PROJECT #18206 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression.

Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease.

There are three dominant alleles (versions) of ApoE that are found in humans.

Each ApoE allele differs only by a single amino acid substitution.

ApoE3 is most common and carries a neutral risk for AD.

Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease.

Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease.

How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression.

Here, we will simulate how one varaiants of ApoE move in solution.

We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease..

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 27 May 2022 17:25:49

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 27 May 2022 17:25:49

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CORE I7-1065G7 CPU @ 1.30GHZ 8 158,018 1,264,144 Intel
2 12TH GEN CORE I9-12900K 24 47,371 1,136,904 Intel
3 RYZEN 9 5950X 16-CORE 32 29,745 951,840 AMD
4 CORE I9-9980XE CPU @ 3.00GHZ 36 21,168 762,048 Intel
5 RYZEN 9 3950X 16-CORE 32 23,253 744,096 AMD
6 12TH GEN CORE I7-12700K 20 28,729 574,580 Intel
7 RYZEN THREADRIPPER 3960X 24-CORE 48 11,460 550,080 AMD
8 RYZEN 9 3900 12-CORE 24 22,904 549,696 AMD
9 RYZEN 7 5800X 8-CORE 16 31,689 507,024 AMD
10 RYZEN 9 3900X 12-CORE 24 20,393 489,432 AMD
11 RYZEN 9 3900XT 12-CORE 24 18,899 453,576 AMD
12 RYZEN 7 5700X 8-CORE 16 27,995 447,920 AMD
13 CORE I9-7920X CPU @ 2.90GHZ 24 17,812 427,488 Intel
14 RYZEN 9 5900X 12-CORE 24 16,778 402,672 AMD
15 11TH GEN CORE I9-11900K @ 3.50GHZ 16 23,963 383,408 Intel
16 RYZEN 7 3800X 8-CORE 16 22,918 366,688 AMD
17 12TH GEN CORE I7-12700 20 18,248 364,960 Intel
18 GENUINE CPU 0000 @ 2.10GHZ 44 8,103 356,532 Intel
19 XEON CPU E5-2690 V4 @ 2.60GHZ 28 11,371 318,388 Intel
20 EPYC 7401P 24-CORE 48 6,235 299,280 AMD
21 RYZEN THREADRIPPER 2970WX 24-CORE 48 5,928 284,544 AMD
22 CORE I9-10850K CPU @ 3.60GHZ 20 13,657 273,140 Intel
23 CORE I9-10900X CPU @ 3.70GHZ 20 13,342 266,840 Intel
24 RYZEN THREADRIPPER 2950X 16-CORE 32 8,326 266,432 AMD
25 12TH GEN CORE I5-12600K 16 16,526 264,416 Intel
26 RYZEN 7 5700G 16 16,485 263,760 AMD
27 XEON CPU E5-2680 V3 @ 2.50GHZ 24 10,632 255,168 Intel
28 XEON CPU E5-2650 V2 @ 2.60GHZ 32 7,823 250,336 Intel
29 RYZEN THREADRIPPER 1950X 16-CORE 32 7,643 244,576 AMD
30 CORE I9-9900X CPU @ 3.50GHZ 20 11,931 238,620 Intel
31 11TH GEN CORE I7-11700K @ 3.60GHZ 16 14,412 230,592 Intel
32 PENTIUM(R) CPU G2020T @ 2.50GHZ 2 112,941 225,882 Intel
33 RYZEN 7 3700X 8-CORE 16 14,021 224,336 AMD
34 XEON CPU E5-2660 V3 @ 2.60GHZ 20 11,160 223,200 Intel
35 RYZEN 5 3600X 6-CORE 12 18,565 222,780 AMD
36 CORE I9-9900K CPU @ 3.60GHZ 16 13,750 220,000 Intel
37 RYZEN 5 5600G 12 17,763 213,156 AMD
38 RYZEN THREADRIPPER 1920X 12-CORE 24 8,720 209,280 AMD
39 CORE I9-9900 CPU @ 3.10GHZ 16 12,923 206,768 Intel
40 CORE I7-5960X CPU @ 3.00GHZ 16 12,843 205,488 Intel
41 XEON W-2175 CPU @ 2.50GHZ 28 7,315 204,820 Intel
42 11TH GEN CORE I9-11900KF @ 3.50GHZ 16 12,501 200,016 Intel
43 RYZEN 9 5900HS 16 11,652 186,432 AMD
44 RYZEN 5 5600X 6-CORE 12 15,463 185,556 AMD
45 RYZEN 7 1700 EIGHT-CORE 16 11,012 176,192 AMD
46 11TH GEN CORE I5-11600K @ 3.90GHZ 12 14,680 176,160 Intel
47 11TH GEN CORE I7-11850H @ 2.50GHZ 16 10,906 174,496 Intel
48 CORE I7-8700 CPU @ 3.20GHZ 12 14,526 174,312 Intel
49 CORE I5-8259U CPU @ 2.30GHZ 8 21,346 170,768 Intel
50 RYZEN 5 3600 6-CORE 12 14,090 169,080 AMD
51 CORE I7-9700K CPU @ 3.60GHZ 8 20,796 166,368 Intel
52 11TH GEN CORE I5-11400F @ 2.60GHZ 12 13,527 162,324 Intel
53 CORE I5-10600 CPU @ 3.30GHZ 12 13,400 160,800 Intel
54 CORE I7-9700KF CPU @ 3.60GHZ 8 19,607 156,856 Intel
55 CORE I7-8700K CPU @ 3.70GHZ 12 12,883 154,596 Intel
56 XEON CPU E5-2697 V2 @ 2.70GHZ 24 6,366 152,784 Intel
57 11TH GEN CORE I9-11900F @ 2.50GHZ 16 8,825 141,200 Intel
58 RYZEN 7 4800H 16 8,796 140,736 AMD
59 RYZEN 7 2700X EIGHT-CORE 16 8,477 135,632 AMD
60 CORE I7-10870H CPU @ 2.20GHZ 16 8,327 133,232 Intel
61 CORE I7-9700 CPU @ 3.00GHZ 8 16,589 132,712 Intel
62 CORE I7-10700 CPU @ 2.90GHZ 16 8,196 131,136 Intel
63 12TH GEN CORE I3-12100F 8 16,176 129,408 Intel
64 RYZEN 5 2600X SIX-CORE 12 10,262 123,144 AMD
65 CORE I5-10400 CPU @ 2.90GHZ 12 9,586 115,032 Intel
66 CORE I3-10105F CPU @ 3.70GHZ 8 14,266 114,128 Intel
67 CORE I5-10400F CPU @ 2.90GHZ 12 9,477 113,724 Intel
68 CORE I7-5820K CPU @ 3.30GHZ 12 8,882 106,584 Intel
69 RYZEN 7 PRO 4750G 16 6,518 104,288 AMD
70 CORE I9-9880H CPU @ 2.30GHZ 16 6,369 101,904 Intel
71 CORE I7-9700T CPU @ 2.00GHZ 8 12,252 98,016 Intel
72 CORE I5-9600K CPU @ 3.70GHZ 6 16,163 96,978 Intel
73 XEON CPU E5-2673 V3 @ 2.40GHZ 24 3,970 95,280 Intel
74 CORE I7-7700 CPU @ 3.60GHZ 8 11,657 93,256 Intel
75 CORE I7-10700T CPU @ 2.00GHZ 16 5,744 91,904 Intel
76 RYZEN 5 3500X 6-CORE 6 15,300 91,800 AMD
77 CORE I7-4790K CPU @ 4.00GHZ 8 11,393 91,144 Intel
78 CORE I7-6700K CPU @ 4.00GHZ 8 10,659 85,272 Intel
79 CELERON(R) CPU G550 @ 2.60GHZ 2 42,518 85,036 Intel
80 EPYC 7251 8-CORE 16 5,240 83,840 AMD
81 XEON CPU E5-2680 0 @ 2.70GHZ 16 5,194 83,104 Intel
82 RYZEN 5 2600 SIX-CORE 12 6,719 80,628 AMD
83 11TH GEN CORE I5-11400 @ 2.60GHZ 12 6,702 80,424 Intel
84 CORE I7-8705G CPU @ 3.10GHZ 8 9,801 78,408 Intel
85 XEON W-10855M CPU @ 2.80GHZ 12 6,512 78,144 Intel
86 RYZEN 5 1600 SIX-CORE 12 6,459 77,508 AMD
87 11TH GEN CORE I7-1185G7 @ 3.00GHZ 8 9,493 75,944 Intel
88 RYZEN 5 5500U 12 6,203 74,436 AMD
89 CORE I3-9100F CPU @ 3.60GHZ 4 18,546 74,184 Intel
90 CORE I7-4790 CPU @ 3.60GHZ 8 9,260 74,080 Intel
91 CORE I7-10750H CPU @ 2.60GHZ 12 5,846 70,152 Intel
92 XEON CPU X5570 @ 2.93GHZ 16 4,333 69,328 Intel
93 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 8,634 69,072 Intel
94 CORE I7-6700 CPU @ 3.40GHZ 8 8,042 64,336 Intel
95 CORE I7-4980HQ CPU @ 2.80GHZ 8 7,610 60,880 Intel
96 CORE I7-3720QM CPU @ 2.60GHZ 8 7,474 59,792 Intel
97 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 7,352 58,816 Intel
98 CORE I9-8950HK CPU @ 2.90GHZ 12 4,744 56,928 Intel
99 CORE I5-8600T CPU @ 2.30GHZ 6 9,251 55,506 Intel
100 CORE I5-7400 CPU @ 3.00GHZ 4 13,829 55,316 Intel
101 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,715 53,720 Intel
102 CORE I7-10510U CPU @ 1.80GHZ 8 6,498 51,984 Intel
103 XEON CPU E5-2450 0 @ 2.10GHZ 10 5,188 51,880 Intel
104 CORE I5-8400 CPU @ 2.80GHZ 6 8,594 51,564 Intel
105 CORE I3-8300 CPU @ 3.70GHZ 4 12,727 50,908 Intel
106 CORE I5-8300H CPU @ 2.30GHZ 8 6,346 50,768 Intel
107 CORE I5-6500 CPU @ 3.20GHZ 4 12,376 49,504 Intel
108 CORE I7-10610U CPU @ 1.80GHZ 8 6,156 49,248 Intel
109 CORE I7-4770 CPU @ 3.40GHZ 8 6,086 48,688 Intel
110 CORE I5-6300HQ CPU @ 2.30GHZ 4 11,975 47,900 Intel
111 CORE I7-4770K CPU @ 3.50GHZ 8 5,898 47,184 Intel
112 CORE I5-6500T CPU @ 2.50GHZ 4 11,642 46,568 Intel
113 CORE I7-4790T CPU @ 2.70GHZ 8 5,757 46,056 Intel
114 CORE I7-8550U CPU @ 1.80GHZ 8 5,711 45,688 Intel
115 CORE I5-4590 CPU @ 3.30GHZ 4 10,749 42,996 Intel
116 CORE I5-4670 CPU @ 3.40GHZ 4 10,748 42,992 Intel
117 CORE I5-6600 CPU @ 3.30GHZ 4 10,682 42,728 Intel
118 CORE I7-3770 CPU @ 3.40GHZ 8 5,326 42,608 Intel
119 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,294 42,352 Intel
120 CORE I5-4570S CPU @ 2.90GHZ 4 10,382 41,528 Intel
121 CORE I5-6600K CPU @ 3.50GHZ 4 10,163 40,652 Intel
122 CORE I7-4765T CPU @ 2.00GHZ 8 5,076 40,608 Intel
123 CORE I5-4570 CPU @ 3.20GHZ 4 10,131 40,524 Intel
124 RYZEN 7 2700 EIGHT-CORE 16 2,520 40,320 AMD
125 RYZEN 7 4700U 8 4,993 39,944 AMD
126 XEON CPU X5670 @ 2.93GHZ 12 3,327 39,924 Intel
127 CORE I7-8650U CPU @ 1.90GHZ 8 4,955 39,640 Intel
128 RYZEN 3 3200G 4 9,853 39,412 AMD
129 RYZEN 5 3500 6-CORE 6 6,425 38,550 AMD
130 XEON E-2124G CPU @ 3.40GHZ 4 9,578 38,312 Intel
131 RYZEN 5 4500U 6 6,338 38,028 AMD
132 CORE I7-7700HQ CPU @ 2.80GHZ 8 4,734 37,872 Intel
133 CORE I5-6400 CPU @ 2.70GHZ 4 9,075 36,300 Intel
134 XEON CPU E3-1220 V2 @ 3.10GHZ 4 9,038 36,152 Intel
135 OPTERON(TM) 6380 64 547 35,008 AMD
136 CORE I5-7600 CPU @ 3.50GHZ 4 8,679 34,716 Intel
137 XEON CPU E5-2620 0 @ 2.00GHZ 12 2,875 34,500 Intel
138 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,724 34,344 Intel
139 CORE I5-4690K CPU @ 3.50GHZ 4 8,350 33,400 Intel
140 CORE I3-6100 CPU @ 3.70GHZ 4 8,332 33,328 Intel
141 CORE I5-8365U CPU @ 1.60GHZ 8 4,143 33,144 Intel
142 CORE I7-8750H CPU @ 2.20GHZ 12 2,719 32,628 Intel
143 XEON CPU E3-1245 V2 @ 3.40GHZ 8 3,969 31,752 Intel
144 RYZEN 5 3400G 8 3,904 31,232 AMD
145 CORE I5-9300H CPU @ 2.40GHZ 8 3,838 30,704 Intel
146 CORE I3-4150 CPU @ 3.50GHZ 4 7,676 30,704 Intel
147 CORE I5-3570 CPU @ 3.40GHZ 4 7,339 29,356 Intel
148 CORE I5-3330 CPU @ 3.00GHZ 4 7,275 29,100 Intel
149 XEON CPU E3-1240 V2 @ 3.40GHZ 8 3,560 28,480 Intel
150 CORE I5-2500K CPU @ 3.30GHZ 4 7,118 28,472 Intel
151 CORE I5-4460 CPU @ 3.20GHZ 4 7,059 28,236 Intel
152 CORE I7-9750H CPU @ 2.60GHZ 12 2,299 27,588 Intel
153 XEON CPU E31245 @ 3.30GHZ 8 3,429 27,432 Intel
154 CORE I3-7100 CPU @ 3.90GHZ 4 6,607 26,428 Intel
155 CORE I7-3610QM CPU @ 2.30GHZ 8 3,261 26,088 Intel
156 CORE I5-7300U CPU @ 2.60GHZ 4 6,374 25,496 Intel
157 FX-8150 EIGHT-CORE 8 3,181 25,448 AMD
158 CORE I5-2520M CPU @ 2.50GHZ 4 6,006 24,024 Intel
159 XEON CPU W3550 @ 3.07GHZ 8 2,951 23,608 Intel
160 CORE I7-2600 CPU @ 3.40GHZ 8 2,856 22,848 Intel
161 FX-8350 EIGHT-CORE 8 2,620 20,960 AMD
162 CORE I5-4278U CPU @ 2.60GHZ 4 5,171 20,684 Intel
163 CORE I5-2400S CPU @ 2.50GHZ 4 5,168 20,672 Intel
164 CORE I5-3470 CPU @ 3.20GHZ 4 5,101 20,404 Intel
165 CORE I7-7Y75 CPU @ 1.30GHZ 4 4,900 19,600 Intel
166 CORE I5-3570K CPU @ 3.40GHZ 4 4,796 19,184 Intel
167 CORE I7-6700HQ CPU @ 2.60GHZ 8 2,357 18,856 Intel
168 RYZEN 3 2200G 4 4,684 18,736 AMD
169 CORE I7-10700K CPU @ 3.80GHZ 16 1,154 18,464 Intel
170 CORE I7 CPU 975 @ 3.33GHZ 8 2,276 18,208 Intel
171 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,229 16,916 Intel
172 CORE I7-6500U CPU @ 2.50GHZ 4 4,133 16,532 Intel
173 CORE I5-4300U CPU @ 1.90GHZ 4 4,130 16,520 Intel
174 CORE I5-7200U CPU @ 2.50GHZ 4 4,051 16,204 Intel
175 CORE I5-6300U CPU @ 2.40GHZ 4 3,881 15,524 Intel
176 11TH GEN CORE I7-11370H @ 3.30GHZ 8 1,917 15,336 Intel
177 FX-8320 EIGHT-CORE 8 1,827 14,616 AMD
178 ATHLON 220GE 4 3,529 14,116 AMD
179 PENTIUM(R) CPU G4600 @ 3.60GHZ 4 3,527 14,108 Intel
180 CORE I3-3240 CPU @ 3.40GHZ 4 3,311 13,244 Intel
181 CORE I3-3220 CPU @ 3.30GHZ 4 3,008 12,032 Intel
182 CORE I3-6006U CPU @ 2.00GHZ 4 2,965 11,860 Intel
183 CORE I3-2120 CPU @ 3.30GHZ 4 2,936 11,744 Intel
184 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,787 11,148 Intel
185 CORE I3-3110M CPU @ 2.40GHZ 4 2,768 11,072 Intel
186 CORE I3-3225 CPU @ 3.30GHZ 4 2,664 10,656 Intel
187 CORE I5-5200U CPU @ 2.20GHZ 4 2,479 9,916 Intel
188 RYZEN 3 3250U 4 2,448 9,792 AMD
189 RYZEN 5 3500U 8 1,187 9,496 AMD
190 A10-6700 APU RADEON(TM) HD GRAPHICS 4 2,233 8,932 AMD
191 CORE I5-3210M CPU @ 2.50GHZ 4 2,161 8,644 Intel
192 A12-9800 RADEON R7, 12 COMPUTE CORES 4C+8G 4 1,497 5,988 AMD
193 CORE M-5Y71 CPU @ 1.20GHZ 4 1,374 5,496 Intel
194 FX-4300 QUAD-CORE 4 1,305 5,220 AMD
195 XEON CPU E5-2670 V3 @ 2.30GHZ 1 4,688 4,688 Intel
196 PHENOM II X4 B55 4 1,096 4,384 AMD
197 ATHLON 200GE 4 1,002 4,008 AMD
198 CORE2 DUO CPU E8400 @ 3.00GHZ 2 1,869 3,738 Intel
199 E2-7110 APU RADEON R2 GRAPHICS 4 930 3,720 AMD
200 A8-6410 APU 4 397 1,588 AMD