Folding project #17417, COVID-19 research

Research section Research projects and references

Project #17417 overview

Project Summary AI Beta

This project looks at the virus part that makes copies of itself. Scientists want to find places on this part where drugs could attach and stop the virus, and see how changes in the virus affect how well drugs work.

Automated summary; simplified and may not be fully accurate.

Project team

Manager(s): Artur Meller
Institution: Washington University in St. Louis

Work unit

Atoms: 186,538
Core: OPENMM_22
Status: Public

Source material

Official Project Description

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

Reading reference

Related Terms Glossary AI Beta

Automated high-level definitions; simplified and may not be fully accurate.

SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

Virus: Biotechnology, MedicineInfectious Disease / Viral Infection

SARS-CoV-2 is the virus that causes COVID-19. It's a type of coronavirus that spreads through respiratory droplets and can lead to severe respiratory illness.

nsp12

Non-structural protein 12

Protein: Biotechnology, MedicineMolecular Biology / Viral Replication

NSP12 is a viral protein essential for replicating the SARS-CoV-2 genome. It acts as an RNA-dependent RNA polymerase, copying the virus's genetic material.

polymerase

An enzyme that catalyzes the formation of polymers (like DNA or RNA) from monomers.

Enzyme: Biotechnology, MedicineMolecular Biology / DNA/RNA Replication

Polymerases are crucial enzymes that build long chains of molecules like DNA and RNA. They play a vital role in processes like gene expression and replication.

druggable pockets

Regions on a protein's surface that can be targeted by drugs.

Pharmacological Target: Biotechnology, PharmaceuticalDrug Discovery / Target Identification

Druggable pockets are specific sites on proteins where drugs can bind and exert their effects. Scientists aim to identify these pockets for developing new therapies.

mutations

Permanent alterations in the DNA sequence.

Genetic Change: Biotechnology, MedicineGenetics / Disease Mechanism

Mutations are changes in the genetic code. They can be harmless or lead to disease by altering protein function.

drug sensitivity

A cell's or organism's susceptibility to the effects of a drug.

Pharmacological Response: Biotechnology, PharmaceuticalDrug Development / Clinical Pharmacology

Drug sensitivity refers to how effectively a drug works on a particular target. Understanding this helps in tailoring treatments for individual patients.

GPU PPD Averages

Rank Project	Model Name Folding@Home Identifier	Make Brand	GPU Model	PPD Average	Points WU Average	WUs Day Average	WU Time Average
1	GeForce RTX 3090 GA102 [GeForce RTX 3090]	Nvidia	GA102	6,902,400	247,059	27.94	0 ^hrs 52 ^mins
2	GeForce RTX 3080 10GB / 20GB GA102 [GeForce RTX 3080 10GB / 20GB]	Nvidia	GA102	5,568,101	230,525	24.15	0 ^hrs 60 ^mins
3	GeForce RTX 2080 Ti Rev. A TU102 [GeForce RTX 2080 Ti Rev. A] M 13448	Nvidia	TU102	5,427,372	228,509	23.75	1 ^hrs 1 ^mins
4	TITAN RTX TU102 [TITAN RTX] 16310	Nvidia	TU102	4,974,636	219,207	22.69	1 ^hrs 3 ^mins
5	GeForce RTX 2080 Ti TU102 [GeForce RTX 2080 Ti] M 13448	Nvidia	TU102	4,270,336	209,575	20.38	1 ^hrs 11 ^mins
6	Quadro RTX 6000/8000 TU102GL [Quadro RTX 6000/8000]	Nvidia	TU102GL	3,362,670	195,604	17.19	1 ^hrs 24 ^mins
7	GeForce RTX 2080 Super TU104 [GeForce RTX 2080 SUPER]	Nvidia	TU104	2,919,159	185,905	15.70	1 ^hrs 32 ^mins
8	GeForce RTX 2080 TU104 [GeForce RTX 2080]	Nvidia	TU104	2,839,976	183,715	15.46	1 ^hrs 33 ^mins
9	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER] 8218	Nvidia	TU104	2,671,299	179,319	14.90	1 ^hrs 37 ^mins
10	GeForce RTX 2070 Rev. A TU106 [GeForce RTX 2070 Rev. A] M 7465	Nvidia	TU106	2,600,660	179,779	14.47	1 ^hrs 40 ^mins
11	GeForce RTX 2070 SUPER TU104 [GeForce RTX 2070 SUPER]	Nvidia	TU104	2,425,301	168,424	14.40	1 ^hrs 40 ^mins
12	GeForce GTX 1080 Ti GP102 [GeForce GTX 1080 Ti] 11380	Nvidia	GP102	2,398,219	173,997	13.78	1 ^hrs 44 ^mins
13	GeForce RTX 2060 Super TU106 [GeForce RTX 2060 SUPER]	Nvidia	TU106	2,287,022	171,178	13.36	1 ^hrs 48 ^mins
14	GeForce RTX 2080 Rev. A TU104 [GeForce RTX 2080 Rev. A] 10068	Nvidia	TU104	1,974,011	127,297	15.51	1 ^hrs 33 ^mins
15	GeForce RTX 2060 TU106 [Geforce RTX 2060]	Nvidia	TU106	1,944,816	161,693	12.03	1 ^hrs 60 ^mins
16	GeForce RTX 2080 SUPER Mobile / Max-Q TU104M [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104M	1,916,296	161,542	11.86	2 ^hrs 1 ^mins
17	GeForce RTX 2070 TU106 [GeForce RTX 2070] M 6497	Nvidia	TU106	1,903,849	158,560	12.01	1 ^hrs 60 ^mins
18	GeForce RTX 2060 TU104 [GeForce RTX 2060]	Nvidia	TU104	1,796,119	157,410	11.41	2 ^hrs 6 ^mins
19	GeForce RTX 2080 SUPER Mobile / Max-Q TU104BM [GeForce RTX 2080 SUPER Mobile / Max-Q]	Nvidia	TU104BM	1,766,597	157,440	11.22	2 ^hrs 8 ^mins

20	Radeon VII Vega 20 [Radeon VII] 13,284	AMD	Vega 20	1,702,741	155,185	10.97	2 ^hrs 11 ^mins
21	GeForce GTX Titan X GM200 [GeForce GTX Titan X] 6144	Nvidia	GM200	1,344,923	143,822	9.35	2 ^hrs 34 ^mins
22	GeForce GTX 1080 GP104 [GeForce GTX 1080] 8873	Nvidia	GP104	1,339,450	142,705	9.39	2 ^hrs 33 ^mins
23	GeForce GTX 1070 Ti GP104 [GeForce GTX 1070 Ti] 8186	Nvidia	GP104	1,309,621	142,688	9.18	2 ^hrs 37 ^mins
24	GeForce GTX 1660 SUPER TU116 [GeForce GTX 1660 SUPER]	Nvidia	TU116	1,223,353	139,590	8.76	2 ^hrs 44 ^mins
25	Tesla T4 TU104GL [Tesla T4] 8141	Nvidia	TU104GL	1,222,704	138,637	8.82	2 ^hrs 43 ^mins
26	GeForce GTX 1070 GP104 [GeForce GTX 1070] 6463	Nvidia	GP104	1,191,752	137,294	8.68	2 ^hrs 46 ^mins
27	Radeon RX Vega 56/64 Vega 10 XL/XT [Radeon RX Vega 56/64]	AMD	Vega 10 XL/XT	1,153,616	136,216	8.47	2 ^hrs 50 ^mins
28	GeForce GTX 980 Ti GM200 [GeForce GTX 980 Ti] 5632	Nvidia	GM200	1,063,117	129,288	8.22	2 ^hrs 55 ^mins
29	Quadro P4200 Mobile GP104GLM [Quadro P4200 Mobile]	Nvidia	GP104GLM	941,896	126,589	7.44	3 ^hrs 14 ^mins
30	GeForce GTX 1060 6GB GP106 [GeForce GTX 1060 6GB] 4372	Nvidia	GP106	797,789	121,216	6.58	3 ^hrs 39 ^mins
31	GeForce GTX 980 GM204 [GeForce GTX 980] 4612	Nvidia	GM204	766,621	119,681	6.41	3 ^hrs 45 ^mins
32	Radeon RX 5600/5600 XT - 5700/5700 XT Navi 10 [Radeon RX 5600 OEM/5600 XT / 5700/5700 XT]	AMD	Navi 10	760,993	116,768	6.52	3 ^hrs 41 ^mins
33	GeForce GTX 1060 3GB GP106 [GeForce GTX 1060 3GB] 3935	Nvidia	GP106	737,127	118,046	6.24	3 ^hrs 51 ^mins
34	P104-100 GP104 [P104-100]	Nvidia	GP104	728,450	117,505	6.20	3 ^hrs 52 ^mins
35	GeForce GTX 970 GM204 [GeForce GTX 970] 3494	Nvidia	GM204	665,538	111,944	5.95	4 ^hrs 2 ^mins
36	GeForce GTX 1650 Ti Mobile TU116M [GeForce GTX 1650 Ti Mobile]	Nvidia	TU116M	631,424	112,545	5.61	4 ^hrs 17 ^mins
37	GeForce GTX 1650 SUPER TU116 [GeForce GTX 1650 SUPER]	Nvidia	TU116	628,196	112,073	5.61	4 ^hrs 17 ^mins
38	GeForce GTX 1650 TU116 [GeForce GTX 1650] 2984	Nvidia	TU116	526,505	105,244	5.00	4 ^hrs 48 ^mins
39	P106-100 GP106 [P106-100]	Nvidia	GP106	515,787	104,707	4.93	4 ^hrs 52 ^mins

40	Quadro P2200 GP106GL [Quadro P2200]	Nvidia	GP106GL	472,707	101,763	4.65	5 ^hrs 10 ^mins
41	Radeon R9 200/300 Series Hawaii [Radeon R9 200/300 Series]	AMD	Hawaii	436,116	89,556	4.87	4 ^hrs 56 ^mins
42	Radeon RX 470/480/570/580/590 Ellesmere XT [Radeon RX 470/480/570/580/590]	AMD	Ellesmere XT	434,215	98,607	4.40	5 ^hrs 27 ^mins
43	GeForce GTX 1050 Ti GP107 [GeForce GTX 1050 Ti] 2138	Nvidia	GP107	417,008	97,563	4.27	5 ^hrs 37 ^mins
44	GeForce GTX 1050 Ti Mobile GP107M [GeForce GTX 1050 Ti Mobile]	Nvidia	GP107M	374,193	87,874	4.26	5 ^hrs 38 ^mins
45	Quadro T1000 Mobile TU117GLM [Quadro T1000 Mobile]	Nvidia	TU117GLM	362,655	93,522	3.88	6 ^hrs 11 ^mins
46	P106-090 GP106 [P106-090]	Nvidia	GP106	329,492	90,109	3.66	6 ^hrs 34 ^mins
47	Radeon R9 200/300X Series Hawaii [Radeon R9 200/300X Series]	AMD	Hawaii	325,776	90,493	3.60	6 ^hrs 40 ^mins
48	GeForce GTX 960 GM206 [GeForce GTX 960] 2308	Nvidia	GM206	325,119	90,084	3.61	6 ^hrs 39 ^mins
49	GeForce GTX 680 GK104 [GeForce GTX 680] 3250	Nvidia	GK104	242,982	81,495	2.98	8 ^hrs 3 ^mins
50	GeForce GTX 770 GK104 [GeForce GTX 770] 3213	Nvidia	GK104	238,682	66,420	3.59	6 ^hrs 41 ^mins
51	GeForce GTX 660 Ti GK104 [GeForce GTX 660 Ti] 2634	Nvidia	GK104	207,776	77,375	2.69	8 ^hrs 56 ^mins
52	Radeon HD 7800 Pitcairn [Radeon HD 7800]	AMD	Pitcairn	127,869	65,479	1.95	12 ^hrs 17 ^mins
53	GeForce GTX 670MX GK106 [GeForce GTX 670MX]	Nvidia	GK106	106,667	61,938	1.72	13 ^hrs 56 ^mins
54	Quadro P400 GP107GL [Quadro P400] 641	Nvidia	GP107GL	52,643	48,926	1.08	22 ^hrs 18 ^mins

Research: COVID-19 Folding Project #17417

Project Summary AI Beta

Project team

Work unit

Official Project Description

Hardware Performance for Project 17417

GPU PPD Averages

Research: COVID-19 Folding Project #17417

Project Summary AI Beta

Project team

Work unit

Related projects

GPU PPD Averages