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Research: CANNABINOID Folding Project #19004

Project #19004 overview

Project Summary AI Beta

Our project investigates how the body's natural chemicals (endocannabinoids) interact with specific receptors (CB1 and CB2). These receptors play a role in pain, appetite, and brain function. We're using computer simulations to study how anandamide, a type of endocannabinoid, binds to these receptors differently. This will help us understand how to develop new medicines that target these receptors more effectively.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Soumajit Dutta
Institution
University of Illinois Urbana-Champaign

Work unit

Atoms
103,284
Core
0xa8
Status
Public
Source material

Official Project Description

Cannabinoid Receptors The endocannabinoid signaling system consists of receptors (Cannabinoid Receptors; CB1 and CB2), endogeneous molecules (Endocannabinoids; 2-AG, Anandamide), and enzymes.

Endocannabinoids are produced in postsynaptic neurons and bind to Cannabinoid Receptors to maintain homeostasis in neuron signaling and a plethora of physiological processes.

These receptors are targeted for pain, obesity, and other central nervous system disorders.

Endocannabinoids show more than 10-fold selectivity towards CB1 compared to CB2.

Therefore, a mechanistic understanding of endocannabinoid selectivity will help us design selective therapeutics.

In this project, we are running binding simulation of anandmide to CB1 and CB2 to decipher ligand selectivity.

Performance data

Hardware Performance for Project 19004

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Sunday, 02 August 2026 21:49:42

CPU PPD Averages Beta

Rank
Project 		CPU Model Logical
Processors (LP) 		PPD-PLP
AVG PPD per 1 LP 		ALL LP-PPD
(Estimated) 		Make
1 RYZEN 9 7950X 16-CORE 32 32,675 1,045,600 AMD
2 12TH GEN CORE I9-12900K 24 29,808 715,392 Intel
3 RYZEN 7 5700G 16 41,513 664,208 AMD
4 RYZEN 9 7900 12-CORE 24 27,204 652,896 AMD
5 RYZEN 9 5900X 12-CORE 24 20,500 492,000 AMD
6 RYZEN 9 5950X 16-CORE 32 14,646 468,672 AMD
7 RYZEN 7 7700X 8-CORE 16 28,440 455,040 AMD
8 13TH GEN CORE I9-13900K 32 13,778 440,896 Intel
9 12TH GEN CORE I7-12700K 20 21,695 433,900 Intel
10 12TH GEN CORE I7-12700F 20 19,477 389,540 Intel
11 RYZEN 7 5800X 8-CORE 16 24,143 386,288 AMD
12 RYZEN 7 5700X 8-CORE 16 23,418 374,688 AMD
13 RYZEN 7 5800X3D 8-CORE 16 22,481 359,696 AMD
14 11TH GEN CORE I7-11700K @ 3.60GHZ 16 20,194 323,104 Intel
15 12TH GEN CORE I5-12600K 16 19,315 309,040 Intel
16 RYZEN 7 3800X 8-CORE 16 18,978 303,648 AMD
17 CORE I7-10700K CPU @ 3.80GHZ 16 15,578 249,248 Intel
18 XEON CPU E5-2680 V2 @ 2.80GHZ 40 6,033 241,320 Intel
19 RYZEN 5 5600X 6-CORE 12 19,209 230,508 AMD
20 RYZEN 5 5600 6-CORE 12 16,683 200,196 AMD
21 RYZEN 5 3500 6-CORE 6 30,878 185,268 AMD
22 RYZEN 5 3600 6-CORE 12 15,120 181,440 AMD
23 13TH GEN CORE I7-13700 24 6,591 158,184 Intel
24 XEON CPU E5-2697 V2 @ 2.70GHZ 24 6,437 154,488 Intel
25 RYZEN 7 3700X 8-CORE 16 7,486 119,776 AMD
26 CORE I7-5930K CPU @ 3.50GHZ 12 9,104 109,248 Intel
27 CORE I7-5820K CPU @ 3.30GHZ 12 8,696 104,352 Intel
28 CORE I7-7700K CPU @ 4.20GHZ 8 11,398 91,184 Intel
29 CORE I9-8950HK CPU @ 2.90GHZ 12 6,196 74,352 Intel
30 CORE I7-8705G CPU @ 3.10GHZ 8 8,131 65,048 Intel
31 XEON CPU L5640 @ 2.27GHZ 24 2,627 63,048 Intel
32 CORE I7-6700K CPU @ 4.00GHZ 8 7,664 61,312 Intel
33 XEON CPU E3-1245 V3 @ 3.40GHZ 8 6,794 54,352 Intel
34 CORE I5-8400 CPU @ 2.80GHZ 6 7,931 47,586 Intel
35 CORE I5-4590 CPU @ 3.30GHZ 4 11,852 47,408 Intel
36 CORE I5-7400 CPU @ 3.00GHZ 4 11,606 46,424 Intel
37 CORE I7-4770HQ CPU @ 2.20GHZ 8 5,733 45,864 Intel
38 RYZEN 9 3900X 12-CORE 24 726 17,424 AMD