Folding project #17400, COVID-19 research

Research section Research projects and references

Project #17400 overview

Project Summary AI Beta

This project looks at the SARS-Cov2 virus's ability to copy its genetic material. Researchers will try to find places on the virus protein that drugs could target and see how changes in the virus affect drug effectiveness.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 192,380
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2

Virus: BiotechnologyPathology / Infectious Disease

SARS-CoV-2 is a virus that causes COVID-19. It's a type of coronavirus that spreads through respiratory droplets from an infected person.

nsp12

Non-structural protein 12

Protein: Biotechnology, PharmacologyPathology / Molecular Biology

NSP12 is a viral protein crucial for replication. It's found in SARS-CoV-2 and acts as an RNA polymerase, copying the virus's genetic material.

Polymerase

An enzyme that synthesizes DNA or RNA from a template.

Enzyme: Biotechnology, PharmacologyPathology / Molecular Biology

Polymerases are essential for copying genetic material. In viruses like SARS-CoV-2, the polymerase helps create more copies of its own genome.

Drug

A substance used to treat or prevent disease.

Medication: Biotechnology, PharmaceuticalsPharmacology / Drug Discovery

Drugs are chemical compounds designed to interact with biological systems and have a specific therapeutic effect. The goal is to develop drugs that target diseases effectively.

Mutation

A permanent alteration in the DNA sequence.

Genetic Change: Biotechnology, GenomicsPathology / Genetics

Mutations are changes in the genetic code. They can arise spontaneously or be induced by environmental factors. Mutations can have various effects, including altering protein function and contributing to disease.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,354,875	250,052	25.41	0 ^hrs 57 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,686,193	241,875	23.51	1 ^hrs 1 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,076,180	232,002	21.88	1 ^hrs 6 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,863,177	211,931	18.23	1 ^hrs 19 ^mins
5	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,946,556	193,933	15.19	1 ^hrs 35 ^mins
6	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,888,822	192,606	15.00	1 ^hrs 36 ^mins
7	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,821,504	186,711	15.11	1 ^hrs 35 ^mins
8	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,533,670	184,663	13.72	1 ^hrs 45 ^mins
9	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,395,603	181,356	13.21	1 ^hrs 49 ^mins
10	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,318,781	178,734	12.97	1 ^hrs 51 ^mins
11	GeForce RTX 2080 SUPER Mobile / Max-Q TU104BM [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104BM	2,207,382	176,284	12.52	1 ^hrs 55 ^mins
12	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	2,160,583	135,036	16.00	1 ^hrs 30 ^mins
13	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,983,946	170,922	11.61	2 ^hrs 4 ^mins
14	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,801,951	164,516	10.95	2 ^hrs 11 ^mins
15	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,727,273	162,266	10.64	2 ^hrs 15 ^mins
16	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,715,132	160,699	10.67	2 ^hrs 15 ^mins
17	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,369,066	150,798	9.08	2 ^hrs 39 ^mins
18	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,262,097	146,428	8.62	2 ^hrs 47 ^mins
19	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,259,432	146,563	8.59	2 ^hrs 48 ^mins

20	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,207,410	143,013	8.44	2 ^hrs 51 ^mins
21	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,192,066	143,211	8.32	2 ^hrs 53 ^mins
22	Tesla T4 TU104GL [Tesla T4] 8141	Nvidia	TU104GL	1,105,807	138,814	7.97	3 ^hrs 1 ^mins
23	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,076,983	136,691	7.88	3 ^hrs 3 ^mins
24	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	1,071,750	139,007	7.71	3 ^hrs 7 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,029,873	136,544	7.54	3 ^hrs 11 ^mins
26	GeForce GTX 1660 Ti TU116 [GeForce GTX 1660 Ti]	Nvidia	TU116	1,027,979	134,389	7.65	3 ^hrs 8 ^mins
27	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	763,957	124,547	6.13	3 ^hrs 55 ^mins
28	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	745,452	120,195	6.20	3 ^hrs 52 ^mins
29	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	743,793	123,173	6.04	3 ^hrs 58 ^mins
30	P104-100 GP104 [P104-100]	Nvidia	GP104	743,194	123,000	6.04	3 ^hrs 58 ^mins
31	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	707,985	120,252	5.89	4 ^hrs 5 ^mins
32	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	651,393	116,246	5.60	4 ^hrs 17 ^mins
33	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	575,024	112,635	5.11	4 ^hrs 42 ^mins
34	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	529,924	57,272	9.25	2 ^hrs 36 ^mins
35	P106-100 GP106 [P106-100]	Nvidia	GP106	517,668	108,132	4.79	5 ^hrs 1 ^mins
36	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	494,702	106,804	4.63	5 ^hrs 11 ^mins
37	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	421,182	101,830	4.14	5 ^hrs 48 ^mins
38	P106-090 GP106 [P106-090]	Nvidia	GP106	339,146	93,916	3.61	6 ^hrs 39 ^mins
39	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	336,794	92,913	3.62	6 ^hrs 37 ^mins

40	GeForce GTX 1050 LP GP107 [GeForce GTX 1050 LP] 1862	Nvidia	GP107	328,492	93,529	3.51	6 ^hrs 50 ^mins
41	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	248,697	85,391	2.91	8 ^hrs 14 ^mins
42	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	220,157	79,844	2.76	8 ^hrs 42 ^mins
43	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	131,935	69,126	1.91	12 ^hrs 34 ^mins
44	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	110,118	26,000	4.24	5 ^hrs 40 ^mins

Research: COVID-19 Folding Project #17400

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17400

GPU PPD Averages

Research: COVID-19 Folding Project #17400

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages