PROJECT #18206 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Tuesday, 26 October 2021 06:56:06

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Tuesday, 26 October 2021 06:56:06

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CORE I7-1065G7 CPU @ 1.30GHZ 8 158,018 1,264,144 Intel
2 RYZEN 9 3950X 16-CORE 32 28,271 904,672 AMD
3 RYZEN THREADRIPPER 3960X 24-CORE 48 11,877 570,096 AMD
4 RYZEN 7 5800X 8-CORE 16 33,955 543,280 AMD
5 RYZEN 9 5950X 16-CORE 32 16,503 528,096 AMD
6 RYZEN 9 3900 12-CORE 24 20,080 481,920 AMD
7 RYZEN 9 5900X 12-CORE 24 17,868 428,832 AMD
8 RYZEN 9 3900XT 12-CORE 24 16,670 400,080 AMD
9 RYZEN 7 3800X 8-CORE 16 24,029 384,464 AMD
10 RYZEN 9 3900X 12-CORE 24 15,020 360,480 AMD
11 XEON CPU E5-2690 V4 @ 2.60GHZ 28 11,309 316,652 Intel
12 RYZEN 7 3700X 8-CORE 16 17,668 282,688 AMD
13 CORE I9-10850K CPU @ 3.60GHZ 20 13,669 273,380 Intel
14 CORE I9-10900X CPU @ 3.70GHZ 20 13,476 269,520 Intel
15 XEON CPU E5-2680 V3 @ 2.50GHZ 24 11,206 268,944 Intel
16 11TH GEN CORE I9-11900K @ 3.50GHZ 16 16,373 261,968 Intel
17 RYZEN THREADRIPPER 2970WX 24-CORE 48 4,807 230,736 AMD
18 CORE I9-9900K CPU @ 3.60GHZ 16 14,283 228,528 Intel
19 PENTIUM(R) CPU G2020T @ 2.50GHZ 2 112,941 225,882 Intel
20 RYZEN 5 3600X 6-CORE 12 18,565 222,780 AMD
21 11TH GEN CORE I7-11700K @ 3.60GHZ 16 13,652 218,432 Intel
22 CORE I5-7400 CPU @ 3.00GHZ 4 53,994 215,976 Intel
23 RYZEN 5 5600G 12 17,763 213,156 AMD
24 RYZEN 5 5600X 6-CORE 12 17,761 213,132 AMD
25 RYZEN THREADRIPPER 1920X 12-CORE 24 8,720 209,280 AMD
26 XEON W-2175 CPU @ 2.50GHZ 28 7,315 204,820 Intel
27 CORE I9-9900 CPU @ 3.10GHZ 16 12,100 193,600 Intel
28 11TH GEN CORE I5-11600K @ 3.90GHZ 12 14,680 176,160 Intel
29 CORE I7-9700K CPU @ 3.60GHZ 8 21,099 168,792 Intel
30 RYZEN 5 3600 6-CORE 12 13,459 161,508 AMD
31 CORE I7-8700 CPU @ 3.20GHZ 12 13,154 157,848 Intel
32 CORE I7-8700K CPU @ 3.70GHZ 12 12,873 154,476 Intel
33 11TH GEN CORE I9-11900F @ 2.50GHZ 16 9,582 153,312 Intel
34 CORE I7-9700 CPU @ 3.00GHZ 8 18,352 146,816 Intel
35 RYZEN 5 3500X 6-CORE 6 23,843 143,058 AMD
36 RYZEN 7 4800H 16 8,796 140,736 AMD
37 CORE I7-10870H CPU @ 2.20GHZ 16 8,290 132,640 Intel
38 RYZEN 7 2700X EIGHT-CORE 16 8,261 132,176 AMD
39 CORE I7-10700 CPU @ 2.90GHZ 16 8,258 132,128 Intel
40 CORE I5-10400F CPU @ 2.90GHZ 12 10,991 131,892 Intel
41 RYZEN 7 PRO 4750G 16 7,171 114,736 AMD
42 CORE I3-10105F CPU @ 3.70GHZ 8 14,266 114,128 Intel
43 CORE I5-10400 CPU @ 2.90GHZ 12 9,379 112,548 Intel
44 RYZEN 5 2600X SIX-CORE 12 8,988 107,856 AMD
45 CORE I7-5820K CPU @ 3.30GHZ 12 8,882 106,584 Intel
46 CORE I7-9700T CPU @ 2.00GHZ 8 12,252 98,016 Intel
47 CORE I7-4790K CPU @ 4.00GHZ 8 11,323 90,584 Intel
48 CELERON(R) CPU G550 @ 2.60GHZ 2 42,518 85,036 Intel
49 EPYC 7251 8-CORE 16 5,240 83,840 AMD
50 CORE I7-7700 CPU @ 3.60GHZ 8 10,478 83,824 Intel
51 CORE I7-6700K CPU @ 4.00GHZ 8 10,297 82,376 Intel
52 CORE I7-8705G CPU @ 3.10GHZ 8 9,791 78,328 Intel
53 XEON W-10855M CPU @ 2.80GHZ 12 6,512 78,144 Intel
54 CORE I3-9100F CPU @ 3.60GHZ 4 18,546 74,184 Intel
55 CORE I7-10750H CPU @ 2.60GHZ 12 5,532 66,384 Intel
56 RYZEN 5 2600 SIX-CORE 12 5,427 65,124 AMD
57 11TH GEN CORE I5-11400 @ 2.60GHZ 12 5,249 62,988 Intel
58 CORE I7-4790 CPU @ 3.60GHZ 8 7,869 62,952 Intel
59 CORE I7-6700 CPU @ 3.40GHZ 8 7,798 62,384 Intel
60 CORE I7-4770K CPU @ 3.50GHZ 8 7,539 60,312 Intel
61 CORE I9-8950HK CPU @ 2.90GHZ 12 4,924 59,088 Intel
62 CORE I5-6500 CPU @ 3.20GHZ 4 13,857 55,428 Intel
63 CORE2 DUO CPU E8400 @ 3.00GHZ 2 27,527 55,054 Intel
64 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,630 53,040 Intel
65 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,577 52,616 Intel
66 CORE I5-8300H CPU @ 2.30GHZ 8 6,511 52,088 Intel
67 CORE I7-10510U CPU @ 1.80GHZ 8 6,498 51,984 Intel
68 CORE I7-4980HQ CPU @ 2.80GHZ 8 6,408 51,264 Intel
69 CORE I5-6300HQ CPU @ 2.30GHZ 4 12,379 49,516 Intel
70 CORE I5-4690K CPU @ 3.50GHZ 4 11,968 47,872 Intel
71 CORE I7-8550U CPU @ 1.80GHZ 8 5,711 45,688 Intel
72 CORE I7-4790T CPU @ 2.70GHZ 8 5,494 43,952 Intel
73 XEON CPU E5-1620 0 @ 3.60GHZ 8 5,294 42,352 Intel
74 CORE I5-4570S CPU @ 2.90GHZ 4 10,382 41,528 Intel
75 RYZEN 7 2700 EIGHT-CORE 16 2,520 40,320 AMD
76 XEON CPU X5670 @ 2.93GHZ 12 3,327 39,924 Intel
77 CORE I5-4590 CPU @ 3.30GHZ 4 9,875 39,500 Intel
78 XEON CPU E5-2620 0 @ 2.00GHZ 12 3,258 39,096 Intel
79 RYZEN 5 4500U 6 6,338 38,028 AMD
80 CORE I7-7700HQ CPU @ 2.80GHZ 8 4,734 37,872 Intel
81 CORE I5-6400 CPU @ 2.70GHZ 4 9,292 37,168 Intel
82 CORE I7-6700HQ CPU @ 2.60GHZ 8 4,462 35,696 Intel
83 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,724 34,344 Intel
84 CORE I3-6100 CPU @ 3.70GHZ 4 8,379 33,516 Intel
85 CORE I5-6600K CPU @ 3.50GHZ 4 8,153 32,612 Intel
86 RYZEN 5 3400G 8 3,904 31,232 AMD
87 CORE I3-4150 CPU @ 3.50GHZ 4 7,676 30,704 Intel
88 CORE I5-7600 CPU @ 3.50GHZ 4 7,665 30,660 Intel
89 CORE I5-5200U CPU @ 2.20GHZ 4 7,469 29,876 Intel
90 CORE I5-3330 CPU @ 3.00GHZ 4 7,275 29,100 Intel
91 CORE I5-9300H CPU @ 2.40GHZ 8 3,627 29,016 Intel
92 CORE I5-4460 CPU @ 3.20GHZ 4 7,059 28,236 Intel
93 RYZEN 5 1600 SIX-CORE 12 2,324 27,888 AMD
94 CORE I3-7100 CPU @ 3.90GHZ 4 6,607 26,428 Intel
95 CORE I7-3610QM CPU @ 2.30GHZ 8 3,261 26,088 Intel
96 CORE I5-2520M CPU @ 2.50GHZ 4 6,004 24,016 Intel
97 CORE I7-2600 CPU @ 3.40GHZ 8 2,984 23,872 Intel
98 XEON CPU W3550 @ 3.07GHZ 8 2,951 23,608 Intel
99 XEON E-2124G CPU @ 3.40GHZ 4 5,749 22,996 Intel
100 FX-8350 EIGHT-CORE 8 2,620 20,960 AMD
101 CORE I5-2400S CPU @ 2.50GHZ 4 5,168 20,672 Intel
102 CORE I5-3570K CPU @ 3.40GHZ 4 4,796 19,184 Intel
103 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 2,149 17,192 Intel
104 CORE I5-4300U CPU @ 1.90GHZ 4 4,260 17,040 Intel
105 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,229 16,916 Intel
106 CORE I5-3570 CPU @ 3.40GHZ 4 4,172 16,688 Intel
107 CORE I5-7200U CPU @ 2.50GHZ 4 4,006 16,024 Intel
108 FX-8320 EIGHT-CORE 8 1,958 15,664 AMD
109 CORE I5-6300U CPU @ 2.40GHZ 4 3,881 15,524 Intel
110 RYZEN 3 3200G 4 3,693 14,772 AMD
111 CORE I3-6006U CPU @ 2.00GHZ 4 3,255 13,020 Intel
112 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,787 11,148 Intel
113 CORE I3-3110M CPU @ 2.40GHZ 4 2,768 11,072 Intel
114 RYZEN 3 3250U 4 2,448 9,792 AMD
115 A10-6700 APU RADEON(TM) HD GRAPHICS 4 2,233 8,932 AMD
116 RYZEN 5 3500U 8 785 6,280 AMD
117 XEON CPU E5-2670 V3 @ 2.30GHZ 1 4,688 4,688 Intel
118 ATHLON 200GE 4 1,002 4,008 AMD
119 A8-6410 APU 4 328 1,312 AMD