PROJECT #18212 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Friday, 30 July 2021 03:40:21

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Friday, 30 July 2021 03:40:21

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3950X 16-CORE 32 29,074 930,368 AMD
2 RYZEN THREADRIPPER 3960X 24-CORE 48 12,606 605,088 AMD
3 RYZEN 9 5950X 16-CORE 32 17,482 559,424 AMD
4 RYZEN 9 5900X 12-CORE 24 20,908 501,792 AMD
5 RYZEN 9 3900XT 12-CORE 24 20,366 488,784 AMD
6 RYZEN 9 3900 12-CORE 24 19,966 479,184 AMD
7 XEON CPU E5-2690 V4 @ 2.60GHZ 28 14,310 400,680 Intel
8 RYZEN 7 5800X 8-CORE 16 22,815 365,040 AMD
9 CORE I3-5005U CPU @ 2.00GHZ 4 91,017 364,068 Intel
10 RYZEN 7 3800X 8-CORE 16 17,342 277,472 AMD
11 11TH GEN CORE I9-11900K @ 3.50GHZ 16 16,588 265,408 Intel
12 RYZEN 5 5600X 6-CORE 12 21,858 262,296 AMD
13 CORE I9-10900X CPU @ 3.70GHZ 20 13,104 262,080 Intel
14 RYZEN 7 3700X 8-CORE 16 14,771 236,336 AMD
15 RYZEN 5 3600X 6-CORE 12 19,186 230,232 AMD
16 XEON CPU E5-2680 V3 @ 2.50GHZ 24 9,287 222,888 Intel
17 11TH GEN CORE I7-11700K @ 3.60GHZ 16 12,414 198,624 Intel
18 RYZEN 5 3600 6-CORE 12 14,724 176,688 AMD
19 CORE I7-9700K CPU @ 3.60GHZ 8 21,085 168,680 Intel
20 11TH GEN CORE I5-11600K @ 3.90GHZ 12 12,639 151,668 Intel
21 RYZEN 7 2700 EIGHT-CORE 16 8,881 142,096 AMD
22 XEON CPU E7- 8870 @ 2.40GHZ 40 3,443 137,720 Intel
23 CORE I7-10870H CPU @ 2.20GHZ 16 8,340 133,440 Intel
24 RYZEN 7 2700X EIGHT-CORE 16 8,288 132,608 AMD
25 CORE I7-8700 CPU @ 3.20GHZ 12 10,955 131,460 Intel
26 CORE I7-10700 CPU @ 2.90GHZ 16 8,089 129,424 Intel
27 CORE I5-10400F CPU @ 2.90GHZ 12 10,389 124,668 Intel
28 CORE I7-8700K CPU @ 3.70GHZ 12 10,046 120,552 Intel
29 CORE I5-10400 CPU @ 2.90GHZ 12 9,437 113,244 Intel
30 CORE I7-9700T CPU @ 2.00GHZ 8 12,058 96,464 Intel
31 RYZEN 5 2600 SIX-CORE 12 7,109 85,308 AMD
32 XEON W-10855M CPU @ 2.80GHZ 12 6,665 79,980 Intel
33 CORE I7-6700K CPU @ 4.00GHZ 8 9,954 79,632 Intel
34 CORE I7-3770 CPU @ 3.40GHZ 8 9,555 76,440 Intel
35 XEON CPU E3-1241 V3 @ 3.50GHZ 8 9,454 75,632 Intel
36 CORE I7-7700 CPU @ 3.60GHZ 8 8,854 70,832 Intel
37 CORE I7-5820K CPU @ 3.30GHZ 12 5,852 70,224 Intel
38 CORE I7-4790K CPU @ 4.00GHZ 8 8,336 66,688 Intel
39 CORE I5-7600 CPU @ 3.50GHZ 4 14,532 58,128 Intel
40 CORE I5-6500 CPU @ 3.20GHZ 4 14,282 57,128 Intel
41 CORE I5-7400 CPU @ 3.00GHZ 4 13,240 52,960 Intel
42 CORE I5-8300H CPU @ 2.30GHZ 8 6,458 51,664 Intel
43 11TH GEN CORE I5-11400 @ 2.60GHZ 12 4,011 48,132 Intel
44 CORE I5-4690K CPU @ 3.50GHZ 4 11,581 46,324 Intel
45 CORE I7-8550U CPU @ 1.80GHZ 8 5,729 45,832 Intel
46 CORE I5-4590 CPU @ 3.30GHZ 4 10,666 42,664 Intel
47 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 5,204 41,632 Intel
48 CORE I5-4570S CPU @ 2.90GHZ 4 10,149 40,596 Intel
49 CORE I7-4790T CPU @ 2.70GHZ 8 5,041 40,328 Intel
50 CORE I7-8750H CPU @ 2.20GHZ 12 3,325 39,900 Intel
51 XEON CPU X5670 @ 2.93GHZ 12 3,261 39,132 Intel
52 CORE I9-9980HK CPU @ 2.40GHZ 16 2,253 36,048 Intel
53 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,657 33,942 Intel
54 CORE I5-9300H CPU @ 2.40GHZ 8 4,018 32,144 Intel
55 CORE I3-7100 CPU @ 3.90GHZ 4 7,576 30,304 Intel
56 RYZEN 7 PRO 4750G 16 1,835 29,360 AMD
57 XEON CPU W3550 @ 3.07GHZ 8 3,567 28,536 Intel
58 RYZEN 5 2600X SIX-CORE 12 2,266 27,192 AMD
59 CORE I5-3330 CPU @ 3.00GHZ 4 6,771 27,084 Intel
60 CORE I7-2600 CPU @ 3.40GHZ 8 3,156 25,248 Intel
61 CORE I7-3610QM CPU @ 2.30GHZ 8 3,011 24,088 Intel
62 CORE I5-4570 CPU @ 3.20GHZ 4 4,407 17,628 Intel
63 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,142 16,568 Intel
64 FX-8320 EIGHT-CORE 8 2,013 16,104 AMD
65 CORE I5-3570 CPU @ 3.40GHZ 4 3,982 15,928 Intel
66 CORE I5-7200U CPU @ 2.50GHZ 4 3,368 13,472 Intel
67 CORE I3-6006U CPU @ 2.00GHZ 4 3,263 13,052 Intel
68 RYZEN 5 3500U 8 1,523 12,184 AMD
69 CORE I3-3110M CPU @ 2.40GHZ 4 2,761 11,044 Intel
70 CORE I5-6300U CPU @ 2.40GHZ 4 2,394 9,576 Intel
71 A10-6700 APU RADEON(TM) HD GRAPHICS 4 2,147 8,588 AMD
72 FX-8800P RADEON R7, 12 COMPUTE CORES 4C+8G 4 2,132 8,528 AMD
73 PENTIUM(R) CPU G3220 @ 3.00GHZ 2 2,414 4,828 Intel
74 CORE2 DUO CPU E8400 @ 3.00GHZ 2 2,290 4,580 Intel
75 CELERON(R) CPU G550 @ 2.60GHZ 2 1,845 3,690 Intel
76 A8-6410 APU 4 321 1,284 AMD