Folding project #17404, COVID-19 research

Research section Research projects and references

Project #17404 overview

Project Summary AI Beta

This project studies the SARS-Cov2 virus's ability to copy its own genetic code. Scientists will use computer simulations to find weak spots on the virus protein that drugs could target, and see how changes in the virus affect drug effectiveness.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 204,149
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2.

Virus: Biotechnology, MedicineInfectious Disease / Viral Infection

SARS-CoV-2 is the virus responsible for causing COVID-19. It's a type of coronavirus that spreads through respiratory droplets and can cause severe respiratory illness.

nsp12

Non-structural protein 12

Protein: Biotechnology, MedicineInfectious Disease / Viral Replication

NSP12 is a viral protein found in coronaviruses like SARS-CoV-2. It's the enzyme responsible for copying the virus's genetic material (RNA) during infection.

polymerase

An enzyme that catalyzes the synthesis of polymers from monomers.

Enzyme: Biotechnology, MedicineMolecular Biology / Genetic Replication

Polymerases are essential enzymes that build long chains of molecules like DNA and RNA. They play a crucial role in processes like DNA replication and gene expression.

RNA-directed RNA polymerase

An enzyme that uses RNA as a template to synthesize new RNA molecules.

Enzyme: Biotechnology, MedicineMolecular Biology / Viral Replication

RNA-directed RNA polymerases are enzymes found in some viruses, including coronaviruses. They copy the virus's RNA genome during infection.

mutations

Changes in the DNA sequence of an organism.

Genetic Change: Biotechnology, MedicineGenetics / Evolutionary Biology

Mutations are alterations in the genetic code. They can be caused by various factors and can lead to changes in an organism's traits.

drug sensitivity

The ability of a cell or organism to respond to the effects of a drug.

Pharmacology: Biotechnology, PharmaceuticalMedicine / Drug Development

Drug sensitivity describes how responsive a particular cell, tissue, or organism is to a specific medication. Understanding this helps determine appropriate dosages and treatment strategies.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,310,384	264,202	23.88	1 ^hrs 0 ^mins
2	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,249,093	246,514	21.29	1 ^hrs 8 ^mins
3	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,567,169	237,817	19.20	1 ^hrs 15 ^mins
4	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	4,397,837	228,878	19.21	1 ^hrs 15 ^mins
5	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,546,962	217,173	16.33	1 ^hrs 28 ^mins
6	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,212,809	210,278	15.28	1 ^hrs 34 ^mins
7	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	3,057,824	208,810	14.64	1 ^hrs 38 ^mins
8	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,872,266	203,142	14.14	1 ^hrs 42 ^mins
9	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,865,123	202,084	14.18	1 ^hrs 42 ^mins
10	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,857,404	202,914	14.08	1 ^hrs 42 ^mins
11	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,806,914	202,758	13.84	1 ^hrs 44 ^mins
12	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,344,013	189,117	12.39	1 ^hrs 56 ^mins
13	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,233,108	185,403	12.04	1 ^hrs 60 ^mins
14	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,864,109	175,724	10.61	2 ^hrs 16 ^mins
15	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,734,430	171,387	10.12	2 ^hrs 22 ^mins
16	GeForce RTX 2060 Mobile TU106M [GeForce RTX 2060 Mobile] 4608	Nvidia	TU106M	1,699,949	171,175	9.93	2 ^hrs 25 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,672,314	169,491	9.87	2 ^hrs 26 ^mins
18	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,632,084	167,458	9.75	2 ^hrs 28 ^mins
19	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,381,853	159,399	8.67	2 ^hrs 46 ^mins

20	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,379,302	158,446	8.71	2 ^hrs 45 ^mins
21	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,363,943	159,249	8.56	2 ^hrs 48 ^mins
22	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,245,212	154,138	8.08	2 ^hrs 58 ^mins
23	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,094,107	146,941	7.45	3 ^hrs 13 ^mins
24	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,022,464	142,806	7.16	3 ^hrs 21 ^mins
25	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,005,350	142,823	7.04	3 ^hrs 25 ^mins
26	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	943,418	140,934	6.69	3 ^hrs 35 ^mins
27	P104-100 GP104 [P104-100]	Nvidia	GP104	738,922	129,565	5.70	4 ^hrs 12 ^mins
28	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	735,933	129,374	5.69	4 ^hrs 13 ^mins
29	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	722,031	127,397	5.67	4 ^hrs 14 ^mins
30	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	713,724	127,990	5.58	4 ^hrs 18 ^mins
31	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	693,738	126,492	5.48	4 ^hrs 23 ^mins
32	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	606,004	121,052	5.01	4 ^hrs 48 ^mins
33	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	564,326	112,444	5.02	4 ^hrs 47 ^mins
34	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	561,601	120,249	4.67	5 ^hrs 8 ^mins
35	P106-100 GP106 [P106-100]	Nvidia	GP106	499,667	113,520	4.40	5 ^hrs 27 ^mins
36	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	475,379	90,385	5.26	4 ^hrs 34 ^mins
37	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	445,658	107,652	4.14	5 ^hrs 48 ^mins
38	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	419,075	107,305	3.91	6 ^hrs 9 ^mins
39	Radeon RX 5500/5500M / Pro 5500M Navi 14 [Radeon RX 5500/5500M / Pro 5500M]	AMD	Navi 14	404,914	106,102	3.82	6 ^hrs 17 ^mins

40	P106-090 GP106 [P106-090]	Nvidia	GP106	341,274	100,168	3.41	7 ^hrs 3 ^mins
41	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	225,799	87,291	2.59	9 ^hrs 17 ^mins
42	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	213,804	83,039	2.57	9 ^hrs 19 ^mins
43	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	175,370	79,091	2.22	10 ^hrs 49 ^mins
44	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	124,197	71,185	1.74	13 ^hrs 45 ^mins
45	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	113,840	69,523	1.64	14 ^hrs 39 ^mins
46	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	53,019	53,842	0.98	24 ^hrs 22 ^mins

Research: COVID-19 Folding Project #17404

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17404

GPU PPD Averages

Research: COVID-19 Folding Project #17404

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages