PROJECT #18201 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Monday, 27 September 2021 14:58:25

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,763,975 501,938 15.47 2 hrs 33 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,964,469 486,521 14.31 2 hrs 41 mins
3 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,475,196 477,016 13.57 2 hrs 46 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,199,465 470,443 13.18 2 hrs 49 mins
5 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 5,600,867 456,822 12.26 2 hrs 57 mins
6 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,763,668 432,479 11.01 2 hrs 11 mins
7 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,712,331 430,101 10.96 2 hrs 11 mins
8 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,568,565 425,656 10.73 2 hrs 14 mins
9 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 4,165,445 410,560 10.15 2 hrs 22 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,887,092 403,927 9.62 2 hrs 30 mins
11 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,029,174 369,734 8.19 3 hrs 56 mins
12 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,011,131 371,351 8.11 3 hrs 58 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,928,880 364,283 8.04 3 hrs 59 mins
14 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,909,023 367,236 7.92 3 hrs 2 mins
15 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,822,114 363,087 7.77 3 hrs 5 mins
16 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,766,233 360,940 7.66 3 hrs 8 mins
17 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,744,009 359,421 7.63 3 hrs 9 mins
18 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,550,842 351,004 7.27 3 hrs 18 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,541,769 350,734 7.25 3 hrs 19 mins
20 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,469,059 347,230 7.11 3 hrs 23 mins
21 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,441,455 345,768 7.06 3 hrs 24 mins
22 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,215,933 335,120 6.61 4 hrs 38 mins
23 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,202,764 328,997 6.70 4 hrs 35 mins
24 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 2,109,355 325,458 6.48 4 hrs 42 mins
25 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,090,817 328,393 6.37 4 hrs 46 mins
26 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,950,744 320,681 6.08 4 hrs 57 mins
27 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,913,890 318,232 6.01 4 hrs 59 mins
28 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 1,889,292 306,914 6.16 4 hrs 54 mins
29 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,883,331 266,805 7.06 3 hrs 24 mins
30 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 1,863,885 311,721 5.98 4 hrs 1 mins
31 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,688,583 305,652 5.52 4 hrs 21 mins
32 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,494,383 293,132 5.10 5 hrs 42 mins
33 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550
Nvidia TU106M 1,486,196 294,143 5.05 5 hrs 45 mins
34 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,485,468 295,093 5.03 5 hrs 46 mins
35 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,389,266 286,544 4.85 5 hrs 57 mins
36 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,372,161 280,551 4.89 5 hrs 54 mins
37 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,335,476 283,154 4.72 5 hrs 5 mins
38 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,330,856 282,781 4.71 5 hrs 6 mins
39 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,294,037 280,306 4.62 5 hrs 12 mins
40 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,256,256 264,527 4.75 5 hrs 3 mins
41 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,251,199 275,949 4.53 5 hrs 18 mins
42 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 1,085,398 265,171 4.09 6 hrs 52 mins
43 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,012,811 258,103 3.92 6 hrs 7 mins
44 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 930,715 251,235 3.70 6 hrs 29 mins
45 P104-100
GP104 [P104-100]
Nvidia GP104 830,260 242,024 3.43 7 hrs 60 mins
46 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 751,055 233,784 3.21 7 hrs 28 mins
47 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 747,016 233,248 3.20 7 hrs 30 mins
48 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 689,495 226,363 3.05 8 hrs 53 mins
49 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 626,636 211,987 2.96 8 hrs 7 mins
50 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 594,315 191,888 3.10 8 hrs 45 mins
51 P106-100
GP106 [P106-100]
Nvidia GP106 545,483 210,433 2.59 9 hrs 16 mins
52 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 522,858 206,741 2.53 9 hrs 29 mins
53 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 475,608 200,858 2.37 10 hrs 8 mins
54 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 454,530 196,384 2.31 10 hrs 22 mins
55 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 389,787 188,104 2.07 12 hrs 35 mins
56 P106-090
GP106 [P106-090]
Nvidia GP106 347,260 180,950 1.92 13 hrs 30 mins
57 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 341,288 179,482 1.90 13 hrs 37 mins
58 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 339,618 164,929 2.06 12 hrs 39 mins
59 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 337,128 179,218 1.88 13 hrs 46 mins
60 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 327,233 177,360 1.85 13 hrs 0 mins
61 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 280,656 167,825 1.67 14 hrs 21 mins
62 Radeon R9 200/300 Series
Tonga [Radeon R9 200/300 Series]
AMD Tonga 264,427 165,248 1.60 15 hrs 60 mins
63 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 264,104 165,085 1.60 15 hrs 0 mins
64 GeForce GTX 760
GK104 [GeForce GTX 760] 2258
Nvidia GK104 222,171 156,342 1.42 17 hrs 53 mins
65 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 217,331 151,298 1.44 17 hrs 42 mins
66 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]
AMD Hawaii 214,881 90,100 2.38 10 hrs 4 mins
67 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 193,541 126,224 1.53 16 hrs 39 mins
68 Quadro K4200
GK104 [Quadro K4200]
Nvidia GK104 192,919 149,107 1.29 19 hrs 33 mins
69 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 191,132 121,858 1.57 15 hrs 18 mins
70 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 162,246 140,449 1.16 21 hrs 47 mins
71 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 157,394 139,142 1.13 21 hrs 13 mins
72 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 155,888 131,966 1.18 20 hrs 19 mins
73 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 132,498 130,719 1.01 24 hrs 41 mins
74 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 121,924 119,806 1.02 24 hrs 35 mins
75 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 115,734 125,517 0.92 26 hrs 2 mins
76 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 110,610 123,683 0.89 27 hrs 50 mins
77 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 104,486 120,951 0.86 28 hrs 47 mins
78 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 99,152 89,016 1.11 22 hrs 33 mins
79 Radeon WX 3100
[Radeon WX 3100]
AMD 93,004 116,940 0.80 30 hrs 11 mins
80 GRID M40
GM107GL [GRID M40]
Nvidia GM107GL 92,710 107,408 0.86 28 hrs 48 mins
81 VGX K2
GK104GL [VGX K2]
GK104GL 69,176 105,903 0.65 37 hrs 45 mins
82 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 57,258 96,715 0.59 41 hrs 32 mins
83 Radeon R7/R6 360 Series
Bonaire [Radeon R7/R6 360 Series]
AMD Bonaire 55,072 87,284 0.63 38 hrs 2 mins
84 Radeon R7 250X/HD 7700/8760
R575A [Radeon R7 250X/HD 7700/8760]
AMD R575A 48,014 79,759 0.60 40 hrs 52 mins
85 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 28,136 67,770 0.42 58 hrs 48 mins
86 GeForce GT 640
GK107 [GeForce GT 640] 693
Nvidia GK107 25,797 67,770 0.38 63 hrs 3 mins
87 GRID K340
GK107 [GRID K340]
GK107 15,138 67,770 0.22 107 hrs 27 mins
88 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 11,862 68,391 0.17 138 hrs 22 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Monday, 27 September 2021 14:58:25

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make