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Research: COVID-19 Folding Project #16602

Project #16602 overview

Project Summary AI Beta

This project uses computer simulations to study how certain drugs might block the SARS-CoV-2 virus. Scientists will look at proteins like nsp12, nsp14, and how they interact with RNA during viral replication. The goal is to find existing drugs that can be repurposed to treat COVID-19.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Xuhui Huang
Institution
Hong Kong University of Science and Technology

Work unit

Atoms
208,201
Core
OPENMM_22
Status
Beta

No related projects listed.

Source material

Official Project Description

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site.

Performance data

Hardware Performance for Project 16602

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:01:43

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]		 Nvidia GA102 5,978,360 89,952 66.46 0 hrs 22 mins
2 GeForce RTX 2080
TU104 [GeForce RTX 2080]		 Nvidia TU104 2,713,127 69,370 39.11 0 hrs 37 mins
3 GeForce RTX 2060
TU104 [GeForce RTX 2060]		 Nvidia TU104 2,641,624 95,571 27.64 0 hrs 52 mins
4 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 2,510,326 67,806 37.02 0 hrs 39 mins
5 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]		 Nvidia TU104 2,265,547 65,385 34.65 0 hrs 42 mins
6 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]		 Nvidia TU106 1,987,624 62,113 32.00 0 hrs 45 mins
7 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]		 Nvidia TU116 859,495 47,562 18.07 1 hrs 20 mins
8 GeForce GTX 1660
TU116 [GeForce GTX 1660]		 Nvidia TU116 844,636 47,317 17.85 1 hrs 21 mins
9 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]		 AMD Hawaii 524,359 39,424 13.30 1 hrs 48 mins