11.95 2 hrs 1 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,374,412 457,897 11.74 2 hrs 3 mins
10 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,294,876 455,388 11.63 2 hrs 4 mins
11 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,051,132 446,656 11.31 2 hrs 7 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,421,804 431,959 10.24 2 hrs 21 mins
13 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,344,650 425,923 10.20 2 hrs 21 mins
14 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,067,387 407,042 9.99 2 hrs 24 mins
15 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,872,887 407,419 9.51 3 hrs 31 mins
16 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,816,483 411,094 9.28 3 hrs 35 mins
17 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,783,885 408,510 9.26 3 hrs 35 mins
18 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 3,413,937 395,175 8.64 3 hrs 47 mins
19 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 3,394,025 393,924 8.62 3 hrs 47 mins
20 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 3,381,729 394,304 8.58 3 hrs 48 mins
21 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,368,900 392,939 8.57 3 hrs 48 mins
22 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,318,138 383,675 8.65 3 hrs 47 mins
23 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 3,318,089 391,520 8.47 3 hrs 50 mins
24 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 3,253,889 389,084 8.36 3 hrs 52 mins
25 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,182,384 383,892 8.29 3 hrs 54 mins
26 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,931,251 373,773 7.84 3 hrs 4 mins
27 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 2,753,275 368,107 7.48 3 hrs 13 mins
28 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,696,770 364,738 7.39 3 hrs 15 mins
29 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,568,914 360,455 7.13 3 hrs 22 mins
30 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 2,528,601 357,025 7.08 3 hrs 23 mins
31 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 2,486,032 349,795 7.11 3 hrs 23 mins
32 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 2,445,230 353,502 6.92 3 hrs 28 mins
33 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,263,158 342,577 6.61 4 hrs 38 mins
34 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,177,841 332,821 6.54 4 hrs 40 mins
35 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 2,139,343 340,373 6.29 4 hrs 49 mins
36 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,117,784 337,515 6.27 4 hrs 49 mins
37 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,106,510 325,683 6.47 4 hrs 43 mins
38 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 2,027,184 321,365 6.31 4 hrs 48 mins
39 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,771,317 290,874 6.09 4 hrs 56 mins
40 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,758,815 309,968 5.67 4 hrs 14 mins
41 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,733,954 314,654 5.51 4 hrs 21 mins
42 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,450,779 302,464 4.80 5 hrs 0 mins
43 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 1,443,964 297,082 4.86 5 hrs 56 mins
44 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,413,294 305,913 4.62 5 hrs 12 mins
45 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,405,174 281,204 5.00 5 hrs 48 mins
46 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 1,404,776 287,320 4.89 5 hrs 55 mins
47 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,397,323 300,401 4.65 5 hrs 10 mins
48 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,394,265 276,491 5.04 5 hrs 46 mins
49 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,317,424 293,601 4.49 5 hrs 21 mins
50 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,309,772 278,736 4.70 5 hrs 6 mins
51 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,290,598 276,506 4.67 5 hrs 9 mins
52 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,251,419 286,933 4.36 6 hrs 30 mins
53 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,239,016 278,089 4.46 5 hrs 23 mins
54 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,230,028 274,379 4.48 5 hrs 21 mins
55 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,189,398 281,203 4.23 6 hrs 40 mins
56 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,106,400 275,283 4.02 6 hrs 58 mins
57 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,083,136 263,133 4.12 6 hrs 50 mins
58 P104-100
GP104 [P104-100]
Nvidia GP104 1,019,209 265,451 3.84 6 hrs 15 mins
59 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 995,270 271,614 3.66 7 hrs 33 mins
60 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 906,704 254,305 3.57 7 hrs 44 mins
61 GeForce RTX 2080 Mobile
TU104M [GeForce RTX 2080 Mobile]
Nvidia TU104M 897,444 205,150 4.37 5 hrs 29 mins
62 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 874,197 255,480 3.42 7 hrs 1 mins
63 Radeon Instinct MI25
Vega 10 [Radeon Instinct MI25]
AMD Vega 10 831,301 247,230 3.36 7 hrs 8 mins
64 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 793,509 241,338 3.29 7 hrs 18 mins
65 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 762,615 239,847 3.18 8 hrs 33 mins
66 P106-100
GP106 [P106-100]
Nvidia GP106 741,973 253,207 2.93 8 hrs 11 mins
67 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 735,728 235,666 3.12 8 hrs 41 mins
68 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 672,122 243,982 2.75 9 hrs 43 mins
69 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 651,100 228,579 2.85 8 hrs 26 mins
70 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 596,680 224,284 2.66 9 hrs 1 mins
71 P106-090
GP106 [P106-090]
Nvidia GP106 527,154 211,578 2.49 10 hrs 38 mins
72 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 499,693 204,257 2.45 10 hrs 49 mins
73 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 488,692 207,995 2.35 10 hrs 13 mins
74 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 451,156 198,885 2.27 11 hrs 35 mins
75 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 447,434 202,219 2.21 11 hrs 51 mins
76 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 441,490 200,988 2.20 11 hrs 56 mins
77 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 393,386 200,603 1.96 12 hrs 14 mins
78 T600
TU117GL [T600]
Intel TU117GL 389,015 192,628 2.02 12 hrs 53 mins
79 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 381,635 179,084 2.13 11 hrs 16 mins
80 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 366,954 182,791 2.01 12 hrs 57 mins
81 Radeon RX Vega M XT/ M GH
[Radeon RX Vega M XT/ M GH]
AMD 356,320 183,857 1.94 12 hrs 23 mins
82 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 343,631 181,306 1.90 13 hrs 40 mins
83 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 311,012 177,259 1.75 14 hrs 41 mins
84 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 297,427 174,690 1.70 14 hrs 6 mins
85 Radeon Pro WX 7100 Graphics
[Radeon Pro WX 7100 Graphics] 4150
AMD 284,634 186,905 1.52 16 hrs 46 mins
86 FirePro Series
Tonga PRO GL [FirePro Series]
Tonga PRO GL 280,103 172,328 1.63 15 hrs 46 mins
87 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 269,305 170,388 1.58 15 hrs 11 mins
88 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 257,880 167,495 1.54 16 hrs 35 mins
89 Radeon RX 6400 / 6500 XT
Navi 24 [Radeon RX 6400 / 6500 XT]
AMD Navi 24 200,427 153,955 1.30 18 hrs 26 mins
90 Radeon Pro WX 5100
Ellesmere Pro [Radeon Pro WX 5100] 122
AMD Ellesmere Pro 195,928 152,775 1.28 19 hrs 43 mins
91 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 193,596 154,291 1.25 19 hrs 8 mins
92 Tesla K20M
GK110 [Tesla K20M] 3524
Nvidia GK110 191,698 151,710 1.26 19 hrs 60 mins
93 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 172,187 146,174 1.18 20 hrs 22 mins
94 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 167,535 70,000 2.39 10 hrs 2 mins
95 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 154,332 141,006 1.09 22 hrs 56 mins
96 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 149,589 151,068 0.99 24 hrs 14 mins
97 GeForce GTX 770
GK104 [GeForce GTX 770] 3213
Nvidia GK104 149,392 139,643 1.07 22 hrs 26 mins
98 Radeon R7/R6 360 Series
Bonaire [Radeon R7/R6 360 Series]
AMD Bonaire 133,003 130,654 1.02 24 hrs 35 mins
99 Radeon Rx 270/370
Curacao Pro [Radeon Rx 270/370]
AMD Curacao Pro 131,137 133,185 0.98 24 hrs 22 mins
100 Radeon 680M
Rembrandt [Radeon 680M]
AMD Rembrandt 128,887 133,350 0.97 25 hrs 50 mins
101 GeForce GTX 950M
GM107 [GeForce GTX 950M] 1439
Nvidia GM107 124,796 131,786 0.95 25 hrs 21 mins
102 GeForce GTX 680
GK104 [GeForce GTX 680] 3250
Nvidia GK104 124,670 128,100 0.97 25 hrs 40 mins
103 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 117,480 134,922 0.87 28 hrs 34 mins
104 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 117,122 133,127 0.88 27 hrs 17 mins
105 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 115,663 126,236 0.92 26 hrs 12 mins
106 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 113,866 127,298 0.89 27 hrs 50 mins
107 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 107,688 122,640 0.88 27 hrs 20 mins
108 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 103,839 122,004 0.85 28 hrs 12 mins
109 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 99,168 121,001 0.82 29 hrs 17 mins
110 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 89,116 121,552 0.73 33 hrs 44 mins
111 Polaris11
Baffin [Polaris11]
AMD Baffin 74,167 125,591 0.59 41 hrs 38 mins
112 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 67,603 106,775 0.63 38 hrs 54 mins
113 GeForce GTX 860M
GM107 [GeForce GTX 860M] 1389
Nvidia GM107 66,315 86,448 0.77 31 hrs 17 mins
114 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 64,790 104,209 0.62 39 hrs 36 mins
115 Radeon WX 3100
[Radeon WX 3100]
AMD 60,696 100,757 0.60 40 hrs 50 mins
116 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 55,633 97,125 0.57 42 hrs 54 mins
117 GeForce 940MX
GM108M [GeForce 940MX]
Nvidia GM108M 49,660 86,185 0.58 42 hrs 39 mins
118 Radeon R9 200/300 Series
Tonga [Radeon R9 200/300 Series]
AMD Tonga 49,548 79,156 0.63 38 hrs 20 mins
119 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 39,456 70,000 0.56 43 hrs 35 mins
120 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 35,612 86,198 0.41 58 hrs 5 mins
121 Radeon Vega Series / Radeon Vega Mobile Series
Picasso/Raven 2 [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Picasso/Raven 2 35,000 70,000 0.50 48 hrs 0 mins
122 Radeon RX Vega 7
Lucienne [Radeon RX Vega 7]
AMD Lucienne 29,184 70,000 0.42 58 hrs 34 mins
123 GeForce 920M
GK208 [GeForce 920M]
Nvidia GK208 28,000 70,000 0.40 60 hrs 0 mins
124 GeForce GT 710
GK208B [GeForce GT 710] 366
Nvidia GK208B 18,089 70,000 0.26 93 hrs 52 mins
125 Radeon R7/R6/R5 Series
Carrizo [Radeon R7/R6/R5 Series]
AMD Carrizo 10,745 70,000 0.15 156 hrs 21 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 02 October 2022 12:16:28

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make