PROJECT #18202 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 22 June 2021 07:03:46

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,626,793 498,625 15.30 2 hrs 34 mins
2 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 5,715,117 436,042 13.11 2 hrs 50 mins
3 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 5,552,033 454,768 12.21 2 hrs 58 mins
4 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 5,386,262 455,089 11.84 2 hrs 2 mins
5 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 5,276,102 440,203 11.99 2 hrs 0 mins
6 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 5,098,384 441,859 11.54 2 hrs 5 mins
7 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,421,404 407,416 10.85 2 hrs 13 mins
8 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 3,816,547 401,657 9.50 3 hrs 32 mins
9 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 3,732,200 396,697 9.41 3 hrs 33 mins
10 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,502,765 390,553 8.97 3 hrs 41 mins
11 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,290,015 378,175 8.70 3 hrs 46 mins
12 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,995,123 370,589 8.08 3 hrs 58 mins
13 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,946,982 362,484 8.13 3 hrs 57 mins
14 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,932,481 366,927 7.99 3 hrs 0 mins
15 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,894,437 366,719 7.89 3 hrs 2 mins
16 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,819,276 363,438 7.76 3 hrs 6 mins
17 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,772,399 360,992 7.68 3 hrs 8 mins
18 RTX A4000
GA104GL [RTX A4000]
GA104GL 2,674,551 355,752 7.52 3 hrs 12 mins
19 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,577,674 352,703 7.31 3 hrs 17 mins
20 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,544,077 351,044 7.25 3 hrs 19 mins
21 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,325,083 336,598 6.91 3 hrs 28 mins
22 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,148,205 331,906 6.47 4 hrs 42 mins
23 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,132,373 330,412 6.45 4 hrs 43 mins
24 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 2,076,720 322,929 6.43 4 hrs 44 mins
25 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 2,013,672 324,886 6.20 4 hrs 52 mins
26 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,770,128 311,159 5.69 4 hrs 13 mins
27 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,713,459 294,987 5.81 4 hrs 8 mins
28 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,468,020 292,446 5.02 5 hrs 47 mins
29 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,457,029 291,344 5.00 5 hrs 48 mins
30 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,407,487 288,510 4.88 5 hrs 55 mins
31 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,374,796 279,378 4.92 5 hrs 53 mins
32 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,261,690 276,167 4.57 5 hrs 15 mins
33 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,255,691 269,801 4.65 5 hrs 9 mins
34 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,196,608 268,681 4.45 5 hrs 23 mins
35 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,159,119 270,834 4.28 6 hrs 36 mins
36 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,150,095 269,502 4.27 6 hrs 37 mins
37 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,123,712 265,338 4.24 6 hrs 40 mins
38 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,059,453 259,460 4.08 6 hrs 53 mins
39 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 1,020,352 255,119 4.00 6 hrs 0 mins
40 P104-100
GP104 [P104-100]
Nvidia GP104 832,094 242,100 3.44 7 hrs 59 mins
41 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 806,855 236,565 3.41 7 hrs 2 mins
42 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 786,492 194,760 4.04 6 hrs 57 mins
43 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 701,121 228,574 3.07 8 hrs 49 mins
44 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 675,854 220,488 3.07 8 hrs 50 mins
45 GeForce GTX 1650 Ti Mobile
TU116M [GeForce GTX 1650 Ti Mobile]
Nvidia TU116M 674,712 225,606 2.99 8 hrs 1 mins
46 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 653,197 219,223 2.98 8 hrs 3 mins
47 P106-100
GP106 [P106-100]
Nvidia GP106 543,521 209,962 2.59 9 hrs 16 mins
48 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 480,348 201,622 2.38 10 hrs 4 mins
49 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 443,463 192,360 2.31 10 hrs 25 mins
50 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 439,983 195,862 2.25 11 hrs 41 mins
51 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 376,928 186,515 2.02 12 hrs 53 mins
52 Radeon R9 280/HD 7900/8950
Tahiti PRO [Radeon R9 280/HD 7900/8950]
AMD Tahiti PRO 346,860 180,778 1.92 13 hrs 31 mins
53 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 326,263 177,398 1.84 13 hrs 3 mins
54 Radeon R9 200/300 Series
Tonga [Radeon R9 200/300 Series]
AMD Tonga 312,551 171,167 1.83 13 hrs 9 mins
55 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 308,470 172,574 1.79 13 hrs 26 mins
56 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 303,362 170,139 1.78 13 hrs 28 mins
57 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 293,893 170,785 1.72 14 hrs 57 mins
58 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 249,380 154,988 1.61 15 hrs 55 mins
59 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 243,615 159,410 1.53 16 hrs 42 mins
60 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 210,653 151,557 1.39 17 hrs 16 mins
61 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 161,363 140,233 1.15 21 hrs 51 mins
62 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 158,277 139,240 1.14 21 hrs 7 mins
63 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 146,500 135,095 1.08 22 hrs 8 mins
64 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 144,684 135,520 1.07 22 hrs 29 mins
65 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 131,548 128,963 1.02 24 hrs 32 mins
66 Radeon Rx 270/370
Curacao Pro [Radeon Rx 270/370]
AMD Curacao Pro 126,598 120,778 1.05 23 hrs 54 mins
67 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 125,455 122,496 1.02 23 hrs 26 mins
68 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 116,276 125,742 0.92 26 hrs 57 mins
69 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 113,621 112,298 1.01 24 hrs 43 mins
70 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 112,998 124,529 0.91 26 hrs 27 mins
71 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 111,206 122,558 0.91 26 hrs 27 mins
72 Radeon R7 200 Series
Hawaii [Radeon R7 200 Series]
AMD Hawaii 89,150 105,188 0.85 28 hrs 19 mins
73 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 52,390 81,157 0.65 37 hrs 11 mins
74 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 33,905 67,770 0.50 48 hrs 58 mins
75 Radeon R7 250/HD 7700
R575A [Radeon R7 250/HD 7700]
AMD R575A 31,223 67,770 0.46 52 hrs 6 mins
76 Quadro P400
GP107GL [Quadro P400] 641
Nvidia GP107GL 28,867 68,923 0.42 57 hrs 18 mins
77 GeForce GTX 670M
GF114 [GeForce GTX 670M]
Nvidia GF114 19,735 67,770 0.29 82 hrs 25 mins
78 GeForce GT 740
GK107 [GeForce GT 740] 762
Nvidia GK107 12,883 67,770 0.19 126 hrs 15 mins
79 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 6,802 67,770 0.10 239 hrs 7 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 22 June 2021 07:03:46

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make