Folding project #17405, COVID-19 research

Research section Research projects and references

Project #17405 overview

Project Summary AI Beta

This project studies the SARS-CoV-2 virus's main copying tool (nsp12). Scientists want to find weak spots on this tool that drugs can target and see how changes in the tool affect drug effectiveness.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 202,600
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

Virus: Biotechnology, HealthcareInfectious Disease / Viral Infections

SARS-CoV-2 is the virus that causes COVID-19. It's a type of coronavirus that spreads easily from person to person through respiratory droplets. Symptoms can range from mild to severe and may include fever, cough, shortness of breath, fatigue, and loss of taste or smell.

nsp12

Non-structural protein 12

Protein: Biotechnology, PharmacologyMolecular Biology / Viral Replication

NSP12 is a key protein produced by SARS-CoV-2. It acts as an RNA polymerase, which means it's responsible for copying the virus's genetic material (RNA). This process is essential for viral replication and spreading.

Polymerase

An enzyme that catalyzes the formation of a polymer from monomers.

Enzyme: Biotechnology, MedicineMolecular Biology / DNA/RNA Synthesis

Polymerases are essential enzymes involved in building long chains of molecules like DNA and RNA. They play crucial roles in processes like DNA replication, transcription (making RNA from DNA), and translation (making proteins from RNA).

Genome

The complete set of genetic information in an organism.

Genetic Material: Biotechnology, MedicineMolecular Biology / Genetics

A genome is the entire collection of DNA within an organism. It contains all the instructions needed to build and maintain that organism. The genome can be thought of as a blueprint for life.

Drug Sensitivity

A measure of how responsive a cell or organism is to the effects of a drug.

Phenomenon: Biotechnology, MedicinePharmacology / Drug Resistance

Drug sensitivity refers to how much of a specific drug is needed to produce a desired effect. Some cells or organisms are more sensitive than others, meaning they respond to lower doses of medication.

Mutations

Permanent alterations in the DNA sequence.

Genetic Change: Biotechnology, MedicineGenetics / Molecular Biology

Mutations are changes that occur in an organism's DNA sequence. They can be caused by various factors like radiation or errors during DNA replication. Mutations can have a range of effects, from being harmless to causing disease.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,116,335	256,821	23.82	1 ^hrs 0 ^mins
2	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	5,261,381	244,689	21.50	1 ^hrs 7 ^mins
3	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,007,583	237,518	21.08	1 ^hrs 8 ^mins
4	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	4,931,497	238,651	20.66	1 ^hrs 10 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	3,772,954	217,786	17.32	1 ^hrs 23 ^mins
6	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,436,385	209,802	16.38	1 ^hrs 28 ^mins
7	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,963,228	201,100	14.74	1 ^hrs 38 ^mins
8	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,958,666	200,854	14.73	1 ^hrs 38 ^mins
9	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,757,071	195,786	14.08	1 ^hrs 42 ^mins
10	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,434,768	188,877	12.89	1 ^hrs 52 ^mins
11	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,311,709	184,631	12.52	1 ^hrs 55 ^mins
12	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,207,160	182,210	12.11	1 ^hrs 59 ^mins
13	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,934,157	174,607	11.08	2 ^hrs 10 ^mins
14	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,755,854	169,318	10.37	2 ^hrs 19 ^mins
15	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,657,234	165,043	10.04	2 ^hrs 23 ^mins
16	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,649,274	166,013	9.93	2 ^hrs 25 ^mins
17	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,589,766	160,219	9.92	2 ^hrs 25 ^mins
18	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,367,964	154,913	8.83	2 ^hrs 43 ^mins
19	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,362,043	155,920	8.74	2 ^hrs 45 ^mins

20	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,257,132	151,344	8.31	2 ^hrs 53 ^mins
21	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,250,297	151,143	8.27	2 ^hrs 54 ^mins
22	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,186,871	148,877	7.97	3 ^hrs 1 ^mins
23	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	999,982	139,681	7.16	3 ^hrs 21 ^mins
24	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	958,955	63,264	15.16	1 ^hrs 35 ^mins
25	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	921,351	128,970	7.14	3 ^hrs 22 ^mins
26	GeForce GTX 1660 TU116 [GeForce GTX 1660]	Nvidia	TU116	907,805	134,643	6.74	3 ^hrs 34 ^mins
27	Quadro P4200 Mobile GP104GLM [Quadro P4200 Mobile]	Nvidia	GP104GLM	853,829	132,147	6.46	3 ^hrs 43 ^mins
28	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	790,109	129,901	6.08	3 ^hrs 57 ^mins
29	P104-100 GP104 [P104-100]	Nvidia	GP104	724,967	126,364	5.74	4 ^hrs 11 ^mins
30	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	673,027	121,630	5.53	4 ^hrs 20 ^mins
31	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	602,136	117,526	5.12	4 ^hrs 41 ^mins
32	Radeon R9 Fury X Fiji XT [Radeon R9 Fury X]	AMD	Fiji XT	596,560	118,675	5.03	4 ^hrs 46 ^mins
33	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	535,880	115,363	4.65	5 ^hrs 10 ^mins
34	P106-100 GP106 [P106-100]	Nvidia	GP106	492,458	110,952	4.44	5 ^hrs 24 ^mins
35	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	485,512	110,410	4.40	5 ^hrs 27 ^mins
36	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	414,333	104,801	3.95	6 ^hrs 4 ^mins
37	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	412,329	104,332	3.95	6 ^hrs 4 ^mins
38	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	383,896	101,990	3.76	6 ^hrs 23 ^mins
39	P106-090 GP106 [P106-090]	Nvidia	GP106	336,044	97,798	3.44	6 ^hrs 59 ^mins

40	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	315,726	96,104	3.29	7 ^hrs 18 ^mins
41	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	276,897	90,824	3.05	7 ^hrs 52 ^mins
42	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	208,627	80,492	2.59	9 ^hrs 16 ^mins
43	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	189,163	79,698	2.37	10 ^hrs 7 ^mins
44	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	112,774	68,085	1.66	14 ^hrs 29 ^mins
45	GeForce GT 1030 GP108 [GeForce GT 1030] 1127	Nvidia	GP108	112,563	68,137	1.65	14 ^hrs 32 ^mins
46	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	104,533	66,279	1.58	15 ^hrs 13 ^mins
47	Radeon HD 7800 Series Pitcairn PRO [Radeon HD 7800 Series]	AMD	Pitcairn PRO	87,697	62,712	1.40	17 ^hrs 10 ^mins
48	Radeon R7 Kaveri [Radeon R7]	AMD	Kaveri	14,320	27,782	0.52	46 ^hrs 34 ^mins

Research: COVID-19 Folding Project #17405

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17405

GPU PPD Averages

Research: COVID-19 Folding Project #17405

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages