PROJECT #18212 RESEARCH FOR ALZHEIMERS
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Alzheimer's disease is a significant cause of death in the USA and there are no effective treatments to halt or reverse disease progression. Genetic polymorphisms (changes to the amino acids that comprise the protein) in apolipoprotein E (ApoE) are one of the strongest predictors of Alzheimer’s disease. There are three dominant alleles (versions) of ApoE that are found in humans. Each ApoE allele differs only by a single amino acid substitution. ApoE3 is most common and carries a neutral risk for AD. Carriers of ApoE2 (R158C) appear protected from Alzehimer's disease, whereas ApoE4 (C112R) carriers are 12-fold more likely to develop Alzheimer's disease. Finally, a recent variant in ApoE3, ApoEchristchurch (R136S) has emerged which also appears to protect from Alzheimer's disease. How these mutations in ApoE contribute to Alzheimer's disease, as well as how mutations in ApoE impact ApoE function, remains unclear. It is clear that ApoE isoforms can protect from Alzheimer's, suggesting that ApoE targeted therapeutics may be a means of reversing or preventing Alzheimer's disease progression. Here, we will simulate how one varaiants of ApoE move in solution. We hope these simulations will lead to a better understanding of how ApoE contributes to Alzheimer's disease.

PROJECT INFO

Manager(s): Justin Miller

Institution: Washington University in St. Louis

PROJECT WORK UNIT SUMMARY

Atoms: 302,700

Core: GRO_A8

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Sunday, 17 October 2021 11:35:57

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
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PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Sunday, 17 October 2021 11:35:57

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 CORE I7-1065G7 CPU @ 1.30GHZ 8 268,382 2,147,056 Intel
2 RYZEN 9 3950X 16-CORE 32 29,348 939,136 AMD
3 RYZEN 9 5950X 16-CORE 32 18,652 596,864 AMD
4 RYZEN THREADRIPPER 3960X 24-CORE 48 12,398 595,104 AMD
5 RYZEN 9 5900X 12-CORE 24 20,691 496,584 AMD
6 RYZEN 7 5800X 8-CORE 16 30,707 491,312 AMD
7 RYZEN 9 3900 12-CORE 24 19,966 479,184 AMD
8 XEON CPU E5-2690 V4 @ 2.60GHZ 28 13,108 367,024 Intel
9 RYZEN 9 3900X 12-CORE 24 15,235 365,640 AMD
10 CORE I3-5005U CPU @ 2.00GHZ 4 91,017 364,068 Intel
11 RYZEN THREADRIPPER 2950X 16-CORE 32 11,059 353,888 AMD
12 RYZEN 7 3800X 8-CORE 16 21,669 346,704 AMD
13 CORE I9-10850K CPU @ 3.60GHZ 20 13,725 274,500 Intel
14 11TH GEN CORE I9-11900K @ 3.50GHZ 16 16,588 265,408 Intel
15 CORE I9-10900X CPU @ 3.70GHZ 20 13,241 264,820 Intel
16 RYZEN 7 3700X 8-CORE 16 15,822 253,152 AMD
17 RYZEN 5 5600X 6-CORE 12 20,323 243,876 AMD
18 XEON CPU E5-2680 V3 @ 2.50GHZ 24 9,758 234,192 Intel
19 RYZEN 5 3600X 6-CORE 12 19,186 230,232 AMD
20 RYZEN THREADRIPPER 1920X 12-CORE 24 8,777 210,648 AMD
21 11TH GEN CORE I7-11700K @ 3.60GHZ 16 12,987 207,792 Intel
22 RYZEN 9 3900XT 12-CORE 24 8,633 207,192 AMD
23 XEON W-2175 CPU @ 2.50GHZ 28 7,321 204,988 Intel
24 CORE I9-9900 CPU @ 3.10GHZ 16 11,194 179,104 Intel
25 RYZEN 5 3600 6-CORE 12 14,882 178,584 AMD
26 CORE I7-9700K CPU @ 3.60GHZ 8 21,110 168,880 Intel
27 CORE I7-9700 CPU @ 3.00GHZ 8 19,542 156,336 Intel
28 11TH GEN CORE I5-11600K @ 3.90GHZ 12 12,898 154,776 Intel
29 CORE I7-8700K CPU @ 3.70GHZ 12 12,402 148,824 Intel
30 CORE I7-8700 CPU @ 3.20GHZ 12 12,130 145,560 Intel
31 RYZEN 7 2700 EIGHT-CORE 16 8,881 142,096 AMD
32 XEON CPU E7- 8870 @ 2.40GHZ 40 3,443 137,720 Intel
33 RYZEN 7 2700X EIGHT-CORE 16 8,493 135,888 AMD
34 CORE I7-10870H CPU @ 2.20GHZ 16 8,340 133,440 Intel
35 RYZEN 7 4800H 16 8,233 131,728 AMD
36 CORE I7-10700 CPU @ 2.90GHZ 16 8,072 129,152 Intel
37 CORE I5-10400F CPU @ 2.90GHZ 12 10,222 122,664 Intel
38 CORE I5-10400 CPU @ 2.90GHZ 12 9,558 114,696 Intel
39 11TH GEN CORE I9-11900F @ 2.50GHZ 16 6,994 111,904 Intel
40 CORE I7-7700 CPU @ 3.60GHZ 8 12,217 97,736 Intel
41 CORE I7-9700T CPU @ 2.00GHZ 8 12,058 96,464 Intel
42 XEON CPU E5-2690 V3 @ 2.60GHZ 12 7,425 89,100 Intel
43 CORE I7-6700K CPU @ 4.00GHZ 8 10,102 80,816 Intel
44 XEON W-10855M CPU @ 2.80GHZ 12 6,535 78,420 Intel
45 CORE I7-8705G CPU @ 3.10GHZ 8 9,569 76,552 Intel
46 CORE I7-3770 CPU @ 3.40GHZ 8 9,555 76,440 Intel
47 XEON CPU E3-1241 V3 @ 3.50GHZ 8 9,454 75,632 Intel
48 RYZEN 5 2600 SIX-CORE 12 6,301 75,612 AMD
49 11TH GEN CORE I7-1165G7 @ 2.80GHZ 8 8,866 70,928 Intel
50 CORE I7-10750H CPU @ 2.60GHZ 12 5,857 70,284 Intel
51 CORE I7-5820K CPU @ 3.30GHZ 12 5,852 70,224 Intel
52 CORE I7-4790K CPU @ 4.00GHZ 8 8,336 66,688 Intel
53 CORE I5-6500 CPU @ 3.20GHZ 4 14,282 57,128 Intel
54 RYZEN 7 PRO 4750G 16 3,528 56,448 AMD
55 CORE I7-4770HQ CPU @ 2.20GHZ 8 6,931 55,448 Intel
56 CORE I5-7600 CPU @ 3.50GHZ 4 13,708 54,832 Intel
57 CORE I5-7400 CPU @ 3.00GHZ 4 13,448 53,792 Intel
58 11TH GEN CORE I5-1135G7 @ 2.40GHZ 8 6,717 53,736 Intel
59 CORE I7-10510U CPU @ 1.80GHZ 8 6,506 52,048 Intel
60 11TH GEN CORE I5-11400 @ 2.60GHZ 12 4,330 51,960 Intel
61 CORE I5-8300H CPU @ 2.30GHZ 8 6,458 51,664 Intel
62 CORE I7-6700 CPU @ 3.40GHZ 8 6,194 49,552 Intel
63 RYZEN 5 1600 SIX-CORE 12 4,115 49,380 AMD
64 CORE I9-8950HK CPU @ 2.90GHZ 12 4,047 48,564 Intel
65 RYZEN 5 3400G 8 5,984 47,872 AMD
66 CORE I5-4690K CPU @ 3.50GHZ 4 11,581 46,324 Intel
67 CORE I7-8550U CPU @ 1.80GHZ 8 5,729 45,832 Intel
68 CORE I7-4790T CPU @ 2.70GHZ 8 5,512 44,096 Intel
69 CORE I5-4690S CPU @ 3.20GHZ 4 10,825 43,300 Intel
70 CORE I5-4590 CPU @ 3.30GHZ 4 10,177 40,708 Intel
71 CORE I5-4570S CPU @ 2.90GHZ 4 10,149 40,596 Intel
72 CORE I7-8750H CPU @ 2.20GHZ 12 3,325 39,900 Intel
73 CORE I7-4980HQ CPU @ 2.80GHZ 8 4,959 39,672 Intel
74 XEON CPU X5670 @ 2.93GHZ 12 3,261 39,132 Intel
75 XEON CPU E5-2620 0 @ 2.00GHZ 12 3,258 39,096 Intel
76 CORE I3-10100 CPU @ 3.60GHZ 8 4,691 37,528 Intel
77 CORE I9-9980HK CPU @ 2.40GHZ 16 2,253 36,048 Intel
78 CORE I3-6100 CPU @ 3.70GHZ 4 8,798 35,192 Intel
79 XEON CPU E5-2678 V3 @ 2.50GHZ 6 5,657 33,942 Intel
80 CORE I5-6600K CPU @ 3.50GHZ 4 8,131 32,524 Intel
81 CORE I5-9300H CPU @ 2.40GHZ 8 4,018 32,144 Intel
82 CORE I3-7100 CPU @ 3.90GHZ 4 7,576 30,304 Intel
83 XEON CPU W3550 @ 3.07GHZ 8 3,567 28,536 Intel
84 RYZEN 5 2600X SIX-CORE 12 2,266 27,192 AMD
85 CORE I5-3330 CPU @ 3.00GHZ 4 6,771 27,084 Intel
86 CORE I7-4770K CPU @ 3.50GHZ 8 3,262 26,096 Intel
87 CORE I7-2600 CPU @ 3.40GHZ 8 3,228 25,824 Intel
88 CORE I7-3610QM CPU @ 2.30GHZ 8 3,102 24,816 Intel
89 FX-8350 EIGHT-CORE 8 2,688 21,504 AMD
90 CORE I5-4570 CPU @ 3.20GHZ 4 4,379 17,516 Intel
91 CORE I5-4300U CPU @ 1.90GHZ 4 4,360 17,440 Intel
92 CORE I5-6300HQ CPU @ 2.30GHZ 4 4,216 16,864 Intel
93 CORE M3-7Y30 CPU @ 1.00GHZ 4 4,128 16,512 Intel
94 FX-8320 EIGHT-CORE 8 2,013 16,104 AMD
95 CORE I5-3570 CPU @ 3.40GHZ 4 3,982 15,928 Intel
96 CORE I5-7200U CPU @ 2.50GHZ 4 3,470 13,880 Intel
97 CORE I3-6006U CPU @ 2.00GHZ 4 3,316 13,264 Intel
98 RYZEN 3 2200G 4 3,286 13,144 AMD
99 RYZEN 5 3500U 8 1,523 12,184 AMD
100 PENTIUM(R) SILVER N5000 CPU @ 1.10GHZ 4 2,846 11,384 Intel
101 CORE I3-3110M CPU @ 2.40GHZ 4 2,761 11,044 Intel
102 CORE I5-6300U CPU @ 2.40GHZ 4 2,394 9,576 Intel
103 A10-6700 APU RADEON(TM) HD GRAPHICS 4 2,147 8,588 AMD
104 FX-8800P RADEON R7, 12 COMPUTE CORES 4C+8G 4 2,132 8,528 AMD
105 RYZEN 3 3250U 4 1,701 6,804 AMD
106 PENTIUM(R) CPU G3220 @ 3.00GHZ 2 2,414 4,828 Intel
107 CORE2 DUO CPU E8400 @ 3.00GHZ 2 2,266 4,532 Intel
108 CELERON(R) CPU G550 @ 2.60GHZ 2 1,845 3,690 Intel
109 A8-6410 APU 4 321 1,284 AMD