PROJECT #18448 RESEARCH FOR INFLUENZA
FOLDING PERFORMANCE PROFILE

PROJECT SUMMARY

Designed miniprotein therapeutics occupy the middle ground between small molecule drugs and monoclonal antibody treatments for infectious disease.

Hemagglutinin is a viral fusion protein that allows H1 influenza A (HA) to bind sialic acid on cell surfaces, as well as being involved in the post-endocytosis mechanism of cellular infection.; The Baker lab at University of Washington has developed de novo designed miniproteins that bind hemagglutinin, and developed ways to improve their binding through affinity maturation.

Many of the mutations seen in affinity-matured sequences are not directly in the binding interface, and it is unclear how these changes lead to higher affinity.

Understanding this mechanism may help us better computationally design better binders.

We aim to use molecular dynamics simulations to examine ab initio binding pathways for these miniprotein binders, and use enhanced sampling methods to study the unbinding reaction.

Pairing these methods together will provide a robust description of the complete binding reaction for this system..

PROJECT INFO

Manager(s): Dylan Novack

Institution: Temple University

Project URL: http://voelzlab.org

PROJECT WORK UNIT SUMMARY

Atoms: 126,828

Core: 0x22

Status: Public

PROJECT FOLDING PPD AVERAGES BY GPU

PPDDB data as of Wednesday, 30 November 2022 06:13:31

Rank
Project
Model Name
Folding@Home Identifier
Make
Brand
GPU
Model
PPD
Average
Points WU
Average
WUs Day
Average
WU Time
Average
1 GeForce RTX 4090
AD102 [GeForce RTX 4090]
Nvidia AD102 12,636,470 380,946 33.17 0 hrs 43 mins
2 GeForce RTX 3090 Ti
GA102 [GeForce RTX 3090 Ti]
Nvidia GA102 8,007,324 332,071 24.11 0 hrs 60 mins
3 GeForce RTX 3080 Ti
GA102 [GeForce RTX 3080 Ti]
Nvidia GA102 6,425,438 306,623 20.96 1 hrs 9 mins
4 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]
Nvidia GA102 6,114,334 303,345 20.16 1 hrs 11 mins
5 GeForce RTX 3080 12GB
GA102 [GeForce RTX 3080 12GB]
Nvidia GA102 5,869,156 281,651 20.84 1 hrs 9 mins
6 GeForce RTX 3090
GA102 [GeForce RTX 3090]
Nvidia GA102 5,843,150 293,838 19.89 1 hrs 12 mins
7 RTX A6000
GA102GL [RTX A6000]
Nvidia GA102GL 5,571,247 293,646 18.97 1 hrs 16 mins
8 Radeon RX 6950 XT
Navi 21 [Radeon RX 6950 XT]
AMD Navi 21 5,569,402 288,856 19.28 1 hrs 15 mins
9 GeForce RTX 3080
GA102 [GeForce RTX 3080]
Nvidia GA102 4,748,672 271,362 17.50 1 hrs 22 mins
10 GeForce RTX 2080 Ti Rev. A
TU102 [GeForce RTX 2080 Ti Rev. A] M 13448
Nvidia TU102 4,709,726 277,604 16.97 1 hrs 25 mins
11 GeForce RTX 2080 Ti
TU102 [GeForce RTX 2080 Ti] M 13448
Nvidia TU102 4,660,318 276,803 16.84 1 hrs 26 mins
12 GeForce RTX 3070 Ti
GA104 [GeForce RTX 3070 Ti]
Nvidia GA104 4,274,042 267,337 15.99 2 hrs 30 mins
13 GeForce RTX 3070
GA104 [GeForce RTX 3070]
Nvidia GA104 3,894,168 259,950 14.98 2 hrs 36 mins
14 GeForce RTX 3070 Lite Hash Rate
GA104 [GeForce RTX 3070 Lite Hash Rate]
Nvidia GA104 3,801,518 261,362 14.55 2 hrs 39 mins
15 GeForce RTX 2080 Rev. A
TU104 [GeForce RTX 2080 Rev. A] 10068
Nvidia TU104 3,455,141 251,033 13.76 2 hrs 45 mins
16 Radeon RX 6900 XT
Navi 21 [Radeon RX 6900 XT]
AMD Navi 21 3,185,054 242,594 13.13 2 hrs 50 mins
17 Radeon RX 6800/6800 XT / 6900 XT
Navi 21 [Radeon RX 6800/6800 XT / 6900 XT]
AMD Navi 21 2,936,875 233,211 12.59 2 hrs 54 mins
18 Radeon RX 6800/6800XT/6900XT
Navi 21 [Radeon RX 6800/6800XT/6900XT]
AMD Navi 21 2,934,649 234,142 12.53 2 hrs 55 mins
19 Quadro RTX 6000/8000
TU102GL [Quadro RTX 6000/8000]
Nvidia TU102GL 2,838,709 235,787 12.04 2 hrs 60 mins
20 GeForce RTX 2080 Super
TU104 [GeForce RTX 2080 SUPER]
Nvidia TU104 2,813,396 233,406 12.05 2 hrs 59 mins
21 GeForce RTX 3060 Ti Lite Hash Rate
GA104 [GeForce RTX 3060 Ti Lite Hash Rate]
Nvidia GA104 2,766,466 232,779 11.88 2 hrs 1 mins
22 TITAN X
GP102 [TITAN X] 6144
Nvidia GP102 2,728,696 232,268 11.75 2 hrs 3 mins
23 GeForce RTX 2070 SUPER
TU104 [GeForce RTX 2070 SUPER] 8218
Nvidia TU104 2,658,484 230,364 11.54 2 hrs 5 mins
24 RTX A4000
GA104GL [RTX A4000]
Nvidia GA104GL 2,616,563 228,843 11.43 2 hrs 6 mins
25 GeForce RTX 3080 Mobile / Max-Q 8GB/16GB
GA104M [GeForce RTX 3080 Mobile / Max-Q 8GB/16GB]
Nvidia GA104M 2,605,265 224,853 11.59 2 hrs 4 mins
26 GeForce RTX 3070 Mobile / Max-Q
GA104M [GeForce RTX 3070 Mobile / Max-Q]
Nvidia GA104M 2,581,193 229,386 11.25 2 hrs 8 mins
27 GeForce RTX 2080
TU104 [GeForce RTX 2080]
Nvidia TU104 2,547,881 226,502 11.25 2 hrs 8 mins
28 GeForce RTX 2070 Rev. A
TU106 [GeForce RTX 2070 Rev. A]
Nvidia TU106 2,426,863 223,185 10.87 2 hrs 12 mins
29 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]
Nvidia GA104 2,258,564 217,288 10.39 2 hrs 19 mins
30 GeForce RTX 2060 Super
TU106 [GeForce RTX 2060 SUPER]
Nvidia TU106 2,253,110 218,418 10.32 2 hrs 20 mins
31 Tesla P100 16GB
GP100GL [Tesla P100 16GB] 9340
Nvidia GP100GL 2,240,483 218,631 10.25 2 hrs 21 mins
32 GeForce RTX 2070
TU106 [GeForce RTX 2070]
Nvidia TU106 2,227,499 216,073 10.31 2 hrs 20 mins
33 TITAN Xp
GP102 [TITAN Xp] 12150
Nvidia GP102 2,108,311 212,807 9.91 2 hrs 25 mins
34 GeForce RTX 3060
GA104 [GeForce RTX 3060]
Nvidia GA104 1,936,581 207,266 9.34 3 hrs 34 mins
35 GeForce RTX 3060
GA106 [GeForce RTX 3060]
Nvidia GA106 1,829,784 204,458 8.95 3 hrs 41 mins
36 GeForce GTX 1080 Ti
GP102 [GeForce GTX 1080 Ti] 11380
Nvidia GP102 1,798,639 197,056 9.13 3 hrs 38 mins
37 Quadro RTX 4000
TU104GL [Quadro RTX 4000]
Nvidia TU104GL 1,695,109 198,272 8.55 3 hrs 48 mins
38 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]
Nvidia GA106 1,680,124 195,366 8.60 3 hrs 47 mins
39 Radeon VII
Vega 20 [Radeon VII] 13,284
AMD Vega 20 1,578,278 186,665 8.46 3 hrs 50 mins
40 Radeon RX 6700/6700XT/6800M
Navi 22 XT-XL [Radeon RX 6700/6700XT/6800M]
AMD Navi 22 XT-XL 1,496,931 185,242 8.08 3 hrs 58 mins
41 GeForce RTX 2060
TU106 [Geforce RTX 2060]
Nvidia TU106 1,490,393 178,703 8.34 3 hrs 53 mins
42 GeForce RTX 2070 Mobile / Max-Q Refresh
TU106M [GeForce RTX 2070 Mobile / Max-Q Refresh]
Nvidia TU106M 1,439,094 190,919 7.54 3 hrs 11 mins
43 Radeon RX 6650XT
Navi 23 [Radeon RX 6650XT]
AMD Navi 23 1,404,903 186,346 7.54 3 hrs 11 mins
44 GeForce RTX 2060
TU104 [GeForce RTX 2060]
Nvidia TU104 1,396,035 199,790 6.99 3 hrs 26 mins
45 GeForce RTX 3060 Mobile / Max-Q
GA106M [GeForce RTX 3060 Mobile / Max-Q]
Nvidia GA106M 1,382,230 179,322 7.71 3 hrs 7 mins
46 Radeon RX 6650 XT
Navi 23 [Radeon RX 6650 XT]
AMD Navi 23 1,341,920 182,802 7.34 3 hrs 16 mins
47 RTX A2000
GA106 [RTX A2000]
GA106 1,326,660 183,195 7.24 3 hrs 19 mins
48 GeForce GTX Titan X
GM200 [GeForce GTX Titan X] 6144
Nvidia GM200 1,185,247 177,752 6.67 4 hrs 36 mins
49 GeForce GTX 980 Ti
GM200 [GeForce GTX 980 Ti] 5632
Nvidia GM200 1,154,633 175,991 6.56 4 hrs 39 mins
50 GeForce GTX 1070
GP104 [GeForce GTX 1070] 6463
Nvidia GP104 1,125,334 174,073 6.46 4 hrs 43 mins
51 GeForce RTX 2060 Mobile / Max-Q
TU106M [GeForce RTX 2060 Mobile / Max-Q]
Nvidia TU106M 1,104,312 168,967 6.54 4 hrs 40 mins
52 Radeon PRO W6600
Navi 23 WKS-XL [Radeon PRO W6600]
AMD Navi 23 WKS-XL 1,064,832 169,311 6.29 4 hrs 49 mins
53 GeForce GTX 1660 Ti
TU116 [GeForce GTX 1660 Ti]
Nvidia TU116 1,059,489 170,770 6.20 4 hrs 52 mins
54 GeForce GTX 1080
GP104 [GeForce GTX 1080] 8873
Nvidia GP104 1,051,814 169,742 6.20 4 hrs 52 mins
55 GeForce GTX 1660 SUPER
TU116 [GeForce GTX 1660 SUPER]
Nvidia TU116 1,028,453 167,484 6.14 4 hrs 55 mins
56 Radeon RX 6700/6700 XT/6750 XT / 6800M
Navi 22 [Radeon RX 6700/6700 XT/6750 XT / 6800M]
AMD Navi 22 1,011,208 161,391 6.27 4 hrs 50 mins
57 Radeon RX 6600/6600 XT/6600M
Navi 23 XT-XL [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 XT-XL 1,008,362 162,506 6.21 4 hrs 52 mins
58 GeForce RTX 3050 Ti Mobile
GA107M [GeForce RTX 3050 Ti Mobile]
Nvidia GA107M 1,008,034 167,422 6.02 4 hrs 59 mins
59 Radeon RX Vega 56/64
Vega 10 XL/XT [Radeon RX Vega 56/64]
AMD Vega 10 XL/XT 1,005,224 167,310 6.01 4 hrs 60 mins
60 Radeon RX 6600/6600 XT/6600M
Navi 23 [Radeon RX 6600/6600 XT/6600M]
AMD Navi 23 996,997 162,542 6.13 4 hrs 55 mins
61 Radeon 680M
Rembrandt [Radeon 680M]
AMD Rembrandt 993,735 93,391 10.64 2 hrs 15 mins
62 Geforce RTX 3050
GA106 [Geforce RTX 3050]
Nvidia GA106 942,086 165,169 5.70 4 hrs 12 mins
63 GeForce GTX 1070 Ti
GP104 [GeForce GTX 1070 Ti] 8186
Nvidia GP104 915,843 152,821 5.99 4 hrs 0 mins
64 Radeon Pro W5700
Navi 10 [Radeon Pro W5700]
AMD Navi 10 895,102 158,728 5.64 4 hrs 15 mins
65 GeForce RTX 2060 Mobile
TU106M [GeForce RTX 2060 Mobile]
Nvidia TU106M 886,822 143,045 6.20 4 hrs 52 mins
66 Radeon RX 5600 OEM/5600 XT/5700/5700 XT
Navi 10 [Radeon RX 5600 OEM/5600 XT/5700/5700 XT]
AMD Navi 10 877,870 163,209 5.38 4 hrs 28 mins
67 Quadro P4000
GP104GL [Quadro P4000]
Nvidia GP104GL 848,834 156,189 5.43 4 hrs 25 mins
68 Radeon VII
Vega 20 [Radeon VII]
AMD Vega 20 843,459 153,404 5.50 4 hrs 22 mins
69 Tesla M40
GM200GL [Tesla M40] 6844
Nvidia GM200GL 825,314 157,093 5.25 5 hrs 34 mins
70 RX 5600 OEM/5600XT/5700/5700XT
Navi 10 [RX 5600 OEM/5600XT/5700/5700XT]
Navi 10 756,065 150,960 5.01 5 hrs 48 mins
71 GeForce GTX 1660
TU116 [GeForce GTX 1660]
Nvidia TU116 730,429 150,494 4.85 5 hrs 57 mins
72 GeForce GTX 1660 Mobile
TU116M [GeForce GTX 1660 Mobile]
Nvidia TU116M 687,093 134,689 5.10 5 hrs 42 mins
73 GeForce GTX 1060 6GB
GP106 [GeForce GTX 1060 6GB] 4372
Nvidia GP106 685,714 146,269 4.69 5 hrs 7 mins
74 Tesla T4
TU104GL [Tesla T4]
Nvidia TU104GL 654,893 144,513 4.53 5 hrs 18 mins
75 P106-100
GP106 [P106-100]
Nvidia GP106 616,853 144,309 4.27 6 hrs 37 mins
76 GeForce GTX 980
GM204 [GeForce GTX 980] 4612
Nvidia GM204 612,409 139,852 4.38 5 hrs 29 mins
77 Tesla P4
GP104GL [Tesla P4] 5704
Nvidia GP104GL 583,426 137,822 4.23 6 hrs 40 mins
78 GeForce GTX 1060 3GB
GP106 [GeForce GTX 1060 3GB] 3935
Nvidia GP106 556,831 142,251 3.91 6 hrs 8 mins
79 GeForce GTX 1060 Mobile
GP106M [GeForce GTX 1060 Mobile]
Nvidia GP106M 528,536 134,529 3.93 6 hrs 7 mins
80 GeForce GTX 1650 SUPER
TU116 [GeForce GTX 1650 SUPER]
Nvidia TU116 526,112 133,498 3.94 6 hrs 5 mins
81 Quadro P2200
GP106GL [Quadro P2200]
Nvidia GP106GL 454,455 128,041 3.55 7 hrs 46 mins
82 RX 5500/5500M/Pro 5500M
Navi 14 [RX 5500/5500M/Pro 5500M]
Navi 14 451,016 127,526 3.54 7 hrs 47 mins
83 Radeon RX 5500/5500M / Pro 5500M
Navi 14 [Radeon RX 5500/5500M / Pro 5500M]
AMD Navi 14 443,025 127,040 3.49 7 hrs 53 mins
84 GeForce GTX 1650 Mobile / Max-Q
TU117M [GeForce GTX 1650 Mobile / Max-Q]
Nvidia TU117M 411,744 129,880 3.17 8 hrs 34 mins
85 RX 470/480/570/580/590
Ellesmere XT [RX 470/480/570/580/590]
Ellesmere XT 410,290 125,333 3.27 7 hrs 20 mins
86 GeForce GTX 1650
TU117 [GeForce GTX 1650]
Nvidia TU117 404,131 121,529 3.33 7 hrs 13 mins
87 Radeon RX 470/480/570/580/590
Ellesmere XT [Radeon RX 470/480/570/580/590]
AMD Ellesmere XT 362,585 121,714 2.98 8 hrs 3 mins
88 GeForce GTX 970
GM204 [GeForce GTX 970] 3494
Nvidia GM204 356,206 121,478 2.93 8 hrs 11 mins
89 GeForce GTX 980M
GM204 [GeForce GTX 980M] 3189
Nvidia GM204 343,026 114,428 3.00 8 hrs 0 mins
90 GeForce GTX 1050 Ti
GP107 [GeForce GTX 1050 Ti] 2138
Nvidia GP107 334,275 119,939 2.79 9 hrs 37 mins
91 P106-090
GP106 [P106-090]
Nvidia GP106 323,570 115,650 2.80 9 hrs 35 mins
92 Quadro T1000 Mobile
TU117GLM [Quadro T1000 Mobile]
Nvidia TU117GLM 276,246 107,760 2.56 9 hrs 22 mins
93 Quadro M4000
GM204GL [Quadro M4000]
Nvidia GM204GL 270,005 110,119 2.45 10 hrs 47 mins
94 GeForce GTX 960
GM206 [GeForce GTX 960] 2308
Nvidia GM206 252,459 104,742 2.41 10 hrs 57 mins
95 Radeon R9 M295X
Amethyst XT [Radeon R9 M295X]
AMD Amethyst XT 231,059 102,591 2.25 11 hrs 39 mins
96 GeForce GTX 950
GM206 [GeForce GTX 950] 1572
Nvidia GM206 213,141 100,826 2.11 11 hrs 21 mins
97 GeForce GTX 1050 LP
GP107 [GeForce GTX 1050 LP] 1862
Nvidia GP107 208,576 106,944 1.95 12 hrs 18 mins
98 R9 380X/R9 M295X
Tonga XT/Amethyst XT [R9 380X/R9 M295X]
AMD Tonga XT/Amethyst XT 200,313 96,949 2.07 12 hrs 37 mins
99 GeForce GTX 1050 Ti Mobile
GP107M [GeForce GTX 1050 Ti Mobile]
Nvidia GP107M 174,382 106,408 1.64 15 hrs 39 mins
100 Quadro P1000
GP107GL [Quadro P1000]
Nvidia GP107GL 172,734 91,824 1.88 13 hrs 45 mins
101 Radeon RX Vega M XL
[Radeon RX Vega M XL]
AMD Vega 169,319 92,211 1.84 13 hrs 4 mins
102 RX Vega M GL
Polaris 22 XL [RX Vega M GL]
Polaris 22 XL 168,498 92,225 1.83 13 hrs 8 mins
103 R9 280X/HD 7900/8970 OEM
Tahiti XT [R9 280X/HD 7900/8970 OEM]
Tahiti XT 166,490 90,470 1.84 13 hrs 2 mins
104 GeForce GTX 650 Ti
GK106 [GeForce GTX 650 Ti]
Nvidia GK106 146,381 55,859 2.62 9 hrs 10 mins
105 GeForce MX450
TU117M [GeForce MX450]
Nvidia TU117M 118,929 81,037 1.47 16 hrs 21 mins
106 Radeon RX 460
Baffin XT [Radeon RX 460]
AMD Baffin XT 115,557 79,748 1.45 17 hrs 34 mins
107 Quadro P620
GP107GL [Quadro P620]
Nvidia GP107GL 113,928 80,616 1.41 17 hrs 59 mins
108 GeForce GTX 750 Ti
GM107 [GeForce GTX 750 Ti] 1389
Nvidia GM107 110,931 84,919 1.31 18 hrs 22 mins
109 Quadro M2000
GM206GL [Quadro M2000]
Nvidia GM206GL 108,890 88,224 1.23 19 hrs 27 mins
110 GeForce GTX 1050 Mobile
GP107M [GeForce GTX 1050 Mobile]
Nvidia GP107M 102,837 77,771 1.32 18 hrs 9 mins
111 R7 370/R9 270X/370X
Curacao XT/Trinidad XT [R7 370/R9 270X/370X]
AMD Curacao XT/Trinidad XT 86,591 74,914 1.16 21 hrs 46 mins
112 GeForce GTX 660 Ti
GK104 [GeForce GTX 660 Ti] 2634
Nvidia GK104 79,343 74,306 1.07 22 hrs 29 mins
113 Quadro K2200
GM107GL [Quadro K2200]
Nvidia GM107GL 79,075 74,686 1.06 23 hrs 40 mins
114 Radeon R9 200 Series
Hawaii [Radeon R9 200 Series]
AMD Hawaii 76,451 71,303 1.07 22 hrs 23 mins
115 Quadro K1200
GM107GL [Quadro K1200]
Nvidia GM107GL 59,453 65,009 0.91 26 hrs 15 mins
116 GeForce GT 1030
GP108 [GeForce GT 1030]
Nvidia GP108 52,530 75,204 0.70 34 hrs 22 mins
117 Quadro K620
GM107GL [Quadro K620]
Nvidia GM107GL 48,216 61,415 0.79 31 hrs 34 mins
118 Vega Mobile 5000 series APU
Cezanne [Vega Mobile 5000 series APU]
AMD Cezanne 47,164 59,530 0.79 30 hrs 18 mins
119 GeForce GT 755M
GK107 [GeForce GT 755M]
Nvidia GK107 15,395 55,859 0.28 87 hrs 5 mins
120 Radeon PRO WX3100
Lexa XT [Radeon PRO WX3100]
AMD Lexa XT 14,146 55,859 0.25 95 hrs 46 mins
121 Radeon Vega Series / Radeon Vega Mobile Series
Picasso/Raven 2 [Radeon Vega Series / Radeon Vega Mobile Series]
AMD Picasso/Raven 2 9,358 55,859 0.17 143 hrs 16 mins

PROJECT FOLDING PPD AVERAGES BY CPU BETA

PPDDB data as of Wednesday, 30 November 2022 06:13:31

Rank
Project
CPU Model Logical
Processors (LP)
PPD-PLP
AVG PPD per 1 LP
ALL LP-PPD
(Estimated)
Make
1 RYZEN 9 3900X 12-CORE 24 199,587 4,790,088 AMD