Research section Research projects and references

Research: COVID-19 Folding Project #16603

Project #16603 overview

Project Summary AI Beta

This project uses computer models to simulate how proteins from the SARS-CoV-2 virus work. Scientists will test existing drugs, like Ribavirin, to see if they can block these proteins and stop the virus from replicating.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Prof. Xuhui Huang
Institution
Hong Kong University of Science and Technology

Work unit

Atoms
208,201
Core
OPENMM_22
Status
Public
Source material

Official Project Description

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site 16603: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16604: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and GTP.

Performance data

Hardware Performance for Project 16603

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 22:01:42

GPU PPD Averages

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 7,277,748 493,774 14.74 1 hrs 38 mins
2 GeForce RTX 3080 10GB / 20GB
GA102 [GeForce RTX 3080 10GB / 20GB]
Nvidia GA102 5,309,115 446,887 11.88 2 hrs 1 mins
3 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,848,062 432,402 11.21 2 hrs 8 mins
4 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,456,796 420,385 10.60 2 hrs 16 mins
5 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 4,242,330 413,382 10.26 2 hrs 20 mins
6 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 3,153,171 374,428 8.42 2 hrs 51 mins
7 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 2,871,625 362,338 7.93 3 hrs 2 mins
8 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A] M 7465
Nvidia TU106 2,656,327 355,014 7.48 3 hrs 12 mins
9 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,528,271 348,327 7.26 3 hrs 18 mins
10 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,423,697 341,940 7.09 3 hrs 23 mins
11 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 2,151,473 329,923 6.52 3 hrs 41 mins
12 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 2,050,965 324,858 6.31 3 hrs 48 mins
13 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,048,165 324,378 6.31 3 hrs 48 mins
14 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,703,479 305,810 5.57 4 hrs 19 mins
15 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,384,418 285,352 4.85 4 hrs 57 mins
16 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 1,245,644 275,622 4.52 5 hrs 19 mins
17 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,209,404 272,388 4.44 5 hrs 24 mins
18 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 1,162,578 268,730 4.33 5 hrs 33 mins
19 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,096,359 263,135 4.17 5 hrs 46 mins
20 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,024,971 257,969 3.97 6 hrs 2 mins
21 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 893,533 246,465 3.63 6 hrs 37 mins
22 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 875,961 245,066 3.57 6 hrs 43 mins
23 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 845,737 241,980 3.50 6 hrs 52 mins
24 P104-100
GP104 [P104-100]
Nvidia GP104 839,665 241,383 3.48 6 hrs 54 mins
25 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 602,372 215,811 2.79 8 hrs 36 mins
26 P106-100
GP106 [P106-100]
Nvidia GP106 553,501 210,052 2.64 9 hrs 6 mins
27 Radeon R9 200/300X Series
Hawaii [Radeon R9 200/300X Series]
AMD Hawaii 426,958 192,824 2.21 10 hrs 50 mins
28 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 399,687 188,514 2.12 11 hrs 19 mins
29 GeForce GTX 1650
TU116 [GeForce GTX 1650] 2984
Nvidia TU116 362,191 182,171 1.99 12 hrs 4 mins
30 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 295,232 170,611 1.73 13 hrs 52 mins
31 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 267,932 165,303 1.62 14 hrs 48 mins
32 Radeon R9 200/300 Series
Hawaii [Radeon R9 200/300 Series]
AMD Hawaii 240,201 118,879 2.02 11 hrs 53 mins
33 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 213,022 152,337 1.40 17 hrs 10 mins
34 Radeon HD 7800
Pitcairn [Radeon HD 7800]
AMD Pitcairn 136,730 131,650 1.04 23 hrs 6 mins
35 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 135,832 131,630 1.03 23 hrs 15 mins
36 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 131,123 130,084 1.01 23 hrs 49 mins
37 Radeon Rx 270/370
Curacao Pro [Radeon Rx 270/370]
AMD Curacao Pro 121,175 117,528 1.03 23 hrs 17 mins
38 Radeon R7 250/HD 7700
R575A [Radeon R7 250/HD 7700]
AMD R575A 24,750 56,630 0.44 54 hrs 55 mins
39 Radeon APU A4-6000 R2
Mullins [Radeon APU A4-6000 R2]
AMD Mullins 5,315 56,630 0.09 255 hrs 43 mins