PROJECT #18201 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,000

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 22 June 2021 07:03:46

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,599,191 501,056 15.17 2 hrs 35 mins
2 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 5,600,867 456,822 12.26 2 hrs 57 mins
3 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 5,207,389 445,648 11.68 2 hrs 3 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,125,838 442,895 11.57 2 hrs 4 mins
5 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 4,909,620 391,012 12.56 2 hrs 55 mins
6 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,498,862 426,869 10.54 2 hrs 17 mins
7 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,019,123 407,057 9.87 2 hrs 26 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,947,429 406,070 9.72 2 hrs 28 mins
9 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,496,017 390,067 8.96 3 hrs 41 mins
10 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,199,601 378,379 8.46 3 hrs 50 mins
11 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,979,328 368,832 8.08 3 hrs 58 mins
12 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,922,220 367,956 7.94 3 hrs 1 mins
13 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,922,169 367,768 7.95 3 hrs 1 mins
14 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,831,966 363,894 7.78 3 hrs 5 mins
15 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,765,349 361,212 7.66 3 hrs 8 mins
16 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,639,438 355,637 7.42 3 hrs 14 mins
17 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,557,482 351,361 7.28 3 hrs 18 mins
18 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,528,424 350,195 7.22 3 hrs 19 mins
19 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 2,327,196 340,981 6.83 4 hrs 31 mins
20 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,005,319 323,993 6.19 4 hrs 53 mins
21 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,906,165 315,552 6.04 4 hrs 58 mins
22 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,715,994 297,602 5.77 4 hrs 10 mins
23 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,448,239 291,515 4.97 5 hrs 50 mins
24 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,410,660 289,129 4.88 5 hrs 55 mins
25 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,352,232 284,512 4.75 5 hrs 3 mins
26 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,317,099 281,645 4.68 5 hrs 8 mins
27 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,168,703 270,768 4.32 6 hrs 34 mins
28 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,161,124 266,562 4.36 6 hrs 31 mins
29 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 1,085,398 265,171 4.09 6 hrs 52 mins
30 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,038,729 261,173 3.98 6 hrs 2 mins
31 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 843,910 243,275 3.47 7 hrs 55 mins
32 P104-100
GP104 [P104-100]
Nvidia GP104 836,883 242,700 3.45 7 hrs 58 mins
33 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 690,320 227,597 3.03 8 hrs 55 mins
34 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 647,761 221,639 2.92 8 hrs 13 mins
35 P106-100
GP106 [P106-100]
Nvidia GP106 548,141 210,634 2.60 9 hrs 13 mins
36 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 474,297 200,681 2.36 10 hrs 9 mins
37 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 389,328 150,114 2.59 9 hrs 15 mins
38 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 327,233 177,360 1.85 13 hrs 0 mins
39 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 296,268 171,578 1.73 14 hrs 54 mins
40 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 271,006 166,465 1.63 15 hrs 45 mins
41 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]
AMD Hawaii 214,881 90,100 2.38 10 hrs 4 mins
42 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 201,881 151,181 1.34 18 hrs 58 mins
43 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 161,930 140,315 1.15 21 hrs 48 mins
44 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 132,332 116,361 1.14 21 hrs 6 mins
45 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 126,560 117,592 1.08 22 hrs 18 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 22 June 2021 07:03:46

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make