Folding project #17402, COVID-19 research

Research section Research projects and references

Project #17402 overview

Project Summary AI Beta

This project studies the SARS-Cov2 virus's copying machine (nsp12). Scientists want to find places on this machine where drugs could fit and block it, and also see how changes in the machine affect drug effectiveness.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 186,544
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

Scientific: Biotechnology, MedicineInfectious Disease / Virus

SARS-CoV-2 is the virus responsible for causing COVID-19. It is a type of coronavirus that primarily affects the respiratory system.

nsp12

Non-structural protein 12

Scientific: Biotechnology, MedicineInfectious Disease / Virus

NSP12 is a viral protein found in SARS-CoV-2. It plays a crucial role in replicating the virus's genetic material (RNA).

Polymerase

An enzyme that catalyzes the synthesis of nucleic acids.

Scientific: Biotechnology, MedicineBiology / Molecular Biology

Polymerase is a type of enzyme that helps build DNA and RNA molecules. In viruses like SARS-CoV-2, polymerase replicates their genetic material.

RNA-directed RNA polymerase

An enzyme that synthesizes RNA from an RNA template.

Scientific: Biotechnology, MedicineBiology / Molecular Biology

RNA-directed RNA polymerase is a specialized type of polymerase found in some viruses. It uses existing RNA to create new RNA copies, which are essential for viral replication.

Genome

The complete set of genetic material in an organism.

Scientific: Biotechnology, MedicineBiology / Genetics

A genome is like the instruction manual for a living thing. It contains all the genes that determine an organism's traits and characteristics.

Mutations

Permanent changes in the DNA sequence.

Scientific: Biotechnology, MedicineBiology / Genetics

Mutations are alterations in the genetic code. They can be caused by various factors and can lead to changes in an organism's traits.

Drug sensitivity

The ability of a microorganism or cell to respond to a drug.

Scientific: Biotechnology, MedicineMedicine / Pharmacology

Drug sensitivity refers to how well an organism responds to a particular medication. It's important for determining effective treatment strategies.

Pockets

Small cavities or depressions on the surface of a molecule.

Technical: Biotechnology, MedicineBiochemistry / Protein Structure

Pockets are often found on proteins and can serve as binding sites for other molecules, such as drugs.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,989,800	258,389	27.05	0 ^hrs 53 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	6,038,015	246,052	24.54	0 ^hrs 59 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,580,943	240,065	23.25	1 ^hrs 2 ^mins
4	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	5,350,055	237,947	22.48	1 ^hrs 4 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,690,281	208,486	17.70	1 ^hrs 21 ^mins
6	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	3,155,576	198,177	15.92	1 ^hrs 30 ^mins
7	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	3,084,846	197,131	15.65	1 ^hrs 32 ^mins
8	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,941,286	194,337	15.13	1 ^hrs 35 ^mins
9	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,499,127	182,057	13.73	1 ^hrs 45 ^mins
10	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,351,013	178,880	13.14	1 ^hrs 50 ^mins
11	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,331,234	179,754	12.97	1 ^hrs 51 ^mins
12	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,923,158	168,653	11.40	2 ^hrs 6 ^mins
13	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,796,036	163,759	10.97	2 ^hrs 11 ^mins
14	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,768,380	163,261	10.83	2 ^hrs 13 ^mins
15	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,639,727	160,441	10.22	2 ^hrs 21 ^mins
16	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,413,412	149,966	9.42	2 ^hrs 33 ^mins
17	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,326,611	149,083	8.90	2 ^hrs 42 ^mins
18	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,301,715	147,843	8.80	2 ^hrs 44 ^mins
19	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	1,296,786	147,923	8.77	2 ^hrs 44 ^mins

20	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,280,581	146,917	8.72	2 ^hrs 45 ^mins
21	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,218,573	141,526	8.61	2 ^hrs 47 ^mins
22	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,214,558	143,325	8.47	2 ^hrs 50 ^mins
23	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,062,995	137,454	7.73	3 ^hrs 6 ^mins
24	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	918,258	127,145	7.22	3 ^hrs 19 ^mins
25	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	854,259	128,724	6.64	3 ^hrs 37 ^mins
26	P104-100 GP104 [P104-100]	Nvidia	GP104	783,085	125,153	6.26	3 ^hrs 50 ^mins
27	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	741,550	119,562	6.20	3 ^hrs 52 ^mins
28	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	727,389	121,979	5.96	4 ^hrs 1 ^mins
29	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	644,255	117,070	5.50	4 ^hrs 22 ^mins
30	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	622,456	116,063	5.36	4 ^hrs 29 ^mins
31	P106-100 GP106 [P106-100]	Nvidia	GP106	543,529	110,765	4.91	4 ^hrs 53 ^mins
32	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	525,838	109,380	4.81	4 ^hrs 60 ^mins
33	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	447,723	103,859	4.31	5 ^hrs 34 ^mins
34	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	390,303	90,782	4.30	5 ^hrs 35 ^mins
35	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	386,672	100,248	3.86	6 ^hrs 13 ^mins
36	P106-090 GP106 [P106-090]	Nvidia	GP106	358,118	96,359	3.72	6 ^hrs 27 ^mins
37	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	259,101	86,846	2.98	8 ^hrs 3 ^mins
38	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	249,630	85,949	2.90	8 ^hrs 16 ^mins
39	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	226,970	79,689	2.85	8 ^hrs 26 ^mins

40	Radeon R9 280/HD 7900/8950 Tahiti PRO [Radeon R9 280/HD 7900/8950]	AMD	Tahiti PRO	204,621	80,049	2.56	9 ^hrs 23 ^mins
41	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	137,130	70,061	1.96	12 ^hrs 16 ^mins
42	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	55,972	51,931	1.08	22 ^hrs 16 ^mins
43	Radeon APU A4-6000 R2 Mullins [Radeon APU A4-6000 R2]	AMD	Mullins	3,188	26,000	0.12	195 ^hrs 44 ^mins

Research: COVID-19 Folding Project #17402

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17402

GPU PPD Averages

Research: COVID-19 Folding Project #17402

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages