PROJECT #18206 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 23 July 2021 12:13:38

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 23 July 2021 12:13:38

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CORE I5-6600K CPU @ 3.50GHZ 4 704,879 2,819,516 Intel
2 CORE I5-7400 CPU @ 3.00GHZ 4 255,583 1,022,332 Intel
3 RYZEN 9 3950X 16-CORE 32 28,401 908,832 AMD
4 RYZEN THREADRIPPER 3960X 24-CORE 48 12,235 587,280 AMD
5 RYZEN 9 5950X 16-CORE 32 16,444 526,208 AMD
6 RYZEN 9 3900 12-CORE 24 20,080 481,920 AMD
7 RYZEN 9 3900XT 12-CORE 24 19,858 476,592 AMD
8 RYZEN 9 5900X 12-CORE 24 18,248 437,952 AMD
9 RYZEN 7 5800X 8-CORE 16 27,110 433,760 AMD
10 XEON CPU E5-2690 V4 @ 2.60GHZ 28 14,059 393,652 Intel
11 RYZEN 5 5600X 6-CORE 12 23,600 283,200 AMD
12 RYZEN 7 3800X 8-CORE 16 17,451 279,216 AMD
13 CORE I9-10900X CPU @ 3.70GHZ 20 13,321 266,420 Intel
14 11TH GEN CORE I9-11900K @ 3.50GHZ 16 16,373 261,968 Intel
15 RYZEN 7 3700X 8-CORE 16 14,702 235,232 AMD
16 RYZEN THREADRIPPER 2970WX 24-CORE 48 4,807 230,736 AMD
17 XEON CPU E5-2680 V3 @ 2.50GHZ 24 9,410 225,840 Intel
18 RYZEN 5 3600X 6-CORE 12 18,565 222,780 AMD
19 11TH GEN CORE I7-11700K @ 3.60GHZ 16 13,377 214,032 Intel
20 CORE I7-9700K CPU @ 3.60GHZ 8 21,484 171,872 Intel
21 RYZEN 5 3600 6-CORE 12 14,072 168,864 AMD
22 11TH GEN CORE I9-11900F @ 2.50GHZ 16 10,058 160,928 Intel
23 11TH GEN CORE I5-11600K @ 3.90GHZ 12 13,274 159,288 Intel
24 CORE I7-8700 CPU @ 3.20GHZ 12 11,312 135,744 Intel
25 CORE I7-10700 CPU @ 2.90GHZ 16 8,440 135,040 Intel
26 CORE I5-10400F CPU @ 2.90GHZ 12 11,251 135,012 Intel
27 CORE I7-10870H CPU @ 2.20GHZ 16 8,231 131,696 Intel
28 RYZEN 7 2700X EIGHT-CORE 16 8,038 128,608 AMD
29 CORE I5-10400 CPU @ 2.90GHZ 12 8,929 107,148 Intel
30 CORE I7-9700T CPU @ 2.00GHZ 8 12,252 98,016 Intel
31 CORE I7-4790K CPU @ 4.00GHZ 8 11,323 90,584 Intel
32 RYZEN 5 2600 SIX-CORE 12 7,130 85,560 AMD
33 CELERON(R) CPU G550 @ 2.60GHZ 2 42,518 85,036 Intel
34 CORE I7-6700K CPU @ 4.00GHZ 8 10,193 81,544 Intel
35 XEON W-10855M CPU @ 2.80GHZ 12 6,756 81,072 Intel
36 CORE I3-9100F CPU @ 3.60GHZ 4 18,546 74,184 Intel
37 CORE I7-7700 CPU @ 3.60GHZ 8 9,091 72,728 Intel
38 CORE I7-10750H CPU @ 2.60GHZ 12 5,381 64,572 Intel
39 CORE I7-4790 CPU @ 3.60GHZ 8 7,869 62,952 Intel
40 CORE I5-7600 CPU @ 3.50GHZ 4 15,050 60,200 Intel
41 CORE I5-6500 CPU @ 3.20GHZ 4 13,857 55,428 Intel
42 CORE I5-8300H CPU @ 2.30GHZ 8 6,575 52,600 Intel
43 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,437 51,496 Intel
44 CORE I7-4770K CPU @ 3.50GHZ 8 5,959 47,672 Intel
45 CORE I5-4690K CPU @ 3.50GHZ 4 11,891 47,564 Intel
46 CORE I7-4790T CPU @ 2.70GHZ 8 5,862 46,896 Intel
47 CORE I7-8550U CPU @ 1.80GHZ 8 5,711 45,688 Intel
48 11TH GEN CORE I5-11400 @ 2.60GHZ 12 3,630 43,560 Intel
49 CORE I5-4590 CPU @ 3.30GHZ 4 10,801 43,204 Intel
50 CORE I5-4570S CPU @ 2.90GHZ 4 10,382 41,528 Intel
51 RYZEN 5 2600X SIX-CORE 12 3,374 40,488 AMD
52 RYZEN 7 2700 EIGHT-CORE 16 2,520 40,320 AMD
53 XEON CPU X5670 @ 2.93GHZ 12 3,327 39,924 Intel
54 CORE I7-6700HQ CPU @ 2.60GHZ 8 4,462 35,696 Intel
55 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,724 34,344 Intel
56 XEON CPU W3550 @ 3.07GHZ 8 3,854 30,832 Intel
57 CORE I5-3330 CPU @ 3.00GHZ 4 7,275 29,100 Intel
58 CORE I5-9300H CPU @ 2.40GHZ 8 3,627 29,016 Intel
59 RYZEN 5 1600 SIX-CORE 12 2,324 27,888 AMD
60 CORE I3-7100 CPU @ 3.90GHZ 4 6,607 26,428 Intel
61 CORE I7-3610QM CPU @ 2.30GHZ 8 3,261 26,088 Intel
62 CORE I5-2400S CPU @ 2.50GHZ 4 5,168 20,672 Intel
63 CORE I7-2600 CPU @ 3.40GHZ 8 2,532 20,256 Intel
64 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,269 17,076 Intel
65 CORE I5-3570 CPU @ 3.40GHZ 4 4,172 16,688 Intel
66 FX-8320 EIGHT-CORE 8 1,958 15,664 AMD
67 CORE I5-6300U CPU @ 2.40GHZ 4 3,881 15,524 Intel
68 CORE I3-6006U CPU @ 2.00GHZ 4 3,253 13,012 Intel
69 CORE I5-7200U CPU @ 2.50GHZ 4 3,174 12,696 Intel
70 CORE I3-3110M CPU @ 2.40GHZ 4 2,768 11,072 Intel
71 A10-6700 APU RADEON(TM) HD GRAPHICS 4 2,233 8,932 AMD
72 XEON CPU E5-2670 V3 @ 2.30GHZ 1 4,688 4,688 Intel
73 CORE2 DUO CPU E8400 @ 3.00GHZ 2 2,065 4,130 Intel
74 A8-6410 APU 4 344 1,376 AMD