Folding project #17418, COVID-19 research

Research section Research projects and references

Project #17418 overview

Project Summary AI Beta

This project studies the SARS-CoV-2 virus's key protein that makes copies of its genetic material. Scientists will use computer models to find areas on this protein where drugs could attach and block its activity. They'll also see how changes in the protein's code affect drug effectiveness.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 179,664
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-CoV2

Severe Acute Respiratory Syndrome Coronavirus 2

Virus: Biotechnology, MedicineInfectious Disease / Virology

SARS-CoV2 is a virus that causes COVID-19. It's a type of coronavirus known for its ability to spread quickly and cause severe respiratory illness.

nsp12

Non-structural protein 12

Protein: Biotechnology, MedicineMolecular Biology / Virology

NSP12 is a key protein in the SARS-CoV2 virus. It's an RNA polymerase, which means it helps the virus copy its genetic material.

Polymerase

An enzyme that synthesizes polymers from monomers.

Enzyme: Biotechnology, MedicineMolecular Biology / Genetics

Polymerases are biological machines that build long chains of molecules. In the case of RNA polymerase, it builds RNA chains using DNA as a template.

Drug Sensitivity

The degree to which a cell or organism responds to a drug.

Characteristic: Biotechnology, MedicinePharmacology / Treatment

Drug sensitivity describes how well a particular substance works against a target. A sensitive organism is easily affected by a drug, while a resistant one requires a higher dose for the same effect.

Mutations

Permanent alterations in the DNA sequence.

Genetic Change: Biotechnology, MedicineGenetics / Evolution

Mutations are changes in the genetic code. They can be small changes in a single letter or large-scale rearrangements of DNA. Mutations are the driving force behind evolution and can lead to new traits.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,363,759	226,091	28.15	0 ^hrs 51 ^mins
2	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,071,184	208,681	24.30	0 ^hrs 59 ^mins
3	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	5,000,486	211,232	23.67	1 ^hrs 1 ^mins
4	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	4,950,226	206,607	23.96	1 ^hrs 0 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,623,648	185,912	19.49	1 ^hrs 14 ^mins
6	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,891,087	172,526	16.76	1 ^hrs 26 ^mins
7	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,698,729	167,756	16.09	1 ^hrs 30 ^mins
8	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,615,030	166,698	15.69	1 ^hrs 32 ^mins
9	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,461,436	165,031	14.91	1 ^hrs 37 ^mins
10	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,455,780	167,698	14.64	1 ^hrs 38 ^mins
11	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,335,650	161,280	14.48	1 ^hrs 39 ^mins
12	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,141,527	156,764	13.66	1 ^hrs 45 ^mins
13	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,818,845	148,087	12.28	1 ^hrs 57 ^mins
14	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,698,203	143,173	11.86	2 ^hrs 1 ^mins
15	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,579,298	138,987	11.36	2 ^hrs 7 ^mins
16	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,358,508	133,451	10.18	2 ^hrs 21 ^mins
17	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,297,081	132,961	9.76	2 ^hrs 28 ^mins
18	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,251,672	131,839	9.49	2 ^hrs 32 ^mins
19	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,208,076	130,155	9.28	2 ^hrs 35 ^mins

20	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,117,774	125,597	8.90	2 ^hrs 42 ^mins
21	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,107,372	126,421	8.76	2 ^hrs 44 ^mins
22	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,102,645	125,445	8.79	2 ^hrs 44 ^mins
23	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	897,091	116,602	7.69	3 ^hrs 7 ^mins
24	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	819,786	112,719	7.27	3 ^hrs 18 ^mins
25	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	755,056	112,220	6.73	3 ^hrs 34 ^mins
26	P104-100 GP104 [P104-100]	Nvidia	GP104	695,625	108,338	6.42	3 ^hrs 44 ^mins
27	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	685,938	107,689	6.37	3 ^hrs 46 ^mins
28	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	671,217	106,858	6.28	3 ^hrs 49 ^mins
29	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	604,249	103,235	5.85	4 ^hrs 6 ^mins
30	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	526,280	80,008	6.58	3 ^hrs 39 ^mins
31	P106-100 GP106 [P106-100]	Nvidia	GP106	485,758	96,097	5.05	4 ^hrs 45 ^mins
32	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	454,651	93,591	4.86	4 ^hrs 56 ^mins
33	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	388,870	87,269	4.46	5 ^hrs 23 ^mins
34	P106-090 GP106 [P106-090]	Nvidia	GP106	324,533	83,868	3.87	6 ^hrs 12 ^mins
35	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	315,184	83,446	3.78	6 ^hrs 21 ^mins
36	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	270,718	79,095	3.42	7 ^hrs 1 ^mins
37	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	233,347	75,265	3.10	7 ^hrs 44 ^mins
38	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	207,372	70,778	2.93	8 ^hrs 11 ^mins
39	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	205,829	71,213	2.89	8 ^hrs 18 ^mins

40	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	123,696	60,944	2.03	11 ^hrs 49 ^mins
41	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	102,978	57,238	1.80	13 ^hrs 20 ^mins

Research: COVID-19 Folding Project #17418

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17418

GPU PPD Averages

Research: COVID-19 Folding Project #17418

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages