Folding project #17406, COVID-19 research

Research section Research projects and references

Project #17406 overview

Project Summary AI Beta

This project studies the SARS-CoV-2 virus's ability to make copies of itself. Scientists are using computer simulations to find weak spots on the virus that drugs could target, and also to see how changes in the virus might affect its sensitivity to these drugs.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 202,598
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-CoV2

Severe Acute Respiratory Syndrome Coronavirus 2, the virus responsible for COVID-19.

Virus: Biotechnology, MedicineInfectious Disease / Viral Infection

SARS-CoV2 is a coronavirus that causes COVID-19. It spreads through respiratory droplets and can lead to severe illness, including pneumonia and death. Scientists are working on vaccines and treatments to combat this virus.

nsp12

Non-structural protein 12

Protein: Biotechnology, MedicineMolecular Biology / Viral Replication

NSP12 is a viral protein essential for the replication of SARS-CoV2. It acts as an RNA polymerase, copying the virus's genetic material to create new copies of the virus.

Polymerase

An enzyme that catalyzes the synthesis of DNA or RNA from a template.

Enzyme: Biotechnology, MedicineMolecular Biology / DNA/RNA Replication

Polymerases are crucial enzymes involved in copying DNA and RNA. They read existing genetic material and build new strands by adding complementary nucleotides.

RNA-directed RNA polymerase

An enzyme that synthesizes RNA from an RNA template.

Enzyme: Biotechnology, MedicineMolecular Biology / Viral Replication

RNA-directed RNA polymerases are essential for viruses like SARS-CoV2 to replicate. They create new copies of the viral RNA genome using the existing RNA as a template.

Genome

The complete set of DNA or RNA that constitutes the genetic material of an organism.

Genetic Material: Biotechnology, MedicineMolecular Biology / Genetics

A genome contains all the instructions needed to build and maintain an organism. It is made up of genes and other regulatory elements.

Infection

The invasion and multiplication of microorganisms such as bacteria, viruses, or fungi in a host organism.

Medical Condition: Medicine, Public HealthInfectious Disease / Pathology

Infection occurs when harmful microorganisms enter the body and start to multiply. This can lead to various symptoms and diseases.

Mutations

Permanent changes in the DNA sequence of an organism.

Genetic Change: Biotechnology, MedicineMolecular Biology / Genetics

Mutations are alterations in the genetic code. They can be caused by various factors, such as errors during DNA replication or exposure to radiation.

Drug Sensitivity

The degree to which a cell or organism responds to a drug.

Pharmacology: Biotechnology, PharmaceuticsMedicine / Drug Development

Drug sensitivity refers to how responsive a particular microorganism or cancer cell is to a specific medication. Understanding this can help doctors choose the most effective treatment.

Druggable Pockets

Regions on a protein's surface that can bind to drugs.

Pharmacology: Biotechnology, PharmaceuticsMedicine / Drug Development

Druggable pockets are specific sites on proteins where medications can attach and exert their effects. Identifying these pockets is crucial for designing new drugs.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,603,380	271,470	24.32	0 ^hrs 59 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,879,642	261,901	22.45	1 ^hrs 4 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,189,438	249,974	20.76	1 ^hrs 9 ^mins
4	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,820,845	225,851	16.92	1 ^hrs 25 ^mins
5	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	3,021,278	209,746	14.40	1 ^hrs 40 ^mins
6	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,964,877	208,264	14.24	1 ^hrs 41 ^mins
7	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	2,890,020	204,041	14.16	1 ^hrs 42 ^mins
8	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,865,036	203,298	14.09	1 ^hrs 42 ^mins
9	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,617,906	199,627	13.11	1 ^hrs 50 ^mins
10	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,414,323	193,823	12.46	1 ^hrs 56 ^mins
11	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,252,857	186,350	12.09	1 ^hrs 59 ^mins
12	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	2,041,368	183,512	11.12	2 ^hrs 9 ^mins
13	Quadro RTX 4000 TU104GL [Quadro RTX 4000]	Nvidia	TU104GL	1,974,817	182,256	10.84	2 ^hrs 13 ^mins
14	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,899,340	179,032	10.61	2 ^hrs 16 ^mins
15	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,816,522	173,352	10.48	2 ^hrs 17 ^mins
16	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,728,537	174,795	9.89	2 ^hrs 26 ^mins
17	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,698,153	171,114	9.92	2 ^hrs 25 ^mins
18	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,438,160	163,156	8.81	2 ^hrs 43 ^mins
19	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,421,798	163,416	8.70	2 ^hrs 46 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,418,533	163,174	8.69	2 ^hrs 46 ^mins
21	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,313,054	158,304	8.29	2 ^hrs 54 ^mins
22	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,220,674	155,079	7.87	3 ^hrs 3 ^mins
23	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,202,145	154,122	7.80	3 ^hrs 5 ^mins
24	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,048,214	145,488	7.20	3 ^hrs 20 ^mins
25	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	1,036,298	147,121	7.04	3 ^hrs 24 ^mins
26	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	905,673	138,675	6.53	3 ^hrs 40 ^mins
27	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	814,057	135,963	5.99	4 ^hrs 1 ^mins
28	P104-100 GP104 [P104-100]	Nvidia	GP104	765,105	132,875	5.76	4 ^hrs 10 ^mins
29	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	743,102	131,734	5.64	4 ^hrs 15 ^mins
30	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	707,112	129,515	5.46	4 ^hrs 24 ^mins
31	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	689,966	128,246	5.38	4 ^hrs 28 ^mins
32	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	581,677	121,477	4.79	5 ^hrs 1 ^mins
33	P106-100 GP106 [P106-100]	Nvidia	GP106	522,759	117,309	4.46	5 ^hrs 23 ^mins
34	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	510,740	114,042	4.48	5 ^hrs 22 ^mins
35	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	436,581	110,556	3.95	6 ^hrs 5 ^mins
36	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	427,040	108,015	3.95	6 ^hrs 4 ^mins
37	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	370,578	100,130	3.70	6 ^hrs 29 ^mins
38	P106-090 GP106 [P106-090]	Nvidia	GP106	350,389	102,568	3.42	7 ^hrs 2 ^mins
39	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	329,313	98,735	3.34	7 ^hrs 12 ^mins

40	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	275,762	94,408	2.92	8 ^hrs 13 ^mins
41	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	255,215	92,336	2.76	8 ^hrs 41 ^mins
42	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	213,131	86,965	2.45	9 ^hrs 48 ^mins
43	Quadro P620 GP107GL [Quadro P620]	Nvidia	GP107GL	158,309	78,713	2.01	11 ^hrs 56 ^mins
44	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	128,209	73,341	1.75	13 ^hrs 44 ^mins
45	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	117,986	71,318	1.65	14 ^hrs 30 ^mins
46	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	100,666	68,043	1.48	16 ^hrs 13 ^mins
47	GeForce GTX 760 GK104 [GeForce GTX 760] 2258	Nvidia	GK104	82,700	63,173	1.31	18 ^hrs 20 ^mins
48	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	55,452	55,388	1.00	23 ^hrs 58 ^mins
49	Ryzen 4900HS mobile Renoir [Ryzen 4900HS mobile]	AMD	Renoir	21,449	40,770	0.53	45 ^hrs 37 ^mins

Research: COVID-19 Folding Project #17406

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17406

GPU PPD Averages

Research: COVID-19 Folding Project #17406

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages