PROJECT #18202 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one varaiants of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: OPENMM_22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 26 June 2022 09:57:00

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 9,279,910 537,722 17.26 1 hrs 23 mins
2 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,790,132 505,862 15.40 2 hrs 34 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 7,789,856 506,140 15.39 2 hrs 34 mins
4 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 6,742,589 484,926 13.90 2 hrs 44 mins
5 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,415,339 473,958 13.54 2 hrs 46 mins
6 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 5,552,033 454,768 12.21 2 hrs 58 mins
7 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 5,409,416 449,489 12.03 2 hrs 60 mins
8 RTX A5000
GA102GL [RTX A5000]
Nvidia GA102GL 5,314,905 448,026 11.86 2 hrs 1 mins
9 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 5,160,360 441,216 11.70 2 hrs 3 mins
10 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 5,151,641 441,718 11.66 2 hrs 3 mins
11 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 4,771,879 424,573 11.24 2 hrs 8 mins
12 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 4,299,413 416,920 10.31 2 hrs 20 mins
13 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 4,263,451 406,516 10.49 2 hrs 17 mins
14 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,259,139 417,399 10.20 2 hrs 21 mins
15 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 3,745,695 402,103 9.32 3 hrs 35 mins
16 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 3,577,894 393,121 9.10 3 hrs 38 mins
17 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 3,572,339 388,594 9.19 3 hrs 37 mins
18 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 3,487,547 388,999 8.97 3 hrs 41 mins
19 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 3,365,070 381,385 8.82 3 hrs 43 mins
20 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 3,242,896 380,601 8.52 3 hrs 49 mins
21 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 3,061,019 372,099 8.23 3 hrs 55 mins
22 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 3,023,712 370,936 8.15 3 hrs 57 mins
23 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 3,020,080 371,525 8.13 3 hrs 57 mins
24 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,953,629 368,390 8.02 3 hrs 60 mins
25 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,868,210 364,472 7.87 3 hrs 3 mins
26 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,798,410 361,786 7.73 3 hrs 6 mins
27 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,765,679 361,076 7.66 3 hrs 8 mins
28 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 2,753,722 355,242 7.75 3 hrs 6 mins
29 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,563,634 354,281 7.24 3 hrs 19 mins
30 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 2,534,787 350,613 7.23 3 hrs 19 mins
31 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 2,476,741 347,643 7.12 3 hrs 22 mins
32 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 2,461,382 347,094 7.09 3 hrs 23 mins
33 GeForce RTX 2070 SUPER Mobile / Max-Q
TU104M [GeForce RTX 2070 SUPER Mobile / Max-Q]
Nvidia TU104M 2,393,330 345,086 6.94 3 hrs 28 mins
34 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 2,379,693 340,950 6.98 3 hrs 26 mins
35 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 2,299,622 337,937 6.80 4 hrs 32 mins
36 GeForce RTX 2070
TU106 [GeForce RTX 2070] M 6497
Nvidia TU106 2,227,694 324,627 6.86 3 hrs 30 mins
37 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,135,324 330,510 6.46 4 hrs 43 mins
38 Radeon RX 6700/6700 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT / 6800M]
AMD Navi 22 2,109,959 321,404 6.56 4 hrs 39 mins
39 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,077,667 318,870 6.52 4 hrs 41 mins
40 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]
AMD Navi 21 2,047,830 315,241 6.50 4 hrs 42 mins
41 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,046,093 326,546 6.27 4 hrs 50 mins
42 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,873,126 313,407 5.98 4 hrs 1 mins
43 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,857,083 309,547 6.00 4 hrs 0 mins
44 Tesla P40
GP102GL [Tesla P40] 11760
Nvidia GP102GL 1,695,955 306,122 5.54 4 hrs 20 mins
45 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,588,427 297,634 5.34 4 hrs 30 mins
46 GeForce RTX 3070 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 1,573,551 291,565 5.40 4 hrs 27 mins
47 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,439,330 290,568 4.95 5 hrs 51 mins
48 Quadro P5000
GP104GL [Quadro P5000]
Nvidia GP104GL 1,349,835 283,140 4.77 5 hrs 2 mins
49 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 1,319,161 269,554 4.89 5 hrs 54 mins
50 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,307,931 284,882 4.59 5 hrs 14 mins
51 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 1,272,221 274,950 4.63 5 hrs 11 mins
52 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,271,308 277,362 4.58 5 hrs 14 mins
53 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,264,025 274,528 4.60 5 hrs 13 mins
54 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,242,756 280,568 4.43 5 hrs 25 mins
55 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 1,205,540 280,370 4.30 6 hrs 35 mins
56 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,187,037 282,927 4.20 6 hrs 43 mins
57 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,130,496 266,151 4.25 6 hrs 39 mins
58 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,066,551 260,922 4.09 6 hrs 52 mins
59 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 1,065,125 264,125 4.03 6 hrs 57 mins
60 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,045,213 248,856 4.20 6 hrs 43 mins
61 P104-100
GP104 [P104-100]
Nvidia GP104 985,365 256,858 3.84 6 hrs 15 mins
62 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 973,012 259,018 3.76 6 hrs 23 mins
63 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 873,100 247,660 3.53 7 hrs 48 mins
64 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 807,475 233,700 3.46 7 hrs 57 mins
65 GeForce GTX 1070 Mobile
GP104M [GeForce GTX 1070 Mobile]
Nvidia GP104M 786,492 194,760 4.04 6 hrs 57 mins
66 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 752,978 233,974 3.22 7 hrs 27 mins
67 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 713,243 230,318 3.10 8 hrs 45 mins
68 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 680,182 224,724 3.03 8 hrs 56 mins
69 GeForce GTX 1650 Ti Mobile
TU116M [GeForce GTX 1650 Ti Mobile]
Nvidia TU116M 674,712 225,606 2.99 8 hrs 1 mins
70 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 666,003 222,822 2.99 8 hrs 2 mins
71 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 641,155 216,264 2.96 8 hrs 6 mins
72 P106-100
GP106 [P106-100]
Nvidia GP106 545,027 210,259 2.59 9 hrs 16 mins
73 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 536,103 210,336 2.55 9 hrs 25 mins
74 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 529,618 212,901 2.49 10 hrs 39 mins
75 Radeon R9 Fury X
Fiji XT [Radeon R9 Fury X]
AMD Fiji XT 525,323 197,665 2.66 9 hrs 2 mins
76 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 525,199 198,055 2.65 9 hrs 3 mins
77 Quadro T2000 Mobile / Max-Q
TU117GLM [Quadro T2000 Mobile / Max-Q]
Nvidia TU117GLM 504,767 204,415 2.47 10 hrs 43 mins
78 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 501,354 203,647 2.46 10 hrs 45 mins
79 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 490,224 201,115 2.44 10 hrs 51 mins
80 P106-090
GP106 [P106-090]
Nvidia GP106 488,173 201,964 2.42 10 hrs 56 mins
81 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 449,187 196,953 2.28 11 hrs 31 mins
82 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 436,335 195,341 2.23 11 hrs 45 mins
83 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 434,145 194,540 2.23 11 hrs 45 mins
84 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 428,368 186,072 2.30 10 hrs 25 mins
85 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 419,802 185,445 2.26 11 hrs 36 mins
86 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 363,320 178,835 2.03 12 hrs 49 mins
87 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 348,344 181,429 1.92 12 hrs 30 mins
88 Radeon R9 280/HD 7900/8950
Tahiti PRO [Radeon R9 280/HD 7900/8950]
AMD Tahiti PRO 346,860 180,778 1.92 13 hrs 31 mins
89 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 326,680 177,482 1.84 13 hrs 2 mins
90 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 293,147 171,437 1.71 14 hrs 2 mins
91 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 290,857 167,989 1.73 14 hrs 52 mins
92 Radeon R9 200/300 Series
Tonga [Radeon R9 200/300 Series]
AMD Tonga 290,211 168,651 1.72 14 hrs 57 mins
93 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 278,335 167,589 1.66 14 hrs 27 mins
94 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 235,574 154,188 1.53 16 hrs 43 mins
95 GeForce GTX 690
GK104 [GeForce GTX 690] 3130
Nvidia GK104 228,805 143,580 1.59 15 hrs 4 mins
96 T600
TU117GL [T600]
Intel TU117GL 173,883 154,446 1.13 21 hrs 19 mins
97 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 170,810 138,970 1.23 20 hrs 32 mins
98 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 162,963 138,063 1.18 20 hrs 20 mins
99 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 149,842 141,038 1.06 23 hrs 35 mins
100 GeForce GTX 660
GK106 [GeForce GTX 660]
Nvidia GK106 146,500 135,095 1.08 22 hrs 8 mins
101 GeForce GTX 750
GM107 [GeForce GTX 750] 1111
Nvidia GM107 144,684 135,520 1.07 22 hrs 29 mins
102 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 135,450 138,127 0.98 24 hrs 28 mins
103 GTX 650 Ti Boost
GK106 [GTX 650 Ti Boost]
Nvidia GK106 132,322 131,193 1.01 24 hrs 48 mins
104 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 130,830 111,992 1.17 21 hrs 33 mins
105 Radeon HD 7800 Series
Pitcairn PRO [Radeon HD 7800 Series]
AMD Pitcairn PRO 129,423 128,648 1.01 24 hrs 51 mins
106 Radeon Rx 270/370
Curacao Pro [Radeon Rx 270/370]
AMD Curacao Pro 126,598 120,778 1.05 23 hrs 54 mins
107 GeForce GT 1030
GP108 [GeForce GT 1030] 1127
Nvidia GP108 119,253 126,910 0.94 26 hrs 32 mins
108 GeForce GTX 960M
GM107 [GeForce GTX 960M] 1439
Nvidia GM107 107,923 107,718 1.00 24 hrs 57 mins
109 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 107,759 121,678 0.89 27 hrs 6 mins
110 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 98,837 113,669 0.87 28 hrs 36 mins
111 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 91,720 113,101 0.81 30 hrs 36 mins
112 Radeon R7 200 Series
Hawaii [Radeon R7 200 Series]
AMD Hawaii 89,150 105,188 0.85 28 hrs 19 mins
113 GRID M40
GM107GL [GRID M40]
Nvidia GM107GL 82,994 101,144 0.82 29 hrs 15 mins
114 Radeon R7/R6 360 Series
Bonaire [Radeon R7/R6 360 Series]
AMD Bonaire 77,850 104,248 0.75 32 hrs 8 mins
115 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 77,176 106,851 0.72 33 hrs 14 mins
116 GeForce GTX 570 HD
GF110 [GeForce GTX 570 HD] 1405
Nvidia GF110 73,542 107,992 0.68 35 hrs 15 mins
117 Ryzen 4900HS mobile
Renoir [Ryzen 4900HS mobile]
AMD Renoir 66,908 104,714 0.64 38 hrs 34 mins
118 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 61,527 105,220 0.58 41 hrs 3 mins
119 Radeon Vega Series / Radeon Vega Mobile Series
Raven Ridge [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Raven Ridge 56,773 97,668 0.58 41 hrs 17 mins
120 Ryzen vega 8 mobile
Raven [Ryzen vega 8 mobile]
AMD Raven 56,619 98,968 0.57 42 hrs 57 mins
121 Quadro P400
GP107GL [Quadro P400] 641
Nvidia GP107GL 39,630 80,877 0.49 49 hrs 59 mins
122 GeForce GT 840M
GM108 [GeForce GT 840M]
Nvidia GM108 36,747 70,323 0.52 46 hrs 56 mins
123 Radeon RX Vega gfx902
raven [Radeon RX Vega gfx902]
AMD raven 33,905 67,770 0.50 48 hrs 58 mins
124 Radeon R7 250/HD 7700
R575A [Radeon R7 250/HD 7700]
AMD R575A 31,277 67,770 0.46 52 hrs 0 mins
125 GeForce GTX 560
GF114 [GeForce GTX 560]
Nvidia GF114 28,534 67,770 0.42 57 hrs 0 mins
126 GeForce GT 730
GK208B [GeForce GT 730] 692.7
Nvidia GK208B 28,267 67,770 0.42 58 hrs 32 mins
127 GeForce GTX 670M
GF114 [GeForce GTX 670M]
Nvidia GF114 19,645 67,770 0.29 83 hrs 48 mins
128 GeForce GT 740
GK107 [GeForce GT 740] 762
Nvidia GK107 12,883 67,770 0.19 126 hrs 15 mins
129 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 6,642 67,770 0.10 245 hrs 53 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 26 June 2022 09:57:00

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make