Folding project #16609, COVID-19 research

Research section Research projects and references

Project #16609 overview

Project Summary AI Beta

This project uses computer simulations to study how SARS-CoV-2's nsp12 and nsp14 proteins work. They'll test existing drugs, like Ribirine, to see if they can block these proteins and stop the virus from replicating.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Prof. Xuhui Huang
Institution: Hong Kong University of Science and Technology

Work unit

Atoms: 473,039
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site 16603: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16604: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and GTP. 16605: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16606: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16607: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16608: RdRp and helicase of SARS-CoV-2 in complex with dsRNA 16609: RdRp and helicase of SARS-CoV-2 in complex with dsRNA.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

Nonstructural protein 12

A viral protein involved in RNA replication.

Technical: BiotechnologyVirology / Coronavirus

Nonstructural protein 12 (nsp12) is a crucial enzyme found in coronaviruses like SARS-CoV-2. It's responsible for copying the virus's genetic material, RNA, which is essential for the virus to replicate and spread.

Nonstructural protein 14

A viral protein involved in RNA proofreading and repair.

Technical: BiotechnologyVirology / Coronavirus

Nonstructural protein 14 (nsp14) plays a vital role in correcting errors during the replication of the coronavirus's RNA genome. It acts like a proofreader, ensuring the genetic information is copied accurately.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

Scientific: BiotechnologyVirology / Coronavirus

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. It's a type of coronavirus that primarily affects the respiratory system, causing symptoms like fever, cough, and difficulty breathing.

NTP

Nucleoside Triphosphate

Acronym: BiotechnologyPharmacology / Drug Development

NTPs are molecules essential for DNA and RNA synthesis. They serve as building blocks for genetic material in cells.

FDA

Food and Drug Administration

Acronym: BiotechnologyRegulatory / Pharmaceutical Approval

The FDA is a US government agency responsible for ensuring the safety and effectiveness of drugs, medical devices, and other products before they are available to the public.

RdRp

RNA-dependent RNA Polymerase

Acronym: BiotechnologyVirology / RNA Replication

RdRp is an enzyme crucial for replicating RNA genomes in viruses like SARS-CoV-2. It reads the viral RNA and synthesizes a new complementary strand.

dsRNA

Double-stranded RNA

Acronym: BiotechnologyVirology / RNA Interactions

dsRNA consists of two complementary RNA strands bound together. It plays a role in various biological processes, including viral replication and gene regulation.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	7,360,790	666,390	11.05	2 ^hrs 10 ^mins
2	GeForce RTX 3080 Ti GA102 [GeForce RTX 3080 Ti]	Nvidia	GA102	7,274,309	667,819	10.89	2 ^hrs 12 ^mins
3	GeForce RTX 3080 Lite Hash Rate GA102 [GeForce RTX 3080 Lite Hash Rate]	Nvidia	GA102	5,893,325	621,475	9.48	2 ^hrs 32 ^mins
4	GeForce RTX 3080 GA102 [GeForce RTX 3080]	Nvidia	GA102	5,773,260	612,405	9.43	2 ^hrs 33 ^mins
5	GeForce RTX 3070 Ti GA104 [GeForce RTX 3070 Ti]	Nvidia	GA104	4,803,153	581,535	8.26	2 ^hrs 54 ^mins
6	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,376,913	565,560	7.74	3 ^hrs 6 ^mins
7	Radeon RX 6800/6800 XT / 6900 XT Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]	AMD	Navi 21	4,366,822	551,192	7.92	3 ^hrs 2 ^mins
8	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,352,883	556,031	7.83	3 ^hrs 4 ^mins
9	GeForce RTX 3070 GA104 [GeForce RTX 3070]	Nvidia	GA104	3,949,206	543,336	7.27	3 ^hrs 18 ^mins
10	GeForce RTX 3070 Lite Hash Rate GA104 [GeForce RTX 3070 Lite Hash Rate]	Nvidia	GA104	3,850,571	541,052	7.12	3 ^hrs 22 ^mins
11	GeForce RTX 3060 Ti GA104 [GeForce RTX 3060 Ti]	Nvidia	GA104	3,155,115	502,355	6.28	3 ^hrs 49 ^mins
12	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,079,814	504,474	6.11	3 ^hrs 56 ^mins
13	GeForce RTX 3060 Ti Lite Hash Rate GA104 [GeForce RTX 3060 Ti Lite Hash Rate]	Nvidia	GA104	2,967,609	475,644	6.24	3 ^hrs 51 ^mins
14	TITAN Xp GP102 [TITAN Xp] 12150	Nvidia	GP102	2,941,356	496,189	5.93	4 ^hrs 3 ^mins
15	Radeon RX 6900 XT Navi 21 [Radeon RX 6900 XT]	AMD	Navi 21	2,815,750	488,000	5.77	4 ^hrs 10 ^mins
16	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,747,185	485,490	5.66	4 ^hrs 14 ^mins
17	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,671,489	480,736	5.56	4 ^hrs 19 ^mins
18	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,671,350	480,843	5.56	4 ^hrs 19 ^mins
19	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,662,663	480,165	5.55	4 ^hrs 20 ^mins

20	GeForce RTX 3060 GA106 [GeForce RTX 3060]	Nvidia	GA106	2,504,069	469,261	5.34	4 ^hrs 30 ^mins
21	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,401,724	460,454	5.22	4 ^hrs 36 ^mins
22	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,358,936	457,997	5.15	4 ^hrs 40 ^mins
23	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	2,220,870	451,112	4.92	4 ^hrs 52 ^mins
24	GeForce RTX 3060 Mobile / Max-Q GA106M [GeForce RTX 3060 Mobile / Max-Q]	Nvidia	GA106M	2,196,087	449,903	4.88	4 ^hrs 55 ^mins
25	TITAN X GP102 [TITAN X] 6144	Nvidia	GP102	2,194,806	449,974	4.88	4 ^hrs 55 ^mins
26	GeForce RTX 3070 Mobile / Max-Q 8GB/16GB GA104M [GeForce RTX 3070 Mobile / Max-Q 8GB/16GB]	Nvidia	GA104M	2,147,349	407,986	5.26	4 ^hrs 34 ^mins
27	GeForce RTX 3060 Lite Hash Rate GA106 [GeForce RTX 3060 Lite Hash Rate]	Nvidia	GA106	2,114,208	404,658	5.22	4 ^hrs 36 ^mins
28	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	2,062,436	407,306	5.06	4 ^hrs 44 ^mins
29	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,837,038	421,318	4.36	5 ^hrs 30 ^mins
30	Tesla P40 GP102GL [Tesla P40] 11760	Nvidia	GP102GL	1,824,394	422,854	4.31	5 ^hrs 34 ^mins
31	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,653,849	409,924	4.03	5 ^hrs 57 ^mins
32	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,278,923	375,013	3.41	7 ^hrs 2 ^mins
33	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,268,987	373,301	3.40	7 ^hrs 4 ^mins
34	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,256,036	374,741	3.35	7 ^hrs 10 ^mins
35	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,252,747	371,248	3.37	7 ^hrs 7 ^mins
36	Radeon RX 5600 OEM/5600 XT/5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]	AMD	Navi 10	1,223,598	365,362	3.35	7 ^hrs 10 ^mins
37	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,182,168	361,275	3.27	7 ^hrs 20 ^mins
38	RTX A2000 Mobile GA107GLM [RTX A2000 Mobile]	Nvidia	GA107GLM	1,151,814	364,191	3.16	7 ^hrs 35 ^mins
39	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,138,138	358,147	3.18	7 ^hrs 33 ^mins

40	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile]	Nvidia	TU106M	1,105,801	336,336	3.29	7 ^hrs 18 ^mins
41	GeForce RTX 2060 Mobile / Max-Q TU106M [GeForce RTX 2060 Mobile / Max-Q] 4550	Nvidia	TU106M	1,068,261	330,643	3.23	7 ^hrs 26 ^mins
42	P104-100 GP104 [P104-100]	Nvidia	GP104	1,035,019	350,741	2.95	8 ^hrs 8 ^mins
43	GeForce GTX 1660 Mobile TU116M [GeForce GTX 1660 Mobile]	Nvidia	TU116M	1,022,377	344,805	2.97	8 ^hrs 6 ^mins
44	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,014,979	348,511	2.91	8 ^hrs 14 ^mins
45	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	943,677	340,100	2.77	8 ^hrs 39 ^mins
46	Radeon RX 6700/6700 XT / 6800M Navi 22 [Radeon RX 6700/6700 XT / 6800M]	AMD	Navi 22	917,718	328,413	2.79	8 ^hrs 35 ^mins
47	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	870,797	331,123	2.63	9 ^hrs 8 ^mins
48	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	745,521	314,609	2.37	10 ^hrs 8 ^mins
49	GeForce GTX 1070 Mobile GP104BM [GeForce GTX 1070 Mobile] 6463	Nvidia	GP104BM	744,220	314,727	2.36	10 ^hrs 9 ^mins
50	Tesla P4 GP104GL [Tesla P4] 5704	Nvidia	GP104GL	730,607	312,382	2.34	10 ^hrs 16 ^mins
51	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	727,089	310,065	2.34	10 ^hrs 14 ^mins
52	P106-100 GP106 [P106-100]	Nvidia	GP106	699,040	307,830	2.27	10 ^hrs 34 ^mins
53	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	689,581	306,563	2.25	10 ^hrs 40 ^mins
54	GeForce GTX 1060 Mobile GP106M [GeForce GTX 1060 Mobile]	Nvidia	GP106M	677,724	304,955	2.22	10 ^hrs 48 ^mins
55	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	619,412	295,737	2.09	11 ^hrs 28 ^mins
56	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	605,378	293,866	2.06	11 ^hrs 39 ^mins
57	Quadro T1200 Mobile TU117GLM [Quadro T1200 Mobile]	Nvidia	TU117GLM	551,529	284,430	1.94	12 ^hrs 23 ^mins
58	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	546,897	284,217	1.92	12 ^hrs 28 ^mins
59	Quadro T2000 Mobile / Max-Q TU117GLM [Quadro T2000 Mobile / Max-Q]	Nvidia	TU117GLM	490,270	261,529	1.87	12 ^hrs 48 ^mins

60	GeForce GTX 1650 TU117 [GeForce GTX 1650]	Nvidia	TU117	383,020	248,148	1.54	15 ^hrs 33 ^mins
61	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	349,659	245,019	1.43	16 ^hrs 49 ^mins
62	P106-090 GP106 [P106-090]	Nvidia	GP106	340,862	242,193	1.41	17 ^hrs 3 ^mins
63	GeForce GTX 1650 Mobile / Max-Q TU117M [GeForce GTX 1650 Mobile / Max-Q]	Nvidia	TU117M	328,258	229,269	1.43	16 ^hrs 46 ^mins
64	GeForce GTX 950 GM206 [GeForce GTX 950] 1572	Nvidia	GM206	292,920	230,376	1.27	18 ^hrs 53 ^mins
65	GeForce GTX 690 GK104 [GeForce GTX 690] 3130	Nvidia	GK104	272,299	222,659	1.22	19 ^hrs 37 ^mins
66	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	245,233	214,627	1.14	21 ^hrs 0 ^mins
67	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	232,778	214,403	1.09	22 ^hrs 6 ^mins
68	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	169,010	100,480	1.68	14 ^hrs 16 ^mins
69	GeForce GTX 750 Ti GM107 [GeForce GTX 750 Ti] 1389	Nvidia	GM107	159,694	188,262	0.85	28 ^hrs 18 ^mins
70	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	110,431	166,398	0.66	36 ^hrs 10 ^mins
71	GeForce 940MX GM107 [GeForce 940MX]	Nvidia	GM107	70,256	143,289	0.49	48 ^hrs 57 ^mins

Research: COVID-19 Folding Project #16609

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 16609

GPU PPD Averages

Research: COVID-19 Folding Project #16609

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages